Pharmacology

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Physiology and Pharmacology April 2018

Endothelial Protein C–Targeting Liposomes Show Enhanced Uptake and Improved Therapeutic Efficacy in Human Retinal Endothelial Cells

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Anthoula Arta; Anne Z. Eriksen; Fredrik Melander; Paul Kempen; Michael Larsen; Thomas L. Andresen; Andrew J. Urquhart
TAGS: endothelial cells, liposomes, endothelial protein c receptor
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):2119-2132. doi: 10.1167/iovs.18-23800

Includes: Supplemental Content

Retina April 2018

Targeted Drug Delivery in the Suprachoroidal Space by Swollen Hydrogel Pushing

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Jae Hwan Jung; Patcharin Desit; Mark R. Prausnitz
TAGS: hydrogel, injection of therapeutic agent, oryctolagus cuniculus, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):2069-2079. doi: 10.1167/iovs.17-23758

Includes: Supplemental Content

Articles April 2018

Inhibitory Effects of Angiotensin II Receptor Blockade on Human Tenon Fibroblast Migration and Reactive Oxygen Species Production in Cell Culture

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Duri Kim; Ushasree Pattamatta; Elizabeth Kelly; Paul R. Healey; Nicole Carnt; Hans Zoellner; Andrew J. R. White
TAGS: angiotensins, irbesartan, cell culture techniques, receptor, angiotensin ii, angiotensin ii, fibroblast, cell count, reactive oxygen species
Trans. Vis. Sci. Tech.. 2018; 7(2):20. doi: 10.1167/tvst.7.2.20

Lens April 2018

Pharmacokinetics of Caffeine in the Lens Capsule/Epithelium After Peroral Intake: A Pilot Randomized Controlled Study

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Martin Kronschläger; Thomas Stimpfl; Manuel Ruiß; Nino Hirnschall; Christoph Leisser; Oliver Findl
TAGS: caffeine, epithelium, lens capsule, crystalline, lens, crystalline, lens (device), pharmacokinetics
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1855-1860. doi: 10.1167/iovs.18-23963

Clinical and Epidemiologic Research April 2018

Plasma Concentrations of Lutein and Zeaxanthin, Macular Pigment Optical Density, and Their Associations With Cognitive Performances Among Older Adults

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Soufiane Ajana; Daniela Weber; Catherine Helmer; Bénédicte M. Merle; Wolfgang Stuetz; Jean-François Dartigues; Marie-Bénédicte Rougier; Jean-François Korobelnik; Tilman Grune; Cécile Delcourt; Catherine Féart
TAGS: plasma drug concentration, cognition, lutein, mental processes, optics, plasma, elderly, cognitive ability, macular pigment
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1828-1835. doi: 10.1167/iovs.17-22656

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2018

Bevacizumab Promotes T-Cell–Mediated Collagen Deposition in the Mouse Model of Conjunctival Scarring

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Li-Fong Seet; Li Zhen Toh; Stephanie Chu; Sharon N. Finger; Florent Ginhoux; Wanjin Hong; Tina T. Wong
TAGS: vascular endothelial growth factor a, cicatrix, collagen, t-lymphocyte, blister, conjunctiva, mice, bevacizumab, collagen synthesis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1682-1692. doi: 10.1167/iovs.17-22694

Cornea March 2018

The Role of 2% Rebamipide Eye Drops Related to Conjunctival Differentiation in Superoxide Dismutase-1 ( Sod1 ) Knockout Mice

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Takashi Kojima; Cem Simsek; Ayako Igarashi; Kazue Aoki; Kazunari Higa; Takahiko Shimizu; Murat Dogru; Kazuo Tsubota; Jun Shimazaki
TAGS: epithelium, goblet cells, mice, knockout, rna, messenger, conjunctiva, mice, eyedrops, rebamipide, sod1 gene, superoxide dismutase 1
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1675-1681. doi: 10.1167/iovs.17-23213

Editorial March 2018

Reviewers

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TAGS: acetylcholine, achondroplasia, barrett's esophagus, cluster headache, arthritis, juvenile rheumatoid, betula genus, burns, calculi, candy, esters, acoustic evoked brain stem potentials, limb, glycogen storage disease type iv, happiness, horns, ilex, kenya, lilium, chewing, monoamine oxidase, mosses, netherlands, ophthalmology, reading (activity), rosales, salmon, tai ji, tolnaftate, zein, christianity, fingers, laparoscopic fundoplication, potassium hydroxide, atrial myxoma with lentigines, hematoma of pinna, ogilvie syndrome, no-observed-effect level, pyogenic sterile arthritis, pyoderma gangrenosum, and acne, community reinforcement and family training, stepp trial, pstpip1 gene, hurricane katrina, bsnd gene, singing, french, cousin, crafts, nongovernmental organizations, whey, liposomal amikacin for inhalation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1539-1546. doi: 10.1167/iovs.18-24048

Editorial March 2018

Reviewers

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TAGS: betula genus, burns, limb, hispanics or latinos, kenya, steel, technology, tolnaftate, vision, fingers, silver, hematoma of pinna, liposomal amikacin for inhalation
Trans. Vis. Sci. Tech.. 2018; 7(2):r. doi: 10.1167/tvst.7.2.r

Immunology and Microbiology March 2018

Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis

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Heather L. Clark; Martin S. Minns; Yan Sun; Tristan de Jesus; Mahmoud G. Ghannoum; Eric Pearlman
TAGS: mitochondria, atovaquone, aspergillus, fusarium, zinc
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1589-1598. doi: 10.1167/iovs.17-22585

Physiology and Pharmacology March 2018

Changes in Blood Pressure and Urine Albumin-Creatinine Ratio in a Randomized Clinical Trial Comparing Aflibercept, Bevacizumab, and Ranibizumab for Diabetic Macular Edema

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Adam R. Glassman; Danni Liu; Lee M. Jampol; Jennifer K. Sun; for the Diabetic Retinopathy Clinical Research Network
TAGS: clinical trials, albumins, blood pressure, creatinine, urine, bevacizumab, macular edema, diabetic, ranibizumab, urine albumin/creatinine ratio, aflibercept, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1199-1205. doi: 10.1167/iovs.17-22853

Retina February 2018

Changes in Choroidal Thickness After Intravitreal Injection of Anti-Vascular Endothelial Growth Factor in Pachychoroid Neovasculopathy

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Noel Padrón-Pérez; Luis Arias; Marcos Rubio; Daniel Lorenzo; Pere García-Bru; Jaume Català-Mora; José M. Caminal
TAGS: endothelial growth factors, follow-up, injection of therapeutic agent, eye, intravitreal injections, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):1119-1124. doi: 10.1167/iovs.17-22144

Retina February 2018

Aflibercept Action in a Rabbit Model of Chronic Retinal Neovascularization: Reversible Inhibition of Pathologic Leakage With Dose-Dependent Duration

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Jingtai Cao; Thomas C. MacPherson; Bibiana V. Iglesias; Yang Liu; Natasha Tirko; George D. Yancopoulos; Stanley J. Wiegand; Carmelo Romano
TAGS: injection of therapeutic agent, oryctolagus cuniculus, retinal neovascularization, diagnostic imaging, eye, aflibercept, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):1033-1044. doi: 10.1167/iovs.17-22897

Physiology and Pharmacology February 2018

A Biodegradable, Sustained-Released, Tacrolimus Microfilm Drug Delivery System for the Management of Allergic Conjunctivitis in a Mouse Model

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Yu-Chi Liu; Xu Wen Ng; Ericia Pei Wen Teo; Heng-Pei Ang; Nyein Chan Lwin; Nicole Shu Wen Chan; Subbu S. Venkatraman; Tina T. Wong; Jodhbir S. Mehta
TAGS: immunohistochemistry, allergic conjunctivitis, drug delivery systems, mice, tacrolimus, drug release
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):675-684. doi: 10.1167/iovs.17-23066

Retinal Cell Biology January 2018

The Role of Angiotensin II/AT1 Receptor Signaling in Regulating Retinal Microglial Activation

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Joanna A. Phipps; Kirstan A. Vessey; Alice Brandli; Nupur Nag; Mai X. Tran; Andrew I. Jobling; Erica L. Fletcher
TAGS: signal transduction, angiotensin ii, microglia, eye, retina, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):487-498. doi: 10.1167/iovs.17-22416

Includes: Multimedia, Supplemental Content

Visual Neuroscience January 2018

Optic Nerve Regeneration After Crush Remodels the Injury Site: Molecular Insights From Imaging Mass Spectrometry

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David T. Stark; David M. G. Anderson; Jacky M. K. Kwong; Nathan Heath Patterson; Kevin L. Schey; Richard M. Caprioli; Joseph Caprioli
TAGS: axon, gangliosides, hyperplasia, mass spectrometry, sulfoglycosphingolipids, body tissue, wounds and injuries, diagnostic imaging, lipids, optic nerve, optic nerve regeneration, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):212-222. doi: 10.1167/iovs.17-22509

Includes: Supplemental Content

Cornea January 2018

Antimicrobial Studies Using the Therapeutic Tissue Cross-Linking Agent, Sodium Hydroxymethylglycinate: Implication for Treating Infectious Keratitis

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Patrick B. Rapuano; Alexandra H. Scanameo; Daeryl E. Amponin; Sefy A. Paulose; Mariya Zyablitskaya; Anna Takaoka; Leejee H. Suh; Takayuki Nagasaki; Stephen L. Trokel; David C. Paik
TAGS: keratitis, body tissue, sodium, antimicrobials, methicillin-resistant staphylococcus aureus, cross-linking
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):332-337. doi: 10.1167/iovs.17-23111

Glaucoma January 2018

Pharmacologic Characterization of Omidenepag Isopropyl, a Novel Selective EP2 Receptor Agonist, as an Ocular Hypotensive Agent

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Tomoko Kirihara; Takazumi Taniguchi; Kenzo Yamamura; Ryo Iwamura; Kenji Yoneda; Noriko Odani-Kawabata; Atsushi Shimazaki; Takeshi Matsugi; Naveed Shams; Jin-Zhong Zhang
TAGS: antihypertensive agents, prostaglandins, intraocular pressure, pharmacology, agonists
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):145-153. doi: 10.1167/iovs.17-22745

Review January 2018

Pharmacology of Corticosteroids for Diabetic Macular Edema

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Scott M. Whitcup; John A. Cidlowski; Karl G. Csaky; Jayakrishna Ambati
TAGS: adrenal corticosteroids, glucocorticoids, mineralocorticoids, macular edema, diabetic
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):1-12. doi: 10.1167/iovs.17-22259

Lens December 2017

The Intraocular Lens as a Drug Delivery Device: In Vitro Screening of Pharmacologic Substances for the Prophylaxis of Posterior Capsule Opacification

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Christian Wertheimer; Stefan Kassumeh; Nick P. Piravej; Olga Nilmayer; Christian Braun; Claudia Priglinger; Nikolaus Luft; Armin Wolf; Wolfgang J. Mayer; Siegfried G. Priglinger; Kirsten H. Eibl-Lindner
TAGS: cell culture techniques, endothelial cells, rapamycin, caffeic acids, drug delivery systems, esters, methotrexate, tretinoin, cornea, intraocular lens implant device, pharmacology, mass or substance concentration per volume, screening, after-cataract, toxic effect, prevention
Invest. Ophthalmol. Vis. Sci.. 2017; 58(14):6408-6418. doi: 10.1167/iovs.17-22555

Includes: Supplemental Content

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Endothelial Protein C–Targeting Liposomes Show Enhanced Uptake and Improved Therapeutic Efficacy in Human Retinal Endothelial Cells

Targeted Drug Delivery in the Suprachoroidal Space by Swollen Hydrogel Pushing

Inhibitory Effects of Angiotensin II Receptor Blockade on Human Tenon Fibroblast Migration and Reactive Oxygen Species Production in Cell Culture

Pharmacokinetics of Caffeine in the Lens Capsule/Epithelium After Peroral Intake: A Pilot Randomized Controlled Study

Plasma Concentrations of Lutein and Zeaxanthin, Macular Pigment Optical Density, and Their Associations With Cognitive Performances Among Older Adults

Bevacizumab Promotes T-Cell–Mediated Collagen Deposition in the Mouse Model of Conjunctival Scarring

The Role of 2% Rebamipide Eye Drops Related to Conjunctival Differentiation in Superoxide Dismutase-1 ( Sod1 ) Knockout Mice

Reviewers

Reviewers

Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis

Changes in Blood Pressure and Urine Albumin-Creatinine Ratio in a Randomized Clinical Trial Comparing Aflibercept, Bevacizumab, and Ranibizumab for Diabetic Macular Edema

Changes in Choroidal Thickness After Intravitreal Injection of Anti-Vascular Endothelial Growth Factor in Pachychoroid Neovasculopathy

Aflibercept Action in a Rabbit Model of Chronic Retinal Neovascularization: Reversible Inhibition of Pathologic Leakage With Dose-Dependent Duration

A Biodegradable, Sustained-Released, Tacrolimus Microfilm Drug Delivery System for the Management of Allergic Conjunctivitis in a Mouse Model

The Role of Angiotensin II/AT1 Receptor Signaling in Regulating Retinal Microglial Activation

Optic Nerve Regeneration After Crush Remodels the Injury Site: Molecular Insights From Imaging Mass Spectrometry

Antimicrobial Studies Using the Therapeutic Tissue Cross-Linking Agent, Sodium Hydroxymethylglycinate: Implication for Treating Infectious Keratitis

Pharmacologic Characterization of Omidenepag Isopropyl, a Novel Selective EP2 Receptor Agonist, as an Ocular Hypotensive Agent

Pharmacology of Corticosteroids for Diabetic Macular Edema

The Intraocular Lens as a Drug Delivery Device: In Vitro Screening of Pharmacologic Substances for the Prophylaxis of Posterior Capsule Opacification

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