Genetics

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Retina January 2019

VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site

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Peter H. Tang; Gabriel Velez; Stephen H. Tsang; Alexander G. Bassuk; Vinit B. Mahajan
TAGS: mutation, exons, gelatinase a, surgical procedures, operative, vitreous body, eye, retina, cytokinesis, tissue degeneration, histopathology tests, proteolysis, proteins, splice-site mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):282-293. doi: 10.1167/iovs.18-25624

Includes: Supplemental Content

Retinal Cell Biology January 2019

Chemokine Expression in Murine RPE/Choroid in Response to Systemic Viral Infection and Elevated Levels of Circulating Interferon-γ

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Carsten Faber; Helene Bæk Juel; Benjamin Anderschou Holbech Jensen; Jan Pravsgaard Christensen; Jan Ulrik Prause; Allan Randrup Thomsen; Mogens Holst Nissen
TAGS: chemokines, genes, interferons, lymphocytic choriomeningitis virus, virus diseases, infection, choroid, mice
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):192-201. doi: 10.1167/iovs.18-25721

Includes: Supplemental Content

Genetics January 2019

Germline Mutations in CTNNB1 Associated With Syndromic FEVR or Norrie Disease

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Wenmin Sun; Xueshan Xiao; Shiqiang Li; Xiaoyun Jia; Panfeng Wang; Qingjiong Zhang
TAGS: mutation, germ-line mutation, familial exudative vitreoretinopathy, congenital progressive oculo-acoustico-cerebral degeneration, beta catenin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):93-97. doi: 10.1167/iovs.18-25142

Includes: Supplemental Content

Articles January 2019

Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy

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Joseph D. Bogaard; Jonathon B. Young; Asad Movahedan; Iris S. Kassem
TAGS: enoxaparin, child, animal model, triamcinolone, eye, fibrin, therapeutic intervention, oryctolagus cuniculus, postoperative care, anterior chamber of eye, inflammation, enzyme-linked immunosorbent assay, did not receive therapy or drug
Trans. Vis. Sci. Tech.. 2019; 8(1):5. doi: 10.1167/tvst.8.1.5

Articles December 2018

A Model to Study Thermal Energy Delivery to the Choroid: A Comparison of Surgical Devices

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Stephen A. LoBue; Prashant Tailor; Jarel K. Gandhi; Paul Loftness; Timothy W. Olsen
TAGS: heat (physical force), surgical procedures, operative, body tissue, body temperature, choroid, mpl gene, temperature
Trans. Vis. Sci. Tech.. 2018; 7(6):39. doi: 10.1167/tvst.7.6.39

Retinal Cell Biology December 2018

Photoreceptor Progenitors Depend Upon Coordination of gdf6a , thrβ , and tbx2b to Generate Precise Populations of Cone Photoreceptor Subtypes

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Michèle G. DuVal; W. Ted Allison
TAGS: genetics, photoreceptors, zebrafish, ultraviolet rays, retinal cone, burkina faso
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6089-6101. doi: 10.1167/iovs.18-24461

Includes: Supplemental Content

Retina December 2018

A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3

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Mark M. Hassall; Alun R. Barnard; Harry O. Orlans; Michelle E. McClements; Peter Charbel Issa; Sher A. Aslam; Robert E. MacLaren
TAGS: mice, retinal cone, mutation, electroretinography, achromatopsia
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6102-6110. doi: 10.1167/iovs.18-24328

Retina December 2018

Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice

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Helen T. Michael; Cari Graff-Cherry; Sung Chin; Corinne Rauck; Amelework D. Habtemichael; Patricia Bunda; Tunde Smith; Maria M. Campos; Kapil Bharti; Heinz Arnheiter; Glenn Merlino; Chi-Ping Day
TAGS: eye, pigment, pigmentation, ectopic gene expression, mitf protein, mice
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6067-6073. doi: 10.1167/iovs.18-25186

Includes: Supplemental Content

Retinal Cell Biology December 2018

Granulin 1 Promotes Retinal Regeneration in Zebrafish

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Kazuhiro Tsuruma; Yuichi Saito; Hiroyuki Okuyoshi; Akihiro Yamaguchi; Masamitsu Shimazawa; Daniel Goldman; Hideaki Hara
TAGS: genes, retina, zebrafish, wounds and injuries, bromodeoxyuridine, grn gene
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6057-6066. doi: 10.1167/iovs.18-24828

Includes: Supplemental Content

Articles December 2018

A New in Vitro Model of GDLD by Knocking Out TACSTD2 and Its Paralogous Gene EpCAM in Human Corneal Epithelial Cells

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Peng Xu; Chifune Kai; Satoshi Kawasaki; Yuki Kobayashi; Kouji Yamamoto; Motokazu Tsujikawa; Ryuhei Hayashi; Kohji Nishida
TAGS: proteins, epcam gene, corneal epithelial cells, antibodies, epithelial cell adhesion molecule, genes, epithelium, cornea
Trans. Vis. Sci. Tech.. 2018; 7(6):30. doi: 10.1167/tvst.7.6.30

Retinal Cell Biology December 2018

Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration

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Wenyi Tang; Jun Ma; Ruiping Gu; Boya Lei; Xinyi Ding; Gezhi Xu
TAGS: apoptosis, polymerase chain reaction, in situ nick-end labeling, photoreceptors, retinal degeneration, retina, lipocalin-2 protein, light exposure, protein overexpression, reactive oxygen species, lentivirus, electroretinography, mitochondria, western blotting, signal transduction, lcn2 gene
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6014-6025. doi: 10.1167/iovs.18-25213

Includes: Supplemental Content

Cornea December 2018

Prevention of Corneal Neovascularization by Adenovirus Encoding Human Vascular Endothelial Growth Factor Soluble Receptor (s-VEGFR1) in Lacrimal Gland

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Luis Fernando Nominato; Ana Carolina Dias; Lara Cristina Dias; Marina Zilio Fantucci; Lilian Eslaine Costa Mendes da Silva; Adriana de Andrade Murashima; Eduardo Melani Rocha
TAGS: cytokine, vascular endothelial growth factor a, gene therapy, corneal neovascularization, eye diseases, body tissue, cornea, lacrimal gland, prevention, alkalies, burns, choroidal neovascularization, adenoviruses, bodily secretions, langer-giedion syndrome, rna, messenger, adenoviral vector, normal saline
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6036-6044. doi: 10.1167/iovs.17-22322

Includes: Supplemental Content

Immunology and Microbiology December 2018

Mechanism of Pseudomonas aeruginosa Small Protease (PASP), a Corneal Virulence Factor

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Aihua Tang; Armando R. Caballero; Mary E. Marquart; Michael A. Bierdeman; Richard J. O'Callaghan
TAGS: pseudomonas aeruginosa, mutation, catalysis, cornea, serine proteases, virulence factors, proteolytic enzymes, proteins, endopeptidases
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5993-6002. doi: 10.1167/iovs.18-25834

Retina December 2018

Prospective Evaluation of Patients With X-Linked Retinoschisis During 18 Months

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Mark E. Pennesi; David G. Birch; K. Thiran Jayasundera; Maria Parker; Ou Tan; Rabia Gurses-Ozden; Carrie Reichley; Kathleen N. Beasley; Paul Yang; Richard G. Weleber; Lea D. Bennett; John R. Heckenlively; Kalyani Kothapalli; Jeffrey D. Chulay; for the XLRS-001 Study Group
TAGS: atrophy, contrast sensitivity, cysts, electroretinography, perimetry, vision, visual acuity, eye, kinetics, retina, x-linked retinoschisis, volume, cutaneous collagenous vasculopathy, reading speed
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5941-5956. doi: 10.1167/iovs.18-24565

Includes: Supplemental Content

Retinal Cell Biology December 2018

Inhibition of Diabetes-Induced Lysyl Oxidase Overexpression Prevents Retinal Vascular Lesions Associated With Diabetic Retinopathy

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Brian Song; Dongjoon Kim; Ngan-Ha Nguyen; Sayon Roy
TAGS: diabetes mellitus, diabetic retinopathy, protein-lysine 6-oxidase, rats, retina, vascular lesions, rna, small interfering, protein overexpression
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5965-5972. doi: 10.1167/iovs.18-25543

Biochemistry and Molecular Biology December 2018

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease

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Anastasia Marie Litke; Sarah Samuelson; Kerry R. Delaney; Yves Sauvé; Robert L. Chow
TAGS: mutation, corneal diseases, electroretinography, keratoconus, luciferases, missense mutation, cornea, diagnostic imaging, mice, pathogenicity
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5824-5835. doi: 10.1167/iovs.18-25490

Includes: Supplemental Content

Articles December 2018

Retinal Toxicity of Intravitreal Injection of Ziv-Aflibercept in Albino Rabbits

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Dan Ramon; Jonathan Shahar; Amir Massarweh; Irit Man; Ido Perlman; Anat Loewenstein
TAGS: albinism, glial fibrillary acidic protein, eye, retina, retinal toxicity, intravitreal injections, ziv-aflibercept, electroretinography, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2018; 7(6):23. doi: 10.1167/tvst.7.6.23

Articles December 2018

Combined Targeted Analysis of Metabolites and Proteins in Tear Fluid With Regard to Clinical Applications

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Sascha Dammeier; Peter Martus; Franziska Klose; Michael Seid; Dario Bosch; Janina D‘Alvise; Focke Ziemssen; Spyridon Dimopoulos; Marius Ueffing
TAGS: eye, proteins, metabolites
Trans. Vis. Sci. Tech.. 2018; 7(6):22. doi: 10.1167/tvst.7.6.22

Includes: Supplemental Content

Retina December 2018

Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure

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Mingzhe Cao; Jiamin Ouyang; Huilin Liang; Jingyi Guo; Siyuan Lin; Shulan Yang; Ting Xie; Shuyi Chen
TAGS: coloboma, genes, optics, zebrafish, eye, retina, rna, laser capture microdissection, fissure, gene expression profiling, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5773-5784. doi: 10.1167/iovs.18-23962

Includes: Supplemental Content

Clinical and Epidemiologic Research December 2018

Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers

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Cecilia Chao; Lakshmi Akileswaran; Jessica N. Cooke Bailey; Mark Willcox; Russell Van Gelder; Carol Lakkis; Fiona Stapleton; Kathryn Richdale
TAGS: cytokine, environmental factors, contact lenses, genotype, cornea, interleukin-6, microbiome, whole exome sequencing
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5752-5761. doi: 10.1167/iovs.18-24845

Includes: Supplemental Content

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VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site

Chemokine Expression in Murine RPE/Choroid in Response to Systemic Viral Infection and Elevated Levels of Circulating Interferon-γ

Germline Mutations in CTNNB1 Associated With Syndromic FEVR or Norrie Disease

Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy

A Model to Study Thermal Energy Delivery to the Choroid: A Comparison of Surgical Devices

Photoreceptor Progenitors Depend Upon Coordination of gdf6a , thrβ , and tbx2b to Generate Precise Populations of Cone Photoreceptor Subtypes

A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3

Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice

Granulin 1 Promotes Retinal Regeneration in Zebrafish

A New in Vitro Model of GDLD by Knocking Out TACSTD2 and Its Paralogous Gene EpCAM in Human Corneal Epithelial Cells

Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration

Prevention of Corneal Neovascularization by Adenovirus Encoding Human Vascular Endothelial Growth Factor Soluble Receptor (s-VEGFR1) in Lacrimal Gland

Mechanism of Pseudomonas aeruginosa Small Protease (PASP), a Corneal Virulence Factor

Prospective Evaluation of Patients With X-Linked Retinoschisis During 18 Months

Inhibition of Diabetes-Induced Lysyl Oxidase Overexpression Prevents Retinal Vascular Lesions Associated With Diabetic Retinopathy

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease

Retinal Toxicity of Intravitreal Injection of Ziv-Aflibercept in Albino Rabbits

Combined Targeted Analysis of Metabolites and Proteins in Tear Fluid With Regard to Clinical Applications

Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure

Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers

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