Eye Anatomy and Disorders

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Cornea & External Disease January 2025

Clinical Characteristics and In Vivo Confocal Microscopic Study in Candida Keratitis

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Yan Peng; Qiankun Chen; Yuan Wei; Leying Wang; Zijun Zhang; Zhenyu Wei; Jinding Pang; Bo Peng; Qingquan Shi; Zhiqun Wang; Yang Zhang; Kexin Chen; Xizhan Xu; Qingfeng Liang
TAGS: candida, keratitis, hyphae, plant spores, reproduction spores
Trans. Vis. Sci. Tech.. 2025; 14(1):23. https://doi.org/10.1167/tvst.14.1.23

Includes: Supplemental Content

Artificial Intelligence January 2025

Explainable Deep Learning for Glaucomatous Visual Field Prediction: Artifact Correction Enhances Transformer Models

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Kornchanok Sriwatana; Chanon Puttanawarut; Yanin Suwan; Titipat Achakulvisut
TAGS: artifacts, datasets, glaucoma, visual fields
Trans. Vis. Sci. Tech.. 2025; 14(1):22. https://doi.org/10.1167/tvst.14.1.22

Includes: Supplemental Content

Glaucoma January 2025

Corneal Stromal Stem Cell-Derived Extracellular Vesicles Attenuate ANGPTL7 Expression in the Human Trabecular Meshwork

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Faycal Moujane; Chi Zhang; Robert Knight; John Y. Lee; Sophie X. Deng; Jie J. Zheng
TAGS: attenuation, cornea, extracellular vesicles, glaucoma, myoc gene, trabecular meshwork, culture media, conditioned, dexamethasone, genes, intraocular pressure
Trans. Vis. Sci. Tech.. 2025; 14(1):21. https://doi.org/10.1167/tvst.14.1.21

Artificial Intelligence January 2025

Noninvasive Anemia Detection and Hemoglobin Estimation from Retinal Images Using Deep Learning: A Scalable Solution for Resource-Limited Settings

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Rehana Khan; Vinod Maseedupally; Kaveri A. Thakoor; Rajiv Raman; Maitreyee Roy
TAGS: anemia, hemoglobin, deep learning, resource-limited settings
Trans. Vis. Sci. Tech.. 2025; 14(1):20. https://doi.org/10.1167/tvst.14.1.20

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology January 2025

Eye Movements and the Intraorbital Subarachnoid Space: Potential Contribution of Altered Cerebrospinal Fluid Pumping in Optic Neuropathies

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Joseph L. Demer; Robert A. Clark; Soh Youn Suh; JoAnn A. Giaconi; Kouros Nouri-Mahdavi; Simon K. Law; Laura Bonelli; Anthony C. Arnold; Peter Quiros; Anne L. Coleman; Joseph Caprioli
TAGS: adduction, cerebrospinal fluid, eye, eye movement, magnetic resonance imaging, open-angle glaucoma, optic nerve, optic nerve disorders, subarachnoid space, volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):53. https://doi.org/10.1167/iovs.66.1.53

Cornea January 2025

Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus

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Loren Moon; Pritpal Kaur; Jiangxia Wang; Akrit Sodhi; Charles Eberhart; Uri Soiberman
TAGS: collagen, corneal epithelial cells, corneal epithelium, keratoconus, wnt10a gene, genes, proteins, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):52. https://doi.org/10.1167/iovs.66.1.52

Includes: Supplemental Content

Cornea January 2025

ROCK Inhibitor Enhances Resilience Against Metabolic Stress Through Increasing Bioenergetic Capacity in Corneal Endothelial Cells

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Wei-Ting Ho; Jung-Shen Chang; Chia-Jen Lei; Tsan-Chi Chen; Jia-Kang Wang; Shu-Wen Chang; Muh-Hwa Yang; Tzuu-Shuh Jou; I-Jong Wang
TAGS: cornea, endothelial cells, metabolic stress, monensin, sodium, stress, chronic exertional compartment syndrome, apoptosis, glycolysis, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):51. https://doi.org/10.1167/iovs.66.1.51

Includes: Supplemental Content

Article January 2025

Pupil responds spontaneously to visuospatial regularity

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Zhiming Kong; Chen Chen; Jianrong Jia
TAGS: arthritis, juvenile rheumatoid, pupil, pupil reaction, perception
Journal of Vision. 2025; 25(1):14. https://doi.org/10.1167/jov.25.1.14

Retina January 2025

Fundus Autofluorescence Variation in Geographic Atrophy of Age-Related Macular Degeneration: A Clinicopathologic Correlation

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Christine A. Curcio; Jeffrey D. Messinger; Andreas Berlin; Kenneth R. Sloan; D. Scott McLeod; Malia M. Edwards; Jacques Bijon; K. Bailey Freund
TAGS: age-related macular degeneration, age-related macular degeneration, nonexudative, atrophic condition of skin, atrophy, autofluorescence, drusen, fundus autofluorescence imaging, histology, pathology, clinical, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):49. https://doi.org/10.1167/iovs.66.1.49

Includes: Multimedia, Supplemental Content

Perspective January 2025

The Landscape of Vascular Endothelial Growth Factor Inhibition in Retinal Diseases

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Joseph B. Lin; Rajendra S. Apte
TAGS: retinal diseases, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):47. https://doi.org/10.1167/iovs.66.1.47

Biochemistry and Molecular Biology January 2025

Pyrimidinergic P2Y1-Like Nucleotide Receptors Are Functional in Rat Conjunctival Goblet Cells

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Ketil A. Fjærvoll; Haakon K. Fjærvoll; Menglu Yang; Jeffrey Bair; Tor P. Utheim; Darlene A. Dartt
TAGS: agonists, conjunctiva, goblet cells, nucleotides, purinoceptor p2y1, bodily secretions, mucins, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):46. https://doi.org/10.1167/iovs.66.1.46

Includes: Supplemental Content

Retina January 2025

Perfusion Capacity as a Predictive Index for Assessing Visual Functional Recovery in Patients With Idiopathic Epiretinal Membrane

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Jinlian Zhan; Chen Chen; Tong Wang; Qi Zhang; Xia Huang; Lin Lu; Xiujuan Zhao
TAGS: epiretinal membrane, perfusion, postoperative care, preoperative care, recovery of function, retinal vasculature, vision, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(1):19. https://doi.org/10.1167/tvst.14.1.19

Includes: Supplemental Content

Glaucoma January 2025

Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical Stress

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Chien-Chia Su; Vaibhav Desikan; Kevin Betsch; Myoung Sup Shim; Kate E. Keller; Paloma B. Liton
TAGS: acetylation, tubulin, microtubules, stress, mechanical
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):43. https://doi.org/10.1167/iovs.66.1.43

Includes: Supplemental Content

Cornea January 2025

Posterior Limbal Mesenchymal Stromal Cells Promote Proliferation and Stemness of Transition Zone Cells: A Novel Insight Into Corneal Endothelial Rejuvenation

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Yuting Xiao; Charles N. J. McGhee; Jie Zhang
TAGS: cornea, endothelium, rejuvenation, mesenchymal stem cells, mice, wounds and injuries, proteins, culture media, conditioned, coculture techniques
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):44. https://doi.org/10.1167/iovs.66.1.44

Includes: Supplemental Content

Glaucoma January 2025

Using a Theoretical Model to Assess the Impact of Vascular Risk Factors on Autoregulation in the Retina

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Brendan C. Fry; Julia C. Arciero; Croix Gyurek; Amanda Albright; Brent Siesky; Alice Verticchio; Alon Harris
TAGS: fluid flow, homeostasis, intraocular pressure, models, theoretical, regulation, retina, risk factors, vascular flow, alveolar ventilation function, cell respiration
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):42. https://doi.org/10.1167/iovs.66.1.42

Lens January 2025

Influence of Lens Power on IOL/Posterior Lens Capsule Interactions and IOL's PCO Potential

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Amjad Chatila; Vicki Ea; Samira Izuagbe; Le Quynh Hoang; Bhavya Vaish; Cynthia M. Co; Trinh M. Luong; Liping Tang
TAGS: adhesions, diopters, incidence, lens (device), lens capsule, crystalline, lens, crystalline, myopia, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):41. https://doi.org/10.1167/iovs.66.1.41

Includes: Supplemental Content

Clinical and Epidemiologic Research January 2025

The Value of Orbital Exenteration for Eyelid Sebaceous Carcinoma in Stages II to IV: A Cohort Study of 78 Patients

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Jie Chen; Tianyu Zhu; Ziyue Huang; Renbing Jia; Shiqiong Xu
TAGS: cohort studies, eye, orbit evisceration, sebaceous adenocarcinoma, sebaceous adenocarcinoma of eyelid, neoplasm metastasis, surgical procedures, operative, recurrence, selenocysteine, cerebral arterial thrombosis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):40. https://doi.org/10.1167/iovs.66.1.40

Includes: Supplemental Content

Lens January 2025

Quantification of the Anterior–Centripetal Movement of the Ciliary Muscle During Accommodation Using Dynamic OCT Imaging

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Iulen Cabeza-Gil; Marco Ruggeri; Fabrice Manns
TAGS: centripetal, ciliary muscle, diagnostic imaging, visual accommodation
Trans. Vis. Sci. Tech.. 2025; 14(1):17. https://doi.org/10.1167/tvst.14.1.17

Includes: Supplemental Content

Retinal Cell Biology January 2025

Stress Granule Induction in Rat Retinas Damaged by Constant LED Light

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María M. Benedetto; Melisa Malcolm; Manuel G. Bruera; Laura G. Penazzi; Mario E. Guido; María A. Contín; Eduardo Garbarino-Pico
TAGS: retina, stress granules, arsenites, sodium, light exposure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):38. https://doi.org/10.1167/iovs.66.1.38

Includes: Supplemental Content

Retina January 2025

Age- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse

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Yan Wang; Dehuan Xu; Yuhang Zhao; Haiyu Zhu; Xiaoyu Xiu; Haiyan Jiang; Yimei Liu; Ge Shan; Shengzhou Wu
TAGS: mice, proteins, retina, serine, alzheimer's disease, regulation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):36. https://doi.org/10.1167/iovs.66.1.36

Includes: Supplemental Content

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Clinical Characteristics and In Vivo Confocal Microscopic Study in Candida Keratitis

Explainable Deep Learning for Glaucomatous Visual Field Prediction: Artifact Correction Enhances Transformer Models

Corneal Stromal Stem Cell-Derived Extracellular Vesicles Attenuate ANGPTL7 Expression in the Human Trabecular Meshwork

Noninvasive Anemia Detection and Hemoglobin Estimation from Retinal Images Using Deep Learning: A Scalable Solution for Resource-Limited Settings

Eye Movements and the Intraorbital Subarachnoid Space: Potential Contribution of Altered Cerebrospinal Fluid Pumping in Optic Neuropathies

Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus

ROCK Inhibitor Enhances Resilience Against Metabolic Stress Through Increasing Bioenergetic Capacity in Corneal Endothelial Cells

Pupil responds spontaneously to visuospatial regularity

Fundus Autofluorescence Variation in Geographic Atrophy of Age-Related Macular Degeneration: A Clinicopathologic Correlation

The Landscape of Vascular Endothelial Growth Factor Inhibition in Retinal Diseases

Pyrimidinergic P2Y1-Like Nucleotide Receptors Are Functional in Rat Conjunctival Goblet Cells

Perfusion Capacity as a Predictive Index for Assessing Visual Functional Recovery in Patients With Idiopathic Epiretinal Membrane

Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical Stress

Posterior Limbal Mesenchymal Stromal Cells Promote Proliferation and Stemness of Transition Zone Cells: A Novel Insight Into Corneal Endothelial Rejuvenation

Using a Theoretical Model to Assess the Impact of Vascular Risk Factors on Autoregulation in the Retina

Influence of Lens Power on IOL/Posterior Lens Capsule Interactions and IOL's PCO Potential

The Value of Orbital Exenteration for Eyelid Sebaceous Carcinoma in Stages II to IV: A Cohort Study of 78 Patients

Quantification of the Anterior–Centripetal Movement of the Ciliary Muscle During Accommodation Using Dynamic OCT Imaging

Stress Granule Induction in Rat Retinas Damaged by Constant LED Light

Age- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse

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