Genetics

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Biochemistry and Molecular Biology September 2018

Effects of the Tyrosinase-Dependent Dopaminergic System on Refractive Error Development in Guinea Pigs

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Liqin Jiang; Sen Zhang; Rongfang Chen; Li Ma; Xiaojun Wang; Yingying Wen; Jia Qu; Xiangtian Zhou
TAGS: dopamine, caviidae, monophenol monooxygenase, refractive errors, eye, uvea, kojic acid
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4631-4638. doi: 10.1167/iovs.17-22315

Genetics September 2018

IFT52 as a Novel Candidate for Ciliopathies Involving Retinal Degeneration

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Xue Chen; Xiaoguang Wang; Chao Jiang; Min Xu; Yang Liu; Rui Qi; Xiaolong Qi; Xiantao Sun; Ping Xie; Qinghuai Liu; Biao Yan; Xunlun Sheng; Chen Zhao
TAGS: mutation, retinal degeneration, cilia, proteins, ciliopathies
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4581-4589. doi: 10.1167/iovs.17-23351

Includes: Supplemental Content

Glaucoma September 2018

Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma

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Larry N. Singh; Jonathan G. Crowston; M. Isabel G. Lopez Sanchez; Nicole J. Van Bergen; Lisa S. Kearns; Alex W. Hewitt; Seyhan Yazar; David A. Mackey; Douglas C. Wallace; Ian A. Trounce
TAGS: glaucoma, disease susceptibility, open-angle glaucoma, dna, mitochondrial
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4598-4602. doi: 10.1167/iovs.18-25085

Includes: Supplemental Content

New Developments in Vision Research September 2018

Translational Retinal Research and Therapies

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Alison J. Hardcastle; Paul A. Sieving; José-Alain Sahel; Samuel G. Jacobson; Artur V. Cideciyan; John G. Flannery; William A. Beltran; Gustavo D. Aguirre
TAGS: gene therapy, mutation, blindness, retinal cone, dog, domestic, genes, genome, animal model, photoreceptors, retinal degeneration, retinitis pigmentosa, rhodopsin, rod photoreceptors, vision, mice, proteins, retina, leber's amaurosis, spatial vectors, optogenetics
Trans. Vis. Sci. Tech.. 2018; 7(5):8. doi: 10.1167/tvst.7.5.8

Glaucoma September 2018

Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina

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Weiwei Sheng; Ye Lu; Feng Mei; Ning Wang; Zhi-Zhi Liu; Ying-Ying Han; Han-Tsing Wang; Suqi Zou; Hong Xu; Xu Zhang
TAGS: polymerase chain reaction, mitochondria, adult, genes, n-methylaspartate, zebrafish, retina, resveratrol, sirtuins, optic atrophy, autosomal dominant
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4542-4551. doi: 10.1167/iovs.18-24539

Includes: Supplemental Content

Genetics September 2018

Confirmation of the Role of DHX38 in the Etiology of Early-Onset Retinitis Pigmentosa

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Zahid Latif; Imen Chakchouk; Isabelle Schrauwen; Kwanghyuk Lee; Regie Lyn P. Santos-Cortez; Izoduwa Abbe; Anushree Acharya; Afeefa Jarral; Imran Ali; Ehsan Ullah; Muhammad Nasim Khan; Ghazanfar Ali; Tufail Hussain Tahir; Michael J. Bamshad; Deborah A. Nickerson; Wasim Ahmad; Muhammad Ansar; Suzanne M. Leal; for The University of Washington Center for Mendelian Genomics (UWCMG) Study Group
TAGS: genetic linkage analysis, dna, family, genes, homozygote, retinitis pigmentosa, dideoxy chain termination dna sequencing, whole exome sequencing, bioinformatics
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4552-4557. doi: 10.1167/iovs.18-23849

Retina September 2018

Progression in X-linked Retinitis Pigmentosa Due to ORF15-RPGR Mutations: Assessment of Localized Vision Changes Over 2 Years

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Artur V. Cideciyan; Jason Charng; Alejandro J. Roman; Rebecca Sheplock; Alexandra V. Garafalo; Elise Heon; Samuel G. Jacobson
TAGS: gene therapy, mutation, retinal cone, perimetry, retinitis pigmentosa, vision, visual fields, x-linked inheritance, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4558-4566. doi: 10.1167/iovs.18-24931

Includes: Supplemental Content

Special Issue September 2018

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy

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Imran A. Bhutto; Shuntaro Ogura; Rajkumar Baldeosingh; D. Scott McLeod; Gerard A. Lutty; Malia M. Edwards
TAGS: phenotype, atrophy, injections, photoreceptors, wounds and injuries, eye, chief complaint
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD143-AMD151. doi: 10.1167/iovs.18-24245

Includes: Supplemental Content

Genetics September 2018

Crystals and Fatty Acid Abnormalities Are Not Present in Circulating Cells From Choroideremia Patients

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Alina Radziwon; Woo Jung Cho; Artur Szkotak; Miyoung Suh; Ian M. MacDonald
TAGS: fatty acids, choroideremia, crystal structure
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4464-4470. doi: 10.1167/iovs.18-25112

Biochemistry and Molecular Biology September 2018

Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

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JaeSang Ko; Ji-Young Kim; Eun Jig Lee; Jin Sook Yoon
TAGS: fibroblasts, 1-phosphatidylinositol 3-kinase, idelalisib
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4477-4485. doi: 10.1167/iovs.18-24509

Includes: Supplemental Content

Anatomy and Pathology/Oncology September 2018

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

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Zachary K. Goldsmith; William Coppess; Andrew S. Irvine; Kelley Yuan; Samuel R. Barsh; Madison K. Ritter; Matthew W. McEwen; Jacqueline Flores-Otero; Aileen Garcia-Vargas; Magaly Martinez-Ferrer; Rachel C. Brennan; Vanessa M. Morales-Tirado; Matthew W. Wilson
TAGS: signal transduction, cell culture techniques, western blotting, enzyme-linked immunosorbent assay, blood platelets, cell proliferation, flow cytometry, cell lines, cell survival, platelet-derived growth factor, platelet-derived growth factor receptor, retinoblastoma, rna, messenger, seeds, spheroids, cellular, vitreous body, diagnostic imaging, eye, neoplasms, rna, small interfering, nuclear translocation, proto-oncogene proteins c-akt, did not receive therapy or drug
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4486-4495. doi: 10.1167/iovs.18-24359

Articles September 2018

Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography

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Maryse Lapierre-Landry; Alison L. Huckenpahler; Brian A. Link; Ross F. Collery; Joseph Carroll; Melissa C. Skala
TAGS: melanins, zebrafish, diagnostic imaging, eye, mosaicism, retina, optical coherence tomography
Trans. Vis. Sci. Tech.. 2018; 7(5):4. doi: 10.1167/tvst.7.5.4

Biochemistry and Molecular Biology August 2018

Role of Cyclic Adenosine Monophosphate in Myopic Scleral Remodeling in Guinea Pigs: A Microarray Analysis

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Nethrajeith Srinivasalu; Chanyi Lu; Miaozhen Pan; Peter Sol Reinach; Yingying Wen; Yang Hu; Jia Qu; Xiangtian Zhou
TAGS: gene expression, collagen, genes, caviidae, myopia, cyclic amp, eye, sclera
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4318-4325. doi: 10.1167/iovs.17-224685

Includes: Supplemental Content

Cornea August 2018

Ophthalmic Nonsteroidal Anti-Inflammatory Drugs as a Therapy for Corneal Dystrophies Caused by SLC4A11 Mutation

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Kumari Alka; Joseph R. Casey
TAGS: mutation, anti-inflammatory agents, non-steroidal, hereditary corneal dystrophy, diclofenac, eye, water, nepafenac
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4258-4267. doi: 10.1167/iovs.18-24301

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2018

Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway

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Na Wang; Chen Zou; Shuzhi Zhao; Yunzhi Wang; Changjing Han; Zhi Zheng
TAGS: apoptosis, diabetes mellitus, inflammation, glucose, diabetic retinopathy, rats, angptl3 gene, fenofibrate, integrins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4210-4217. doi: 10.1167/iovs.18-24155

Cornea August 2018

Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Corneal Endothelial Cell Proliferation

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Makiko Nakahara; Naoki Okumura; Shinichiro Nakano; Noriko Koizumi
TAGS: endothelial cells, corneal endothelium, cornea, mitogen-activated protein kinase inhibitor, mitogen-activated protein kinase p38
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4218-4227. doi: 10.1167/iovs.18-24394

Includes: Supplemental Content

Retina August 2018

Residual Cone Structure in Patients With X-Linked Cone Opsin Mutations

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Emily J. Patterson; Angelos Kalitzeos; Melissa Kasilian; Jessica C. Gardner; Jay Neitz; Alison J. Hardcastle; Maureen Neitz; Joseph Carroll; Michel Michaelides
TAGS: mutation, retinal cone, x-linked inheritance, opsin
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4238-4248. doi: 10.1167/iovs.18-24699

Includes: Supplemental Content

Immunology and Microbiology August 2018

Detection of Complement Activators in Immune Attack Eyes After iPS-Derived Retinal Pigment Epithelial Cell Transplantation

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Sunao Sugita; Kenichi Makabe; Shota Fujii; Masayo Takahashi
TAGS: complement system proteins, eye, transplantation, transcriptional activation, idiopathic pneumonia syndrome, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4198-4209. doi: 10.1167/iovs.18-24769

Includes: Supplemental Content

Retina August 2018

The Spectrum of Structural and Functional Abnormalities in Female Carriers of Pathogenic Variants in the RPGR Gene

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Mays Talib; Mary J. van Schooneveld; Caroline Van Cauwenbergh; Jan Wijnholds; Jacoline B. ten Brink; Ralph J. Florijn; Nicoline E. Schalij-Delfos; Gislin Dagnelie; Maria M. van Genderen; Elfride De Baere; Magda A. Meester-Smoor; Julie De Zaeytijd; Frans P. M. Cremers; L. Ingeborgh van den Born; Alberta A. Thiadens; Carel B. Hoyng; Caroline C. Klaver; Bart P. Leroy; Arthur A. Bergen; Camiel J. F. Boon
TAGS: phenotype, genes, heterozygote, signs and symptoms
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4123-4133. doi: 10.1167/iovs.17-23453

Includes: Supplemental Content

Genetics August 2018

Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect

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Sherin Shaaban; Sarah MacKinnon; Caroline Andrews; Sandra E. Staffieri; Gail D. E. Maconachie; Wai-Man Chan; Mary C. Whitman; Sarah U. Morton; Seyhan Yazar; Stuart MacGregor; James E. Elder; Elias I. Traboulsi; Irene Gottlob; Alex W. Hewitt; Strabismus Genetics Research Consortium; David G. Hunter; David A. Mackey; Elizabeth C. Engle
TAGS: meta-analysis, esotropia, cohort studies, disease susceptibility, genome, parent, single nucleotide polymorphism, strabismus, genetics, genome-wide association study
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4054-4064. doi: 10.1167/iovs.18-24082

Includes: Supplemental Content

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Effects of the Tyrosinase-Dependent Dopaminergic System on Refractive Error Development in Guinea Pigs

IFT52 as a Novel Candidate for Ciliopathies Involving Retinal Degeneration

Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma

Translational Retinal Research and Therapies

Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina

Confirmation of the Role of DHX38 in the Etiology of Early-Onset Retinitis Pigmentosa

Progression in X-linked Retinitis Pigmentosa Due to ORF15-RPGR Mutations: Assessment of Localized Vision Changes Over 2 Years

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy

Crystals and Fatty Acid Abnormalities Are Not Present in Circulating Cells From Choroideremia Patients

Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography

Role of Cyclic Adenosine Monophosphate in Myopic Scleral Remodeling in Guinea Pigs: A Microarray Analysis

Ophthalmic Nonsteroidal Anti-Inflammatory Drugs as a Therapy for Corneal Dystrophies Caused by SLC4A11 Mutation

Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway

Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Corneal Endothelial Cell Proliferation

Residual Cone Structure in Patients With X-Linked Cone Opsin Mutations

Detection of Complement Activators in Immune Attack Eyes After iPS-Derived Retinal Pigment Epithelial Cell Transplantation

The Spectrum of Structural and Functional Abnormalities in Female Carriers of Pathogenic Variants in the RPGR Gene

Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect

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