Nanotechnology and Regenerative Medicine

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Cornea June 2018

Directed Differentiation of Human Corneal Endothelial Cells From Human Embryonic Stem Cells by Using Cell-Conditioned Culture Media

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Xiaoniao Chen; Lingling Wu; Zongjin Li; Ying Dong; Xuetao Pei; Yifei Huang; Liqiang Wang
TAGS: embryonic stem cells, endothelial cells, conditioning (psychology), culture media, culture media, conditioned, cornea, signal pathway, chronic exertional compartment syndrome
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3028-3036. doi: 10.1167/iovs.17-23627

Glaucoma June 2018

Active Lymphatic Drainage From the Eye Measured by Noninvasive Photoacoustic Imaging of Near-Infrared Nanoparticles

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Yeni H. Yücel; Kirsten Cardinell; Shireen Khattak; Xun Zhou; Michael Lapinski; Fang Cheng; Neeru Gupta
TAGS: fluorescence, injection of therapeutic agent, diagnostic imaging, eye, mice, drainage of lymphatics, nanoparticles
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2699-2707. doi: 10.1167/iovs.17-22850

Includes: Supplemental Content

Retinal Cell Biology May 2018

Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats

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Bryce T. McLelland; Bin Lin; Anuradha Mathur; Robert B. Aramant; Biju B. Thomas; Gabriel Nistor; Hans S. Keirstead; Magdalene J. Seiler
TAGS: organoids, photoreceptors, rats, nude, vision, rats, retina, transplantation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2586-2603. doi: 10.1167/iovs.17-23646

Includes: Supplemental Content

Cornea May 2018

Labial Salivary Gland Transplantation for Severe Dry Eye in a Rhesus Monkey Model

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Yi Qin; Yingnan Zhang; Qingfeng Liang; Xiaolin Xu; Qian Li; Zhiqiang Pan; Antoine Labbé
TAGS: cytology, dry eye syndromes, macaca mulatta, surgical procedures, operative, tissue transplants, conjunctiva, eye, lip, salivary glands, transplantation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2478-2486. doi: 10.1167/iovs.18-23966

Includes: Supplemental Content

Glaucoma May 2018

Mechanical Strain Induces Distinct Human Scleral Fibroblast Lineages: Differential Roles in Cell Proliferation, Apoptosis, Migration, and Differentiation

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Chen Qiu; Minjie Chen; Jing Yao; Xinghuai Sun; Jianjiang Xu; Rong Zhang; Xin Wang; Gang Li; Shaohong Qian
TAGS: apoptosis, cell proliferation, fibroblasts, sclera
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2401-2410. doi: 10.1167/iovs.18-23855

Includes: Supplemental Content

Articles April 2018

Inhibitory Effects of Angiotensin II Receptor Blockade on Human Tenon Fibroblast Migration and Reactive Oxygen Species Production in Cell Culture

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Duri Kim; Ushasree Pattamatta; Elizabeth Kelly; Paul R. Healey; Nicole Carnt; Hans Zoellner; Andrew J. R. White
TAGS: angiotensins, irbesartan, cell culture techniques, receptor, angiotensin ii, angiotensin ii, fibroblasts, cell count, reactive oxygen species
Trans. Vis. Sci. Tech.. 2018; 7(2):20. doi: 10.1167/tvst.7.2.20

Cornea March 2018

Visualizing the Fate of Transplanted K14-Confetti Corneal Epithelia in a Mouse Model of Limbal Stem Cell Deficiency

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Alexander Richardson; Mijeong Park; Stephanie L. Watson; Denis Wakefield; Nick Di Girolamo
TAGS: corneal epithelium, mice, transplantation, limbal stem cell deficiency, donors, corneal epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1630-1640. doi: 10.1167/iovs.17-23557

Includes: Supplemental Content

Glaucoma March 2018

Induced Pluripotent Stem Cells Promote Retinal Ganglion Cell Survival After Transplant

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Suqian Wu; Kun-Che Chang; Michael Nahmou; Jeffrey L. Goldberg
TAGS: coculture techniques, retinal ganglion cells, retina, transplantation, stem cells, pluripotent
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1571-1576. doi: 10.1167/iovs.17-23648

Cornea March 2018

Human Conjunctival Epithelial Sheets Grown on Poly(Lactic-Co-Glycolic) Acid Membranes and Cocultured With Human Tenon's Fibroblasts for Corneal Repair

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Soyoung Hong; Je Hwan Yun; Eun-Soon Kim; Ji Seon Kim; Hungwon Tchah; Changmo Hwang
TAGS: positron-emission tomography, epithelium, fibroblasts, coculture techniques, tissue membrane, conjunctiva, cornea, pet animal
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1475-1485. doi: 10.1167/iovs.17-22719

Includes: Supplemental Content

Retina March 2018

Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates

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Trevor J. McGill; Jonathan Stoddard; Lauren M. Renner; Ilhem Messaoudi; Kapil Bharti; Shoukhrat Mitalipov; Andreas Lauer; David J. Wilson; Martha Neuringer
TAGS: primates, tissue transplants, diagnostic imaging, transplantation, idiopathic pneumonia syndrome, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1374-1383. doi: 10.1167/iovs.17-22467

Cornea February 2018

Novel Combination BMP7 and HGF Gene Therapy Instigates Selective Myofibroblast Apoptosis and Reduces Corneal Haze In Vivo

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Suneel Gupta; Michael K. Fink; Arkasubhra Ghosh; Ratnakar Tripathi; Prashant R. Sinha; Ajay Sharma; Nathan P. Hesemann; Shyam S. Chaurasia; Elizabeth A. Giuliano; Rajiv R. Mohan
TAGS: apoptosis, gene therapy, fibrosis, corneal opacity, genes, oryctolagus cuniculus, cornea, myofibroblast
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):1045-1057. doi: 10.1167/iovs.17-23308

Retinal Cell Biology February 2018

Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell–Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning

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Wataru Kobayashi; Akishi Onishi; Hung-Ya Tu; Yuji Takihara; Michiru Matsumura; Kazuko Tsujimoto; Masaru Inatani; Toru Nakazawa; Masayo Takahashi
TAGS: immunohistochemistry, organoids, retinal ganglion cells, mice, retina, stem cells, pluripotent, neuronal outgrowth
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):776-787. doi: 10.1167/iovs.17-22406

Includes: Supplemental Content

Cornea February 2018

Preoperative Aqueous Cytokine Levels are Associated With Endothelial Cell Loss After Descemet's Stripping Automated Endothelial Keratoplasty

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Hiroyuki Yazu; Takefumi Yamaguchi; Naohiko Aketa; Kazunari Higa; Terumasa Suzuki; Yukari Yagi-Yaguchi; Yoshiyuki Satake; Takayuki Abe; Kazuo Tsubota; Jun Shimazaki
TAGS: cytokine, endothelial cells, keratoplasty, endothelium, postoperative care, preoperative care, proteins, descemet stripping endothelial keratoplasty
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):612-620. doi: 10.1167/iovs.17-23049

Includes: Supplemental Content

Visual Neuroscience January 2018

Optic Nerve Regeneration After Crush Remodels the Injury Site: Molecular Insights From Imaging Mass Spectrometry

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David T. Stark; David M. G. Anderson; Jacky M. K. Kwong; Nathan Heath Patterson; Kevin L. Schey; Richard M. Caprioli; Joseph Caprioli
TAGS: axon, gangliosides, hyperplasia, mass spectrometry, sulfoglycosphingolipids, body tissue, wounds and injuries, diagnostic imaging, lipids, optic nerve, optic nerve regeneration, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):212-222. doi: 10.1167/iovs.17-22509

Includes: Supplemental Content

Cornea January 2018

Assessment of Human Corneas Prior to Transplantation Using High-Resolution Two-Photon Imaging

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Ana Batista; Hans Georg Breunig; Aisada König; Andreas Schindele; Tobias Hager; Berthold Seitz; António Miguel Morgado; Karsten König
TAGS: collagen, photons, cornea, diagnostic imaging, transplantation, mohr-tranebjaerg syndrome
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):176-184. doi: 10.1167/iovs.17-22002

Cornea November 2017

Photodynamic Therapy Leads to Time-Dependent Regression of Pathologic Corneal (Lymph) Angiogenesis and Promotes High-Risk Corneal Allograft Survival

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Yanhong Hou; Viet Nhat Hung Le; Thomas Clahsen; Ann-Charlott Schneider; Felix Bock; Claus Cursiefen
TAGS: angiogenesis, keratoplasty, graft survival, injection of therapeutic agent, lymph, photochemotherapy, cornea, mice, verteporfin, allografting, lymphangiogenesis
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5862-5869. doi: 10.1167/iovs.17-22904

Cornea November 2017

Moxifloxacin Modulated TGF-β1-Related Interleukin-12 Secretion in Corneal Fibroblasts

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Tsan-Chi Chen; Shu-Wen Chang
TAGS: fibroblasts, bodily secretions, interleukin-12, cornea, moxifloxacin
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5692-5702. doi: 10.1167/iovs.17-21944

Cornea November 2017

Manipulation of Panx1 Activity Increases the Engraftment of Transplanted Lacrimal Gland Epithelial Progenitor Cells

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Liana V. Basova; Xin Tang; Takeshi Umasume; Anastasia Gromova; Tatiana Zyrianova; Taisia Shmushkovich; Alexey Wolfson; Dillon Hawley; Driss Zoukhri; Valery I. Shestopalov; Helen P. Makarenkova
TAGS: polymerase chain reaction, immunohistochemistry, inflammation, stem cells, epithelium, injection of therapeutic agent, langer-giedion syndrome, thrombospondin 1, wounds and injuries, mice, rna, lacrimal gland, engraftment, donors
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5654-5665. doi: 10.1167/iovs.17-22071

Includes: Multimedia, Supplemental Content

Anatomy and Pathology/Oncology October 2017

Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics

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Rachel E. Doherty; Karen Sisley; David W. Hammond; Ian G. Rennie; Neil A. Cross
TAGS: phenotype, aldehyde dehydrogenases, stem cells, cd44 antigens, cell lines, neoplasms, homing-associated cell adhesion molecule, intraocular melanoma, cancer stem cells
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5387-5395. doi: 10.1167/iovs.17-22272

Includes: Supplemental Content

Cornea October 2017

Evaluation of Decellularized Porcine Jejunum as a Matrix for Lacrimal Gland Reconstruction In Vitro for Treatment of Dry Eye Syndrome

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Isobel Massie; Kristina Spaniol; Andreas Barbian; Gereon Poschmann; Kai Stühler; Gerd Geerling; Marco Metzger; Sonja Mertsch; Stefan Schrader
TAGS: dry eye syndromes, lactoferrin, reconstructive surgical procedures, suidae, tissue engineering, jejunum, proteins, lacrimal gland, epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5564-5574. doi: 10.1167/iovs.16-20759

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Directed Differentiation of Human Corneal Endothelial Cells From Human Embryonic Stem Cells by Using Cell-Conditioned Culture Media

Active Lymphatic Drainage From the Eye Measured by Noninvasive Photoacoustic Imaging of Near-Infrared Nanoparticles

Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats

Labial Salivary Gland Transplantation for Severe Dry Eye in a Rhesus Monkey Model

Mechanical Strain Induces Distinct Human Scleral Fibroblast Lineages: Differential Roles in Cell Proliferation, Apoptosis, Migration, and Differentiation

Inhibitory Effects of Angiotensin II Receptor Blockade on Human Tenon Fibroblast Migration and Reactive Oxygen Species Production in Cell Culture

Visualizing the Fate of Transplanted K14-Confetti Corneal Epithelia in a Mouse Model of Limbal Stem Cell Deficiency

Induced Pluripotent Stem Cells Promote Retinal Ganglion Cell Survival After Transplant

Human Conjunctival Epithelial Sheets Grown on Poly(Lactic-Co-Glycolic) Acid Membranes and Cocultured With Human Tenon's Fibroblasts for Corneal Repair

Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates

Novel Combination BMP7 and HGF Gene Therapy Instigates Selective Myofibroblast Apoptosis and Reduces Corneal Haze In Vivo

Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell–Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning

Preoperative Aqueous Cytokine Levels are Associated With Endothelial Cell Loss After Descemet's Stripping Automated Endothelial Keratoplasty

Optic Nerve Regeneration After Crush Remodels the Injury Site: Molecular Insights From Imaging Mass Spectrometry

Assessment of Human Corneas Prior to Transplantation Using High-Resolution Two-Photon Imaging

Photodynamic Therapy Leads to Time-Dependent Regression of Pathologic Corneal (Lymph) Angiogenesis and Promotes High-Risk Corneal Allograft Survival

Moxifloxacin Modulated TGF-β1-Related Interleukin-12 Secretion in Corneal Fibroblasts

Manipulation of Panx1 Activity Increases the Engraftment of Transplanted Lacrimal Gland Epithelial Progenitor Cells

Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics

Evaluation of Decellularized Porcine Jejunum as a Matrix for Lacrimal Gland Reconstruction In Vitro for Treatment of Dry Eye Syndrome

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