Genetics

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Cornea July 2025

DJ-1 Promotes Diabetic Corneal Epithelial Wound Healing by Attenuating Hyperglycemia-Induced Oxidative Stress Through Inhibiting PTEN

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Haoyu Li; Hanhan Peng; Benteng Ma; Xinyue Sun; Liwei Zhang; Baihua Chen
TAGS: cornea, diabetes mellitus, epithelium, hyperglycemia, oxidative stress, proteins, pten gene, wound healing, antioxidants, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):20. https://doi.org/10.1167/iovs.66.9.20

Includes: Supplemental Content

Glaucoma July 2025

Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization

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Victor A. de Vries; Anita Szabo; Joëlle E. Vergroesen; Siyin Liu; Karin A. van Garderen; Kirithika Muthusamy; Petra Liskova; Lubica Dudakova; Anthony P. Khawaja; Stephen J. Tuft; Caroline C. W. Klaver; Alice E. Davidson; Wishal D. Ramdas
TAGS: cardiac ct, cohort studies, cornea, glaucoma, mendelian randomization analysis, genetic risk score, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):22. https://doi.org/10.1167/iovs.66.9.22

Includes: Supplemental Content

Cornea & External Disease July 2025

Systematic Druggable-Proteome-Wide Mendelian Randomization Identifies Potential Therapeutic Targets for Allergic Conjunctivitis

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Jianqi Chen; Xiaohua Zhuo; Yuyao Ling; Yingting Zhu; Yangyang Li; Xinyue Shen; Yehong Zhuo; Hongmei Tan; Zhidong Li
TAGS: allergic conjunctivitis, mendelian randomization analysis, proteins, proteome, cd36 antigens
Trans. Vis. Sci. Tech.. 2025; 14(7):6. https://doi.org/10.1167/tvst.14.7.6

Includes: Supplemental Content

Glaucoma July 2025

Exploring the Mechanisms Linking Depression and Glaucoma: A Cohort Study of UK Biobank

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Xueming Yao; Yuhan Jiang; Hongxi Yang; Ju Guo; Xiaohong Wang; Andrzej Grzybowski; Mulin Jun Li; Hua Yan
TAGS: depressive disorders, glaucoma, cohort studies, uk biobank, genetics
Trans. Vis. Sci. Tech.. 2025; 14(7):5. https://doi.org/10.1167/tvst.14.7.5

Includes: Supplemental Content

Genetics July 2025

Quantitative Choroidal Analysis of Molecularly Characterized Retinitis Pigmentosa

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Kirk A. J. Stephenson; Tiffany Tse; Jiwon Hwang; Andrii Kavetskyi; Shanil R. Dhanji; Olubayo U. Kolawole; Cheryl Y. Gregory-Evans; Kaivon Pakzad-Vaezi; Zaid N. Mammo; Kevin Gregory-Evans; Myeong Jin Ju
TAGS: cardiovascular imaging, cortical blindness, eye, genotype, retinitis pigmentosa, myopia, cohort studies, pseudophakia, volume, choroid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):11. https://doi.org/10.1167/iovs.66.9.11

Includes: Supplemental Content

Visual Neuroscience July 2025

Evidence for M 2 Muscarinic Receptor Antagonist Delay of Myopia Development Through Activation of Kir3.4 Channel in the Retina of Guinea Pigs

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Hong Zhou; Guimei Zhou; Qin Yang; Jiahao Niu; Runzhe Wang; Huilan Liu; Suwen Hou; Hongsheng Bi; Xuan Liao
TAGS: antagonists, caviidae, muscarinic acetylcholine receptor, myopia, retina, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):5. https://doi.org/10.1167/iovs.66.9.5

Retina July 2025

Retinal Angiogenesis in Methamphetamine Self-Administration Rats

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Minsup Lee; Bo J. Wood; Hyeon Hak Jeong; Hyung W. Nam; Courtney M. Keller; Bonggi Lee; Jae-Il Kim; Kevin S. Murnane; Nicholas E. Goeders; Norman R. Harris
TAGS: angiogenesis, methamphetamine, rats, self administration, retina, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):8. https://doi.org/10.1167/iovs.66.9.8

Glaucoma July 2025

Polygenic Risk Prediction for Normal-Tension Glaucoma

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Maryam Marzban; Santiago Diaz Torres; Regina Yu; Weixiong He; David A. Mackey; Ayellet V. Segrè; Janey Wiggs; Stuart MacGregor; Puya Gharahkhani; on behalf of the International Glaucoma Genetics Consortium
TAGS: datasets, low tension glaucoma, polygenic risk score, genome-wide association study
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):4. https://doi.org/10.1167/iovs.66.9.4

Includes: Supplemental Content

Genetics July 2025

A Phenotypic Study of CRB1 Retinopathy Secondary to the Variant p.(Pro836Thr) Prevalent in Those of Black African Ancestry

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Wendy M. Wong; Anthony G. Robson; Rebecca A. Baker; Gavin Arno; Joseph Van Aerschot; Siying Lin; Mariya Moosajee; Michel Michaelides; Omar A. Mahroo; Andrew R. Webster
TAGS: phenotype, retinal diseases, electroretinography, retinal dystrophies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):3. https://doi.org/10.1167/iovs.66.9.3

Includes: Supplemental Content

Cornea July 2025

Inhibitor of DNA-Binding 3 Is a Novel Regulator of Limbal Epithelial Cell Migration Via the EphA2/Akt Signaling Pathway

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Elwin D. Clutter; Wending Yang; Jacob Han; Nihal Kaplan; Han Peng
TAGS: akt signaling pathway, cell motility, dna, epithelial cells, proto-oncogene proteins c-akt, signal transduction, wound healing, wounds and injuries, cornea, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):2. https://doi.org/10.1167/iovs.66.9.2

Includes: Supplemental Content

Article July 2025

Variations in sensory eye dominance along the horizontal meridian

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Chris L. E. Paffen
TAGS: eye, masks, meridians, ocular dominance, nose, visual fields
Journal of Vision. 2025; 25(8):1. https://doi.org/10.1167/jov.25.8.1

Glaucoma June 2025

Multi-Omic Insight Into the Molecular Networks of Mitochondrial Dysfunction in the Pathogenesis of Primary Open-Angle Glaucoma

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Li-Hua Chen; Hai-Jiang Zhang; Qing-Ao Xiao
TAGS: methylation, mitochondria, mitochondrial diseases, open-angle glaucoma, pathogenesis, pathophysiology, multiomics, genes
Trans. Vis. Sci. Tech.. 2025; 14(6):37. https://doi.org/10.1167/tvst.14.6.37

Includes: Supplemental Content

Neuro-ophthalmology June 2025

Inflammatory Proteins Mediate the Effect of Gut Microbiota on Graves’ Ophthalmopathy: A Mendelian Randomization Study

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Yipao Li; Lu Chen; Shaokai Lin; Wei An; Linfeng Miao; Minghui Wan; Binjun Zhang
TAGS: gastrointestinal microbiome, graves' ophthalmopathy, idiopathic pneumonia syndrome, mendelian randomization analysis, proteins
Trans. Vis. Sci. Tech.. 2025; 14(6):34. https://doi.org/10.1167/tvst.14.6.34

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2025

Single-Cell RNA Sequencing of Rabbit Sclera at Different Developmental Stages: Unveiling Scleral Cells Atlas and the Heterogeneity of Fibroblasts

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Fayuan Li; Chengqi Gu; Chengpeng Liang; Yang Li; Shuo Wang; Qingqing Tang; Huan Jiang; Shaorong Linghu; Tingting Dan; Rong Shi; Xin Luo; Taixiang Liu
TAGS: developmental stages, fibroblasts, oryctolagus cuniculus, sclera, sequence analysis, rna, genes, heterogeneity, follicular bronchiolitis, foreign bodies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):83. https://doi.org/10.1167/iovs.66.6.83

Includes: Supplemental Content

Retina June 2025

Increment Thresholds in Retinitis Pigmentosa: Association With Retinal Thickness

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Robert A. Hyde; Jason C. Park; J. Jason McAnany
TAGS: retinitis pigmentosa, fovea centralis, retinal cone, visual fields
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):78. https://doi.org/10.1167/iovs.66.6.78

Cornea June 2025

FGF10 Protects the Corneal Epithelium From Dry Eye-Induced Oxidative and ER Stress Via Upregulation of SLC7A11

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Zhiwei Zha; Juan Li; Shuang Xie; Xunjie Shang; Zixin Xu; Haiyuan Chang; Kaisheng Wang; Yang Liu; Wei Chen
TAGS: dry eye syndromes, endoplasmic reticulum stress, fgf10 protein, human, mice, cornea, corneal epithelium, up-regulation (physiology), eye, body tissue, stress
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):72. https://doi.org/10.1167/iovs.66.6.72

Includes: Supplemental Content

Genetics June 2025

Does the Association Between Eye Disease and Cognitive Function Vary by Genetic Risk of Cognitive Decline? An Analysis of Hospital Data With Replication in the Canadian Longitudinal Study on Aging

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Emily Tran; Mohan Rakesh; Gisele Li; Ellen E. Freeman; Marie-Hélène Roy-Gagnon
TAGS: aging, cognitive ability, cognitive impairment, eye diseases, genetic risk, hospitals, longitudinal studies, mental processes, montreal, glaucoma
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):71. https://doi.org/10.1167/iovs.66.6.71

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2025

Three-Dimensional Culture of Orbital Fibroblasts From Thyroid Eye Disease Induce In Vivo-Like Tissue Remodeling and Fibrosis

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Xiaoli Bao; Zhihui Xu; Xi Wang; Te Zhang; Huijing Ye; Huasheng Yang
TAGS: body tissue, fibroblasts, fibrosis, graves' ophthalmopathy, tissue remodeling, spheroids, cellular, genes, polymerase chain reaction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):67. https://doi.org/10.1167/iovs.66.6.67

Includes: Supplemental Content

Retina June 2025

Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes

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Abraham Hang; Andy Shao; Michael Shea; Michel J. Roux; Denise M. Imai-Leonard; David J. Adams; Takanori Amano; Oana V. Amarie; Zorana Berberovic; Raphaël Bour; Lynette Bower; Brian C. Leonard; Steve D. Brown; Soo Young Cho; Sharon Clementson-Mobbs; Abigail J. D'Souza; Mary Dickinson; Mohammad Eskandarian; Ann M. Flenniken; Helmut Fuchs; Valerie Gailus-Durner; Jason Heaney; Yann Hérault; Martin Hrabe de Angelis; Chih-Wei Hsu; Shundan Jin; Russell Joynson; Yeon Kyung Kang; Haerim Kim; Hiroshi Masuya; Ki-Hoan Nam; Hyuna Noh; Lauryl M. J. Nutter; Marcela Palkova; Jan Prochazka; Miles Joseph Raishbrook; Fabrice Riet; Jason Salazar; John Richard Seavitt; Radislav Sedlacek; Mohammed Selloum; Kyoung Yul Seo; Je Kyung Seong; Hae-Sol Shin; Toshihiko Shiroishi; Tania Sorg; Michelle Stewart; Masaru Tamura; Heather Tolentino; Uchechukwu Udensi; Sara Wells; Wolfgang Wurst; Atsushi Yoshiki; Hamid Meziane; Glenn C. Yiu; Paul A. Sieving; Louise Lanoue; K C. Kent Lloyd; Colin McKerlie; Ala Moshiri; for the International Mouse Phenotyping Consortium (IMPC)
TAGS: adult, genes, mice, mice, knockout, phenotype, phenotype determination
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):64. https://doi.org/10.1167/iovs.66.6.64

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2025

Machine Learning Identifies Key Gene Markers Related to Fetal Retina Development at Single-Cell Transcription Level

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Jiyu Zhang; Tong Du; Yiqing Jin; Yusheng Bao; Qinglan Ma; Yu-Dong Cai; Jian Zhang
TAGS: fetus, genes, retina, machine learning, rod photoreceptors, retinal cone, retinal diseases, classification algorithms
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):60. https://doi.org/10.1167/iovs.66.6.60

Includes: Supplemental Content

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DJ-1 Promotes Diabetic Corneal Epithelial Wound Healing by Attenuating Hyperglycemia-Induced Oxidative Stress Through Inhibiting PTEN

Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization

Systematic Druggable-Proteome-Wide Mendelian Randomization Identifies Potential Therapeutic Targets for Allergic Conjunctivitis

Exploring the Mechanisms Linking Depression and Glaucoma: A Cohort Study of UK Biobank

Quantitative Choroidal Analysis of Molecularly Characterized Retinitis Pigmentosa

Evidence for M 2 Muscarinic Receptor Antagonist Delay of Myopia Development Through Activation of Kir3.4 Channel in the Retina of Guinea Pigs

Retinal Angiogenesis in Methamphetamine Self-Administration Rats

Polygenic Risk Prediction for Normal-Tension Glaucoma

A Phenotypic Study of CRB1 Retinopathy Secondary to the Variant p.(Pro836Thr) Prevalent in Those of Black African Ancestry

Inhibitor of DNA-Binding 3 Is a Novel Regulator of Limbal Epithelial Cell Migration Via the EphA2/Akt Signaling Pathway

Variations in sensory eye dominance along the horizontal meridian

Multi-Omic Insight Into the Molecular Networks of Mitochondrial Dysfunction in the Pathogenesis of Primary Open-Angle Glaucoma

Inflammatory Proteins Mediate the Effect of Gut Microbiota on Graves’ Ophthalmopathy: A Mendelian Randomization Study

Single-Cell RNA Sequencing of Rabbit Sclera at Different Developmental Stages: Unveiling Scleral Cells Atlas and the Heterogeneity of Fibroblasts

Increment Thresholds in Retinitis Pigmentosa: Association With Retinal Thickness

FGF10 Protects the Corneal Epithelium From Dry Eye-Induced Oxidative and ER Stress Via Upregulation of SLC7A11

Does the Association Between Eye Disease and Cognitive Function Vary by Genetic Risk of Cognitive Decline? An Analysis of Hospital Data With Replication in the Canadian Longitudinal Study on Aging

Three-Dimensional Culture of Orbital Fibroblasts From Thyroid Eye Disease Induce In Vivo-Like Tissue Remodeling and Fibrosis

Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes

Machine Learning Identifies Key Gene Markers Related to Fetal Retina Development at Single-Cell Transcription Level

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