Nanotechnology and Regenerative Medicine

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Cornea February 2019

A Novel Tissue-Engineered Corneal Stromal Equivalent Based on Amniotic Membrane and Keratocytes

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Xin Che; Han Wu; Changkai Jia; Huimin Sun; Shangkun Ou; Junqi Wang; M. Vimalin Jeyalatha; Xin He; Jingwen Yu; Chengyou Zuo; Zuguo Liu; Wei Li
TAGS: amnion, corneal stroma, keratoplasty, body tissue, cornea, central serous chorioretinopathy, keratocytes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):517-527. doi: 10.1167/iovs.18-24869

Includes: Multimedia, Supplemental Content

Glaucoma January 2019

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway

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Yiwen Wang; Deborah Osakue; Enzhi Yang; Yi Zhou; Haiyan Gong; Xiaobo Xia; Yiqin Du
TAGS: stress response, stem cells, endoplasmic reticulum, trabecular meshwork, stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):265-273. doi: 10.1167/iovs.18-25477

Includes: Supplemental Content

Biochemistry and Molecular Biology January 2019

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

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Sun Woong Kim; Hye-In Kim; Bikash Thapa; Selikem Nuwromegbe; Keunwook Lee
TAGS: signal transduction, fibroblasts, pterygium, myofibroblasts, proto-oncogene proteins c-akt, hpfs trial, mechanistic target of rapamycin complex 2, mtor serine-threonine kinases
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):82-92. doi: 10.1167/iovs.18-25376

Cornea January 2019

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

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Sheyla González; Denise Oh; Elfren R. Baclagon; Jie J. Zheng; Sophie X. Deng
TAGS: signal transduction, stem cells, molecule, small molecule, regulation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):107-112. doi: 10.1167/iovs.18-25740

Retina December 2018

In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis

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Brandon Bosse; Samir Damle; Abraham Akinin; Yi Jing; Dirk-Uwe Bartsch; Lingyun Cheng; Nicholas Oesch; Yu-Hwa Lo; Gert Cauwenberghs; William R. Freeman
TAGS: evoked potentials, visual, oryctolagus cuniculus, silicon, surgical procedures, operative, retina, implantation procedure, nanowires, implants, prostheses, visual prosthesis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5885-5892. doi: 10.1167/iovs.18-24554

Articles November 2018

Comparison of Artificial Anterior Chamber Internal Pressures and Cutting Systems for Descemet's Stripping Automated Endothelial Keratoplasty

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Sota Nishisako; Dai Aoki; Chiaki Sasaki; Kazunari Higa; Jun Shimazaki
TAGS: endothelial cells, anterior chamber of eye, keratoplasty, endothelium, tissue transplants, cornea, pressure-physical agent, significance, descemet stripping endothelial keratoplasty, donors
Trans. Vis. Sci. Tech.. 2018; 7(6):11. doi: 10.1167/tvst.7.6.11

Special Issue November 2018

Regeneration of Lacrimal Gland Function to Maintain the Health of the Ocular Surface

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Tetsuya Kawakita
TAGS: inflammation, stem cells, epithelium, graft-versus-host disease, cicatrix, dry eye syndromes, health, langer-giedion syndrome, animal model, body tissue, wounds and injuries, mice, lacrimal gland, tear production, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES169-DES173. doi: 10.1167/iovs.17-23576

Special Issue November 2018

Advances in Functional Restoration of the Lacrimal Glands

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Masatoshi Hirayama
TAGS: stem cells, epithelium, body tissue, transplantation, lacrimal gland, injection therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES174-DES182. doi: 10.1167/iovs.17-23528

Articles November 2018

Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma

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Ian Pitha; Ericka Oglesby; Amanda Chow; Elizabeth Kimball; Mary Ellen Pease; Julie Schaub; Harry Quigley
TAGS: fibroblasts, glaucoma, collagen, patient isolation, phosphotransferases, transforming growth factors, eye, intraocular pressure, sclera, myofibroblasts
Trans. Vis. Sci. Tech.. 2018; 7(6):6. doi: 10.1167/tvst.7.6.6

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology October 2018

Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis

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Mary C. Whitman; Elaine H. Nguyen; Jessica L. Bell; Alan P. Tenney; Alon Gelber; Elizabeth C. Engle
TAGS: signal transduction, axon, embryo, motor neurons, oculomotor nerve, cxcr4 receptors, synkinesis, oculomotor synkinesis, stromal cell-derived factor 1
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5201-5209. doi: 10.1167/iovs.18-25190

Includes: Multimedia, Supplemental Content

Cornea October 2018

Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts

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Koji Sugioka; Aya Kodama-Takahshi; Tomoko Sato; Kiyotaka Okada; Junko Murakami; Ah-Mee Park; Hiroshi Mishima; Yoshikazu Shimomura; Shunji Kusaka; Teruo Nishida
TAGS: urokinase, fibroblasts, collagen, gel, plasminogen, cornea, catabolism
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5098-5107. doi: 10.1167/iovs.18-24925

Articles October 2018

Universal Corneal Epithelial-Like Cells Derived from Human Embryonic Stem Cells for Cellularization of a Corneal Scaffold

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Juan Yang; Jung Woo Park; Dejin Zheng; Ren-He Xu
TAGS: immunohistochemistry, embryonic stem cells, epithelium, cornea, eye, mice
Trans. Vis. Sci. Tech.. 2018; 7(5):23. doi: 10.1167/tvst.7.5.23

Includes: Supplemental Content

Retina October 2018

A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye – Implications for Ocular Gene Therapy

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Shyamtanu Datta; Marian Renwick; Viet Q. Chau; Fang Zhang; Emily R. Nettesheim; Daniel M. Lipinski; John D. Hulleman
TAGS: gene therapy, dihydrofolate reductase, visual acuity, eye, mice, retina, potable water, regulation, proteins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4909-4920. doi: 10.1167/iovs.18-24987

Includes: Supplemental Content

Perspective October 2018

Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members

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W. Daniel Stamer; Andrew M. Williams; Stephen Pflugfelder; Sarah E. Coupland
TAGS: research personnel, body tissue, eye, surveys, quality
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4783-4792. doi: 10.1167/iovs.18-25319

New Developments in Vision Research September 2018

Translational Retinal Research and Therapies

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Alison J. Hardcastle; Paul A. Sieving; José-Alain Sahel; Samuel G. Jacobson; Artur V. Cideciyan; John G. Flannery; William A. Beltran; Gustavo D. Aguirre
TAGS: gene therapy, mutation, blindness, retinal cone, dog, domestic, genes, genome, animal model, photoreceptors, retinal degeneration, retinitis pigmentosa, rhodopsin, rod photoreceptors, vision, mice, proteins, retina, leber's amaurosis, spatial vectors, optogenetics
Trans. Vis. Sci. Tech.. 2018; 7(5):8. doi: 10.1167/tvst.7.5.8

Biochemistry and Molecular Biology September 2018

Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

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JaeSang Ko; Ji-Young Kim; Eun Jig Lee; Jin Sook Yoon
TAGS: fibroblasts, 1-phosphatidylinositol 3-kinase, idelalisib
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4477-4485. doi: 10.1167/iovs.18-24509

Includes: Supplemental Content

Immunology and Microbiology August 2018

Detection of Complement Activators in Immune Attack Eyes After iPS-Derived Retinal Pigment Epithelial Cell Transplantation

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Sunao Sugita; Kenichi Makabe; Shota Fujii; Masayo Takahashi
TAGS: complement system proteins, eye, transplantation, transcriptional activation, idiopathic pneumonia syndrome, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4198-4209. doi: 10.1167/iovs.18-24769

Includes: Supplemental Content

Cornea August 2018

Resolvin E1 Inhibits Corneal Allograft Rejection in High-Risk Corneal Transplantation

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Han Wang; Qingqing Zhao; Dan Luo; Yizhou Yin; Ting Li; Min Zhao
TAGS: cytokine, keratoplasty, rejection (psychology), tissue transplants, cornea, transplantation, allografting, transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3911-3919. doi: 10.1167/iovs.18-24562

Cornea July 2018

Stemness and Regenerative Potential of Corneal Stromal Stem Cells and Their Secretome After Long-Term Storage: Implications for Ocular Regeneration

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Ajay Kumar; Yi Xu; Enzhi Yang; Yiqin Du
TAGS: stem cells, fibroblasts, fibrosis, wound healing, cornea, stem cell, mesenchymal, keratocytes
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3728-3738. doi: 10.1167/iovs.18-23824

Includes: Supplemental Content

Special Issue July 2018

New Insights Into the Development and Progression of Geographic Atrophy After Full Thickness Autologous Choroidal Graft

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Grazia Pertile; Maurizio Mete; Antonio Peroglio Deiro; Massimo Guerriero; Mauro Sartore; Alessandro Alfano; Antonio Polito
TAGS: atrophy, tissue transplants
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD93-AMD103. doi: 10.1167/iovs.18-24229

Includes: Supplemental Content

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A Novel Tissue-Engineered Corneal Stromal Equivalent Based on Amniotic Membrane and Keratocytes

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis

Comparison of Artificial Anterior Chamber Internal Pressures and Cutting Systems for Descemet's Stripping Automated Endothelial Keratoplasty

Regeneration of Lacrimal Gland Function to Maintain the Health of the Ocular Surface

Advances in Functional Restoration of the Lacrimal Glands

Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma

Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis

Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts

Universal Corneal Epithelial-Like Cells Derived from Human Embryonic Stem Cells for Cellularization of a Corneal Scaffold

A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye – Implications for Ocular Gene Therapy

Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members

Translational Retinal Research and Therapies

Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

Detection of Complement Activators in Immune Attack Eyes After iPS-Derived Retinal Pigment Epithelial Cell Transplantation

Resolvin E1 Inhibits Corneal Allograft Rejection in High-Risk Corneal Transplantation

Stemness and Regenerative Potential of Corneal Stromal Stem Cells and Their Secretome After Long-Term Storage: Implications for Ocular Regeneration

New Insights Into the Development and Progression of Geographic Atrophy After Full Thickness Autologous Choroidal Graft

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