Genetics

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Retinal Cell Biology March 2019

Dual Properties of Lactate in Müller Cells: The Effect of GPR81 Activation

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Rupali Vohra; Blanca I. Aldana; Helle Waagepetersen; Linda H. Bergersen; Miriam Kolko
TAGS: lactates, glutamate, glucose
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):999-1008. doi: 10.1167/iovs.18-25458

Immunology and Microbiology March 2019

Impaired Autophagic Degradation of Transforming Growth Factor-β-Induced Protein by Macrophages in Lattice Corneal Dystrophy

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Ji Han; Ming Zhang; Hai-Yan Lin; Feng-Ying Huang; Ying-Ying Lin; Guang-Hong Tan; Zhen-You Zheng
TAGS: autophagy, proteins, catabolism, macrophages, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):978-989. doi: 10.1167/iovs.18-25838

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2019

Electrophysiological Changes During Early Steps of Retinitis Pigmentosa

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Ulisse Bocchero; Beatrice M. Tam; Colette N. Chiu; Vincent Torre; Orson L. Moritz
TAGS: animals, transgenic, darkness, electroretinography, photons, phototransduction, retinitis pigmentosa, rhodopsin, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):933-943. doi: 10.1167/iovs.18-25347

Includes: Supplemental Content

Special Issue February 2019

IMI – Myopia Genetics Report

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Milly S. Tedja; Annechien E. G. Haarman; Magda A. Meester-Smoor; Jaakko Kaprio; David A. Mackey; Jeremy A. Guggenheim; Christopher J. Hammond; Virginie J. M. Verhoeven; Caroline C. W. Klaver; for the CREAM Consortium
TAGS: genes, myopia, refractive errors, genetics, genome-wide association study, universities
Invest. Ophthalmol. Vis. Sci.. 2019; 60(3):M89-M105. doi: 10.1167/iovs.18-25965

Cornea February 2019

Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

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Naoki Okumura; Ryosuke Hayashi; Masakazu Nakano; Kengo Yoshii; Kei Tashiro; Takahiko Sato; Derek J. Blake; Ross Aleff; Malinda Butz; Edward W. Highsmith; Eric D. Wieben; Michael P. Fautsch; Keith H. Baratz; Yuya Komori; Makiko Nakahara; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Noriko Koizumi
TAGS: polymerase chain reaction, hereditary corneal dystrophy, dna, endothelium, corneal endothelium, genome, rna, messenger, trinucleotide repeat expansion, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):779-786. doi: 10.1167/iovs.18-25760

Includes: Supplemental Content

Article February 2019

Statistics of natural images as a function of dynamic range

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Antoine Grimaldi; David Kane; Marcelo Bertalmío
TAGS: photoreceptors, histogram, gata3 gene, pixel, homologous recombinational dna repair, dynamic range, natural scenes
Journal of Vision. 2019; 19(2):13. doi: 10.1167/19.2.13

Cornea February 2019

KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27

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Anil Tiwari; Sudha Swamynathan; Nicholas Alexander; John Gnalian; Shenghe Tian; Paul R. Kinchington; Shivalingappa K. Swamynathan
TAGS: signal transduction, corneal epithelium, cornea, rna, ablation, corneal epithelial cells, cyclin-dependent kinase inhibitors
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):731-740. doi: 10.1167/iovs.18-26423

Includes: Supplemental Content

Cornea February 2019

Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea

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Justin Ma; Peter Lwigale
TAGS: cornea, mice, junctional premature complex, mesenchyme, genes, embryo
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):661-676. doi: 10.1167/iovs.18-26018

Includes: Supplemental Content

Biochemistry and Molecular Biology February 2019

DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B

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Guangying Luo; Xia Jing; Shuai Yang; Dewei Peng; Jing Dong; Li Li; Peter S. Reinach; Dongsheng Yan
TAGS: epithelium, dna, dna methylation, wound healing, wounds and injuries, cornea, hypermethylation, dna (cytosine-5-)-methyltransferase 1, cdkn2b gene, rna, small interfering, methylation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):650-660. doi: 10.1167/iovs.18-25443

Includes: Supplemental Content

Articles February 2019

A Novel Method for the Objective Identification of Hyperautofluorescent Ring in Retinitis Pigmentosa Using Binarization Processing

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Yohei Hashimoto; Tatsuya Inoue; Takashi Ono; Jinhee Lee; Saori Tsuneyoshi; Asahi Fujita; Yuji Inoue; Shun Ogawa; Ryo Asaoka; Ryo Obata
TAGS: retinitis pigmentosa
Trans. Vis. Sci. Tech.. 2019; 8(1):20. doi: 10.1167/tvst.8.1.20

Anatomy and Pathology/Oncology February 2019

A Genome-Wide Association Study for Susceptibility to Visual Experience-Induced Myopia

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Yu Huang; Chea-su Kee; Paul M. Hocking; Cathy Williams; Shea Ping Yip; Jeremy A. Guggenheim; for The UK Biobank Eye and Vision Consortium and The CREAM Consortium
TAGS: child, genetics, myopia, refractive errors, genome-wide association study, disease susceptibility
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):559-569. doi: 10.1167/iovs.18-25597

Includes: Supplemental Content

Retina February 2019

Suppression of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells by an MRTF-A Inhibitor

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Masaaki Kobayashi; Kazuhiro Tokuda; Yuka Kobayashi; Chiemi Yamashiro; Sho-Hei Uchi; Makoto Hatano; Kazuhiro Kimura
TAGS: fibrosis, cell motility, choroidal neovascularization, gelatin, gelatinase a, immunoblotting, mice, proteins, epithelial to mesenchymal transition, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):528-537. doi: 10.1167/iovs.18-25678

Retina January 2019

VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site

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Peter H. Tang; Gabriel Velez; Stephen H. Tsang; Alexander G. Bassuk; Vinit B. Mahajan
TAGS: mutation, exons, gelatinase a, surgical procedures, operative, vitreous body, eye, retina, cytokinesis, tissue degeneration, histopathology tests, proteolysis, proteins, splice-site mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):282-293. doi: 10.1167/iovs.18-25624

Includes: Supplemental Content

Retinal Cell Biology January 2019

Chemokine Expression in Murine RPE/Choroid in Response to Systemic Viral Infection and Elevated Levels of Circulating Interferon-γ

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Carsten Faber; Helene Bæk Juel; Benjamin Anderschou Holbech Jensen; Jan Pravsgaard Christensen; Jan Ulrik Prause; Allan Randrup Thomsen; Mogens Holst Nissen
TAGS: chemokines, genes, interferons, lymphocytic choriomeningitis virus, virus diseases, infection, choroid, mice
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):192-201. doi: 10.1167/iovs.18-25721

Includes: Supplemental Content

Genetics January 2019

Germline Mutations in CTNNB1 Associated With Syndromic FEVR or Norrie Disease

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Wenmin Sun; Xueshan Xiao; Shiqiang Li; Xiaoyun Jia; Panfeng Wang; Qingjiong Zhang
TAGS: mutation, germ-line mutation, familial exudative vitreoretinopathy, congenital progressive oculo-acoustico-cerebral degeneration, beta catenin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):93-97. doi: 10.1167/iovs.18-25142

Includes: Supplemental Content

Articles January 2019

Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy

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Joseph D. Bogaard; Jonathon B. Young; Asad Movahedan; Iris S. Kassem
TAGS: enoxaparin, child, animal model, triamcinolone, eye, fibrin, therapeutic intervention, oryctolagus cuniculus, postoperative care, anterior chamber of eye, inflammation, enzyme-linked immunosorbent assay, did not receive therapy or drug
Trans. Vis. Sci. Tech.. 2019; 8(1):5. doi: 10.1167/tvst.8.1.5

Articles December 2018

A Model to Study Thermal Energy Delivery to the Choroid: A Comparison of Surgical Devices

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Stephen A. LoBue; Prashant Tailor; Jarel K. Gandhi; Paul Loftness; Timothy W. Olsen
TAGS: heat (physical force), surgical procedures, operative, body tissue, body temperature, choroid, mpl gene, temperature
Trans. Vis. Sci. Tech.. 2018; 7(6):39. doi: 10.1167/tvst.7.6.39

Retinal Cell Biology December 2018

Photoreceptor Progenitors Depend Upon Coordination of gdf6a , thrβ , and tbx2b to Generate Precise Populations of Cone Photoreceptor Subtypes

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Michèle G. DuVal; W. Ted Allison
TAGS: genetics, photoreceptors, zebrafish, ultraviolet rays, retinal cone, burkina faso
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6089-6101. doi: 10.1167/iovs.18-24461

Includes: Supplemental Content

Retina December 2018

A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3

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Mark M. Hassall; Alun R. Barnard; Harry O. Orlans; Michelle E. McClements; Peter Charbel Issa; Sher A. Aslam; Robert E. MacLaren
TAGS: mice, retinal cone, mutation, electroretinography, achromatopsia
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6102-6110. doi: 10.1167/iovs.18-24328

Retina December 2018

Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice

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Helen T. Michael; Cari Graff-Cherry; Sung Chin; Corinne Rauck; Amelework D. Habtemichael; Patricia Bunda; Tunde Smith; Maria M. Campos; Kapil Bharti; Heinz Arnheiter; Glenn Merlino; Chi-Ping Day
TAGS: eye, pigment, pigmentation, ectopic gene expression, mitf protein, mice
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6067-6073. doi: 10.1167/iovs.18-25186

Includes: Supplemental Content

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Dual Properties of Lactate in Müller Cells: The Effect of GPR81 Activation

Impaired Autophagic Degradation of Transforming Growth Factor-β-Induced Protein by Macrophages in Lattice Corneal Dystrophy

Electrophysiological Changes During Early Steps of Retinitis Pigmentosa

IMI – Myopia Genetics Report

Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

Statistics of natural images as a function of dynamic range

KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27

Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea

DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B

A Novel Method for the Objective Identification of Hyperautofluorescent Ring in Retinitis Pigmentosa Using Binarization Processing

A Genome-Wide Association Study for Susceptibility to Visual Experience-Induced Myopia

Suppression of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells by an MRTF-A Inhibitor

VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site

Chemokine Expression in Murine RPE/Choroid in Response to Systemic Viral Infection and Elevated Levels of Circulating Interferon-γ

Germline Mutations in CTNNB1 Associated With Syndromic FEVR or Norrie Disease

Use of a Juvenile Rabbit Animal Model to Evaluate Therapeutic Interventions for Postoperative Inflammation and Fibrin Formation After Lensectomy

A Model to Study Thermal Energy Delivery to the Choroid: A Comparison of Surgical Devices

Photoreceptor Progenitors Depend Upon Coordination of gdf6a , thrβ , and tbx2b to Generate Precise Populations of Cone Photoreceptor Subtypes

A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3

Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice

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