Pharmacology

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Biochemistry and Molecular Biology June 2017

Identification of Novel G Protein–Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism

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Elisabetta De Filippo; Prashiela Manga; Anke C. Schiedel
TAGS: albinism, ocular, arrestin, chinese hamster ovary cell, ethacridine, lactates, levodopa, ligands, melanins, melanocyte, monophenol monooxygenase, niclosamide, pimozide, pharmacology, proteins, g-protein-coupled receptors, x-linked inheritance, screening, lysate
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3118-3126. doi: 10.1167/iovs.16-21128

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology June 2017

Effect of Gabapentin/Memantine on the Infantile Nystagmus Syndrome in the Zebrafish Model: Implications for the Therapy of Ocular Motor Diseases

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Stefan Yu Bögli; Maresa Afthinos; Melody Ying-Yu Huang
TAGS: gabapentin, memantine, pathologic nystagmus, syndrome, zebrafish, pharmacology, nystagmus, spontaneous
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3149-3157. doi: 10.1167/iovs.16-21308

Physiology and Pharmacology June 2017

A Compact Whole-Eye Perfusion System to Evaluate Pharmacologic Responses of Outflow Facility

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Enhua H. Zhou; Michael Paolucci; Thaddeus P. Dryja; Ted Manley; Chuanxi Xiang; Dennis S. Rice; Ganesh Prasanna; Amy Chen
TAGS: endothelin-1, perfusion, eye
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2991-3003. doi: 10.1167/iovs.16-20974

Includes: Supplemental Content

Retinal Cell Biology June 2017

High Glucose Induces Mitochondrial Dysfunction in Retinal Müller Cells: Implications for Diabetic Retinopathy

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Thomas Tien; Joyce Zhang; Tetsuya Muto; Dongjoon Kim; Vijay P. Sarthy; Sayon Roy
TAGS: mitochondria, glucose, diabetic retinopathy, cytochrome c, mitomycin, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2915-2921. doi: 10.1167/iovs.16-21355

Multidisciplinary Ophthalmic Imaging June 2017

Preclinical PET Study of Intravitreal Injections

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Anxo Fernández-Ferreiro; Andrea Luaces-Rodríguez; Pablo Aguiar; Juan Pardo-Montero; Miguel González-Barcia; Lara García-Varela; Michel Herranz; Jesús Silva-Rodríguez; María Gil-Martínez; María A. Bermúdez; Alba Vieites-Prado; José Blanco-Méndez; María Jesús Lamas; Francisco Gómez-Ulla; Álvaro Ruibal; Francisco Javier Otero-Espinar; Francisco González
TAGS: positron-emission tomography, fluorodeoxyglucose f18, choline, sodium fluoride, diagnostic imaging, eye, computed tomography/positron emission tomography imaging, molecule, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2843-2851. doi: 10.1167/iovs.17-21812

Physiology and Pharmacology May 2017

Development of a Sustained-Release Voriconazole-Containing Thermogel for Subconjunctival Injection in Horses

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Rosemary S. Cuming; Eva M. Abarca; Sue Duran; Anne A. Wooldridge; Allison J. Stewart; William Ravis; R. Jayachandra Babu; Yuh-Jing Lin; Terri Hathcock
TAGS: equus caballus, injection of therapeutic agent, cornea, voriconazole
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2746-2754. doi: 10.1167/iovs.16-20899

Nantotechnology and Regenerative Medicine May 2017

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides

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Felicity de Cogan; Lisa J. Hill; Aisling Lynch; Peter J. Morgan-Warren; Judith Lechner; Matthew R. Berwick; Anna F. A. Peacock; Mei Chen; Robert A. H. Scott; Heping Xu; Ann Logan
TAGS: choroidal neovascularization, peptides, cornea, eye, mice, retina, bevacizumab, eyedrops, cpps trial, complex, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2578-2590. doi: 10.1167/iovs.16-20072

Special Issue May 2017

Biomarkers and Surrogate Endpoints in Drug Development: A European Regulatory View

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Kerstin Wickström; Jane Moseley
TAGS: biological markers, drug development, surrogate endpoints
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO27-BIO33. doi: 10.1167/iovs.17-21778

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology April 2017

Experimental Anterior Ischemic Optic Neuropathy in Diabetic Mice Exhibited Severe Retinal Swelling Associated With VEGF Elevation

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Ming-Hui Sun; Mohammad Ali Shariati; Yaping Joyce Liao
TAGS: vascular endothelial growth factor a, diabetes mellitus, edema, mice, anterior ischemic optic neuropathy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2296-2305. doi: 10.1167/iovs.16-20308

Clinical Trials April 2017

A New Viscous Cysteamine Eye Drops Treatment for Ophthalmic Cystinosis: An Open-Label Randomized Comparative Phase III Pivotal Study

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Hong Liang; Antoine Labbé; Jeannie Le Mouhaër; Céline Plisson; Christophe Baudouin
TAGS: cystinosis, phase 3 clinical trials, photophobia, safety, cornea, eye, eyedrops, cysteamine
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2275-2283. doi: 10.1167/iovs.16-21080

Glaucoma April 2017

Development of a Δ 9 -Tetrahydrocannabinol Amino Acid-Dicarboxylate Prodrug With Improved Ocular Bioavailability

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Goutham R. Adelli; Prakash Bhagav; Pranjal Taskar; Tushar Hingorani; Sara Pettaway; Waseem Gul; Mahmoud A. ElSohly; Michael A. Repka; Soumyajit Majumdar
TAGS: prodrugs, tetrahydrocannabinol, body tissue
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2167-2179. doi: 10.1167/iovs.16-20757

Physiology and Pharmacology April 2017

Inhibition of Stat3 by a Small Molecule Inhibitor Slows Vision Loss in a Rat Model of Diabetic Retinopathy

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Phillip A. Vanlandingham; Didier J. Nuno; Alexander B. Quiambao; Eric Phelps; Ronald A. Wassel; Jian-Xing Ma; Krysten M. Farjo; Rafal A. Farjo
TAGS: diabetes mellitus, blindness, diabetic retinopathy, cataract, streptozocin, rats, retina, stat3 protein, small molecule
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2095-2105. doi: 10.1167/iovs.16-20641

Anatomy and Pathology/Oncology March 2017

A Bioengineering Approach to Myopia Control Tested in a Guinea Pig Model

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Mariana B. Garcia; Amit K. Jha; Kevin E. Healy; Christine F. Wildsoet
TAGS: biomedical engineering field, guinea, injection of therapeutic agent, myopia, refractive errors, surgical procedures, operative, eye, surgery specialty, implants, episcleral block, buffers, sclera, hydrogel
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1875-1886. doi: 10.1167/iovs.16-20694

Includes: Supplemental Content

Letters to the Editor March 2017

Functional and Anatomic Outcomes in Patients With Serous Retinal Detachment in Diabetic Macular Edema Treated With Ranibizumab

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Mohammed Ashraf
TAGS: macular edema, diabetic, ranibizumab, exudative retinal detachment
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1856-1856. doi: 10.1167/iovs.17-21655

Letters to the Editor March 2017

Author Response: Functional and Anatomic Outcomes in Patients With Serous Retinal Detachment in Diabetic Macular Edema Treated With Ranibizumab

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Audrey Giocanti-Auregan; Franck Fajnkuchen
TAGS: macular edema, diabetic, ranibizumab, exudative retinal detachment
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1857-1857. doi: 10.1167/iovs.17-21726

Retina March 2017

Recurrence of Retinopathy of Prematurity After Intravitreal Ranibizumab Monotherapy: Timing and Risk Factors

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Jiao Lyu; Qi Zhang; Chun-Li Chen; Yu Xu; Xun-Da Ji; Jia-Kai Li; Qiu-Jing Huang; Pei-Quan Zhao
TAGS: recurrence, retinopathy of prematurity, risk factors, ranibizumab
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1719-1725. doi: 10.1167/iovs.16-20680

Articles March 2017

Time-Dependent Decline in Multifocal Electroretinogram Requires Faster Recording Procedures in Anesthetized Pigs

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Nina Buus Sørensen; Anders Tolstrup Christiansen; Troels Wesenberg Kjær; Kristian Klemp; Morten la Cour; Jens Folke Kiilgaard
TAGS: anesthetics, electroretinography, injection of therapeutic agent, isoflurane, propofol, family suidae
Trans. Vis. Sci. Tech.. 2017; 6(2):6. doi: 10.1167/tvst.6.2.6

Cornea March 2017

Therapeutic Efficacy of Nanocomplex of Poly(Ethylene Glycol) and Catechin for Dry Eye Disease in a Mouse Model

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Hyesook Lee; Whuisu Shim; Chae Eun Kim; So Yeon Choi; Haeshin Lee; Jaewook Yang
TAGS: catechin, dry eye syndromes, cornea, ethylene glycol, mice
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1682-1691. doi: 10.1167/iovs.16-20843

Cornea March 2017

Topical Cryopreserved Amniotic Membrane and Umbilical Cord Eye Drops Promote Re-Epithelialization in a Murine Corneal Abrasion Model

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Sean Tighe; Hamid-Reza Moein; Lorraine Chua; Anny Cheng; Pedram Hamrah; Scheffer C. G. Tseng
TAGS: corneal abrasion, epithelium, amnion, cryopreservation, umbilical cord, cornea, mice, eyedrops, epithelialization, abrasion
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1586-1593. doi: 10.1167/iovs.16-20834

Anatomy and Pathology/Oncology March 2017

Determination of a No-Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Dutch Belted Rabbits

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Vladimir Bantseev; Paul E. Miller; Ellison Bentley; Chris Schuetz; Tim M. Streit; Brian J. Christian; Cindy Farman; Helen Booler; Evan A. Thackaberry
TAGS: endotoxins, oryctolagus cuniculus, eye, no-observed-effect level, intravitreal injections, dutch
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1545-1552. doi: 10.1167/iovs.16-21356

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Identification of Novel G Protein–Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism

Effect of Gabapentin/Memantine on the Infantile Nystagmus Syndrome in the Zebrafish Model: Implications for the Therapy of Ocular Motor Diseases

A Compact Whole-Eye Perfusion System to Evaluate Pharmacologic Responses of Outflow Facility

High Glucose Induces Mitochondrial Dysfunction in Retinal Müller Cells: Implications for Diabetic Retinopathy

Preclinical PET Study of Intravitreal Injections

Development of a Sustained-Release Voriconazole-Containing Thermogel for Subconjunctival Injection in Horses

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides

Biomarkers and Surrogate Endpoints in Drug Development: A European Regulatory View

Experimental Anterior Ischemic Optic Neuropathy in Diabetic Mice Exhibited Severe Retinal Swelling Associated With VEGF Elevation

A New Viscous Cysteamine Eye Drops Treatment for Ophthalmic Cystinosis: An Open-Label Randomized Comparative Phase III Pivotal Study

Development of a Δ 9 -Tetrahydrocannabinol Amino Acid-Dicarboxylate Prodrug With Improved Ocular Bioavailability

Inhibition of Stat3 by a Small Molecule Inhibitor Slows Vision Loss in a Rat Model of Diabetic Retinopathy

A Bioengineering Approach to Myopia Control Tested in a Guinea Pig Model

Functional and Anatomic Outcomes in Patients With Serous Retinal Detachment in Diabetic Macular Edema Treated With Ranibizumab

Author Response: Functional and Anatomic Outcomes in Patients With Serous Retinal Detachment in Diabetic Macular Edema Treated With Ranibizumab

Recurrence of Retinopathy of Prematurity After Intravitreal Ranibizumab Monotherapy: Timing and Risk Factors

Time-Dependent Decline in Multifocal Electroretinogram Requires Faster Recording Procedures in Anesthetized Pigs

Therapeutic Efficacy of Nanocomplex of Poly(Ethylene Glycol) and Catechin for Dry Eye Disease in a Mouse Model

Topical Cryopreserved Amniotic Membrane and Umbilical Cord Eye Drops Promote Re-Epithelialization in a Murine Corneal Abrasion Model

Determination of a No-Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Dutch Belted Rabbits

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