Genetics

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Biochemistry and Molecular Biology April 2025

NMN Supplementation Inhibits Endothelial Cell ROS-Mediated Src/Pi3k/Akt Signaling Pathway to Protect High-Altitude Blood-Retinal Barrier

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Siyuan Liu; Ning Du; Keke Ge; Jiayue Hu; Wenfang Zhang
TAGS: 1-phosphatidylinositol 3-kinase, endothelial cells, high altitude, hypoxia, cadherins, akt signaling pathway, mice, fluorescent antibody technique, evans blue stain, blood-retinal barrier
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):51. https://doi.org/10.1167/iovs.66.4.51

Includes: Supplemental Content

Cornea & External Disease April 2025

A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing

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Mark Dibbs; Mitchelle Matesva; Despoina Theotoka; Christina Jayaraj; Beruk Metiku; Patrick Demkowicz; Jacob S. Heng; Yvonne Wang; Christine Y. Bakhoum; Jessica Chow; Mathieu F. Bakhoum
TAGS: bacteria, corneal ulcer, nanopore sequencing, pathogenic organism, ulcer, eye, cornea
Trans. Vis. Sci. Tech.. 2025; 14(4):19. https://doi.org/10.1167/tvst.14.4.19

Includes: Supplemental Content

Immunology and Microbiology April 2025

Application of Metagenomic Long-Read Sequencing for the Diagnosis of Herpetic Uveitis

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Yoshito Koyanagi; Ai Fujita Sajiki; Kenya Yuki; Hiroaki Ushida; Kenichi Kawano; Kosuke Fujita; Hideyuki Shimizu; Daishi Okuda; Mitsuki Kosaka; Kazuhisa Yamada; Ayana Suzumura; Shu Kachi; Hiroki Kaneko; Hiroyuki Komatsu; Yoshihiko Usui; Hiroshi Goto; Koji M. Nishiguchi
TAGS: reading (activity), uveitis, metagenomic sequencing, nanopores, fluid flow
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):50. https://doi.org/10.1167/iovs.66.4.50

Includes: Supplemental Content

Glaucoma April 2025

Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models

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Xinlei Zhu; Benxiang Qi; Zhongmei Ren; Lin Cong; Xiaojing Pan; Qingjun Zhou; Bi Ning Zhang; Lixin Xie
TAGS: glaucoma, injections, gene therapy, neuroprotection, retinal ganglion cells, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):48. https://doi.org/10.1167/iovs.66.4.48

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

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Wei-Qi Song; Wen-Fang Zhong; Zhi-Hao Li; Dan Liu; Jiao-Jiao Ren; Dong Shen; Jian Gao; Pei-Liang Chen; Jin Yang; Xiao-Meng Wang; Fang-Fei You; Chuan Li; Huan Chen; Jia-Hao Xie; Chen Mao
TAGS: glaucoma, genetic predisposition to disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):47. https://doi.org/10.1167/iovs.66.4.47

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology April 2025

The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice

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Xuechun Wang; Kuan Li; Lingzhi Guo; Xinlong Liu; Yatu Guo; Wei Zhang
TAGS: mice, microglia, visual cortex, interneurons, neurons, small nuclear rna, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):45. https://doi.org/10.1167/iovs.66.4.45

Includes: Supplemental Content

Cornea April 2025

Quantitative Changes in the Proteome of Chronically Inflamed Lacrimal Glands From a Sjögren's Disease Animal Model

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Danny Toribio; Junji Morokuma; Dante Pellino; Markus Hardt; Driss Zoukhri
TAGS: animal model, langer-giedion syndrome, peptides, proteins, proteome, sjogren's syndrome, liquid chromatography-mass spectrometry, lacrimal gland, fluorescent antibody technique, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):44. https://doi.org/10.1167/iovs.66.4.44

Includes: Supplemental Content

Visual Neuroscience April 2025

TUT7-Mediated Uridine Degradation of MCPIP1 in the Pterygium to Regulate TRAF6-Mediated Autophagy

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Juanjuan Li; Hao Ji; Yanze Xu; Weijia Zhang; Yuru Yin; Yubing Zhao; Yan Du; Anni He; Dandan Zhao
TAGS: autophagy, pterygium, fibroblasts, rna, messenger, proteins, uridine, rna, catabolism
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):41. https://doi.org/10.1167/iovs.66.4.41

Includes: Supplemental Content

Lens April 2025

Transcriptome Meta-Analysis Uncovers Cell-Specific Regulatory Relationships in Embryonic, Juvenile, Adult, and Aged Mouse Lens Epithelium and Fibers

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Matthieu Duot; Sarah Y. Coomson; Sanjaya K. Shrestha; M. V. Murali Krishna Nagulla; Yann Audic; Ruteja A. Barve; Hongzhan Huang; Carole Gautier-Courteille; Luc Paillard; Salil A. Lachke
TAGS: datasets, embryo, epithelium, genes, lens epithelium, meta-analysis, mice, lens (device), lens, crystalline, adult
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):42. https://doi.org/10.1167/iovs.66.4.42

Includes: Supplemental Content

Genetics April 2025

Clinical Spectrum and Molecular Characteristics of Inherited Ocular Diseases in a Cohort of Pediatric Patients With Infantile Nystagmus Syndrome

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Xiaoming Gong; Ian P. Boydstun; William T. Lawhon; Nancy N. Hanna; Palak B. Wall; Aaron Flickinger; E. Eugenie Hartmann; Richard W. Hertle
TAGS: cohort studies, eye diseases, genes, genetics, pathologic nystagmus, pediatrics, syndrome, genetic screening
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):39. https://doi.org/10.1167/iovs.66.4.39

Includes: Supplemental Content

Retina April 2025

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

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Xing Wei; Sisi Ma; Yunyu Zhou; Haoliang Cui; Shan Zhang; Duanyang Wang; Yingying Fu; Wei Li; Huihui Han; Yamei Li; Wuyi Li; Huixin Liu; Zixi Sun; Xiaoxu Han; Xuan Zou; Hui Li; Cheng Wang; Ruifang Sui
TAGS: electroretinography, mice, gene therapy, capsid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):37. https://doi.org/10.1167/iovs.66.4.37

Includes: Supplemental Content

Cornea April 2025

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

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Xiaoqi Li; Anqi Liu; Yannan Zhou; Haolan Qi; Junyi Wang; Mingxiong Chen; Tunan Sun; Jie Wu; Yifei Huang; Liqiang Wang
TAGS: cornea, endothelium, mice, ppar alpha, chronic exertional compartment syndrome, fenofibrate, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):36. https://doi.org/10.1167/iovs.66.4.36

Includes: Supplemental Content

Anatomy and Pathology/Oncology April 2025

Novel OCT Angiography Features, von Hippel–Lindau Disease Association, and Genetic Characterization of Juxtapapillary Retinal Capillary Hemangiomas

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Xiaonan Zhuang; Fengjuan Gao; Yi Xuan; Zhongcui Sun; Xiaofeng Ye; Xin Huang; Rui Jiang; Jihong Wu; Min Wang; Qing Chang; Gezhi Xu; Wei Liu
TAGS: angiogram, atypical, eye, genetics, retinal capillary hemangioma, von hippel-lindau syndrome, follow-up
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):34. https://doi.org/10.1167/iovs.66.4.34

Includes: Supplemental Content

Genetics April 2025

Clinical and Molecular Landscape of GLRA2 in X-Linked Early-Onset High Myopia

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Xiaoxia Li; Siyu Wang; Yuhan Wang; Ruru Chen; Xinjie Mao; Ying Mei; Meiping Xu; Lan Hu; Chuan Qin; Shilai Xing; Xiaoguang Yu; Liya Qiao
TAGS: genes, myopia, x-linked inheritance, rna splicing, genetics, validity of results, mutation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):30. https://doi.org/10.1167/iovs.66.4.30

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging April 2025

A Narrowband 635 nm Autofluorescence Peak in Albino Mouse Eyes Found With Multi-Modal Imaging Reveals the Presence of Protoporphyrin IX in the Choroid

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Pengfei Zhang; Suman K. Manna; Mayank Goswami; Robert J. Zawadzki; Edward N. Pugh, Jr
TAGS: albinism, autofluorescence, diagnostic imaging, eye, mice, protoporphyrins, action spectrum, choroid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):29. https://doi.org/10.1167/iovs.66.4.29

Includes: Supplemental Content

Cornea April 2025

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

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Yuzhou Wang; Zhiqiang Xu; Linzhi Wei; Yang Lu; Yizhou Shi; Shiyu Wen; Xiujuan Lv; Kaiyan Huang; Fan Lu; Jia Qu; Liang Hu
TAGS: hmgb1 protein, mice, toll-like receptor 4, inflammation, dry eye syndromes, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):28. https://doi.org/10.1167/iovs.66.4.28

Includes: Supplemental Content

Retina April 2025

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

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Kao-Jung Chang; Ching-Yun Wang; Hsin-Yu Wu; Pei-Yu Weng; Chia-Hsin Lu; Wei Chiu; Wei-Chieh Fang; Chong-En Kao; Cheng-Yi Li; Yi-Ting Chung; Yu-Chun Chen; Ai-Ru Hsieh; Shih-Hwa Chiou; Chih-Chien Hsu; Tai-Chi Lin; Shih-Jen Chen; De-Kuang Hwang
TAGS: biological markers, polygenic risk score, retinal detachment, screening, ultrasonography, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(4):16. https://doi.org/10.1167/tvst.14.4.16

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2025

Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling

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Shuting Lu; Qian Liu; Fan Ye; Ziran Zhang; Lianjun Shi; Xiumiao Li; Wan Mu; Qin Jiang; Biao Yan
TAGS: cholesterol metabolism, lymphangiogenesis, lymphatic vessels, rna, cornea, sutures, circular rna, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):26. https://doi.org/10.1167/iovs.66.4.26

Includes: Supplemental Content

Cornea & External Disease April 2025

Causal Relationship Between Common Allergic Diseases and Keratoconus: A Two-Sample Mendelian Randomization Study

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Xiru Yang; Xinyao Yu; Shan Gao; Pinghui Wei; Guoge Han
TAGS: extrinsic asthma, hypersensitivity, keratoconus, mendelian randomization analysis, atopic dermatitis, urticaria
Trans. Vis. Sci. Tech.. 2025; 14(4):14. https://doi.org/10.1167/tvst.14.4.14

Cornea & External Disease April 2025

Metabolic Biomarkers Mediate Allergic Conjunctivitis via Circulating Inflammatory Proteins: Evidence From a Mendelian Randomization Study

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Xiang Cao; Zijiao Xu; Boyang Zhang; Qingyu Li; Zhixin Jiang; Xiaoyong Yuan
TAGS: allergic conjunctivitis, biological markers, mendelian randomization analysis, modified barium swallow, proteins
Trans. Vis. Sci. Tech.. 2025; 14(4):12. https://doi.org/10.1167/tvst.14.4.12

Includes: Supplemental Content

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NMN Supplementation Inhibits Endothelial Cell ROS-Mediated Src/Pi3k/Akt Signaling Pathway to Protect High-Altitude Blood-Retinal Barrier

A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing

Application of Metagenomic Long-Read Sequencing for the Diagnosis of Herpetic Uveitis

Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice

Quantitative Changes in the Proteome of Chronically Inflamed Lacrimal Glands From a Sjögren's Disease Animal Model

TUT7-Mediated Uridine Degradation of MCPIP1 in the Pterygium to Regulate TRAF6-Mediated Autophagy

Transcriptome Meta-Analysis Uncovers Cell-Specific Regulatory Relationships in Embryonic, Juvenile, Adult, and Aged Mouse Lens Epithelium and Fibers

Clinical Spectrum and Molecular Characteristics of Inherited Ocular Diseases in a Cohort of Pediatric Patients With Infantile Nystagmus Syndrome

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

Novel OCT Angiography Features, von Hippel–Lindau Disease Association, and Genetic Characterization of Juxtapapillary Retinal Capillary Hemangiomas

Clinical and Molecular Landscape of GLRA2 in X-Linked Early-Onset High Myopia

A Narrowband 635 nm Autofluorescence Peak in Albino Mouse Eyes Found With Multi-Modal Imaging Reveals the Presence of Protoporphyrin IX in the Choroid

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling

Causal Relationship Between Common Allergic Diseases and Keratoconus: A Two-Sample Mendelian Randomization Study

Metabolic Biomarkers Mediate Allergic Conjunctivitis via Circulating Inflammatory Proteins: Evidence From a Mendelian Randomization Study

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