Immunology and Microbiology

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Articles April 2021

Corneal Immune Cells Are Increased in Patients With Multiple Sclerosis

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Adnan Khan; Yi Li; Georgios Ponirakis; Naveed Akhtar; Hoda Gad; Pooja George; Faiza M. Ibrahim; Ioannis N. Petropoulos; Beatriz G. Canibano; Dirk Deleu; Ashfaq Shuaib; Saadat Kamran; Rayaz A. Malik
TAGS: cornea, multiple sclerosis, neurons, ciliary motility disorders, multiple sclerosis, relapsing-remitting, microscopy, confocal
Trans. Vis. Sci. Tech.. 2021; 10(4):19. doi: https://doi.org/10.1167/tvst.10.4.19

Retinal Cell Biology April 2021

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

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Yi Chen; Binxin Wu; Jian Feng He; Jingyao Chen; Zi Wei Kang; Dandan Liu; Junjie Luo; Kexin Fang; Xiaoxu Leng; Haibin Tian; Jingying Xu; Caixia Jin; Jieping Zhang; Juan Wang; Jingfa Zhang; Qingjian Ou; Lixia Lu; Furong Gao; Guo-Tong Xu
TAGS: epithelial to mesenchymal transition, retinal pigment cell, signal transduction inhibitor, primary eosinophilic endomyocardial cardiomyopathy
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):21. doi: https://doi.org/10.1167/iovs.62.4.21

Includes: Supplemental Content

Cornea April 2021

IL-36α Exerts Proinflammatory Effects in A spergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB

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Yawen Niu; Changjie Ren; Xudong Peng; Cui Li; Qiang Xu; Liting Hu; Ziyue Zhang; Guiqiu Zhao; Jing Lin
TAGS: aspergillus fumigatus, cornea, cytokine, keratitis, macrophages, mice, proteins, interleukin-6, rna, messenger, infections
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):16. doi: https://doi.org/10.1167/iovs.62.4.16

Articles April 2021

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

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Fumihito Hikage; Yosuke Ida; Yuika Ouchi; Megumi Watanabe; Hiroshi Ohguro
TAGS: agonists, fibroblasts, organoids, prostaglandins
Trans. Vis. Sci. Tech.. 2021; 10(4):6. doi: https://doi.org/10.1167/tvst.10.4.6

Includes: Supplemental Content

Cornea April 2021

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease

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Yong Woo Ji; Hyun Goo Kang; Jong Suk Song; Ji Won Jun; Kyusun Han; Tae-im Kim; Kyoung Yul Seo; Hyung Keun Lee
TAGS: dopamine, dopamine receptors, dry eye syndromes, langer-giedion syndrome, mice, cornea
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):14. doi: https://doi.org/10.1167/iovs.62.4.14

Articles April 2021

Association Between the Types of Posterior Staphyloma and Their Risk Factors in Pathological Myopia

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Guangqi An; Fangfang Dai; Rui Wang; Zhenhui Liu; Ju Guo; Meng Pan; Xuemin Jin; Bo Lei
TAGS: 3d mri, eye, myopia, risk factors, staphyloma, shape
Trans. Vis. Sci. Tech.. 2021; 10(4):5. doi: https://doi.org/10.1167/tvst.10.4.5

Retina April 2021

Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage

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Balasubramaniam Annamalai; Nathaniel Parsons; Crystal Nicholson; Elisabeth Obert; Bryan Jones; Bärbel Rohrer
TAGS: complement system proteins, familial hypercholesterolemia, family history, mice, adeno-associated virus
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):11. doi: https://doi.org/10.1167/iovs.62.4.11

Visual Neuroscience April 2021

Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy

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Qian Wu; Hao Hu; Wen Chen; Huan-Huan Chen; Lu Chen; Jiang Zhou; Hu Liu; Fei-Yun Wu; Xiao-Quan Xu
TAGS: brain, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):5. doi: https://doi.org/10.1167/iovs.62.4.5

Includes: Supplemental Content

Glaucoma April 2021

TGF-β2 Promotes Oxidative Stress in Human Trabecular Meshwork Cells by Selectively Enhancing NADPH Oxidase 4 Expression

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Vidhya R. Rao; Evan B. Stubbs, Jr
TAGS: nadph oxidase 4, oxidative stress, proteins, trabecular meshwork, nadph oxidases, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):4. doi: https://doi.org/10.1167/iovs.62.4.4

Review April 2021

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

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Ying Kai Chan; Andrew D. Dick; Sara Mary Hall; Thomas Langmann; Curtis L. Scribner; Brian C. Mansfield; for the Ocular Gene Therapy Inflammation Working Group
TAGS: blindness, gene therapy, inflammation, spatial vectors, disease vectors
Trans. Vis. Sci. Tech.. 2021; 10(4):3. doi: https://doi.org/10.1167/tvst.10.4.3

Cornea March 2021

Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines

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Xue Tian; Xudong Peng; Jing Lin; Yingxue Zhang; Lu Zhan; Jiao Yin; Ranran Zhang; Guiqiu Zhao
TAGS: antifungal agents, anti-inflammatory agents, cytokine, keratitis, mice, pattern recognition receptors, aspergillus fumigatus, dimethyl sulfoxide, cornea
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):38. doi: https://doi.org/10.1167/iovs.62.3.38

Retinal Cell Biology March 2021

CSF1/CSF1R-mediated Crosstalk Between Choroidal Vascular Endothelial Cells and Macrophages Promotes Choroidal Neovascularization

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Yamei Zhou; Jia Zeng; Yuanyuan Tu; Lele Li; Shu Du; Linling Zhu; Xiaomin Cang; Jiajie Lu; Manhui Zhu; Xiaojuan Liu
TAGS: choroidal neovascularization, endothelial cells, macrophage colony-stimulating factor, macrophage colony-stimulating factor receptor, macrophages, hypoxia, proto-oncogene proteins c-akt, forkhead box protein o1
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):37. doi: https://doi.org/10.1167/iovs.62.3.37

Articles March 2021

Contrast Sensitivity Loss in Patients With Posttreatment Lyme Disease

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Alison W. Rebman; Ting Yang; John N. Aucott; Erica A. Mihm; Sheila K. West
TAGS: contrast sensitivity, lyme disease, posttransplant lymphoproliferative disorder, impairment
Trans. Vis. Sci. Tech.. 2021; 10(3):27. doi: https://doi.org/10.1167/tvst.10.3.27

Articles March 2021

Face Mask-Related Ocular Surface Modifications During COVID-19 Pandemic: A Clinical, In Vivo Confocal Microscopy, and Immune-Cytology Study

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Leonardo Mastropasqua; Manuela Lanzini; Lorenza Brescia; Rossella D'Aloisio; Mario Nubile; Marco Ciancaglini; Claudio D'Amario; Luca Agnifili; Rodolfo Mastropasqua
TAGS: coronavirus pandemic, covid-19, cytology, face, masks, microscopy, confocal, hla-dr antigens, dry eye syndromes, conjunctiva, questionnaires
Trans. Vis. Sci. Tech.. 2021; 10(3):22. doi: https://doi.org/10.1167/tvst.10.3.22

Immunology and Microbiology March 2021

Murine Model of Primary Acquired Ocular Toxoplasmosis: Fluorescein Angiography and Multiplex Immune Mediator Profiles in the Aqueous Humor

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Kexin Li; Xue Feng; Kenji Hikosaka; Kazumi Norose
TAGS: aqueous humor, fluorescein angiography, hypertension, immune mediator, infections, mice, ocular toxoplasmosis, eye
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):9. doi: https://doi.org/10.1167/iovs.62.3.9

Immunology and Microbiology February 2021

Characterization of Gene Therapy Associated Uveitis Following Intravitreal Adeno-Associated Virus Injection in Mice

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Gayathri Tummala; Adam Crain; Jessica Rowlan; Kathryn L. Pepple
TAGS: adeno-associated virus, eye, gene therapy, inflammation, injections, intravitreal injections, mice, uveitis, spatial vectors, flow cytometry
Invest. Ophthalmol. Vis. Sci.. 2021; 62(2):41. doi: https://doi.org/10.1167/iovs.62.2.41

Includes: Supplemental Content

Immunology and Microbiology February 2021

Altered Corneal Epithelial Dendritic Cell Morphology and Phenotype Following Acute Exposure to Hyperosmolar Saline

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Kirthana Senthil; Haihan Jiao; Laura E. Downie; Holly R. Chinnery
TAGS: cornea, dendritic cells, epithelium, hyperosmolality, language morphology, morphology, phenotype, saline solutions, mosmol, mice
Invest. Ophthalmol. Vis. Sci.. 2021; 62(2):38. doi: https://doi.org/10.1167/iovs.62.2.38

Includes: Supplemental Content

Biochemistry and Molecular Biology February 2021

Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R)

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Jeanee Bullock; Federica Polato; Mones Abu-Asab; Alexandra Bernardo-Colón; Elma Aflaki; Martin-Paul Agbaga; S. Patricia Becerra
TAGS: catabolism, epithelium, lipids, mice, phagocytosis, photoreceptors, pigment, proteins, retinal pigment epithelium, rhodopsin
Invest. Ophthalmol. Vis. Sci.. 2021; 62(2):30. doi: https://doi.org/10.1167/iovs.62.2.30

Includes: Supplemental Content

Retina February 2021

EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development

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Xiaowen Cao; Jianhong An; Yuqing Cao; Juan Lv; Jiawei Wang; Yang Ding; Xinhua Lin; Xiangtian Zhou
TAGS: mice, neural development, proteins, retina
Invest. Ophthalmol. Vis. Sci.. 2021; 62(2):31. doi: https://doi.org/10.1167/iovs.62.2.31

Includes: Supplemental Content

Retinal Cell Biology February 2021

Hypoxia Induces Galectin-1 Expression Via Autoinduction of Placental Growth Factor in Retinal Pigment Epithelium Cells

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Taku Yamamoto; Atsuhiro Kanda; Satoru Kase; Susumu Ishida
TAGS: galectin 1, hypoxia, placenta growth factor, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2021; 62(2):22. doi: https://doi.org/10.1167/iovs.62.2.22

Includes: Supplemental Content

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Corneal Immune Cells Are Increased in Patients With Multiple Sclerosis

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

IL-36α Exerts Proinflammatory Effects in A spergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease

Association Between the Types of Posterior Staphyloma and Their Risk Factors in Pathological Myopia

Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage

Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy

TGF-β2 Promotes Oxidative Stress in Human Trabecular Meshwork Cells by Selectively Enhancing NADPH Oxidase 4 Expression

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines

CSF1/CSF1R-mediated Crosstalk Between Choroidal Vascular Endothelial Cells and Macrophages Promotes Choroidal Neovascularization

Contrast Sensitivity Loss in Patients With Posttreatment Lyme Disease

Face Mask-Related Ocular Surface Modifications During COVID-19 Pandemic: A Clinical, In Vivo Confocal Microscopy, and Immune-Cytology Study

Murine Model of Primary Acquired Ocular Toxoplasmosis: Fluorescein Angiography and Multiplex Immune Mediator Profiles in the Aqueous Humor

Characterization of Gene Therapy Associated Uveitis Following Intravitreal Adeno-Associated Virus Injection in Mice

Altered Corneal Epithelial Dendritic Cell Morphology and Phenotype Following Acute Exposure to Hyperosmolar Saline

Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R)

EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development

Hypoxia Induces Galectin-1 Expression Via Autoinduction of Placental Growth Factor in Retinal Pigment Epithelium Cells

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Immunology and Microbiology

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