Nanotechnology and Regenerative Medicine

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Articles July 2017

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

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Anna P. Salvetti; Maria I. Patrício; Alun R. Barnard; Harry O. Orlans; Doron G. Hickey; Robert E. MacLaren
TAGS: gene therapy, cell survival, dyes, injection of therapeutic agent, surgical procedures, operative, toxic effect, spatial vectors
Trans. Vis. Sci. Tech.. 2017; 6(4):4. doi: 10.1167/tvst.6.4.4

Includes: Supplemental Content

Cornea July 2017

Silk Fibroin Films for Corneal Endothelial Regeneration: Transplant in a Rabbit Descemet Membrane Endothelial Keratoplasty

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Natalia Vázquez; Carlos A. Rodríguez-Barrientos; Salvador D. Aznar-Cervantes; Manuel Chacón; José L. Cenis; Ana C. Riestra; Ronald M. Sánchez-Avila; Mairobi Persinal; Agustín Brea-Pastor; Luis Fernández-Vega Cueto; Álvaro Meana; Jesús Merayo-Lloves
TAGS: keratoplasty, endothelium, fibroins, oryctolagus cuniculus, cornea, transplantation, chronic exertional compartment syndrome, descemet membrane endothelial keratoplasty
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3357-3365. doi: 10.1167/iovs.17-21797

Articles June 2017

Da Vinci Xi Robot–Assisted Penetrating Keratoplasty

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Jimmy Chammas; Arnaud Sauer; Joëlle Pizzuto; Fabienne Pouthier; David Gaucher; Jacques Marescaux; Didier Mutter; Tristan Bourcier
TAGS: keratoplasty, penetrating, ophthalmologic surgical procedures, surgical procedures, operative, sutures, cornea, spectral-domain optical coherence tomography
Trans. Vis. Sci. Tech.. 2017; 6(3):21. doi: 10.1167/tvst.6.3.21

Articles June 2017

Long-Term Efficacy of GMP Grade Xeno-Free hESC-Derived RPE Cells Following Transplantation

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Trevor J. McGill; Osnat Bohana-Kashtan; Jonathan W. Stoddard; Michael D. Andrews; Neelay Pandit; Lior R. Rosenberg-Belmaker; Ofer Wiser; Limor Matzrafi; Eyal Banin; Benjamin Reubinoff; Nir Netzer; Charles Irving
TAGS: photoreceptors, eye, retina, transplantation, good manufacturing practice, retinal pigment cell
Trans. Vis. Sci. Tech.. 2017; 6(3):17. doi: 10.1167/tvst.6.3.17

Cornea June 2017

Rat Limbal Niche Cells Prevent Epithelial Stem/Progenitor Cells From Differentiation and Proliferation by Inhibiting Notch Signaling Pathway In Vitro

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Jing Li; Szu-Yu Chen; Xin-Yue Zhao; Ming-Chang Zhang; Hua-Tao Xie
TAGS: signal transduction, western blotting, stem cells, epithelium, ligands, cornea, notch signaling pathway, dual antiplatelet therapy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2968-2976. doi: 10.1167/iovs.16-20642

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2017

Transforming Growth Factor β1–Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts

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Karl David Brown; Manisha H. Shah; Guei-Sheung Liu; Elsa C. Chan; Jonathan G. Crowston; Hitesh M. Peshavariya
TAGS: fibroblast, collagen, curcumin, hydrogen peroxide, nadp, protein isoforms, transforming growth factors, conjunctiva, oxidase, collagen synthesis
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3011-3017. doi: 10.1167/iovs.16-20633

Includes: Supplemental Content

Cornea May 2017

Xeno-Free Cultivation of Mesenchymal Stem Cells From the Corneal Stroma

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Steffi Matthyssen; Sorcha Ní Dhubhghaill; Veerle Van Gerwen; Nadia Zakaria
TAGS: flow cytometry, cell size, corneal stroma, cornea, stem cell, mesenchymal, donors
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2659-2665. doi: 10.1167/iovs.17-21676

Articles May 2017

Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate

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Jennifer R. Chao; Deepak A. Lamba; Todd R. Klesert; Anna La Torre; Akina Hoshino; Russell J. Taylor; Anu Jayabalu; Abbi L. Engel; Thomas H. Khuu; Ruikang K. Wang; Maureen Neitz; Jay Neitz; Thomas A. Reh
TAGS: embryo, primates, diagnostic imaging, eye, optic nerve, retina, transplantation
Trans. Vis. Sci. Tech.. 2017; 6(3):4. doi: 10.1167/tvst.6.3.4

Nantotechnology and Regenerative Medicine May 2017

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides

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Felicity de Cogan; Lisa J. Hill; Aisling Lynch; Peter J. Morgan-Warren; Judith Lechner; Matthew R. Berwick; Anna F. A. Peacock; Mei Chen; Robert A. H. Scott; Heping Xu; Ann Logan
TAGS: choroidal neovascularization, peptides, cornea, eye, mice, retina, bevacizumab, eyedrops, cpps trial, complex, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2578-2590. doi: 10.1167/iovs.16-20072

Biochemistry and Molecular Biology May 2017

Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy

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JaeSang Ko; Min Kyoung Chae; Joon H. Lee; Eun Jig Lee; Jin Sook Yoon
TAGS: western blotting, fibroblast, fibrosis, proteins, sphingosine-1-phosphate phosphatase
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2544-2553. doi: 10.1167/iovs.16-20684

Includes: Supplemental Content

Glaucoma April 2017

Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma

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Yuka Aoyama-Araki; Megumi Honjo; Takatoshi Uchida; Reiko Yamagishi; Kuniyuki Kano; Junken Aoki; Makoto Aihara
TAGS: polymerase chain reaction, fibrosis, glaucoma, collagen, postoperative care, rna, messenger, trabeculectomy, blister, conjunctiva, antagonists, sphingosine-1-phosphate phosphatase, fibroblast, filtering surgery
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2258-2265. doi: 10.1167/iovs.16-21288

Cornea April 2017

Suppression by an RAR-γ Agonist of Collagen Degradation Mediated by Corneal Fibroblasts

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Kazuhiro Kimura; Hongyan Zhou; Tomoko Orita; Masaaki Kobayashi; Teruo Nishida; Koh-Hei Sonoda
TAGS: fibroblast, collagen, oryctolagus cuniculus, cornea, agonists, catabolism
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2250-2257. doi: 10.1167/iovs.15-18701

Glaucoma April 2017

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

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Wei Zhu; Ankur Jain; Oliver W. Gramlich; Budd A. Tucker; Val C. Sheffield; Markus H. Kuehn
TAGS: glaucoma, mice, transgenic, trabecular meshwork, aqueous humor, eye, intraocular pressure, mice, transplantation, myoc gene, painful bladder syndrome
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2054-2062. doi: 10.1167/iovs.16-20672

Nantotechnology and Regenerative Medicine March 2017

Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice

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Benjamin J. Yungher; Márcio Ribeiro; Kevin K. Park
TAGS: axon, ciliary neurotrophic factor, retinal ganglion cells, wounds and injuries, mice, optic nerve, axon guidance
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1743-1750. doi: 10.1167/iovs.16-19873

Includes: Supplemental Content

Retina March 2017

Rearing Light Intensity Affects Inner Retinal Pathology in a Mouse Model of X-Linked Retinoschisis but Does Not Alter Gene Therapy Outcome

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Dario Marangoni; Zeng Yong; Sten Kjellström; Camasamudram Vijayasarathy; Paul A. Sieving; Ronald A. Bush
TAGS: gene therapy, electroretinography, mice, pathology, x-linked retinoschisis, light intensity
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1656-1664. doi: 10.1167/iovs.16-21016

Letters to the Editor March 2017

Adipose-Derived Mesenchymal Stem Cells Reduce Lymphocytic Infiltration in a Rabbit Model of Induced Autoimmune Dacryoadenitis: Some Discussions

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Ying Liu
TAGS: oryctolagus cuniculus, stem cell, mesenchymal, dacryoadenitis, lymphocyte, autoimmunity
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1585-1585. doi: 10.1167/iovs.17-21694

Cornea March 2017

Extracellular Collagen Promotes Interleukin-1β–Induced Urokinase-Type Plasminogen Activator Production by Human Corneal Fibroblasts

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Koji Sugioka; Aya Kodama-Takahashi; Koji Yoshida; Keiichi Aomatsu; Kiyotaka Okada; Teruo Nishida; Yoshikazu Shimomura
TAGS: urokinase, fibroblast, collagen, gel, interleukins, cornea
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1487-1498. doi: 10.1167/iovs.16-20685

Cornea February 2017

PDGFRα Is a Key Regulator of T1 and T3's Differential Effect on SMA Expression in Human Corneal Fibroblasts

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Sriniwas Sriram; Jennifer A. Tran; Xiaoqing Guo; Audrey E. K. Hutcheon; Hetian Lei; Andrius Kazlauskas; James D. Zieske
TAGS: polymerase chain reaction, transcription, genetic, fibroblast, cell line, fluorescent antibody technique, growth factor, platelet-derived growth factor, protein isoforms, cornea, transforming growth factor beta3
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):1179-1186. doi: 10.1167/iovs.16-20016

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology February 2017

Development of a Chromatic Pupillography Protocol for the First Gene Therapy Trial in Patients With CNGA3 -Linked Achromatopsia

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Jolanta Lisowska; Lukasz Lisowski; Carina Kelbsch; Fumiatsu Maeda; Paul Richter; Susanne Kohl; Ditta Zobor; Torsten Strasser; Krunoslav Stingl; Eberhart Zrenner; Tobias Peters; Helmut Wilhelm; M. Dominik Fischer; Barbara Wilhelm; for the RD-CURE Consortium
TAGS: gene therapy, retinal cone, dark adaptation, light, lighting, pupil, rod photoreceptors, cornea, achromatopsia, pupil reaction
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):1274-1282. doi: 10.1167/iovs.16-20505

Includes: Supplemental Content

Retinal Cell Biology February 2017

Integration of Subretinal Suspension Transplants of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in a Large-Eyed Model of Geographic Atrophy

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Sandra Petrus-Reurer; Hammurabi Bartuma; Monica Aronsson; Sofie Westman; Fredrik Lanner; Helder André; Anders Kvanta
TAGS: immunohistochemistry, atrophy, embryo, injection of therapeutic agent, oryctolagus cuniculus, blister, eye, transplantation, tissue degeneration, retinal pigment cell, painful bladder syndrome
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):1314-1322. doi: 10.1167/iovs.16-20738

Includes: Supplemental Content

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Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

Silk Fibroin Films for Corneal Endothelial Regeneration: Transplant in a Rabbit Descemet Membrane Endothelial Keratoplasty

Da Vinci Xi Robot–Assisted Penetrating Keratoplasty

Long-Term Efficacy of GMP Grade Xeno-Free hESC-Derived RPE Cells Following Transplantation

Rat Limbal Niche Cells Prevent Epithelial Stem/Progenitor Cells From Differentiation and Proliferation by Inhibiting Notch Signaling Pathway In Vitro

Transforming Growth Factor β1–Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts

Xeno-Free Cultivation of Mesenchymal Stem Cells From the Corneal Stroma

Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides

Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy

Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma

Suppression by an RAR-γ Agonist of Collagen Degradation Mediated by Corneal Fibroblasts

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice

Rearing Light Intensity Affects Inner Retinal Pathology in a Mouse Model of X-Linked Retinoschisis but Does Not Alter Gene Therapy Outcome

Adipose-Derived Mesenchymal Stem Cells Reduce Lymphocytic Infiltration in a Rabbit Model of Induced Autoimmune Dacryoadenitis: Some Discussions

Extracellular Collagen Promotes Interleukin-1β–Induced Urokinase-Type Plasminogen Activator Production by Human Corneal Fibroblasts

PDGFRα Is a Key Regulator of T1 and T3's Differential Effect on SMA Expression in Human Corneal Fibroblasts

Development of a Chromatic Pupillography Protocol for the First Gene Therapy Trial in Patients With CNGA3 -Linked Achromatopsia

Integration of Subretinal Suspension Transplants of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in a Large-Eyed Model of Geographic Atrophy

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