Biochemistry and Molecular Biology

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Retina May 2022

Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse

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Wanjing Huang; Qiang Xu; Feng Liu; Jing Su; Dongchang Xiao; Lei Tang; Zhao-Zhe Hao; Ruifeng Liu; Kangjian Xiang; Yalan Bi; Zhichao Miao; Xialin Liu; Yizhi Liu; Sheng Liu
TAGS: abdominal compartment syndrome, acute coronary syndromes, american cancer society, american college of surgeons, mice, retina, immunohistochemistry, amacrine cells
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):13. doi: https://doi.org/10.1167/iovs.63.5.13

Includes: Supplemental Content

Cornea May 2022

Shotgun Proteomics for the Identification and Profiling of the Tear Proteome of Keratoconus Patients

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Maite López-López; Uxía Regueiro; Susana Belén Bravo; María del Pilar Chantada-Vázquez; Carmen Pena; Elío Díez-Feijoo; Pablo Hervella; Isabel Lema
TAGS: keratoconus, proteins, proteome, proteomics, enzyme-linked immunosorbent assay
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):12. doi: https://doi.org/10.1167/iovs.63.5.12

Includes: Supplemental Content

Cornea May 2022

Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway

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Ren Liu; Jing Li; Yue Xu; Ziyan Chen; Huijing Ye; Jinhui Tang; Lai Wei; Lingyi Liang
TAGS: cytokine, epithelial cells, lipogenesis, meibomian gland, melatonin, mitogen-activated protein kinases, proteins, toll-like receptor 4
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):6. doi: https://doi.org/10.1167/iovs.63.5.6

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2022

The Protective Effects of KAT5 Inhibition on Ocular Inflammation by Mediating the PI3K/AKT Pathway in a Murine Model of Allergic Conjunctivitis

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Fei Luo; Yu Tao; Mengyu Wang; Liuqing Yang; Ruifeng Su; Zhiqiang Pan; Xiaobo Tan
TAGS: 1-phosphatidylinositol 3-kinase, mice, phosphoinositide 3-kinase, eye inflammation, protein overexpression, allergic conjunctivitis, inflammatory response, proto-oncogene proteins c-akt, phenotype, akt signaling pathway
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):4. doi: https://doi.org/10.1167/iovs.63.5.4

Retina April 2022

Depletion of miR-96 Delays, But Does Not Arrest, Photoreceptor Development in Mice

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Lue Xiang; Juan Zhang; Feng-Qin Rao; Qiao-Li Yang; Hui-Yi Zeng; Sheng-Hai Huang; Zhen-Xiang Xie; Ji-Neng Lv; Dan Lin; Xue-Jiao Chen; Kun-Chao Wu; Fan Lu; Xiu-Feng Huang; Qi Chen
TAGS: mice, photoreceptors, developmental delay
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):24. doi: https://doi.org/10.1167/iovs.63.4.24

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2022

Atypical U3 snoRNA Suppresses the Process of Pterygium Through Modulating 18S Ribosomal RNA Synthesis

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Xin Zhang; Yaping Jiang; Qian Wang; Weishu An; Xiaoyan Zhang; Ming Xu; Yihui Chen
TAGS: pterygium, rna, ribosomal, 18s, small nucleolar rna, atypical
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):17. doi: https://doi.org/10.1167/iovs.63.4.17

Includes: Supplemental Content

Retina April 2022

Targeted Analysis of Tears Revealed Specific Altered Metal Homeostasis in Age-Related Macular Degeneration

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Eva Valencia; Montserrat García; Beatriz Fernández-Vega; Rosario Pereiro; Lara Lobo; Héctor González-Iglesias
TAGS: age-related macular degeneration, homeostasis, metals, proteins, tear film finding, s100 calcium binding protein a6
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):10. doi: https://doi.org/10.1167/iovs.63.4.10

Includes: Supplemental Content

Retinal Cell Biology April 2022

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis

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Taku Wakabayashi; Hisamichi Naito; Tomohiro Iba; Kohji Nishida; Nobuyuki Takakura
TAGS: cell separation, choroid, endothelium, fluorescence, mice, retina, stem cells, electroconvulsive therapy, cd31 antigens, epidural cortical stimulation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):5. doi: https://doi.org/10.1167/iovs.63.4.5

Includes: Supplemental Content

Articles April 2022

Derivation and Characterization of Murine and Amphibian Müller Glia Cell Lines

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Ryan A. Gallo; Farhan Qureshi; Thomas A. Strong; Steven H. Lang; Kevin A. Pino; Galina Dvoriantchikova; Daniel Pelaez
TAGS: amphibia, anura, calcium, cell lines, mice, neuroglia, signal transduction, retina
Trans. Vis. Sci. Tech.. 2022; 11(4):4. doi: https://doi.org/10.1167/tvst.11.4.4

Includes: Multimedia, Supplemental Content

Cornea April 2022

Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation

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Kye-Im Jeon; Ankita Kumar; Kaitlin T. Wozniak; Keith Nehrke; Krystel R. Huxlin
TAGS: cornea, fibroblasts, fibrosis, mitochondria, myofibroblasts, phosphorylation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):2. doi: https://doi.org/10.1167/iovs.63.4.2

Includes: Supplemental Content

Cornea March 2022

Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway

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Peng Zhang; Lei Tian; Jiayu Bao; Shang Li; Ao Li; Ya Wen; Jingyi Wang; Ying Jie
TAGS: isotretinoin, meibomian gland, meibomian gland dysfunction
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):29. doi: https://doi.org/10.1167/iovs.63.3.29

Editorial March 2022

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2022; 11(3):25. doi: https://doi.org/10.1167/tvst.11.3.25

Editorial March 2022

Reviewers

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TAGS: christianity, reading (activity), alexia, cataract-alopecia-sclerodactyly syndrome, esters, glycogen storage disease type iv, sennosides, vacterl association with hydrocephalus, vision, aries trial
Journal of Vision. 2022; 22(4):10. doi: https://doi.org/10.1167/jov.22.4.10

Biochemistry and Molecular Biology March 2022

Intravitreal Injection of PACAP Attenuates Acute Ocular Hypertension–Induced Retinal Injury Via Anti-Apoptosis and Anti-Inflammation in Mice

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Peng Lu; Yuxun Shi; Dan Ye; Xi Lu; Xiaoyu Tang; Lu Cheng; Yue Xu; Jingjing Huang
TAGS: pituitary adenylate cyclase activating polypeptide, retina, wounds and injuries, inflammation, mice
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):18. doi: https://doi.org/10.1167/iovs.63.3.18

Anatomy and Pathology/Oncology March 2022

SP2509, a Selective Inhibitor of LSD1, Suppresses Retinoblastoma Growth by Downregulating β-catenin Signaling

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Alan Jiang; Weiqi Wu; Caixia Xu; Longbing Mao; Sha Ao; Huifeng Guo; Xiantao Sun; Jing Tao; Yi Sang; Guofu Huang
TAGS: cell proliferation, proteins, retinoblastoma, signal transduction, western blotting, transplantation, heterologous, apoptosis, body tissue, neoplasms, protein overexpression
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):20. doi: https://doi.org/10.1167/iovs.63.3.20

Articles March 2022

Serum Iba-1, GLUT5, and TSPO in Patients With Diabetic Retinopathy: New Biomarkers for Early Retinal Neurovascular Alterations? A Pilot Study

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Maria Consiglia Trotta; Carlo Gesualdo; Francesco Petrillo; Giancuomo Cavasso; Alberto Della Corte; Giovanbattista D'Amico; Anca Hermenean; Francesca Simonelli; Settimio Rossi
TAGS: biological markers, diabetes mellitus, diabetic retinopathy, hepatorenal syndrome, hrs trial, pilot projects, cytokine, nonproliferative diabetic retinopathy, arginase, chemokines
Trans. Vis. Sci. Tech.. 2022; 11(3):16. doi: https://doi.org/10.1167/tvst.11.3.16

Immunology and Microbiology March 2022

The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells

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Andrew R. Griswold; Hsin-Che Huang; Daniel A. Bachovchin
TAGS: cornea, corneal epithelial cells, cytokine, inflammasomes, pyroptosis, value-based purchasing
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):2. doi: https://doi.org/10.1167/iovs.63.3.2

Includes: Supplemental Content

Retina March 2022

Aqueous Humor Biomarkers of Retinal Glial Cell Activation in Patients With or Without Age-Related Cataracts and With Different Stages of Diabetic Retinopathy

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Minjie Zhao; Shuzhi Zhao; Min Tang; Tao Sun; Zhi Zheng; Mingming Ma
TAGS: hypertension, biological markers, diabetic retinopathy, neuroglia, aquaporin 1, cataract, senile, cataract, aqueous humor, glial fibrillary acidic protein
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):8. doi: https://doi.org/10.1167/iovs.63.3.8

Retina March 2022

LECT2 Ameliorates Blood–Retinal Barrier Impairment Secondary to Diabetes Via Activation of the Tie2/Akt/mTOR Signaling Pathway

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Yuan-Jun Qin; Ke Xiao; Zheng Zhong; Yin Zhao; Tian Yu; Xu-Fang Sun
TAGS: diabetes mellitus, diabetes mellitus, type 2, mtor signaling pathway, proto-oncogene proteins c-akt, retina, hyperglycemia, blood-retinal barrier, impairment, proteins, cadherins
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):7. doi: https://doi.org/10.1167/iovs.63.3.7

Includes: Supplemental Content

Articles March 2022

Subretinal Drusenoid Deposit Formation: Insights From Turing Patterns

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Benjamin K. Young; Liangbo L. Shen; Lucian V. Del Priore
TAGS: diffusion, digestive tract decontamination, transcriptional activation, kinetics
Trans. Vis. Sci. Tech.. 2022; 11(3):5. doi: https://doi.org/10.1167/tvst.11.3.5

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Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse

Shotgun Proteomics for the Identification and Profiling of the Tear Proteome of Keratoconus Patients

Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway

The Protective Effects of KAT5 Inhibition on Ocular Inflammation by Mediating the PI3K/AKT Pathway in a Murine Model of Allergic Conjunctivitis

Depletion of miR-96 Delays, But Does Not Arrest, Photoreceptor Development in Mice

Atypical U3 snoRNA Suppresses the Process of Pterygium Through Modulating 18S Ribosomal RNA Synthesis

Targeted Analysis of Tears Revealed Specific Altered Metal Homeostasis in Age-Related Macular Degeneration

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis

Derivation and Characterization of Murine and Amphibian Müller Glia Cell Lines

Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation

Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

Reviewers

Intravitreal Injection of PACAP Attenuates Acute Ocular Hypertension–Induced Retinal Injury Via Anti-Apoptosis and Anti-Inflammation in Mice

SP2509, a Selective Inhibitor of LSD1, Suppresses Retinoblastoma Growth by Downregulating β-catenin Signaling

Serum Iba-1, GLUT5, and TSPO in Patients With Diabetic Retinopathy: New Biomarkers for Early Retinal Neurovascular Alterations? A Pilot Study

The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells

Aqueous Humor Biomarkers of Retinal Glial Cell Activation in Patients With or Without Age-Related Cataracts and With Different Stages of Diabetic Retinopathy

LECT2 Ameliorates Blood–Retinal Barrier Impairment Secondary to Diabetes Via Activation of the Tie2/Akt/mTOR Signaling Pathway

Subretinal Drusenoid Deposit Formation: Insights From Turing Patterns

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