Showing 1 – 19 of 19
SORT:
VIEW: Basic | Expanded
  • ARVO Annual Meeting Abstract April 2011

    Rita Maccarone; Linda Colecchi; Fabiana Di Marco; Lavinia Fiorani; Benedetto Falsini; Silvia Bisti

    Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5456. doi:

  • Investigative Ophthalmology & Visual Science >
    Figure 1. Left : Representative fERG functions, recorded from AMD patient 22 ( Table 1 ) at baseline and after 90 days of saffron or placebo supplementation, are shown in plots of response amplitudes as a function of modulation depth. Arrows : fERG modulation thresholds determined for each fERG function. Right : a color fundus photograph from the study eye, showing confluent soft drusen in the foveal region.
  • Investigative Ophthalmology & Visual Science >
    Figure 2. ( A ) Mean (±SEM) fERG log amplitudes recorded in patients at baseline and after saffron or placebo supplementation, are plotted as a function of log modulation depth. Data at the lowest modulation have been omitted from the plot, since there were too few data points at baseline to allow a suitable comparison of the group means. ( B ) fERG slopes and thresholds recorded at baseline and after saffron or placebo supplementation are shown as box plots. In each box, the symbol is the mean, the box indicates the median and interquartile range, and the bars the 99 percentiles.
  • Investigative Ophthalmology & Visual Science >
    Figure 3. Mean fERG phases (±SEM), recorded from patients at baseline and after saffron or placebo supplementation, are plotted as a function of modulation depth.
  • Investigative Ophthalmology & Visual Science >
    Figure 4. Individual fERG log amplitudes at the various modulation depths, recorded from all patients at baseline and after saffron or placebo supplementation. Each symbol indicates an individual patient.
  • Investigative Ophthalmology & Visual Science >
    In recent work, Maccarone et al. 27 provided evidence of the neuroprotective potential of saffron treatment in albino rats, in which an artificial induction of apoptosis was obtained in photoreceptors by exposure to high-intensity light. Cell death was thought to have resulted from oxidative stress induced by prolonged increase in oxygen tension and photo-oxidation. Saffron extracted from the stigmata of Crocus sativus contains high concentrations of two major compounds, crocin and crocetin, 34 whose multiple C C bonds confer the stigmata color, fragrance, taste, and antioxidant potential. 35 – 37 Crocin and crocetin, the carotenoid derivatives, may act through a protective mechanism similar to that seen with carotenoid supplementation. 20 , 21 , 23 It has been recently reported 34 that crocins are able to activate metabolic pathways to protect cells from apoptosis and to reduce light-induced death in isolated photoreceptors, 35 , 36 whereas crocetin 34 increases oxygen diffusivity through liquids, such as plasma. Kanakis et al. 37 showed that metabolites of antioxidant flavonoids bind directly to DNA and induce its partial conformation to β-DNA, thereby protecting the cell from damage. These components have the potential of acting in humans as protective agents against oxidative damage for the aging and AMD retinas, whose disease pathophysiology has been linked (see, for example, Ref. 38 ) to light-induced oxidative damage to the outer retina.