Genetics

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Glaucoma January 2025

Corneal Stromal Stem Cell-Derived Extracellular Vesicles Attenuate ANGPTL7 Expression in the Human Trabecular Meshwork

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Faycal Moujane; Chi Zhang; Robert Knight; John Y. Lee; Sophie X. Deng; Jie J. Zheng
TAGS: attenuation, cornea, extracellular vesicles, glaucoma, myoc gene, trabecular meshwork, culture media, conditioned, dexamethasone, genes, intraocular pressure
Trans. Vis. Sci. Tech.. 2025; 14(1):21. https://doi.org/10.1167/tvst.14.1.21

Cornea January 2025

ROCK Inhibitor Enhances Resilience Against Metabolic Stress Through Increasing Bioenergetic Capacity in Corneal Endothelial Cells

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Wei-Ting Ho; Jung-Shen Chang; Chia-Jen Lei; Tsan-Chi Chen; Jia-Kang Wang; Shu-Wen Chang; Muh-Hwa Yang; Tzuu-Shuh Jou; I-Jong Wang
TAGS: cornea, endothelial cells, metabolic stress, monensin, sodium, stress, chronic exertional compartment syndrome, apoptosis, glycolysis, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):51. https://doi.org/10.1167/iovs.66.1.51

Includes: Supplemental Content

Retinal Cell Biology January 2025

DNA-Dependent Protein Kinase Catalytic Subunit Prevents Ferroptosis in Retinal Pigment Epithelial Cells

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Xueying Wang; Xi Wang; Zhenzhen Zhao; Qian Wang; Xiaoman Zhu; Qingjian Ou; Jing-Ying Xu; Lixia Lu; Furong Gao; Juan Wang; Yanlong Bi; Guo-Tong Xu; Caixia Jin; Haibin Tian
TAGS: ferroptosis, prkdc gene, retinal pigment cell, catalytic domain, dna damage, phosphorylation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):50. https://doi.org/10.1167/iovs.66.1.50

Includes: Supplemental Content

Genetics January 2025

Safety of Human USH1C Transgene Expression Following Subretinal Injection in Wild-Type Pigs

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Peter Kiraly; Joshua Klein; Immanuel P. Seitz; Felix F. Reichel; Tobias Peters; Taras Ardan; Jana Juhasova; Stefan Juhás; Zdenka Ellederova; Yaroslav Nemesh; Ruslan Nyshchuk; Nikolai Klymiuk; Kerstin Nagel-Wolfrum; Ashley R. Winslow; Uwe Wolfrum; Jan Motlik; M. Dominik Fischer
TAGS: disease vectors, gene therapy, injections, safety, spatial vectors, suidae, transgenes, retina, histopathology tests, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):48. https://doi.org/10.1167/iovs.66.1.48

Includes: Supplemental Content

Glaucoma January 2025

Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical Stress

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Chien-Chia Su; Vaibhav Desikan; Kevin Betsch; Myoung Sup Shim; Kate E. Keller; Paloma B. Liton
TAGS: acetylation, tubulin, microtubules, stress, mechanical
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):43. https://doi.org/10.1167/iovs.66.1.43

Includes: Supplemental Content

Cornea January 2025

Posterior Limbal Mesenchymal Stromal Cells Promote Proliferation and Stemness of Transition Zone Cells: A Novel Insight Into Corneal Endothelial Rejuvenation

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Yuting Xiao; Charles N. J. McGhee; Jie Zhang
TAGS: cornea, endothelium, rejuvenation, mesenchymal stem cells, mice, wounds and injuries, proteins, culture media, conditioned, coculture techniques
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):44. https://doi.org/10.1167/iovs.66.1.44

Includes: Supplemental Content

Retina January 2025

High-Resolution OCT Reveals Age-Associated Variation in the Region Posterior to the External Limiting Membrane

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Muhammad Usman Jamil; Jungeun Won; Stefan B. Ploner; Anna Marmalidou; Hiroyuki Takahashi; Stephanie Kaiser; Yunchan Hwang; Omar Abu-Qamar; Antonio Yaghy; Andre J. Witkin; Peter Y. Zhao; Shilpa Desai; Jay S. Duker; Andreas Maier; James G. Fujimoto; Nadia K. Waheed
TAGS: embryonic lethal mutation, tissue membrane, diagnostic imaging, volume, motion
Trans. Vis. Sci. Tech.. 2025; 14(1):16. https://doi.org/10.1167/tvst.14.1.16

Includes: Supplemental Content

Cornea January 2025

S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway

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Yankai Wei; Mei Sun; Xinyu Zhang; Chengyuan Zhang; Chao Yang; Hong Nian; Bei Du; Ruihua Wei
TAGS: dry eye syndromes, mice, sjogren's syndrome, stat3 protein, th17 cells, langer-giedion syndrome, dendritic cells, t-lymphocytes, mice, inbred nod, polymerase chain reaction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):35. https://doi.org/10.1167/iovs.66.1.35

Includes: Supplemental Content

Retina January 2025

A Comprehensive Analysis of Sex-Biased Gene Expression in the Aging Human Retina Through a Combination of Single-Cell and Bulk RNA Sequencing

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Hongling Liu; Xue Zhang; Qing Wang; Bowen Li; Baishijiao Bian; Yong Liu
TAGS: aging, gene expression, genes, retina, rna, small cytoplasmic, sequence analysis, rna, sex characteristics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):28. https://doi.org/10.1167/iovs.66.1.28

Includes: Supplemental Content

Cornea January 2025

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

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Ling Wang; Ye Tian; Hui Zhang; Yongxiao Dong; Xia Hua; Xiaoyong Yuan
TAGS: caspase-3, cornea, dry eye syndromes, epithelium, mice, proteins, pyroptosis, apoptosis, genes, western blotting
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):24. https://doi.org/10.1167/iovs.66.1.24

Includes: Supplemental Content

Letters to the Editor January 2025

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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Blondy Kayembe Mulumba; Karen Leffondré; Pierre Joly; Marie-Noëlle Delyfer; Cécile Delcourt
TAGS: age-related macular degeneration, genetics, statins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):25. https://doi.org/10.1167/iovs.66.1.25

Biochemistry and Molecular Biology January 2025

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3

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Qiongjie Cao; Wenji Xu; Xiaoyan Chen; Guangying Luo; Peter S. Reinach; Dongsheng Yan
TAGS: arginine, cornea, epigenetics, epithelium, methylation, wound healing, regulation, mice, western blotting, histones
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):22. https://doi.org/10.1167/iovs.66.1.22

Includes: Supplemental Content

Cornea January 2025

miRNA Expression Profile in Primary Limbal Epithelial Cells of Aniridia Patients

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Mahsa Nastaranpour; Shweta Suiwal; Tanja Stachon; Fabian N. Fries; Maryam Amini; Berthold Seitz; Eckart Meese; Nicole Ludwig; Nóra Szentmáry
TAGS: aniridia, epithelial cells, micrornas, candidate disease gene
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):20. https://doi.org/10.1167/iovs.66.1.20

Includes: Supplemental Content

Retina January 2025

Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis

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Shizhen Lei; Yani Liu
TAGS: gastrointestinal microbiome, genetic correlation analysis, genetics, mendelian randomization analysis, retinal vein occlusion
Trans. Vis. Sci. Tech.. 2025; 14(1):5. https://doi.org/10.1167/tvst.14.1.5

Includes: Supplemental Content

Anatomy and Pathology/Oncology January 2025

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

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Xiaoting Pei; Mengru Ba; Tingting Yang; Shuting Xuan; Duliurui Huang; Di Qi; Dingli Lu; Shenzhen Huang; Zhijie Li
TAGS: diabetes mellitus, diabetes mellitus, type 2, insulin, mice, langer-giedion syndrome, circadian rhythms, dry eye syndromes, gene expression
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):19. https://doi.org/10.1167/iovs.66.1.19

Includes: Supplemental Content

Physiology and Pharmacology January 2025

Chronic Jet Lag Disrupts Circadian Rhythms and Induces Hyperproliferation in Murine Lacrimal Glands via ROS Accumulation

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Shenzhen Huang; Wenxiao Zhang; Mengru Ba; Shuting Xuan; Duliurui Huang; Di Qi; Xiaoting Pei; Dingli Lu; Zhijie Li
TAGS: circadian rhythm disorders, circadian rhythms, jet lag syndrome, mice, gene expression, rhythm, genes, cell proliferation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):12. https://doi.org/10.1167/iovs.66.1.12

Includes: Supplemental Content

Lens January 2025

Aqueous Proteomic and Metabolomic Profiles in Low-Energy vs High-Energy Femtosecond Laser-Assisted Cataract Surgery

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Chang Liu; Xinyue Wang; Hon Shing Ong; Marcus Ang; Soon-Phaik Chee; Jianhong Ching; Kee Voon Chua; Sharon Hong Yu Han; Jodhbir S. Mehta; Lei Zhou; Yu-Chi Liu
TAGS: cataract surgery, lasers, metabolomics, proteins, proteomics, metabolites
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):10. https://doi.org/10.1167/iovs.66.1.10

Includes: Supplemental Content

Retina January 2025

A Penetrable AAV2 Capsid Variant for Efficient Intravitreal Gene Delivery to the Retina

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Xiaoyu He; Yidian Fu; Yangfan Xu; Liang Ma; Peiwei Chai; Hanhan Shi; Yizheng Yao; Shengfang Ge; Renbing Jia; Xuyang Wen; Zhi Yang; Xianqun Fan
TAGS: capsid, gene therapy, genes, intravitreal injections, mice, retina, injections, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):6. https://doi.org/10.1167/iovs.66.1.6

Includes: Supplemental Content

Retina January 2025

Deep Learning–Based SD-OCT Layer Segmentation Quantifies Outer Retina Changes in Patients With Biallelic RPE65 Mutations Undergoing Gene Therapy

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German Pinedo-Diaz; Birgit Lorenz; Sandrine H. Künzel; Sarah Thiele; Susana Ortega-Cisneros; Eduardo Bayro Corrochano; Frank G. Holz; Alexander Effland
TAGS: retina, rpe65 protein, spectral domain-optical coherence tomography, biological markers, deep learning, mutation, gene therapy, datasets
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):5. https://doi.org/10.1167/iovs.66.1.5

Includes: Supplemental Content

Retina January 2025

Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

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Deng Pan; Ge Hu; Jiayue Li; Zixu Wang; Yaoxing Chen; Jing Cao
TAGS: autophagy, chickens, stress, retina, blue light, endoplasmic reticulum, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):3. https://doi.org/10.1167/iovs.66.1.3

Includes: Supplemental Content

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Corneal Stromal Stem Cell-Derived Extracellular Vesicles Attenuate ANGPTL7 Expression in the Human Trabecular Meshwork

ROCK Inhibitor Enhances Resilience Against Metabolic Stress Through Increasing Bioenergetic Capacity in Corneal Endothelial Cells

DNA-Dependent Protein Kinase Catalytic Subunit Prevents Ferroptosis in Retinal Pigment Epithelial Cells

Safety of Human USH1C Transgene Expression Following Subretinal Injection in Wild-Type Pigs

Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical Stress

Posterior Limbal Mesenchymal Stromal Cells Promote Proliferation and Stemness of Transition Zone Cells: A Novel Insight Into Corneal Endothelial Rejuvenation

High-Resolution OCT Reveals Age-Associated Variation in the Region Posterior to the External Limiting Membrane

S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway

A Comprehensive Analysis of Sex-Biased Gene Expression in the Aging Human Retina Through a Combination of Single-Cell and Bulk RNA Sequencing

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3

miRNA Expression Profile in Primary Limbal Epithelial Cells of Aniridia Patients

Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

Chronic Jet Lag Disrupts Circadian Rhythms and Induces Hyperproliferation in Murine Lacrimal Glands via ROS Accumulation

Aqueous Proteomic and Metabolomic Profiles in Low-Energy vs High-Energy Femtosecond Laser-Assisted Cataract Surgery

A Penetrable AAV2 Capsid Variant for Efficient Intravitreal Gene Delivery to the Retina

Deep Learning–Based SD-OCT Layer Segmentation Quantifies Outer Retina Changes in Patients With Biallelic RPE65 Mutations Undergoing Gene Therapy

Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

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