Genetics

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Retina June 2019

Treatment Potential for Macular Cone Vision in Leber Congenital Amaurosis Due to CEP290 or NPHP5 Mutations: Predictions From Artificial Intelligence

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Alexander Sumaroka; Alexandra V. Garafalo; Evelyn P. Semenov; Rebecca Sheplock; Arun K. Krishnan; Alejandro J. Roman; Samuel G. Jacobson; Artur V. Cideciyan
TAGS: artificial intelligence, leber's amaurosis, mutation, retina, retinal cone, vision, fovea centralis, perimetry, machine learning
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2551-2562. doi: 10.1167/iovs.19-27156

Includes: Supplemental Content

Retinal Cell Biology June 2019

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

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Matthew J. Hayes; Thomas Burgoyne; Silene T. Wavre-Shapton; Tanya Tolmachova; Miguel C. Seabra; Clare E. Futter
TAGS: epithelium, inner ear, mice, osmosis, pigment, retinal pigment cell, tissue membrane, eye, face, mitochondria, organelles
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2515-2524. doi: 10.1167/iovs.19-26784

Includes: Multimedia, Supplemental Content

Articles June 2019

Reliability of Spectral-Domain OCT Ellipsoid Zone Area and Shape Measurements in Retinitis Pigmentosa

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Travis B. Smith; Maria A. Parker; Peter N. Steinkamp; Albert Romo; Laura R. Erker; Brandon J. Lujan; Ning Smith
TAGS: face, reliability, retinitis pigmentosa, shape, spectral-domain optical coherence tomography
Trans. Vis. Sci. Tech.. 2019; 8(3):37. doi: 10.1167/tvst.8.3.37

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2019

Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations

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Getachew Boru; Colleen M. Cebulla; Klarke M. Sample; James B. Massengill; Frederick H. Davidorf; Mohamed H. Abdel-Rahman
TAGS: heterogeneity, intraocular melanoma, mitogen-activated protein kinases, mutation, neoplasms, cell lines, immunohistochemistry, transfection
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2474-2480. doi: 10.1167/iovs.18-26452

Includes: Supplemental Content

Retina June 2019

Quantifying Retinal Pigment Epithelium Dysmorphia and Loss of Histologic Autofluorescence in Age-Related Macular Degeneration

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J. Alan Gambril; Kenneth R. Sloan; Thomas A. Swain; Carrie Huisingh; Anna V. Zarubina; Jeffrey D. Messinger; Thomas Ach; Christine A. Curcio
TAGS: age-related macular degeneration, autofluorescence, phenotype, retinal pigment epithelium, diagnostic imaging, eye
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2481-2493. doi: 10.1167/iovs.19-26949

Includes: Supplemental Content

Articles May 2019

Extracellular Matrix Protein Coating of Processed Fish Scales Improves Human Corneal Endothelial Cell Adhesion and Proliferation

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Yi-Jen Hsueh; David Hui-Kang Ma; Kathleen Sheng-Chuan Ma; Tze-Kai Wang; Cheng-Hung Chou; Chien-Cheng Lin; Min-Chang Huang; Li-Jyuan Luo; Jui-Yang Lai; Hung-Chi Chen
TAGS: cell proliferation, endothelial cells, extracellular matrix proteins, adhesions, cornea, proteins, weight measurement scales
Trans. Vis. Sci. Tech.. 2019; 8(3):27. doi: 10.1167/tvst.8.3.27

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2019

REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice

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William P. Miller; Allyson L. Toro; Alistair J. Barber; Michael D. Dennis
TAGS: oxidative stress, diabetes mellitus, hyperglycemia, glucose, cell death, feedback, mice, proteins, retina, glycogen synthase kinase 3, proto-oncogene proteins c-akt, hyperglycemic agents
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2369-2379. doi: 10.1167/iovs.19-26606

Genetics May 2019

Characteristic Ocular Features in Cases of Autosomal Recessive PROM1 Cone-Rod Dystrophy

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Frederick T. Collison; Gerald A. Fishman; Takayuki Nagasaki; Jana Zernant; J. Jason McAnany; Jason C. Park; Rando Allikmets
TAGS: color, electroretinography, family, retinitis pigmentosa, diagnostic imaging, autosomal recessive inheritance, genetic analysis, progressive cone-rod dystrophy, autofluorescence, spectral-domain optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2347-2356. doi: 10.1167/iovs.19-26993

Cornea May 2019

MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells

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Kyu-Yeon Han; Jin-Hong Chang; Dimitri T. Azar
TAGS: endothelial cells, proteins, exosomes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2321-2329. doi: 10.1167/iovs.18-26277

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology May 2019

Head and Gaze Behavior in Retinitis Pigmentosa

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Samuel A. Titchener; Lauren N. Ayton; Carla J. Abbott; James B. Fallon; Mohit N. Shivdasani; Emily Caruso; Pyrawy Sivarajah; Matthew A. Petoe
TAGS: head movements, pursuit, smooth, retinitis pigmentosa, saccades, eye, gaze
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2263-2273. doi: 10.1167/iovs.18-26121

Cornea May 2019

Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome

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Mathias Kaurstad Morthen; Sara Tellefsen; Stephen M. Richards; Scott M. Lieberman; Raheleh Rahimi Darabad; Wendy R. Kam; David A. Sullivan
TAGS: androgens, testosterone, gene expression, autoimmunity, genes, mice, inbred nod, sjogren's syndrome, body tissue, mice
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2181-2197. doi: 10.1167/iovs.19-26815

Article May 2019

Limits on visual awareness of object targets in the context of other object category masks: Investigating bottlenecks in the continuous flash suppression paradigm with hand and tool stimuli

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Regine Zopf; Stefan R. Schweinberger; Anina N. Rich
TAGS: masks, hand
Journal of Vision. 2019; 19(5):17. doi: 10.1167/19.5.17

Retina May 2019

The Efemp1 R345W Macular Dystrophy Mutation Causes Amplified Circadian and Photophobic Responses to Light in Mice

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Stewart Thompson; Frederick R. Blodi; Demelza R. Larson; Michael G. Anderson; Steven F. Stasheff
TAGS: mutation, perceptual masking, mice, retina, macular dystrophy, melanopsin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2110-2117. doi: 10.1167/iovs.19-26881

Includes: Supplemental Content

Glaucoma May 2019

Transforming Growth Factor-β1–induced Human Subconjunctival Fibrosis is Mediated by MicroRNA 143/145 Expression

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Young Hoon Hwang; Sun-Ah Jung; Jungmook Lyu; Yong Yeon Kim; Joon H. Lee
TAGS: fibrosis, micrornas
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2064-2071. doi: 10.1167/iovs.19-26797

Genetics May 2019

Extending the Spectrum of EYS -Associated Retinal Disease to Macular Dystrophy

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Laurence H. M. Pierrache; Muriël Messchaert; Alberta A. H. J. Thiadens; Lonneke Haer-Wigman; Yvonne de Jong-Hesse; Wendy A. G. van Zelst-Stams; Rob W. J. Collin; Caroline C. W. Klaver; L. Ingeborgh van den Born
TAGS: phenotype, genotype, retinal diseases, vision, macular dystrophy
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2049-2063. doi: 10.1167/iovs.18-25531

Includes: Supplemental Content

Physiology and Pharmacology May 2019

Short-term High Fructose Intake Reprograms the Transcriptional Clock Rhythm of the Murine Extraorbital Lacrimal Gland

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Dingli Lu; Cuipei Lin; Xinwei Jiao; Zongming Song; Liya Wang; Jianqin Gu; Zhijie Li
TAGS: transcription, genetic, diet, mice, rna, rhythm, lacrimal gland, genes, fructose
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2038-2048. doi: 10.1167/iovs.18-26030

Includes: Supplemental Content

Perspective May 2019

Antibodies Used to Detect Glaucoma-Associated Myocilin: More or Less Than Meets the Eye?

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Athéna C. Patterson-Orazem; Raquel L. Lieberman
TAGS: glaucoma, antibodies, eye, myoc gene
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2034-2037. doi: 10.1167/iovs.19-26843

Articles May 2019

Digital Image Analysis of BAP-1 Accurately Predicts Uveal Melanoma Metastasis

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Gustav Stålhammar; Thonnie Rose O. See; Stephen Phillips; Stefan Seregard; Hans E. Grossniklaus
TAGS: gene expression, cohort studies, neoplasm metastasis, neoplasms, intraocular melanoma, digital image analysis, digital immunoassays
Trans. Vis. Sci. Tech.. 2019; 8(3):11. doi: 10.1167/tvst.8.3.11

Includes: Supplemental Content

Retina May 2019

Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability

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Shinsuke Nakamura; Tetsuro Noguchi; Yuki Inoue; Shuji Sakurai; Anri Nishinaka; Yoshifumi Hida; Tomomi Masuda; Yasuhiro Nakagami; Naoto Horai; Hideshi Tsusaki; Hideaki Hara; Masamitsu Shimazawa
TAGS: angiogenesis, oxygen, vascular endothelial growth factor a, vascular diseases, cell motility, cercopithecidae, choroidal neovascularization, lasers, neovascularization, pathologic, retinal diseases, tight junctions, mice, proteins, transcriptional activation, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):1943-1952. doi: 10.1167/iovs.18-25745

Includes: Supplemental Content

Glaucoma May 2019

Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma

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Gaurang C. Patel; J. Cameron Millar; Abbot F. Clark
TAGS: glaucoma, glucocorticoids, injections, ocular hypertension, glucocorticoid receptors, trans-activation (genetics), intraocular pressure, mice, medication therapy management
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):1967-1978. doi: 10.1167/iovs.18-26383

Includes: Supplemental Content

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Treatment Potential for Macular Cone Vision in Leber Congenital Amaurosis Due to CEP290 or NPHP5 Mutations: Predictions From Artificial Intelligence

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

Reliability of Spectral-Domain OCT Ellipsoid Zone Area and Shape Measurements in Retinitis Pigmentosa

Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations

Quantifying Retinal Pigment Epithelium Dysmorphia and Loss of Histologic Autofluorescence in Age-Related Macular Degeneration

Extracellular Matrix Protein Coating of Processed Fish Scales Improves Human Corneal Endothelial Cell Adhesion and Proliferation

REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice

Characteristic Ocular Features in Cases of Autosomal Recessive PROM1 Cone-Rod Dystrophy

MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells

Head and Gaze Behavior in Retinitis Pigmentosa

Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome

Limits on visual awareness of object targets in the context of other object category masks: Investigating bottlenecks in the continuous flash suppression paradigm with hand and tool stimuli

The Efemp1 R345W Macular Dystrophy Mutation Causes Amplified Circadian and Photophobic Responses to Light in Mice

Transforming Growth Factor-β1–induced Human Subconjunctival Fibrosis is Mediated by MicroRNA 143/145 Expression

Extending the Spectrum of EYS -Associated Retinal Disease to Macular Dystrophy

Short-term High Fructose Intake Reprograms the Transcriptional Clock Rhythm of the Murine Extraorbital Lacrimal Gland

Antibodies Used to Detect Glaucoma-Associated Myocilin: More or Less Than Meets the Eye?

Digital Image Analysis of BAP-1 Accurately Predicts Uveal Melanoma Metastasis

Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability

Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma

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