Multidisciplinary Ophthalmic Imaging

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Retina July 2025

In Vivo Characterization of Bruch’s Membrane Breaks in Neovascular Age-Related Macular Degeneration Using High-Resolution Optical Coherence Tomography

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Mai Alhelaly; Ceren Soylu; Giulia Corradetti; Federico Corvi; Alireza Mahmoudi; Rouzbeh Abbasgholizadeh; Giovanni Bellisario; Ye He; Alberto Quarta; Muneeswar G. Nittala; Giovanni Staurenghi; SriniVas R. Sadda
TAGS: bruch's basal membrane, exudative age-related macular degeneration, eye, macular neovascularization, optical coherence tomography, injections, diagnostic imaging, visual acuity, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):19. https://doi.org/10.1167/iovs.66.9.19

Lens June 2025

Hyperopic Eyes Are Structurally More Dynamic Than Myopic Eyes During Accommodation: An In Vivo Investigation

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Tuyishime Didier Fidele Uwacu; Saugat Bhattacharyya; Kathryn J. Saunders; Julie-Anne Little
TAGS: eye, visual accommodation, refractive errors, lens, crystalline, lens (device)
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):51. https://doi.org/10.1167/iovs.66.6.51

Includes: Multimedia, Supplemental Content

Multidisciplinary Ophthalmic Imaging June 2025

Choroidal Hyperreflective Foci Represent a Common Finding Across Different Types of Macular Atrophy

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Lorena Ulla; Claudio Foti; Alessandro Arrigo; Maurizio Battaglia Parodi; Maria Vittoria Cicinelli; Paola Marolo; Elisabetta Miserocchi; Mario Peronetti; Francesco Bandello; Enrico Borrelli; Michele Reibaldi
TAGS: atrophoderma maculatum
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):42. https://doi.org/10.1167/iovs.66.6.42

Includes: Supplemental Content

Retina June 2025

High-Resolution, Motion-Corrected, Volume-Fused OCT for Investigating Longitudinal Changes in Subretinal Drusenoid Deposits in Intermediate AMD

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Jungeun Won; Antonio Yaghy; Stefan B. Ploner; Stephanie Kaiser; Jessica M. Girgis; Yunchan Hwang; Muhammad Usman Jamil; Andreas Maier; Nadia K. Waheed; James G. Fujimoto
TAGS: face, motion, volume, eye, diagnostic imaging
Trans. Vis. Sci. Tech.. 2025; 14(6):15. https://doi.org/10.1167/tvst.14.6.15

Cornea & External Disease June 2025

Far-Red, High-Resolution, Reflection-Free Images of the Anterior Segment in Retro-Illumination

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Anthony Ain; Sylvain Poinard; Thierry Lepine; Oliver Dorado-Cortez; Sébastien Urbaniak; Jean-Marie Papillon; Philippe Gain; Gilles Thuret
TAGS: diagnostic imaging, lighting, slit lamps, light
Trans. Vis. Sci. Tech.. 2025; 14(6):11. https://doi.org/10.1167/tvst.14.6.11

Artificial Intelligence June 2025

AI Quantification of Vascular Lesions in Mouse Fundus Fluorescein Angiography

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Vinodhini Jayananthan; Tyler Heisler Taylor; David Henry Greentree; Bryce Collison; Nagaraj Kerur
TAGS: choroidal neovascularization, fluorescein angiography, lasers, mice, precision, training, vascular lesions, very low density lipoprotein receptor, mental recall, datasets
Trans. Vis. Sci. Tech.. 2025; 14(6):4. https://doi.org/10.1167/tvst.14.6.4

Includes: Supplemental Content

Retina May 2025

Clic6 Deficiency Triggers Aberrant Apical Microvilli in RPE

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Sangwan Park; Naran Suvarnpradip; Niusha Kasiri; Glenn Yiu; Sara M. Thomasy; Denise M. Imai; K. C. Kent Lloyd; Brian C. Leonard; Ala Moshiri
TAGS: mice, microvilli, precipitating factors, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):44. https://doi.org/10.1167/iovs.66.5.44

Includes: Supplemental Content

Retina May 2025

Discrepancies Between Autofluorescence Imaging Modalities in CNGB3 -Associated Achromatopsia and Correlation With Ellipsoid Zone Continuity

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Haseeb N. Akhtar; Chun Fung Jeffrey Lam; Siying Lin; Gavin Arno; Jose S. Pulido; Andrew R. Webster; Michel Michaelides; Omar A. Mahroo
TAGS: achromatopsia, autofluorescence, diagnostic imaging, eye
Trans. Vis. Sci. Tech.. 2025; 14(5):24. https://doi.org/10.1167/tvst.14.5.24

Retina May 2025

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases

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Olubayo U. Kolawole; Ethan Bensinger; Jessica Wong; Nicholas Rinella; Katharina G. Foote; Hao Zhou; Ruikang K. Wang; Jacque L. Duncan; Austin Roorda
TAGS: diagnostic imaging, eye, macular disorders, atrophoderma maculatum, retinal cone, fovea centralis, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):18. https://doi.org/10.1167/iovs.66.5.18

Includes: Supplemental Content

Retina May 2025

Age-Related Regional Changes in Choroidal Vascularity in Healthy Emmetropic Eyes

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Ghazal Valizadeh; Hosein Hoseini-Yazdi; Scott Read; David Alonso-Caneiro; Michael Collins
TAGS: adult, cardiovascular imaging, child, cortical blindness, diagnostic imaging, eye, macula lutea, nose, fovea centralis, choroid
Trans. Vis. Sci. Tech.. 2025; 14(5):3. https://doi.org/10.1167/tvst.14.5.3

Multidisciplinary Ophthalmic Imaging April 2025

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

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Yan-Jie Li; Zeng-Yu Zhang; Tian-Yue Liu; Hai-Yan Liu; Lu-Lu Shi; Rong-Xia Cao; Chao-Ran Lv; Zeng-Hui Zhang
TAGS: angiogram, fluid flow, microcirculation, optical coherence tomography, retina, thyroid carcinoma, papillary, carcinoma, perfusion, inflammation, inspection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):73. https://doi.org/10.1167/iovs.66.4.73

Retina April 2025

Relationships Between Retinal Vascular Characteristics and Systemic Indicators in Patients With Diabetes Mellitus

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Xingyu Xiao; Jianchun Zhao; Shiqun Lin; Yajie Yang; Wenhui Li; Yan Zhou; Xiao Zhang; Rongping Dai
TAGS: diabetes mellitus, nonproliferative diabetic retinopathy, retinal vessels, renal function, biological markers
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):72. https://doi.org/10.1167/iovs.66.4.72

Retina April 2025

Quantifications of Outer Retinal Bands in Geographic Atrophy by Comparing Superior Axial Resolution and Conventional OCT

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Sophie Frank-Publig; Hrvoje Bogunovic; Klaudia Birner; Markus Gumpinger; Philipp Fuchs; Leonard M. Coulibaly; Virginia Mares; Friedrich Michel; Fiona Sophia Schmidt; Ursula Schmidt-Erfurth; Gregor S. Reiter
TAGS: age-related macular degeneration, nonexudative, eye, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):65. https://doi.org/10.1167/iovs.66.4.65

Retina April 2025

Fluorescence Lifetime Imaging Ophthalmoscopy, Vision, and Chorioretinal Asymmetries in Aging and Age-Related Macular Degeneration: ALSTAR2

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Lukas Goerdt; Mark E. Clark; Tracy N. Thomas; Liyan Gao; Gerald McGwin, Jr.; Martin Hammer; Jason N. Crosson; Kenneth R. Sloan; Cynthia Owsley; Christine A. Curcio
TAGS: age-related macular degeneration, aging, diagnostic imaging, eye, fluorescence, ophthalmoscopy, vision, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):56. https://doi.org/10.1167/iovs.66.4.56

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging April 2025

A Narrowband 635 nm Autofluorescence Peak in Albino Mouse Eyes Found With Multi-Modal Imaging Reveals the Presence of Protoporphyrin IX in the Choroid

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Pengfei Zhang; Suman K. Manna; Mayank Goswami; Robert J. Zawadzki; Edward N. Pugh, Jr
TAGS: albinism, autofluorescence, diagnostic imaging, eye, mice, protoporphyrins, action spectrum, choroid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):29. https://doi.org/10.1167/iovs.66.4.29

Includes: Supplemental Content

Retina April 2025

Nonperfused Retinal Capillaries—A New Method Developed on OCT and OCTA

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Min Gao; Yukun Guo; Tristan T. Hormel; Jie Wang; Elizabeth White; Dong-Wouk Park; Thomas S. Hwang; Steven T. Bailey; Yali Jia
TAGS: biological markers, blood capillaries, diagnostic imaging, eye, face, noise, angiogram
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):22. https://doi.org/10.1167/iovs.66.4.22

Retina April 2025

Volumetric Measures of Capillary Nonperfusion on Optical Coherence Tomography Angiography Detect Early Ischemia in Diabetes Without Retinopathy

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Janice X. Ong; Hunter J. Lee; Nicole L. Decker; Daniela Castellanos-Canales; Hisashi Fukuyama; Amani A. Fawzi
TAGS: angiogram, blood capillaries, diabetes mellitus, diabetes mellitus, type 2, ischemia, optical coherence tomography, retinal diseases, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):2. https://doi.org/10.1167/iovs.66.4.2

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract April 2025

Poster Session: On the relationship between chromatic sensitivity and vividness of illusory colored signals

Paolo Antonino Grasso; Federico Tommasi; Elisabetta Baldanzi; Alessandro Farini; Massimo Gurioli
TAGS: posters
Journal of Vision. 2025; 25(5):48. https://doi.org/10.1167/jov.25.5.48

Optica Fall Vision Meeting Abstract April 2025

Invited Session III: Machine Learning and AI Approaches to Retinal Diagnostics: Using AI to predict age, sex and disease from retinal OCT images

Anya Hurlbert
TAGS: machine learning
Journal of Vision. 2025; 25(5):30. https://doi.org/10.1167/jov.25.5.30

Retina March 2025

Topographic Analysis of Two-Wavelength Autofluorescence Supports Higher Macular Xanthophyll Pigment in AMD Than Aging: ALSTAR2 Baseline

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Lukas Goerdt; Andreas Berlin; Liyan Gao; Thomas A. Swain; Sarah S. Kim; Gerald McGwin; Mark E. Clark; Deepayan Kar; Cynthia Owsley; Kenneth R. Sloan; Christine A. Curcio
TAGS: aging, autofluorescence, eye, lutein, pigment, maps, meridians, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):61. https://doi.org/10.1167/iovs.66.3.61

Includes: Supplemental Content

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In Vivo Characterization of Bruch’s Membrane Breaks in Neovascular Age-Related Macular Degeneration Using High-Resolution Optical Coherence Tomography

Hyperopic Eyes Are Structurally More Dynamic Than Myopic Eyes During Accommodation: An In Vivo Investigation

Choroidal Hyperreflective Foci Represent a Common Finding Across Different Types of Macular Atrophy

High-Resolution, Motion-Corrected, Volume-Fused OCT for Investigating Longitudinal Changes in Subretinal Drusenoid Deposits in Intermediate AMD

Far-Red, High-Resolution, Reflection-Free Images of the Anterior Segment in Retro-Illumination

AI Quantification of Vascular Lesions in Mouse Fundus Fluorescein Angiography

Clic6 Deficiency Triggers Aberrant Apical Microvilli in RPE

Discrepancies Between Autofluorescence Imaging Modalities in CNGB3 -Associated Achromatopsia and Correlation With Ellipsoid Zone Continuity

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases

Age-Related Regional Changes in Choroidal Vascularity in Healthy Emmetropic Eyes

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

Relationships Between Retinal Vascular Characteristics and Systemic Indicators in Patients With Diabetes Mellitus

Quantifications of Outer Retinal Bands in Geographic Atrophy by Comparing Superior Axial Resolution and Conventional OCT

Fluorescence Lifetime Imaging Ophthalmoscopy, Vision, and Chorioretinal Asymmetries in Aging and Age-Related Macular Degeneration: ALSTAR2

A Narrowband 635 nm Autofluorescence Peak in Albino Mouse Eyes Found With Multi-Modal Imaging Reveals the Presence of Protoporphyrin IX in the Choroid

Nonperfused Retinal Capillaries—A New Method Developed on OCT and OCTA

Volumetric Measures of Capillary Nonperfusion on Optical Coherence Tomography Angiography Detect Early Ischemia in Diabetes Without Retinopathy

Poster Session: On the relationship between chromatic sensitivity and vividness of illusory colored signals

Invited Session III: Machine Learning and AI Approaches to Retinal Diagnostics: Using AI to predict age, sex and disease from retinal OCT images

Topographic Analysis of Two-Wavelength Autofluorescence Supports Higher Macular Xanthophyll Pigment in AMD Than Aging: ALSTAR2 Baseline

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