External Eye Disease

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Cornea July 2019

Induction of DDIT4 Impairs Autophagy Through Oxidative Stress in Dry Eye

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Bowen Wang; Lulu Peng; Hong Ouyang; Li Wang; Dalian He; Jing Zhong; Yichen Xiao; Yuqing Deng; Meng Li; Saiqun Li; Jin Yuan
TAGS: autophagy, dry eye syndromes, oxidative stress, western blotting, stress, mice, cell survival
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2836-2847. doi: 10.1167/iovs.19-27072

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2019

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

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Ikram El Zaoui; Maya Bucher; Donata Rimoldi; Michael Nicolas; Gurkan Kaya; Rosanna Pescini Gobert; Nicola Bedoni; Ann Schalenbourg; Ezziat Sakina; Leonidas Zografos; Serge Leyvraz; Nicolo Riggi; Carlo Rivolta; Alexandre P. Moulin
TAGS: 1-phosphatidylinositol 3-kinase, malignant melanoma of conjunctiva, mitogen-activated protein kinases, molecular targeted therapy, mtor serine-threonine kinases, phosphoinositide 3-kinase, braf gene, proto-oncogene proteins c-akt, melanoma, mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2764-2772. doi: 10.1167/iovs.18-26508

Includes: Supplemental Content

Cornea June 2019

Expression and Role of Nucleotide-Binding Oligomerization Domain 2 (NOD2) in the Ocular Surface of Murine Dry Eye

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Ying Li; Rujun Jin; Lan Li; Hyeon Jeong Yoon; Joo-Hee Choi; Jong-Hwan Park; Zuguo Liu; Wei Li; Zhengri Li; Kyung Chul Yoon
TAGS: body tissue, conjunctiva, cornea, dry eye syndromes, mice, nucleotides, cytokine, in situ nick-end labeling, ripk2 gene, interleukin-6, stress, tumor necrosis factors, flow cytometry
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2641-2649. doi: 10.1167/iovs.19-27144

Cornea June 2019

Dysregulated Tear Fluid Nociception-Associated Factors, Corneal Dendritic Cell Density, and Vitamin D Levels in Evaporative Dry Eye

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Pooja Khamar; Archana Padmanabhan Nair; Rohit Shetty; Tanuja Vaidya; Murali Subramani; Murugeswari Ponnalagu; Kamesh Dhamodaran; Sharon D'souza; Anuprita Ghosh; Natasha Pahuja; Rashmi Deshmukh; Prerna Ahuja; Kanchan Sainani; Rudy M. M. A. Nuijts; Debashish Das; Arkasubhra Ghosh; Swaminathan Sethu
TAGS: cornea, dendritic cells, dry eye syndromes, pain perception, signs and symptoms, vitamin d
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2532-2542. doi: 10.1167/iovs.19-26914

Includes: Supplemental Content

Articles June 2019

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

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Young Hyun Kim; Andrew D. Graham; Wing Li; Clayton J. Radke; Meng C. Lin
TAGS: evaporation, eye, heterogeneity of variance, loa, sample size, tear production, dry eye syndromes, humidity, reading (activity), anesthetics, clinical trial protocol document, body temperature
Trans. Vis. Sci. Tech.. 2019; 8(3):40. doi: 10.1167/tvst.8.3.40

Cornea May 2019

Human Meibum Cholesteryl and Wax Ester Variability With Age, Sex, and Meibomian Gland Dysfunction

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Douglas Borchman; Aparna Ramasubramanian; Gary N. Foulks
TAGS: cohort studies, dry eye syndromes, esters, meibomian gland, lipids, molar tooth, vibration, pathophysiology, donors
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2286-2293. doi: 10.1167/iovs.19-26812

Cornea May 2019

Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome

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Mathias Kaurstad Morthen; Sara Tellefsen; Stephen M. Richards; Scott M. Lieberman; Raheleh Rahimi Darabad; Wendy R. Kam; David A. Sullivan
TAGS: androgens, testosterone, gene expression, autoimmunity, genes, mice, inbred nod, sjogren's syndrome, body tissue, mice
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2181-2197. doi: 10.1167/iovs.19-26815

Anatomy and Pathology/Oncology May 2019

A Murine Model of Acute Allergic Conjunctivitis Induced by Continuous Exposure to Particulate Matter 2.5

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Yu-Jun Tang; Han-Hsin Chang; Chun-Yi Chiang; Chane-Yu Lai; Min-Yen Hsu; King-Rong Wang; Hsin-Hsuan Han; Ling-Yun Chen; David Pei-Cheng Lin
TAGS: allergic conjunctivitis, eyelid, goblet cells, metals, heavy, signs and symptoms, conjunctiva, eye, mice, lichtenberg figures, cervical mucous arborization, volume, eyelid edema, particulate matter, scratching
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2118-2126. doi: 10.1167/iovs.18-26214

Cornea May 2019

The Application of Strip Meniscometry to the Evaluation of Tear Volume in Mice

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Megumi Shinzawa; Murat Dogru; Keiichi Miyasaka; Takashi Kojima; Kazuo Tsubota
TAGS: dry eye syndromes, mice, stress, volume
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2088-2091. doi: 10.1167/iovs.19-26850

Cornea May 2019

Automated Measurement of Tear Meniscus Height with the Kowa DR-1α Tear Interferometer in Both Healthy Subjects and Dry Eye Patients

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Reiko Arita; Katsumi Yabusaki; Taisuke Hirono; Takanori Yamauchi; Tadashi Ichihashi; Shima Fukuoka; Naoyuki Morishige
TAGS: dry eye syndromes, joint meniscus
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2092-2101. doi: 10.1167/iovs.18-24850

Clinical Trials May 2019

A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

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Christine Mun; Shilpa Gulati; Sapna Tibrewal; Yi-Fan Chen; Seungwon An; Bayasgalan Surenkhuu; Ilangovan Raju; Morgan Buwick; Anna Ahn; Ji-Eun Kwon; Nour Atassi; Anubhav Pradeep; Damiano Rondelli; Sandeep Jain
TAGS: deoxyribonuclease i, deoxyribonucleases, dry eye syndromes, placebos, eyedrops
Trans. Vis. Sci. Tech.. 2019; 8(3):10. doi: 10.1167/tvst.8.3.10

Cornea May 2019

Relationship Between Sleep and Symptoms of Tear Dysfunction in Singapore Malays and Indians

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Elizabeth Wen Ling Lim; Miao Li Chee; Charumathi Sabanayagam; Shivani Majithia; Yijin Tao; Tien Yin Wong; Ching-Yu Cheng; Louis Tong
TAGS: dry eye syndromes, signs and symptoms, singapore, sleep, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):1889-1897. doi: 10.1167/iovs.19-26810

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2019

InflammAging at Ocular Surface: Clinical and Biomolecular Analyses in Healthy Volunteers

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Antonio Di Zazzo; Alessandra Micera; Marco Coassin; Giuseppe Varacalli; William Foulsham; Maria De Piano; Stefano Bonini
TAGS: polymerase chain reaction, fluorescent antibody technique, intercellular adhesion molecule 1, middle-aged adult, signs and symptoms, voluntary workers, inflammation, tear film finding
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1769-1775. doi: 10.1167/iovs.18-25822

Includes: Supplemental Content

Cornea March 2019

Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice

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Bum-Joo Cho; Jin Sun Hwang; Young Joo Shin; Jeong Won Kim; Tae-Young Chung; Joon Young Hyon
TAGS: inflammation, rapamycin, dry eye syndromes, endoplasmic reticulum, mice, stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1254-1264. doi: 10.1167/iovs.18-25583

Biochemistry and Molecular Biology March 2019

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

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Kailin Chen; Kairan Lai; Xiaobo Zhang; Zhenwei Qin; Qiuli Fu; Chenqi Luo; Xiuming Jin; Jianghua Hu; Siyu Liu; Ke Yao
TAGS: fibroblasts, conjunctiva, pterygium, proto-oncogene proteins c-akt, bromfenac, hpfs trial
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1156-1164. doi: 10.1167/iovs.18-24743

Includes: Supplemental Content

Cornea March 2019

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

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Hyesook Lee; Sangwon Jeon; Chae Eun Kim; Young-Joon Park; Jaewook Yang
TAGS: dry eye syndromes, cornea, eye, stress, mucins, dosage forms, desiccation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1076-1087. doi: 10.1167/iovs.18-24935

Articles February 2019

Multimodal Assessment of Corneal Erosions Using Optical Coherence Tomography and Automated Grading of Fluorescein Staining in a Rabbit Dry Eye Model

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Ifat Sher; Adi Tzameret; Alicja M. Szalapak; Tomer Carmeli; Estela Derazne; Noa Avni-Zauberman; Arie L. Marcovich; Guy Ben Simon; Ygal Rotenstreich
TAGS: epithelium, dry eye syndromes, fluorescein, cornea, erosion, optical coherence tomography, fluorescein stain method, software, desiccation, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2019; 8(1):27. doi: 10.1167/tvst.8.1.27

Includes: Supplemental Content

Glaucoma February 2019

A Highly Selective Rho-Kinase Inhibitor (ITRI-E-212) Potentially Treats Glaucoma Upon Topical Administration With Low Incidence of Ocular Hyperemia

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Cherng-Ru Hsu; Yi-Hsun Chen; Chih-Peng Liu; Chih-Hung Chen; Kuo-Kuei Huang; Jui-Wen Huang; Meng-Nan Lin; Chih-Lung Lin; Wan-Ru Chen; Yi-Ling Hsu; Tze-chung Lee; Shuen-Hsiang Chou; Chia-Mu Tu; Chrong-Shiong Hwang; Yu Chuan Huang; Da-Wen Lu
TAGS: hypertension, glaucoma, incidence, intraocular pressure, conjunctival injection, oryctolagus cuniculus, phosphotransferases, administration, topical, erythema
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):624-633. doi: 10.1167/iovs.18-25252

Cornea February 2019

Changes in Murine Subbasal Corneal Nerves After Scopolamine-Induced Dry Eye Stress Exposure

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Cem Simsek; Takashi Kojima; Taeko Nagata; Murat Dogru; Kazuo Tsubota
TAGS: dry eye syndromes, neurons, cornea, mice, stress, scopolamine
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):615-623. doi: 10.1167/iovs.18-26318

Biochemistry and Molecular Biology January 2019

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

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Sun Woong Kim; Hye-In Kim; Bikash Thapa; Selikem Nuwromegbe; Keunwook Lee
TAGS: signal transduction, fibroblasts, pterygium, myofibroblasts, proto-oncogene proteins c-akt, hpfs trial, mechanistic target of rapamycin complex 2, mtor serine-threonine kinases
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):82-92. doi: 10.1167/iovs.18-25376

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Induction of DDIT4 Impairs Autophagy Through Oxidative Stress in Dry Eye

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

Expression and Role of Nucleotide-Binding Oligomerization Domain 2 (NOD2) in the Ocular Surface of Murine Dry Eye

Dysregulated Tear Fluid Nociception-Associated Factors, Corneal Dendritic Cell Density, and Vitamin D Levels in Evaporative Dry Eye

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

Human Meibum Cholesteryl and Wax Ester Variability With Age, Sex, and Meibomian Gland Dysfunction

Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome

A Murine Model of Acute Allergic Conjunctivitis Induced by Continuous Exposure to Particulate Matter 2.5

The Application of Strip Meniscometry to the Evaluation of Tear Volume in Mice

Automated Measurement of Tear Meniscus Height with the Kowa DR-1α Tear Interferometer in Both Healthy Subjects and Dry Eye Patients

A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

Relationship Between Sleep and Symptoms of Tear Dysfunction in Singapore Malays and Indians

InflammAging at Ocular Surface: Clinical and Biomolecular Analyses in Healthy Volunteers

Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

Multimodal Assessment of Corneal Erosions Using Optical Coherence Tomography and Automated Grading of Fluorescein Staining in a Rabbit Dry Eye Model

A Highly Selective Rho-Kinase Inhibitor (ITRI-E-212) Potentially Treats Glaucoma Upon Topical Administration With Low Incidence of Ocular Hyperemia

Changes in Murine Subbasal Corneal Nerves After Scopolamine-Induced Dry Eye Stress Exposure

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

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