Cornea

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Cornea May 2025

Assessment of Corneal Endothelial Barrier Function Based on “Y-Junctions”: A Finite Element Analysis

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Dongfang Li; Haoyun Duan; Xinhang Wang; Zhan Lin; Kun Dai; Xiangyue Hu; Xintian Zhao; Qingjun Zhou; Zongyi Li; Lixin Xie
TAGS: chronic exertional compartment syndrome, cornea, endothelium, finite element analysis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):33. https://doi.org/10.1167/iovs.66.5.33

Cornea May 2025

Metabolomic Profiling of Ocular Fluid Identifies Host Response Factors for Risk Stratification in Bacterial Endophthalmitis

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Naren Shetty; Padmamalini Mahendradas; Ramaraj Kannan; Samayitree Das; Priyanka Sathe; Rohit Shetty; Arkasubhra Ghosh; Vrushali Deshpande
TAGS: bacterial endophthalmitis, metabolites, metabolomics, immune response, stratification
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):27. https://doi.org/10.1167/iovs.66.5.27

Includes: Supplemental Content

Cornea May 2025

Autophagy Impairment-Derived SQSTM1 Accumulation Promotes Ferroptosis in Corneal Epithelial Cells Through ACSL4 in Dry Eye

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Runze Zhang; Lihong Liang; Kai Liao; Hao Zeng; Xue Yang; Xiaoran Wang; Bowen Wang; Jin Yuan
TAGS: corneal epithelial cells, dry eye syndromes, ferroptosis, stress, autophagy, western blotting, impairment
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):23. https://doi.org/10.1167/iovs.66.5.23

Includes: Supplemental Content

Cornea May 2025

Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease Via Macrophages

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Xujiao Zhou; Yuqing Wu; Yirou Zhang; Binbin Chu; Kan Yang; Jiaxu Hong; Yao He
TAGS: agonists, cornea, dry eye syndromes, inflammation, macrophages, neuroinflammatory diseases, nicotinic receptors, linear gingival erythema, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):13. https://doi.org/10.1167/iovs.66.5.13

Includes: Supplemental Content

Genetics May 2025

Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies

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Andrew Briere; Peter Vo; Benjamin Yang; David Adams; Takanori Amano; Oana Amarie; Zorana Berberovic; Lynette Bower; Steve D. M. Brown; Samantha Burrill; Soo Young Cho; Sharon Clementson-Mobbs; Abigail D'souza; Mohammad Eskandarian; Ann M. Flenniken; Helmut Fuchs; Valerie Gailus-Durner; Yann Hérault; Martin Hrabe de Angelis; Shundan Jin; Russell Joynson; Yeon Kyung Kang; Haerim Kim; Hiroshi Masuya; Hamid Meziane; Ki-Hoan Nam; Hyuna Noh; Lauryl M. J. Nutter; Marcela Palkova; Jan Prochazka; Miles Joseph Raishbrook; Fabrice Riet; Jason Salazar; Radislav Sedlacek; Mohammed Selloum; Kyoung Yul Seo; Je Kyung Seong; Hae-Sol Shin; Toshihiko Shiroishi; Michelle Stewart; Karen Svenson; Masaru Tamura; Heather Tolentino; Sara Wells; Wolfgang Wurst; Atsushi Yoshiki; Louise Lanoue; K. C. Kent Lloyd; Brian C. Leonard; Michel J. Roux; Colin McKerlie; Ala Moshiri; for The International Mouse Phenotyping Consortium
TAGS: genes, hereditary corneal dystrophy, mice, knockout, phenotype determination, proteins, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):7. https://doi.org/10.1167/iovs.66.5.7

Includes: Supplemental Content

Cornea May 2025

Retinoic Acid Receptor Alpha- and Beta-Mediated Signaling Regulates Conjunctival Epithelial Cell Keratinization

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Hokoru Yoshioka; Mayumi Ueta; Seiichi Yokoo; Norihiko Yokoi; Katsura Mizushima; Yuji Naito; Shigeru Kinoshita; Chie Sotozono
TAGS: conjunctival epithelial cells, keratinization, retinoic acid receptor, retinoic acid receptor alpha, signal transduction, tretinoin, vitamin a, polymerase chain reaction, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):6. https://doi.org/10.1167/iovs.66.5.6

Includes: Supplemental Content

Cornea April 2025

Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

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An Wang; Zongyuan Li; Yilin Jiang; Mingxiong Chen; Hanrui Yu; Zhao Li; Shengshu Sun; Ge Bai; Qun Wang; Yifei Huang; Liqiang Wang
TAGS: alkalies, burns, cornea, corneal injuries, limbal stem cells, lymphatic vessels, prospero-related homeobox 1 protein, recovery of function, epithelium, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):81. https://doi.org/10.1167/iovs.66.4.81

Includes: Supplemental Content

Cornea April 2025

Enhanced Therapeutic Effect of IL-10-ADSCs on Rabbit Autoimmune Dacryoadenitis By Suppressing T Follicular Helper Cell Responses Via miR-142-5p/RC3H1 Axis

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Lu Zhao; Na Li; Xinrui Shi; Jiachen Zhang; Min Gao; Yankai Wei; Xuejia Li; Bei Du; Deming Sun; Hong Nian; Ruihua Wei
TAGS: autoimmunity, dacryoadenitis, dry eye syndromes, oryctolagus cuniculus, t follicular helper cells, attenuation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):66. https://doi.org/10.1167/iovs.66.4.66

Includes: Supplemental Content

Cornea April 2025

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

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Min Wang; Rong Chen; Yao Wang; Ya Li; Qingjun Zhou; Rui Cao; Yizhou Li; Hongqi Ge; Xiaolei Wang; Lingling Yang
TAGS: cornea, keratins, limbal stem cells, proteins, stress, epithelium, mice, corneal epithelium, rna, messenger, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):55. https://doi.org/10.1167/iovs.66.4.55

Includes: Supplemental Content

Cornea April 2025

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

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Haiqi Xiao; Li Hu; Xiongshi Lin; Linchang Liu; Xing Dong; Liting Yang; Ying Liu; Zhichong Wang; Ying Tian; Shuangyong Wang
TAGS: pax6 transcription factor, soluble fms-like tyrosine kinase 1
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):52. https://doi.org/10.1167/iovs.66.4.52

Includes: Supplemental Content

Cornea & External Disease April 2025

A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing

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Mark Dibbs; Mitchelle Matesva; Despoina Theotoka; Christina Jayaraj; Beruk Metiku; Patrick Demkowicz; Jacob S. Heng; Yvonne Wang; Christine Y. Bakhoum; Jessica Chow; Mathieu F. Bakhoum
TAGS: bacteria, corneal ulcer, nanopore sequencing, pathogenic organism, ulcer, eye, cornea
Trans. Vis. Sci. Tech.. 2025; 14(4):19. https://doi.org/10.1167/tvst.14.4.19

Includes: Supplemental Content

Cornea & External Disease April 2025

A Novel Approach to Fabricate Early Keratoconus Phantom Models

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Hui Tong; Mingjue Wu; Jianqiang Han; Lin Li; Haixia Zhang
TAGS: cornea, keratoconus, phantoms, imaging, silicones
Trans. Vis. Sci. Tech.. 2025; 14(4):18. https://doi.org/10.1167/tvst.14.4.18

Cornea April 2025

Quantitative Stain-Free Conjunctival Collagen Imaging in Cicatrizing Conjunctivitis Using Second Harmonic Generation-Two Photon Excitation Technology

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Ralene Sim; Andri K. Riau; Nuur Shahinda Humaira binte Halim; Jodhbir S. Mehta; Hon Shing Ong
TAGS: collagen, conjunctiva, conjunctivitis, diagnostic imaging, excitation, harmonics, photons, technology, cicatrix
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):49. https://doi.org/10.1167/iovs.66.4.49

Includes: Supplemental Content

Cornea April 2025

Quantitative Changes in the Proteome of Chronically Inflamed Lacrimal Glands From a Sjögren's Disease Animal Model

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Danny Toribio; Junji Morokuma; Dante Pellino; Markus Hardt; Driss Zoukhri
TAGS: animal model, langer-giedion syndrome, peptides, proteins, proteome, sjogren's syndrome, liquid chromatography-mass spectrometry, lacrimal gland, fluorescent antibody technique, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):44. https://doi.org/10.1167/iovs.66.4.44

Includes: Supplemental Content

Anatomy and Pathology/Oncology April 2025

Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice

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Senmao Li; Jingbin Xie; Jiayan Xiang; Ruyu Yan; Jiangman Liu; Qiwei Fan; Liyuan Lu; Jiaxin Wu; Jun Liu; Yunxia Xue; Ting Fu; Zhijie Li
TAGS: cornea, lacrimal gland, nerve injuries, neurons, rhythm, circadian rhythms, nerve supply, mice, wounds and injuries, sensory nerves
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):40. https://doi.org/10.1167/iovs.66.4.40

Includes: Supplemental Content

Cornea April 2025

Antigen Presentation by Extracellular Vesicles in the Acute Phase of Corneal Transplantation

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Toshiki Shimizu; Takahiko Hayashi; Junki Kurita; Kentaro Yuda; Nobuhisa Mizuki; Satoru Yamagami
TAGS: antigen processing and presentation, extracellular vesicles, keratoplasty, tissue transplants, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):38. https://doi.org/10.1167/iovs.66.4.38

Includes: Supplemental Content

Cornea April 2025

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

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Xiaoqi Li; Anqi Liu; Yannan Zhou; Haolan Qi; Junyi Wang; Mingxiong Chen; Tunan Sun; Jie Wu; Yifei Huang; Liqiang Wang
TAGS: cornea, endothelium, mice, ppar alpha, chronic exertional compartment syndrome, fenofibrate, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):36. https://doi.org/10.1167/iovs.66.4.36

Includes: Supplemental Content

Visual Neuroscience April 2025

Depth-Related Visuomotor Performance in Keratoconus and Its Relationship to Stereopsis

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Preetirupa Devi; Christa M. Bhengra; Deepak Kumar; Rashmi Deshmukh; Pravin K. Vaddavalli; Joshua A. Solomon; Christopher W. Tyler; Shrikant R. Bharadwaj
TAGS: depth perception, keratoconus, task performance and analysis, vision, contact lenses, muscle rigidity, image quality
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):31. https://doi.org/10.1167/iovs.66.4.31

Cornea April 2025

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

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Yuzhou Wang; Zhiqiang Xu; Linzhi Wei; Yang Lu; Yizhou Shi; Shiyu Wen; Xiujuan Lv; Kaiyan Huang; Fan Lu; Jia Qu; Liang Hu
TAGS: hmgb1 protein, mice, toll-like receptor 4, inflammation, dry eye syndromes, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):28. https://doi.org/10.1167/iovs.66.4.28

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2025

Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling

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Shuting Lu; Qian Liu; Fan Ye; Ziran Zhang; Lianjun Shi; Xiumiao Li; Wan Mu; Qin Jiang; Biao Yan
TAGS: cholesterol metabolism, lymphangiogenesis, lymphatic vessels, rna, cornea, sutures, circular rna, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):26. https://doi.org/10.1167/iovs.66.4.26

Includes: Supplemental Content

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Assessment of Corneal Endothelial Barrier Function Based on “Y-Junctions”: A Finite Element Analysis

Metabolomic Profiling of Ocular Fluid Identifies Host Response Factors for Risk Stratification in Bacterial Endophthalmitis

Autophagy Impairment-Derived SQSTM1 Accumulation Promotes Ferroptosis in Corneal Epithelial Cells Through ACSL4 in Dry Eye

Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease Via Macrophages

Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies

Retinoic Acid Receptor Alpha- and Beta-Mediated Signaling Regulates Conjunctival Epithelial Cell Keratinization

Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

Enhanced Therapeutic Effect of IL-10-ADSCs on Rabbit Autoimmune Dacryoadenitis By Suppressing T Follicular Helper Cell Responses Via miR-142-5p/RC3H1 Axis

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing

A Novel Approach to Fabricate Early Keratoconus Phantom Models

Quantitative Stain-Free Conjunctival Collagen Imaging in Cicatrizing Conjunctivitis Using Second Harmonic Generation-Two Photon Excitation Technology

Quantitative Changes in the Proteome of Chronically Inflamed Lacrimal Glands From a Sjögren's Disease Animal Model

Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice

Antigen Presentation by Extracellular Vesicles in the Acute Phase of Corneal Transplantation

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

Depth-Related Visuomotor Performance in Keratoconus and Its Relationship to Stereopsis

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling

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