Biochemistry and Molecular Biology

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Retina February 2019

MMP Inhibition Preserves Integrin Ligation and FAK Activation to Induce Survival and Regeneration in RGCs Following Optic Nerve Damage

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Philippe M. D'Onofrio; Alireza P. Shabanzadeh; Brian K. Choi; Mathias Bähr; Paulo D. Koeberle
TAGS: immunohistochemistry, integrins, axon, axotomy, injections, ligation, matrix metalloproteinases, stromelysin 1, wounds and injuries, optic nerve, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):634-649. doi: 10.1167/iovs.18-25257

Glaucoma February 2019

Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon's Capsule + Conjunctival Model

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Rachel Gater; Tugce Ipek; Salman Sadiq; Dan Nguyen; Lynval Jones; Alicia El Haj; Ying Yang
TAGS: actins, tumor necrosis factors, vascular endothelial growth factor a, enzyme-linked immunosorbent assay, fibroblasts, fibrosis, glaucoma, growth factor, suidae, aqueous humor, conjunctiva, tenon's capsule, shear stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):605-614. doi: 10.1167/iovs.18-25335

Article February 2019

When predictions fail: Correction for extrapolation in the flash-grab effect

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Tessel Blom; Qianchen Liang; Hinze Hogendoorn
TAGS: illusions, motion, perception
Journal of Vision. 2019; 19(2):3. doi: 10.1167/19.2.3

Anatomy and Pathology/Oncology February 2019

A Genome-Wide Association Study for Susceptibility to Visual Experience-Induced Myopia

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Yu Huang; Chea-su Kee; Paul M. Hocking; Cathy Williams; Shea Ping Yip; Jeremy A. Guggenheim; for The UK Biobank Eye and Vision Consortium and The CREAM Consortium
TAGS: child, genetics, myopia, refractive errors, genome-wide association study, disease susceptibility
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):559-569. doi: 10.1167/iovs.18-25597

Includes: Supplemental Content

Retinal Cell Biology February 2019

Characterization and Regulation of Carrier Proteins of Mitochondrial Glutathione Uptake in Human Retinal Pigment Epithelium Cells

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Mo Wang; Lin-Ing Lau; Parameswaran G. Sreekumar; Christine Spee; David R. Hinton; Srinivas R. Sadda; Ram Kannan
TAGS: apoptosis, mitochondria, glutathione, carrier proteins, fluorescent antibody technique, mice, proteins, regulation, retinal pigment epithelium, caspase-3, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):500-516. doi: 10.1167/iovs.18-25686

Includes: Supplemental Content

Retina February 2019

Suppression of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells by an MRTF-A Inhibitor

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Masaaki Kobayashi; Kazuhiro Tokuda; Yuka Kobayashi; Chiemi Yamashiro; Sho-Hei Uchi; Makoto Hatano; Kazuhiro Kimura
TAGS: fibrosis, cell motility, choroidal neovascularization, gelatin, gelatinase a, immunoblotting, mice, proteins, epithelial to mesenchymal transition, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):528-537. doi: 10.1167/iovs.18-25678

Retina January 2019

Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1

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Wei Zhang; Yang Wang; Yichun Kong
TAGS: diabetes mellitus, hyperglycemia, inflammation, glucose, retinitis, rats, stem cell, mesenchymal, exosomes, hmgb1 protein
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):294-303. doi: 10.1167/iovs.18-25617

Retina January 2019

VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site

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Peter H. Tang; Gabriel Velez; Stephen H. Tsang; Alexander G. Bassuk; Vinit B. Mahajan
TAGS: mutation, exons, gelatinase a, surgical procedures, operative, vitreous body, eye, retina, cytokinesis, tissue degeneration, histopathology tests, proteolysis, proteins, splice-site mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):282-293. doi: 10.1167/iovs.18-25624

Includes: Supplemental Content

Biochemistry and Molecular Biology January 2019

Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers

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Saima Limi; Yilin Zhao; Peng Guo; Melissa Lopez-Jones; Deyou Zheng; Robert H. Singer; Arthur I. Skoultchi; Ales Cvekl
TAGS: crystallins, lens, crystalline, lens (device), rna, messenger, mice, rna, genes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):234-244. doi: 10.1167/iovs.18-25921

Includes: Supplemental Content

Biochemistry and Molecular Biology January 2019

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

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Sun Woong Kim; Hye-In Kim; Bikash Thapa; Selikem Nuwromegbe; Keunwook Lee
TAGS: signal transduction, fibroblasts, pterygium, myofibroblasts, proto-oncogene proteins c-akt, hpfs trial, mechanistic target of rapamycin complex 2, mtor serine-threonine kinases
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):82-92. doi: 10.1167/iovs.18-25376

Retina January 2019

Systemic Levels of Interleukin-6 Correlate With Progression Rate of Geographic Atrophy Secondary to Age-Related Macular Degeneration

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Marie Krogh Nielsen; Yousif Subhi; Christopher Rue Molbech; Mads Krüger Falk; Mogens Holst Nissen; Torben Lykke Sørensen
TAGS: inflammation, atrophy, plasma, c-reactive protein, interleukin-6, age-related macular degeneration, atrophic condition of skin, exudative age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):202-208. doi: 10.1167/iovs.18-25878

Includes: Supplemental Content

Visual Neuroscience January 2019

Retinal Characterization of the Thy1-GCaMP3 Transgenic Mouse Line After Optic Nerve Transection

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Stephanie N. Blandford; Michele L. Hooper; Takeshi Yabana; Balwantray C. Chauhan; William H. Baldridge; Spring R. M. Farrell
TAGS: calcium, diagnostic imaging, optic nerve, retina, mice, transgenic, fluorescence, immunohistochemistry, khat
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):183-191. doi: 10.1167/iovs.18-25861

Includes: Supplemental Content

Cornea January 2019

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

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Sheyla González; Denise Oh; Elfren R. Baclagon; Jie J. Zheng; Sophie X. Deng
TAGS: signal transduction, stem cells, molecule, small molecule, regulation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):107-112. doi: 10.1167/iovs.18-25740

Visual Neuroscience January 2019

Cone Photoreceptor Dysfunction in Early-Stage Diabetic Retinopathy: Association Between the Activation Phase of Cone Phototransduction and the Flicker Electroretinogram

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J. Jason McAnany; Jason C. Park
TAGS: photopsia, diabetic retinopathy, diabetes mellitus, pathophysiology, phototransduction, electroretinography, retinal cone, nonproliferative diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):64-72. doi: 10.1167/iovs.18-25946

Article January 2019

The separable effects of feature precision and item load in visual short-term memory

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Simon D. Lilburn; Philip L. Smith; David K. Sewell
TAGS: sample size, diffusion, memory, visual working memory, precision
Journal of Vision. 2019; 19(1):2. doi: 10.1167/19.1.2

Articles January 2019

Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy

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Joseph D. Bogaard; Jonathon B. Young; Asad Movahedan; Iris S. Kassem
TAGS: enoxaparin, child, animal model, triamcinolone, eye, fibrin, therapeutic intervention, oryctolagus cuniculus, postoperative care, anterior chamber of eye, inflammation, enzyme-linked immunosorbent assay, did not receive therapy or drug
Trans. Vis. Sci. Tech.. 2019; 8(1):5. doi: 10.1167/tvst.8.1.5

Retina December 2018

A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3

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Mark M. Hassall; Alun R. Barnard; Harry O. Orlans; Michelle E. McClements; Peter Charbel Issa; Sher A. Aslam; Robert E. MacLaren
TAGS: mice, retinal cone, mutation, electroretinography, achromatopsia
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6102-6110. doi: 10.1167/iovs.18-24328

Articles December 2018

A New in Vitro Model of GDLD by Knocking Out TACSTD2 and Its Paralogous Gene EpCAM in Human Corneal Epithelial Cells

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Peng Xu; Chifune Kai; Satoshi Kawasaki; Yuki Kobayashi; Kouji Yamamoto; Motokazu Tsujikawa; Ryuhei Hayashi; Kohji Nishida
TAGS: proteins, epcam gene, corneal epithelial cells, antibodies, epithelial cell adhesion molecule, genes, epithelium, cornea
Trans. Vis. Sci. Tech.. 2018; 7(6):30. doi: 10.1167/tvst.7.6.30

Immunology and Microbiology December 2018

Mechanism of Pseudomonas aeruginosa Small Protease (PASP), a Corneal Virulence Factor

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Aihua Tang; Armando R. Caballero; Mary E. Marquart; Michael A. Bierdeman; Richard J. O'Callaghan
TAGS: pseudomonas aeruginosa, mutation, catalysis, cornea, serine proteases, virulence factors, proteolytic enzymes, proteins, endopeptidases
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5993-6002. doi: 10.1167/iovs.18-25834

Biochemistry and Molecular Biology December 2018

The Effect of Prostaglandin Analogue Bimatoprost on Thyroid-Associated Orbitopathy

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Catherine J. Choi; Wensi Tao; Ravi Doddapaneni; Zenith Acosta-Torres; Nathan W. Blessing; Bradford W. Lee; Daniel Pelaez; Sara T. Wester
TAGS: prostaglandins, synthetic, bimatoprost
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5912-5923. doi: 10.1167/iovs.18-25134

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MMP Inhibition Preserves Integrin Ligation and FAK Activation to Induce Survival and Regeneration in RGCs Following Optic Nerve Damage

Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon's Capsule + Conjunctival Model

When predictions fail: Correction for extrapolation in the flash-grab effect

A Genome-Wide Association Study for Susceptibility to Visual Experience-Induced Myopia

Characterization and Regulation of Carrier Proteins of Mitochondrial Glutathione Uptake in Human Retinal Pigment Epithelium Cells

Suppression of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells by an MRTF-A Inhibitor

Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1

VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site

Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

Systemic Levels of Interleukin-6 Correlate With Progression Rate of Geographic Atrophy Secondary to Age-Related Macular Degeneration

Retinal Characterization of the Thy1-GCaMP3 Transgenic Mouse Line After Optic Nerve Transection

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

Cone Photoreceptor Dysfunction in Early-Stage Diabetic Retinopathy: Association Between the Activation Phase of Cone Phototransduction and the Flicker Electroretinogram

The separable effects of feature precision and item load in visual short-term memory

Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy

A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3

A New in Vitro Model of GDLD by Knocking Out TACSTD2 and Its Paralogous Gene EpCAM in Human Corneal Epithelial Cells

Mechanism of Pseudomonas aeruginosa Small Protease (PASP), a Corneal Virulence Factor

The Effect of Prostaglandin Analogue Bimatoprost on Thyroid-Associated Orbitopathy

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