Genetics

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Immunology and Microbiology August 2018

Detection of Complement Activators in Immune Attack Eyes After iPS-Derived Retinal Pigment Epithelial Cell Transplantation

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Sunao Sugita; Kenichi Makabe; Shota Fujii; Masayo Takahashi
TAGS: complement system proteins, eye, transplantation, transcriptional activation, idiopathic pneumonia syndrome, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4198-4209. doi: 10.1167/iovs.18-24769

Includes: Supplemental Content

Retina August 2018

The Spectrum of Structural and Functional Abnormalities in Female Carriers of Pathogenic Variants in the RPGR Gene

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Mays Talib; Mary J. van Schooneveld; Caroline Van Cauwenbergh; Jan Wijnholds; Jacoline B. ten Brink; Ralph J. Florijn; Nicoline E. Schalij-Delfos; Gislin Dagnelie; Maria M. van Genderen; Elfride De Baere; Magda A. Meester-Smoor; Julie De Zaeytijd; Frans P. M. Cremers; L. Ingeborgh van den Born; Alberta A. Thiadens; Carel B. Hoyng; Caroline C. Klaver; Bart P. Leroy; Arthur A. Bergen; Camiel J. F. Boon
TAGS: phenotype, genes, heterozygote, signs and symptoms
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4123-4133. doi: 10.1167/iovs.17-23453

Includes: Supplemental Content

Genetics August 2018

Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect

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Sherin Shaaban; Sarah MacKinnon; Caroline Andrews; Sandra E. Staffieri; Gail D. E. Maconachie; Wai-Man Chan; Mary C. Whitman; Sarah U. Morton; Seyhan Yazar; Stuart MacGregor; James E. Elder; Elias I. Traboulsi; Irene Gottlob; Alex W. Hewitt; Strabismus Genetics Research Consortium; David G. Hunter; David A. Mackey; Elizabeth C. Engle
TAGS: meta-analysis, esotropia, cohort studies, disease susceptibility, genome, parent, single nucleotide polymorphism, strabismus, genetics, genome-wide association study
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4054-4064. doi: 10.1167/iovs.18-24082

Includes: Supplemental Content

Cornea August 2018

Instability of TCF4 Triplet Repeat Expansion With Parent–Child Transmission in Fuchs' Endothelial Corneal Dystrophy

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Joanna S. Saade; Chao Xing; Xin Gong; Zhengyang Zhou; V. Vinod Mootha
TAGS: alleles, child, hereditary corneal dystrophy, endothelium, parent, trinucleotide repeats
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4065-4070. doi: 10.1167/iovs.18-24119

Includes: Supplemental Content

Letters to the Editor August 2018

Author Response: Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics

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Hidenori Takahashi; Yasuo Yanagi
TAGS: vascular endothelial growth factor a, therapeutics, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4107-4107. doi: 10.1167/iovs.18-25216

Retina August 2018

Rhythmic Regulation of Photoreceptor and RPE Genes Important for Vision and Genetically Associated With Severe Retinal Diseases

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Patrick Vancura; Erika Csicsely; Annalisa Leiser; P. Michael Iuvone; Rainer Spessert
TAGS: genes, periodicity, photoreceptors, retinal diseases, vision, choroid, mice, retina, rhythm, regulation, arrestins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3789-3799. doi: 10.1167/iovs.18-24558

Biochemistry and Molecular Biology August 2018

Murine Retinal Citrullination Declines With Age and is Mainly Dependent on Peptidyl Arginine Deiminase 4 (PAD4)

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T. J. Hollingsworth; Marko Z. Radic; Sarka Beranova-Giorgianni; Francesco Giorgianni; Yanming Wang; Alessandro Iannaccone
TAGS: western blotting, arginine, peptides, antibodies, mice, retina, citrullination
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3808-3815. doi: 10.1167/iovs.18-24118

Includes: Supplemental Content

Glaucoma August 2018

Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury

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Hongdou Luo; Jiejie Zhuang; Piaopiao Hu; Wei Ye; Shanshan Chen; Yulian Pang; Ningfeng Li; Cong Deng; Xu Zhang
TAGS: apoptosis, inflammation, gliosis, reperfusion injury, wounds and injuries, retina, resveratrol, attenuation, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3879-3888. doi: 10.1167/iovs.18-23806

Special Issue July 2018

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

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Sayan Ghosh; Peng Shang; Hiroto Terasaki; Nadezda Stepicheva; Stacey Hose; Meysam Yazdankhah; Joseph Weiss; Taiji Sakamoto; Imran A. Bhutto; Shuli Xia; J. Samuel Zigler, Jr; Ram Kannan; Jiang Qian; James T. Handa; Debasish Sinha
TAGS: crystallins, age-related macular degeneration, epithelial to mesenchymal transition, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD104-AMD113. doi: 10.1167/iovs.18-24132

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2018

The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation

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Ying Yuan; Min Li; Chi Ho To; Thomas Chuen Lam; Peng Wang; Yunjie Yu; Qingzhong Chen; Xiaojun Hu; Bilian Ke
TAGS: signal transduction pathways, fibroblasts, sclera, signal pathway, rhoa gtp-binding protein, myofibroblast
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3619-3629. doi: 10.1167/iovs.17-23580

Retinal Cell Biology July 2018

Capn5 Expression in the Healthy and Regenerating Zebrafish Retina

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Cagney E. Coomer; Ann C. Morris
TAGS: zebrafish, rod photoreceptors, retina, photoreceptors, retinal cone, tissue degeneration, adult
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3643-3654. doi: 10.1167/iovs.18-24278

Includes: Supplemental Content

Perspective July 2018

Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps

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Jacque L. Duncan; Eric A. Pierce; Amy M. Laster; Stephen P. Daiger; David G. Birch; John D. Ash; Alessandro Iannaccone; John G. Flannery; José A. Sahel; Donald J. Zack; Marco A. Zarbin; and the Foundation Fighting Blindness Scientific Advisory Board
TAGS: mutation, genetics, genes, animal model, retinal degeneration, comprehension
Trans. Vis. Sci. Tech.. 2018; 7(4):6. doi: 10.1167/tvst.7.4.6

Retina July 2018

Surgical Removal of Internal Limiting Membrane and Layering of AAV Vector on the Retina Under Air Enhances Gene Transfection in a Nonhuman Primate

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Kelvin Yi Chong Teo; Shu Yen Lee; Amutha Veluchamy Barathi; Sai Bo Bo Tun; Licia Tan; Ian Jeffery Constable
TAGS: genes, tissue membrane, primates, transfection, diagnostic imaging, eye, retina, excision, spatial vectors
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3574-3583. doi: 10.1167/iovs.18-24333

Lens July 2018

Aldose Reductase Inhibition Prevents Development of Posterior Capsular Opacification in an In Vivo Model of Cataract Surgery

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Leonid M. Zukin; Michelle G. Pedler; Sergio Groman-Lupa; Mina Pantcheva; David A. Ammar; J. Mark Petrash
TAGS: aldehyde reductase, cataract surgery, lens, crystalline, lens (device), postoperative care, surgical procedures, operative, genetics, mice, pathogenesis, opacification, epithelial to mesenchymal transition
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3591-3598. doi: 10.1167/iovs.18-23935

Biochemistry and Molecular Biology July 2018

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells

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David W. Sant; Vladimir Camarena; Sushmita Mustafi; Yiwen Li; Zachary Wilkes; Derek Van Booven; Rong Wen; Gaofeng Wang
TAGS: vascular endothelial growth factor a, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3608-3618. doi: 10.1167/iovs.18-24101

Includes: Supplemental Content

Retinal Cell Biology July 2018

Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells

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Junwon Lee; Sang-Hwi Choi; Young-Beom Kim; Ikhyun Jun; Jin Jea Sung; Dongjin R. Lee; Yang In Kim; Myung Soo Cho; Suk Ho Byeon; Dae-Sung Kim; Dong-Wook Kim
TAGS: mitochondria, fibroblast growth factor 2, patient isolation, prescriptions, drug, eye, stem cells, pluripotent, pax6 transcription factor, enhanced s-cone syndrome, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3531-3542. doi: 10.1167/iovs.17-23439

Includes: Multimedia, Supplemental Content

Retina July 2018

Significant Relationship of Visual Field Sensitivity in Central 10° to Thickness of Retinal Layers in Retinitis Pigmentosa

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Akira Sayo; Shinji Ueno; Taro Kominami; Satoshi Okado; Daiki Inooka; Shiori Komori; Hiroko Terasaki
TAGS: retinitis pigmentosa, visual fields, retinal nerve fiber layer, spectral-domain optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3469-3475. doi: 10.1167/iovs.18-24635

Clinical and Epidemiologic Research July 2018

A Cross-Sectional and Longitudinal Study of Retinal Sensitivity in RPE65 -Associated Leber Congenital Amaurosis

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Neruban Kumaran; Gary S. Rubin; Angelos Kalitzeos; Kaoru Fujinami; James W. B. Bainbridge; Richard G. Weleber; Michel Michaelides
TAGS: cohort studies, contrast sensitivity, genotype, longitudinal studies, perimetry, questionnaires, software, vision, visual acuity, visual fields, eye, quality of life, reliability, leber's amaurosis, pathogenicity
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3330-3339. doi: 10.1167/iovs.18-23873

Includes: Supplemental Content

Cornea June 2018

Fuchs' Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy, Type 1

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Nelson S. Winkler; Margherita Milone; Jennifer M. Martinez-Thompson; Harish Raja; Ross A. Aleff; Sanjay V. Patel; Michael P. Fautsch; Eric D. Wieben; Keith H. Baratz
TAGS: myotonic dystrophy, hereditary corneal dystrophy, endothelium, family, genes, rna
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3053-3057. doi: 10.1167/iovs.17-23160

Includes: Supplemental Content

Retina June 2018

Phenotype Variations Caused by Mutations in the RP1L1 Gene in a Large Mainly German Cohort

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Ditta Zobor; Gergely Zobor; Stephanie Hipp; Britta Baumann; Nicole Weisschuh; Saskia Biskup; Ieva Sliesoraityte; Eberhart Zrenner; Susanne Kohl
TAGS: phenotype, mutation, cohort studies, electroretinography, genes, heterozygote, german, spectral-domain optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3041-3052. doi: 10.1167/iovs.18-24033

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Detection of Complement Activators in Immune Attack Eyes After iPS-Derived Retinal Pigment Epithelial Cell Transplantation

The Spectrum of Structural and Functional Abnormalities in Female Carriers of Pathogenic Variants in the RPGR Gene

Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect

Instability of TCF4 Triplet Repeat Expansion With Parent–Child Transmission in Fuchs' Endothelial Corneal Dystrophy

Author Response: Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics

Rhythmic Regulation of Photoreceptor and RPE Genes Important for Vision and Genetically Associated With Severe Retinal Diseases

Murine Retinal Citrullination Declines With Age and is Mainly Dependent on Peptidyl Arginine Deiminase 4 (PAD4)

Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation

Capn5 Expression in the Healthy and Regenerating Zebrafish Retina

Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps

Surgical Removal of Internal Limiting Membrane and Layering of AAV Vector on the Retina Under Air Enhances Gene Transfection in a Nonhuman Primate

Aldose Reductase Inhibition Prevents Development of Posterior Capsular Opacification in an In Vivo Model of Cataract Surgery

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells

Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells

Significant Relationship of Visual Field Sensitivity in Central 10° to Thickness of Retinal Layers in Retinitis Pigmentosa

A Cross-Sectional and Longitudinal Study of Retinal Sensitivity in RPE65 -Associated Leber Congenital Amaurosis

Fuchs' Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy, Type 1

Phenotype Variations Caused by Mutations in the RP1L1 Gene in a Large Mainly German Cohort

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