External Eye Disease

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Cornea May 2022

Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway

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Ren Liu; Jing Li; Yue Xu; Ziyan Chen; Huijing Ye; Jinhui Tang; Lai Wei; Lingyi Liang
TAGS: cytokine, epithelial cells, lipogenesis, meibomian gland, melatonin, mitogen-activated protein kinases, proteins, toll-like receptor 4
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):6. doi: https://doi.org/10.1167/iovs.63.5.6

Includes: Supplemental Content

Articles May 2022

Tear Strip Meniscometry and Its Clinical Application: Analysis of More Than 2000 Cases

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Keiichi Miyasaka; Masahiko Ayaki; Kazuno Negishi
TAGS: cornea, dry eye syndromes, fluorescein stain method, ocular surfaces, pain, schirmer tear test procedure, signs and symptoms, roc curve, joint meniscus, fluorescein
Trans. Vis. Sci. Tech.. 2022; 11(5):3. doi: https://doi.org/10.1167/tvst.11.5.3

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2022

The Protective Effects of KAT5 Inhibition on Ocular Inflammation by Mediating the PI3K/AKT Pathway in a Murine Model of Allergic Conjunctivitis

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Fei Luo; Yu Tao; Mengyu Wang; Liuqing Yang; Ruifeng Su; Zhiqiang Pan; Xiaobo Tan
TAGS: 1-phosphatidylinositol 3-kinase, mice, phosphoinositide 3-kinase, eye inflammation, protein overexpression, allergic conjunctivitis, inflammatory response, proto-oncogene proteins c-akt, phenotype, akt signaling pathway
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):4. doi: https://doi.org/10.1167/iovs.63.5.4

Biochemistry and Molecular Biology April 2022

Atypical U3 snoRNA Suppresses the Process of Pterygium Through Modulating 18S Ribosomal RNA Synthesis

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Xin Zhang; Yaping Jiang; Qian Wang; Weishu An; Xiaoyan Zhang; Ming Xu; Yihui Chen
TAGS: pterygium, rna, ribosomal, 18s, small nucleolar rna, atypical
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):17. doi: https://doi.org/10.1167/iovs.63.4.17

Includes: Supplemental Content

Articles March 2022

Impact of Incomplete Blinking Analyzed Using a Deep Learning Model With the Keratograph 5M in Dry Eye Disease

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Qinxiang Zheng; Lei Wang; Han Wen; Yueping Ren; Shenghai Huang; Furong Bai; Na Li; Jennifer P. Craig; Louis Tong; Wei Chen
TAGS: blinking, deep learning, dry eye syndromes
Trans. Vis. Sci. Tech.. 2022; 11(3):38. doi: https://doi.org/10.1167/tvst.11.3.38

Includes: Supplemental Content

Cornea March 2022

Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway

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Peng Zhang; Lei Tian; Jiayu Bao; Shang Li; Ao Li; Ya Wen; Jingyi Wang; Ying Jie
TAGS: isotretinoin, meibomian gland, meibomian gland dysfunction
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):29. doi: https://doi.org/10.1167/iovs.63.3.29

Articles March 2022

The Role of Different Tear Volume Detection Methods in the Evaluation and Diagnosis of Mild Dry Eye Disease

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Yuzhou Wang; Zhiqiang Xu; Qianwen Gong; Wenjun Ren; Lin Chen; Fan Lu; Liang Hu
TAGS: dry eye syndromes, volume, trimethylamine, ocular surfaces, tissue microarray
Trans. Vis. Sci. Tech.. 2022; 11(3):15. doi: https://doi.org/10.1167/tvst.11.3.15

Articles March 2022

The Impact of Image Quality and Trachomatous Inflammation on Using Photography for Trachoma Prevalence Surveys

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Michelle Odonkor; Fahd Naufal; Harran Mkocha; Nicodemus Funga; Beatriz Muñoz; Sheila K. West
TAGS: image quality, inflammation, photography, surveys, trachoma, mismatch, eye, prevalence
Trans. Vis. Sci. Tech.. 2022; 11(3):11. doi: https://doi.org/10.1167/tvst.11.3.11

Cornea March 2022

Obstructive Sleep Apnea Affects Lacrimal Gland Function

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Shaopan Wang; Xin He; Qingmin Li; Yuhan Zhang; Jiaoyue Hu; Rongrong Zong; Jingyi Zhuang; Andrew J. Quantock; Yingying Gao; Wei Li; Zuguo Liu
TAGS: lacrimal gland, mice, obstructive sleep apnea, tear production, lipids, hypoxia, fenofibrate, fluorescent antibody technique, immunohistochemistry, inflammation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):3. doi: https://doi.org/10.1167/iovs.63.3.3

Includes: Supplemental Content

Cornea February 2022

Transmembrane Mucin 1 Blocks Fluorescein Ingress to Corneal Epithelium

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Yi-Chen Sun; Kai-Feng Hung; Tzu-Yun Li; Yu-An Chang; Po-Ting Yeh; Fung-Rong Hu
TAGS: fluorescein, mucins, corneal epithelium, dry eye syndromes
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):31. doi: https://doi.org/10.1167/iovs.63.2.31

Includes: Supplemental Content

Articles February 2022

Validation of the Modified Schein Dry Eye Symptom Questionnaire and Comparison With the Ocular Surface Disease Index

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Jerry R. Paugh; Elaine Chen; Justin Kwan; Tiffany Nguyen; Alan Sasai; Melinda Thomas De Jesus; Andrew Loc Nguyen; Michael T. Christensen; David Meadows
TAGS: dry eye syndromes, questionnaires, signs and symptoms, ocular surfaces
Trans. Vis. Sci. Tech.. 2022; 11(2):27. doi: https://doi.org/10.1167/tvst.11.2.27

Cornea January 2022

A Novel Rat Model of Dry Eye Induced by Aerosol Exposure of Particulate Matter

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Ning Mu; He Wang; Dongyan Chen; Fan Wang; Ling Ji; Can Zhang; Mingxin Li; Peirong Lu
TAGS: aerosols, cornea, dry eye syndromes, inflammation, ocular surfaces, particulate matter, tear film finding, epithelium, volume, eye
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):39. doi: https://doi.org/10.1167/iovs.63.1.39

Cornea January 2022

Hyperglycemia Induces Meibomian Gland Dysfunction

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Yuli Guo; Houjian Zhang; Zhongyang Zhao; Xin Luo; Minjie Zhang; Jinghua Bu; Minghui Liang; Han Wu; Jingwen Yu; Hui He; Rongrong Zong; Yongxiong Chen; Zuguo Liu; Wei Li
TAGS: diabetes mellitus, hyperglycemia, meibomian gland dysfunction, rats, western blotting
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):30. doi: https://doi.org/10.1167/iovs.63.1.30

Includes: Supplemental Content

Physiology and Pharmacology January 2022

Pathogenic Mechanism of Dry Eye–Induced Chronic Ocular Pain and a Mechanism-Based Therapeutic Approach

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Yuto Tei; Yoshinori Mikami; Masanori Ito; Taichiro Tomida; Daisuke Ohshima; Yuichi Hori; Satomi Adachi-Akahane
TAGS: dry eye syndromes, eye, trigeminal nuclei, hypersensitivity, hyperalgesia, linear gingival erythema, ocular pain, pregabalin, cornea
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):7. doi: https://doi.org/10.1167/iovs.63.1.7

Includes: Supplemental Content

Articles December 2021

Changes in Meibum Lipid Composition With Ocular Demodex Infestation

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Hui Gao; Hua Chen; Hua-Tao Xie; Kang-Kang Xu; Bing-Jie Shi; Yu-Kan Huang
TAGS: demodex infestations, lipids
Trans. Vis. Sci. Tech.. 2021; 10(14):6. doi: https://doi.org/10.1167/tvst.10.14.6

Includes: Supplemental Content

Cornea November 2021

Optogenetic Inhibition of Na v 1.8 Expressing Corneal Afferents Reduces Persistent Dry Eye Pain

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Neal E. Mecum; Rachel Russell; Jun Lee; Cara Sullivan; Ian D. Meng
TAGS: cornea, dry eye syndromes, linear gingival erythema, mice, optogenetics, pain, persistence, conditioning (psychology)
Invest. Ophthalmol. Vis. Sci.. 2021; 62(14):15. doi: https://doi.org/10.1167/iovs.62.14.15

Cornea October 2021

Hyperkeratinization and Proinflammatory Cytokine Expression in Meibomian Glands Induced by Staphylococcus aureus

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Hua Chen; Hui Gao; Hua-Tao Xie; Shu-Ting Liu; Yu-Kan Huang; Ming-Chang Zhang
TAGS: cytokine, meibomian gland, mice, staphylococcus aureus, proteins
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):11. doi: https://doi.org/10.1167/iovs.62.13.11

Biochemistry and Molecular Biology September 2021

Effects of Aging on Human Meibum

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Igor A. Butovich; Tomo Suzuki
TAGS: aging, lipids, significance, meibomian gland dysfunction
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):23. doi: https://doi.org/10.1167/iovs.62.12.23

Includes: Supplemental Content

Immunology and Microbiology September 2021

Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease

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Zhang Zhang; Xinrong Zou; Wenwen Xue; Pei Zhang; Shanshan Wang; Haidong Zou
TAGS: diabetes mellitus, dry eye syndromes, microbiome
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):13. doi: https://doi.org/10.1167/iovs.62.12.13

Includes: Supplemental Content

Articles September 2021

In Vivo Efficacy of Imatinib Mesylate, a Tyrosine Kinase Inhibitor, in the Treatment of Chemically Induced Dry Eye in Animal Models

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Yi-Yong Baek; Bokyung Sung; Jun-Sub Choi; Hyeon-Kyu Go; Do-Hyung Kim; Joon Young Hyon; Ji Chang You
TAGS: animal model, dry eye syndromes, imatinib mesylate, protein-tyrosine kinase inhibitor, bronchioloalveolar carcinoma, blood alcohol concentration
Trans. Vis. Sci. Tech.. 2021; 10(11):14. doi: https://doi.org/10.1167/tvst.10.11.14

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Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway

Tear Strip Meniscometry and Its Clinical Application: Analysis of More Than 2000 Cases

The Protective Effects of KAT5 Inhibition on Ocular Inflammation by Mediating the PI3K/AKT Pathway in a Murine Model of Allergic Conjunctivitis

Atypical U3 snoRNA Suppresses the Process of Pterygium Through Modulating 18S Ribosomal RNA Synthesis

Impact of Incomplete Blinking Analyzed Using a Deep Learning Model With the Keratograph 5M in Dry Eye Disease

Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway

The Role of Different Tear Volume Detection Methods in the Evaluation and Diagnosis of Mild Dry Eye Disease

The Impact of Image Quality and Trachomatous Inflammation on Using Photography for Trachoma Prevalence Surveys

Obstructive Sleep Apnea Affects Lacrimal Gland Function

Transmembrane Mucin 1 Blocks Fluorescein Ingress to Corneal Epithelium

Validation of the Modified Schein Dry Eye Symptom Questionnaire and Comparison With the Ocular Surface Disease Index

A Novel Rat Model of Dry Eye Induced by Aerosol Exposure of Particulate Matter

Hyperglycemia Induces Meibomian Gland Dysfunction

Pathogenic Mechanism of Dry Eye–Induced Chronic Ocular Pain and a Mechanism-Based Therapeutic Approach

Changes in Meibum Lipid Composition With Ocular Demodex Infestation

Optogenetic Inhibition of Na v 1.8 Expressing Corneal Afferents Reduces Persistent Dry Eye Pain

Hyperkeratinization and Proinflammatory Cytokine Expression in Meibomian Glands Induced by Staphylococcus aureus

Effects of Aging on Human Meibum

Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease

In Vivo Efficacy of Imatinib Mesylate, a Tyrosine Kinase Inhibitor, in the Treatment of Chemically Induced Dry Eye in Animal Models

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