Nanotechnology and Regenerative Medicine

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Anatomy and Pathology/Oncology October 2017

Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics

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Rachel E. Doherty; Karen Sisley; David W. Hammond; Ian G. Rennie; Neil A. Cross
TAGS: phenotype, aldehyde dehydrogenases, stem cells, cd44 antigens, cell line, neoplasms, homing-associated cell adhesion molecule, intraocular melanoma, cancer stem cells
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5387-5395. doi: 10.1167/iovs.17-22272

Includes: Supplemental Content

Biochemistry and Molecular Biology October 2017

A PPAR-Gamma Agonist Rosiglitazone Suppresses Fibrotic Response in Human Pterygium Fibroblasts by Modulating the p38 MAPK Pathway

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Selikem Abla Nuwormegbe; Joon Hyung Sohn; Sun Woong Kim
TAGS: rosiglitazone, fibroblast, pterygium, peroxisome proliferator-activated receptors, agonists, mitogen-activated protein kinase p38
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5217-5226. doi: 10.1167/iovs.17-22203

Includes: Supplemental Content

Physiology and Pharmacology October 2017

Sustaining Intravitreal Residence With L-Arginine Peptide-Conjugated Nanocarriers

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Hao Li; Wenzhong Liu; Christine M. Sorenson; Nader Sheibani; Daniel M. Albert; Thulani Senanayake; Serguei Vinogradov; Jack Henkin; Hao F. Zhang
TAGS: half-life, arginine, diffusion, fluorescence, injection of therapeutic agent, peptides, vitreous body, nanoparticles, drug release
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5142-5150. doi: 10.1167/iovs.17-22160

Includes: Supplemental Content

Cornea September 2017

Corneal Epithelium-Derived Neurotrophic Factors Promote Nerve Regeneration

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Guohu Di; Xia Qi; Xiaowen Zhao; Songmei Zhang; Patrik Danielson; Qingjun Zhou
TAGS: diabetes mellitus, epithelium, corneal epithelium, cornea, mice, glial cell-line derived neurotrophic factor, nerve regeneration, nerve growth factors
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4695-4702. doi: 10.1167/iovs.16-21372

Includes: Supplemental Content

Cornea September 2017

Allogeneic Descemet's Membrane Transplantation Enhances Corneal Endothelial Monolayer Formation and Restores Functional Integrity Following Descemet's Stripping

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Maninder Bhogal; Chan N. Lwin; Xin-Yi Seah; Gary Peh; Jodhbir S. Mehta
TAGS: endothelial dysfunction, endothelial cells, descemet's membrane, endothelium, fluorescent antibody technique, wound healing, wounds and injuries, cornea, transplantation, personal integrity
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4249-4260. doi: 10.1167/iovs.17-22106

Includes: Multimedia, Supplemental Content

Cornea September 2017

Mesenchymal Stem Cells Promote Diabetic Corneal Epithelial Wound Healing Through TSG-6–Dependent Stem Cell Activation and Macrophage Switch

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Guohu Di; Xianli Du; Xia Qi; Xiaowen Zhao; Haoyun Duan; Suxia Li; Lixin Xie; Qingjun Zhou
TAGS: diabetes mellitus, stem cells, epithelium, macrophage, wound healing, cornea, stem cell, mesenchymal
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4344-4354. doi: 10.1167/iovs.17-21506

Includes: Supplemental Content

Cornea September 2017

Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation

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Tarsis F. Gesteira; Mingxia Sun; Yvette M. Coulson-Thomas; Yu Yamaguchi; Lung-Kun Yeh; Vincent Hascall; Vivien J. Coulson-Thomas
TAGS: debridement, stem cells, epithelium, alkalies, burns, wounds and injuries, cornea, mice, epithelial cells, hyaluronan, stem cell niche
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4407-4421. doi: 10.1167/iovs.17-22326

Includes: Supplemental Content

Retina August 2017

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

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G. Alex Ochakovski; Tobias Peters; Stylianos Michalakis; Barbara Wilhelm; Bernd Wissinger; Martin Biel; K. Ulrich Bartz-Schmidt; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: gene therapy, injection of therapeutic agent, primates, safety, surgical procedures, operative, eye, retina, serotonin uptake inhibitors
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4155-4160. doi: 10.1167/iovs.17-22402

Includes: Supplemental Content

Articles July 2017

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

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Anna P. Salvetti; Maria I. Patrício; Alun R. Barnard; Harry O. Orlans; Doron G. Hickey; Robert E. MacLaren
TAGS: gene therapy, cell survival, dyes, injection of therapeutic agent, surgical procedures, operative, toxic effect, spatial vectors
Trans. Vis. Sci. Tech.. 2017; 6(4):4. doi: 10.1167/tvst.6.4.4

Includes: Supplemental Content

Cornea July 2017

Silk Fibroin Films for Corneal Endothelial Regeneration: Transplant in a Rabbit Descemet Membrane Endothelial Keratoplasty

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Natalia Vázquez; Carlos A. Rodríguez-Barrientos; Salvador D. Aznar-Cervantes; Manuel Chacón; José L. Cenis; Ana C. Riestra; Ronald M. Sánchez-Avila; Mairobi Persinal; Agustín Brea-Pastor; Luis Fernández-Vega Cueto; Álvaro Meana; Jesús Merayo-Lloves
TAGS: keratoplasty, endothelium, fibroins, oryctolagus cuniculus, cornea, transplantation, chronic exertional compartment syndrome, descemet membrane endothelial keratoplasty
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3357-3365. doi: 10.1167/iovs.17-21797

Articles June 2017

Da Vinci Xi Robot–Assisted Penetrating Keratoplasty

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Jimmy Chammas; Arnaud Sauer; Joëlle Pizzuto; Fabienne Pouthier; David Gaucher; Jacques Marescaux; Didier Mutter; Tristan Bourcier
TAGS: keratoplasty, penetrating, ophthalmologic surgical procedures, surgical procedures, operative, sutures, cornea, spectral-domain optical coherence tomography
Trans. Vis. Sci. Tech.. 2017; 6(3):21. doi: 10.1167/tvst.6.3.21

Articles June 2017

Long-Term Efficacy of GMP Grade Xeno-Free hESC-Derived RPE Cells Following Transplantation

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Trevor J. McGill; Osnat Bohana-Kashtan; Jonathan W. Stoddard; Michael D. Andrews; Neelay Pandit; Lior R. Rosenberg-Belmaker; Ofer Wiser; Limor Matzrafi; Eyal Banin; Benjamin Reubinoff; Nir Netzer; Charles Irving
TAGS: photoreceptors, eye, retina, transplantation, good manufacturing practice, retinal pigment cell
Trans. Vis. Sci. Tech.. 2017; 6(3):17. doi: 10.1167/tvst.6.3.17

Cornea June 2017

Rat Limbal Niche Cells Prevent Epithelial Stem/Progenitor Cells From Differentiation and Proliferation by Inhibiting Notch Signaling Pathway In Vitro

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Jing Li; Szu-Yu Chen; Xin-Yue Zhao; Ming-Chang Zhang; Hua-Tao Xie
TAGS: signal transduction, western blotting, stem cells, epithelium, ligands, cornea, notch signaling pathway, dual antiplatelet therapy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2968-2976. doi: 10.1167/iovs.16-20642

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2017

Transforming Growth Factor β1–Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts

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Karl David Brown; Manisha H. Shah; Guei-Sheung Liu; Elsa C. Chan; Jonathan G. Crowston; Hitesh M. Peshavariya
TAGS: fibroblast, collagen, curcumin, hydrogen peroxide, nadp, protein isoforms, transforming growth factors, conjunctiva, oxidase, collagen synthesis
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3011-3017. doi: 10.1167/iovs.16-20633

Includes: Supplemental Content

Cornea May 2017

Xeno-Free Cultivation of Mesenchymal Stem Cells From the Corneal Stroma

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Steffi Matthyssen; Sorcha Ní Dhubhghaill; Veerle Van Gerwen; Nadia Zakaria
TAGS: flow cytometry, cell size, corneal stroma, cornea, stem cell, mesenchymal, donors
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2659-2665. doi: 10.1167/iovs.17-21676

Articles May 2017

Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate

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Jennifer R. Chao; Deepak A. Lamba; Todd R. Klesert; Anna La Torre; Akina Hoshino; Russell J. Taylor; Anu Jayabalu; Abbi L. Engel; Thomas H. Khuu; Ruikang K. Wang; Maureen Neitz; Jay Neitz; Thomas A. Reh
TAGS: embryo, primates, diagnostic imaging, eye, optic nerve, retina, transplantation
Trans. Vis. Sci. Tech.. 2017; 6(3):4. doi: 10.1167/tvst.6.3.4

Nantotechnology and Regenerative Medicine May 2017

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides

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Felicity de Cogan; Lisa J. Hill; Aisling Lynch; Peter J. Morgan-Warren; Judith Lechner; Matthew R. Berwick; Anna F. A. Peacock; Mei Chen; Robert A. H. Scott; Heping Xu; Ann Logan
TAGS: choroidal neovascularization, peptides, cornea, eye, mice, retina, bevacizumab, eyedrops, cpps trial, complex, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2578-2590. doi: 10.1167/iovs.16-20072

Biochemistry and Molecular Biology May 2017

Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy

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JaeSang Ko; Min Kyoung Chae; Joon H. Lee; Eun Jig Lee; Jin Sook Yoon
TAGS: western blotting, fibroblast, fibrosis, proteins, sphingosine-1-phosphate phosphatase
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2544-2553. doi: 10.1167/iovs.16-20684

Includes: Supplemental Content

Glaucoma April 2017

Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma

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Yuka Aoyama-Araki; Megumi Honjo; Takatoshi Uchida; Reiko Yamagishi; Kuniyuki Kano; Junken Aoki; Makoto Aihara
TAGS: polymerase chain reaction, fibrosis, glaucoma, collagen, postoperative care, rna, messenger, trabeculectomy, blister, conjunctiva, antagonists, sphingosine-1-phosphate phosphatase, fibroblast, filtering surgery
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2258-2265. doi: 10.1167/iovs.16-21288

Cornea April 2017

Suppression by an RAR-γ Agonist of Collagen Degradation Mediated by Corneal Fibroblasts

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Kazuhiro Kimura; Hongyan Zhou; Tomoko Orita; Masaaki Kobayashi; Teruo Nishida; Koh-Hei Sonoda
TAGS: fibroblast, collagen, oryctolagus cuniculus, cornea, agonists, catabolism
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2250-2257. doi: 10.1167/iovs.15-18701

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Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics

A PPAR-Gamma Agonist Rosiglitazone Suppresses Fibrotic Response in Human Pterygium Fibroblasts by Modulating the p38 MAPK Pathway

Sustaining Intravitreal Residence With L-Arginine Peptide-Conjugated Nanocarriers

Corneal Epithelium-Derived Neurotrophic Factors Promote Nerve Regeneration

Allogeneic Descemet's Membrane Transplantation Enhances Corneal Endothelial Monolayer Formation and Restores Functional Integrity Following Descemet's Stripping

Mesenchymal Stem Cells Promote Diabetic Corneal Epithelial Wound Healing Through TSG-6–Dependent Stem Cell Activation and Macrophage Switch

Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

Silk Fibroin Films for Corneal Endothelial Regeneration: Transplant in a Rabbit Descemet Membrane Endothelial Keratoplasty

Da Vinci Xi Robot–Assisted Penetrating Keratoplasty

Long-Term Efficacy of GMP Grade Xeno-Free hESC-Derived RPE Cells Following Transplantation

Rat Limbal Niche Cells Prevent Epithelial Stem/Progenitor Cells From Differentiation and Proliferation by Inhibiting Notch Signaling Pathway In Vitro

Transforming Growth Factor β1–Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts

Xeno-Free Cultivation of Mesenchymal Stem Cells From the Corneal Stroma

Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides

Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy

Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma

Suppression by an RAR-γ Agonist of Collagen Degradation Mediated by Corneal Fibroblasts

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