Biochemistry and Molecular Biology

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Glaucoma July 2025

Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization

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Victor A. de Vries; Anita Szabo; Joëlle E. Vergroesen; Siyin Liu; Karin A. van Garderen; Kirithika Muthusamy; Petra Liskova; Lubica Dudakova; Anthony P. Khawaja; Stephen J. Tuft; Caroline C. W. Klaver; Alice E. Davidson; Wishal D. Ramdas
TAGS: cardiac ct, cohort studies, cornea, glaucoma, mendelian randomization analysis, genetic risk score, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):22. https://doi.org/10.1167/iovs.66.9.22

Includes: Supplemental Content

Cornea & External Disease July 2025

Systematic Druggable-Proteome-Wide Mendelian Randomization Identifies Potential Therapeutic Targets for Allergic Conjunctivitis

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Jianqi Chen; Xiaohua Zhuo; Yuyao Ling; Yingting Zhu; Yangyang Li; Xinyue Shen; Yehong Zhuo; Hongmei Tan; Zhidong Li
TAGS: allergic conjunctivitis, mendelian randomization analysis, proteins, proteome, cd36 antigens
Trans. Vis. Sci. Tech.. 2025; 14(7):6. https://doi.org/10.1167/tvst.14.7.6

Includes: Supplemental Content

Cornea & External Disease July 2025

Investigating the Role of Autonomic Dysfunction in the Pathogenesis of Depression-Related Dry Eye

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Dan Wang; Yueni Ma; Mengyu Zhang; Fei Li; Ning Gao; Yuanyuan Qi; Zhenying Shang; Ruibo Yang
TAGS: autonomic dysfunction, depressive disorders, dry eye syndromes, pathogenesis, apoptosis, rats, bodily secretions, oxidative stress, sympathectomy
Trans. Vis. Sci. Tech.. 2025; 14(7):4. https://doi.org/10.1167/tvst.14.7.4

Includes: Supplemental Content

Retina July 2025

Retinal Angiogenesis in Methamphetamine Self-Administration Rats

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Minsup Lee; Bo J. Wood; Hyeon Hak Jeong; Hyung W. Nam; Courtney M. Keller; Bonggi Lee; Jae-Il Kim; Kevin S. Murnane; Nicholas E. Goeders; Norman R. Harris
TAGS: angiogenesis, methamphetamine, rats, self administration, retina, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):8. https://doi.org/10.1167/iovs.66.9.8

Glaucoma July 2025

Polygenic Risk Prediction for Normal-Tension Glaucoma

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Maryam Marzban; Santiago Diaz Torres; Regina Yu; Weixiong He; David A. Mackey; Ayellet V. Segrè; Janey Wiggs; Stuart MacGregor; Puya Gharahkhani; on behalf of the International Glaucoma Genetics Consortium
TAGS: datasets, low tension glaucoma, polygenic risk score, genome-wide association study
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):4. https://doi.org/10.1167/iovs.66.9.4

Includes: Supplemental Content

Cornea July 2025

Inhibitor of DNA-Binding 3 Is a Novel Regulator of Limbal Epithelial Cell Migration Via the EphA2/Akt Signaling Pathway

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Elwin D. Clutter; Wending Yang; Jacob Han; Nihal Kaplan; Han Peng
TAGS: akt signaling pathway, cell motility, dna, epithelial cells, proto-oncogene proteins c-akt, signal transduction, wound healing, wounds and injuries, cornea, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):2. https://doi.org/10.1167/iovs.66.9.2

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2025

Studies of All- trans Retinoic Acid Transport in the Eye

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Saptarshi Chatterjee; Ankana Roy; Jianshi Yu; Arthur Thomas Read; Melissa R. Bentley-Ford; Machelle T. Pardue; Maureen A. Kane; M. G. Finn; C. Ross Ethier
TAGS: tretinoin, proteins, fluorescence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):84. https://doi.org/10.1167/iovs.66.6.84

Includes: Supplemental Content

Neuro-ophthalmology June 2025

Inflammatory Proteins Mediate the Effect of Gut Microbiota on Graves’ Ophthalmopathy: A Mendelian Randomization Study

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Yipao Li; Lu Chen; Shaokai Lin; Wei An; Linfeng Miao; Minghui Wan; Binjun Zhang
TAGS: gastrointestinal microbiome, graves' ophthalmopathy, idiopathic pneumonia syndrome, mendelian randomization analysis, proteins
Trans. Vis. Sci. Tech.. 2025; 14(6):34. https://doi.org/10.1167/tvst.14.6.34

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2025

Single-Cell RNA Sequencing of Rabbit Sclera at Different Developmental Stages: Unveiling Scleral Cells Atlas and the Heterogeneity of Fibroblasts

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Fayuan Li; Chengqi Gu; Chengpeng Liang; Yang Li; Shuo Wang; Qingqing Tang; Huan Jiang; Shaorong Linghu; Tingting Dan; Rong Shi; Xin Luo; Taixiang Liu
TAGS: developmental stages, fibroblasts, oryctolagus cuniculus, sclera, sequence analysis, rna, genes, heterogeneity, follicular bronchiolitis, foreign bodies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):83. https://doi.org/10.1167/iovs.66.6.83

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2025

The Sialome of the Retina, Alteration in Age-Related Macular Degeneration Pathology, and Potential Impacts on Complement Factor H

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Jaclyn Swan; Christopher B. Toomey; Max Bergstrand; Hector A. Cuello; Jesse Robie; Hai Yu; Yue Yuan; Anoopjit Singh Kooner; Xi Chen; Jutamas Shaughnessy; Sanjay Ram; Ajit Varki; Pascal Gagneux
TAGS: age-related macular degeneration, complement factor h, n-acetylneuraminic acid, pathology, retina, polysaccharides, biological response modifiers, proteins, 3,3-dimethylbutan-1-ol, high pressure liquid chromatography procedure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):81. https://doi.org/10.1167/iovs.66.6.81

Includes: Supplemental Content

Cornea June 2025

FGF10 Protects the Corneal Epithelium From Dry Eye-Induced Oxidative and ER Stress Via Upregulation of SLC7A11

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Zhiwei Zha; Juan Li; Shuang Xie; Xunjie Shang; Zixin Xu; Haiyuan Chang; Kaisheng Wang; Yang Liu; Wei Chen
TAGS: dry eye syndromes, endoplasmic reticulum stress, fgf10 protein, human, mice, cornea, corneal epithelium, up-regulation (physiology), eye, body tissue, stress
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):72. https://doi.org/10.1167/iovs.66.6.72

Includes: Supplemental Content

Retina June 2025

Small-Molecule Inhibition of the Hippo Pathway Induces Regeneration of Retinal Pigment Epithelium

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Erik A. Souverein; Sanyukta Oak; Zachary Fouladian; Mark W. Reid; G. Esteban Fernandez; Andrew Salas; Jennifer G. Aparicio; Aaron Nagiel; Ksenia Gnedeva
TAGS: cell proliferation, hippo signaling pathway, lasers, long-acting thyroid stimulator, phosphotransferases, retinal pigment epithelium, small molecule, wound healing, wounds and injuries, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):69. https://doi.org/10.1167/iovs.66.6.69

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2025

Three-Dimensional Culture of Orbital Fibroblasts From Thyroid Eye Disease Induce In Vivo-Like Tissue Remodeling and Fibrosis

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Xiaoli Bao; Zhihui Xu; Xi Wang; Te Zhang; Huijing Ye; Huasheng Yang
TAGS: body tissue, fibroblasts, fibrosis, graves' ophthalmopathy, tissue remodeling, spheroids, cellular, genes, polymerase chain reaction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):67. https://doi.org/10.1167/iovs.66.6.67

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2025

Circadian Rhythms in Murine Ocular Tissues Including Sclera Are Affected by Neurobasal A Medium Preincubation and Mouse Strain, but Not Sex

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Nemanja Milićević; Cristina Sandu; Etienne Challet; Teemu O. Ihalainen; Soile Nymark; Marie-Paule Felder-Schmittbuhl
TAGS: bioluminescence, body tissue, circadian rhythms, mice, sclera, rhythm, pectoral compartment nerve block type 1, picture exchange communication system, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):62. https://doi.org/10.1167/iovs.66.6.62

Includes: Supplemental Content

Retina June 2025

Alteration of Tear Metabolomics Profiling in Infants With Retinopathy of Prematurity

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Zixin Fan; Shuo Yang; Xiaofeng Lu; Sifan Zhang; Xianlu Zeng; Lin Lin; Duo Yuan; Jian Zeng; Guoming Zhang
TAGS: biological markers, infant, metabolites, metabolomics, retinopathy of prematurity, birth weight
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):61. https://doi.org/10.1167/iovs.66.6.61

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2025

Machine Learning Identifies Key Gene Markers Related to Fetal Retina Development at Single-Cell Transcription Level

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Jiyu Zhang; Tong Du; Yiqing Jin; Yusheng Bao; Qinglan Ma; Yu-Dong Cai; Jian Zhang
TAGS: fetus, genes, retina, machine learning, rod photoreceptors, retinal cone, retinal diseases, classification algorithms
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):60. https://doi.org/10.1167/iovs.66.6.60

Includes: Supplemental Content

Cornea June 2025

RIPK3-Mediated Necroptosis Drives Macrophage Infiltration and Corneal Neovascularization After Alkali Burn

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Yue Li; Boyu Yang; Qi Chen; Yuchen Zhou; Wen Hu; Xiaojia Huang; Guangyi Huang; Ningning Tang; Fen Tang; Hui Huang; Qianqian Lan; Wenjing He; Fan Xu; Yiming Ye; Li Jiang
TAGS: alkalies, burns, cornea, corneal neovascularization, macrophages, necroptosis, fluorescent antibody technique, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):54. https://doi.org/10.1167/iovs.66.6.54

Includes: Supplemental Content

Physiology and Pharmacology June 2025

Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases

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Jessica R. Crawshaw; Eamonn A. Gaffney; Michael Gertz; Philip K. Maini; Antonello Caruso
TAGS: aqueous humor, ranibizumab, vascular endothelial growth factor a, pharmacodynamics, eye diseases, pharmacokinetics, mathematical model
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):20. https://doi.org/10.1167/iovs.66.6.20

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology June 2025

Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder

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Neringa Jurkute; Heiko Brennenstuhl; Monika Kustermann; Lindsey Van Haute; Christian D. Mutti; Enrico Bugiardini; Takayuki Handa; Masaru Shimura; Axel Petzold; James Acheson; Anthony G. Robson; William L. Macken; Michael G. Hanna; Robert D. S. Pitceathly; Ashirwad Merve; Urania Kotzaeridou; Stefan Kölker; Michael Freilinger; Marcus Erdler; Reginald E. Bittner; Johannes A. Mayr; Yasushi Okazaki; Kei Murayama; Holger Prokisch; Andrew R. Webster; Michal Minczuk; Gavin Arno; Berthold Pemp; Georg F. Hoffmann; Wolfgang M. Schmidt; Patrick Yu-Wai-Man
TAGS: family, mitochondrial diseases, optic atrophy, phenotype, mitochondria, optic nerve disorders, respiratory chain
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):17. https://doi.org/10.1167/iovs.66.6.17

Includes: Supplemental Content

Immunology and Microbiology June 2025

Disruption of Epidermal Growth Factor Receptor Signaling in RPE Cells Increases Resistance to Ocular Toxoplasmosis

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Amelia Pfaff; Alyssa Hubal; Sarah Vos; Vera Bonilha; Carlos S. Subauste
TAGS: epidermal growth factor receptors, ocular toxoplasmosis, retinal pigment cell, signal transduction, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):11. https://doi.org/10.1167/iovs.66.6.11

Includes: Supplemental Content

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Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization

Systematic Druggable-Proteome-Wide Mendelian Randomization Identifies Potential Therapeutic Targets for Allergic Conjunctivitis

Investigating the Role of Autonomic Dysfunction in the Pathogenesis of Depression-Related Dry Eye

Retinal Angiogenesis in Methamphetamine Self-Administration Rats

Polygenic Risk Prediction for Normal-Tension Glaucoma

Inhibitor of DNA-Binding 3 Is a Novel Regulator of Limbal Epithelial Cell Migration Via the EphA2/Akt Signaling Pathway

Studies of All- trans Retinoic Acid Transport in the Eye

Inflammatory Proteins Mediate the Effect of Gut Microbiota on Graves’ Ophthalmopathy: A Mendelian Randomization Study

Single-Cell RNA Sequencing of Rabbit Sclera at Different Developmental Stages: Unveiling Scleral Cells Atlas and the Heterogeneity of Fibroblasts

The Sialome of the Retina, Alteration in Age-Related Macular Degeneration Pathology, and Potential Impacts on Complement Factor H

FGF10 Protects the Corneal Epithelium From Dry Eye-Induced Oxidative and ER Stress Via Upregulation of SLC7A11

Small-Molecule Inhibition of the Hippo Pathway Induces Regeneration of Retinal Pigment Epithelium

Three-Dimensional Culture of Orbital Fibroblasts From Thyroid Eye Disease Induce In Vivo-Like Tissue Remodeling and Fibrosis

Circadian Rhythms in Murine Ocular Tissues Including Sclera Are Affected by Neurobasal A Medium Preincubation and Mouse Strain, but Not Sex

Alteration of Tear Metabolomics Profiling in Infants With Retinopathy of Prematurity

Machine Learning Identifies Key Gene Markers Related to Fetal Retina Development at Single-Cell Transcription Level

RIPK3-Mediated Necroptosis Drives Macrophage Infiltration and Corneal Neovascularization After Alkali Burn

Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases

Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder

Disruption of Epidermal Growth Factor Receptor Signaling in RPE Cells Increases Resistance to Ocular Toxoplasmosis

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