Nanotechnology and Regenerative Medicine

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Cornea July 2019

Differentiation Capacity of Human Mesenchymal Stem Cells into Keratocyte Lineage

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Aurelie Dos Santos; Alis Balayan; Martha L. Funderburgh; John Ngo; James L. Funderburgh; Sophie X. Deng
TAGS: keratocytes, stem cell, mesenchymal, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3013-3023. doi: 10.1167/iovs.19-27008

Includes: Supplemental Content

Cornea July 2019

Inhibition by Epigallocatechin Gallate of IL-1–Induced Urokinase-Type Plasminogen Activator Expression and Collagen Degradation by Corneal Fibroblasts

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Koji Sugioka; Koji Yoshida; Junko Murakami; Motoki Itahashi; Hiroshi Mishima; Teruo Nishida; Shunji Kusaka
TAGS: catabolism, collagen, cornea, fibroblasts, urokinase, interleukin-1, plasmin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2895-2903. doi: 10.1167/iovs.19-27306

Articles June 2019

Subretinal Transplantation of Human Central Nervous System Stem Cells Stimulates Controlled Proliferation of Endogenous Retinal Pigment Epithelium

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Trevor J. McGill; Linda Osborne; Bin Lu; Jonathan Stoddard; Stephen Huhn; Ann Tsukamoto; Alexandra Capela
TAGS: bromodeoxyuridine, central nervous system, retinal pigment cell, retinal pigment epithelium, stem cells, tissue transplants, transplantation, ki-67 antigen, retina, eye, rats
Trans. Vis. Sci. Tech.. 2019; 8(3):43. doi: 10.1167/tvst.8.3.43

Cornea June 2019

Magnetic Human Corneal Endothelial Cell Transplant: Delivery, Retention, and Short-Term Efficacy

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Xin Xia; Melissa Atkins; Roopa Dalal; Olga Kuzmenko; Kun-Che Chang; Catalina B. Sun; C. Andres Benatti; Dillon J. Rak; Michael Nahmou; Noelia J. Kunzevitzky; Jeffrey L. Goldberg
TAGS: endothelial cells, oryctolagus cuniculus, cornea, transplantation, cell therapy, injections
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2438-2448. doi: 10.1167/iovs.18-26001

Includes: Supplemental Content

Articles May 2019

Transplantation of Mature Photoreceptors in Rodents With Retinal Degeneration

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Henri Lorach; Seungbum Kang; Mohajeet B. Bhuckory; Alix Trouillet; Roopa Dalal; Michael Marmor; Daniel Palanker
TAGS: photoreceptors, retinal degeneration, rodentia, tissue transplants, retina, transplantation
Trans. Vis. Sci. Tech.. 2019; 8(3):30. doi: 10.1167/tvst.8.3.30

Includes: Multimedia, Supplemental Content

Cornea May 2019

MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells

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Kyu-Yeon Han; Jin-Hong Chang; Dimitri T. Azar
TAGS: endothelial cells, proteins, exosomes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2321-2329. doi: 10.1167/iovs.18-26277

Articles April 2019

Relationship Between Neutralizing Antibodies Against Adeno-Associated Virus in the Vitreous and Serum: Effects on Retinal Gene Therapy

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Suhwan Lee; Im Kyeung Kang; Ji Hyun Kim; Bok Kyoung Jung; Keerang Park; Heesoon Chang; Joo Yong Lee; Heuiran Lee
TAGS: gene therapy, vitreous body, adeno-associated virus, neutralizing antibodies, serotype
Trans. Vis. Sci. Tech.. 2019; 8(2):14. doi: 10.1167/tvst.8.2.14

Includes: Supplemental Content

Immunology and Microbiology April 2019

Mycoplasma Ocular Infection in Subretinal Graft Transplantation of iPS Cells-Derived Retinal Pigment Epithelial Cells

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Kenichi Makabe; Sunao Sugita; Ayumi Hono; Hiroyuki Kamao; Masayo Takahashi
TAGS: cercopithecidae, tissue transplants, mycoplasma, transplantation, retinal pigment cell, idiopathic pneumonia syndrome, mycoplasma infections
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1298-1308. doi: 10.1167/iovs.18-26222

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2019

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

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Kailin Chen; Kairan Lai; Xiaobo Zhang; Zhenwei Qin; Qiuli Fu; Chenqi Luo; Xiuming Jin; Jianghua Hu; Siyu Liu; Ke Yao
TAGS: fibroblasts, conjunctiva, pterygium, proto-oncogene proteins c-akt, bromfenac, hpfs trial
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1156-1164. doi: 10.1167/iovs.18-24743

Includes: Supplemental Content

Cornea February 2019

A Novel Tissue-Engineered Corneal Stromal Equivalent Based on Amniotic Membrane and Keratocytes

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Xin Che; Han Wu; Changkai Jia; Huimin Sun; Shangkun Ou; Junqi Wang; M. Vimalin Jeyalatha; Xin He; Jingwen Yu; Chengyou Zuo; Zuguo Liu; Wei Li
TAGS: amnion, corneal stroma, keratoplasty, body tissue, cornea, central serous chorioretinopathy, keratocytes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):517-527. doi: 10.1167/iovs.18-24869

Includes: Multimedia, Supplemental Content

Glaucoma January 2019

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway

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Yiwen Wang; Deborah Osakue; Enzhi Yang; Yi Zhou; Haiyan Gong; Xiaobo Xia; Yiqin Du
TAGS: stress response, stem cells, endoplasmic reticulum, trabecular meshwork, stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):265-273. doi: 10.1167/iovs.18-25477

Includes: Supplemental Content

Biochemistry and Molecular Biology January 2019

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

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Sun Woong Kim; Hye-In Kim; Bikash Thapa; Selikem Nuwromegbe; Keunwook Lee
TAGS: signal transduction, fibroblasts, pterygium, myofibroblasts, proto-oncogene proteins c-akt, hpfs trial, mechanistic target of rapamycin complex 2, mtor serine-threonine kinases
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):82-92. doi: 10.1167/iovs.18-25376

Cornea January 2019

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

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Sheyla González; Denise Oh; Elfren R. Baclagon; Jie J. Zheng; Sophie X. Deng
TAGS: signal transduction, stem cells, molecule, small molecule, regulation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):107-112. doi: 10.1167/iovs.18-25740

Retina December 2018

In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis

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Brandon Bosse; Samir Damle; Abraham Akinin; Yi Jing; Dirk-Uwe Bartsch; Lingyun Cheng; Nicholas Oesch; Yu-Hwa Lo; Gert Cauwenberghs; William R. Freeman
TAGS: evoked potentials, visual, oryctolagus cuniculus, silicon, surgical procedures, operative, retina, implantation procedure, nanowires, implants, prostheses, visual prosthesis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5885-5892. doi: 10.1167/iovs.18-24554

Articles November 2018

Comparison of Artificial Anterior Chamber Internal Pressures and Cutting Systems for Descemet's Stripping Automated Endothelial Keratoplasty

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Sota Nishisako; Dai Aoki; Chiaki Sasaki; Kazunari Higa; Jun Shimazaki
TAGS: endothelial cells, anterior chamber of eye, keratoplasty, endothelium, tissue transplants, cornea, pressure-physical agent, significance, descemet stripping endothelial keratoplasty, donors
Trans. Vis. Sci. Tech.. 2018; 7(6):11. doi: 10.1167/tvst.7.6.11

Special Issue November 2018

Regeneration of Lacrimal Gland Function to Maintain the Health of the Ocular Surface

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Tetsuya Kawakita
TAGS: inflammation, stem cells, epithelium, graft-versus-host disease, cicatrix, dry eye syndromes, health, langer-giedion syndrome, animal model, body tissue, wounds and injuries, mice, lacrimal gland, tear production, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES169-DES173. doi: 10.1167/iovs.17-23576

Special Issue November 2018

Advances in Functional Restoration of the Lacrimal Glands

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Masatoshi Hirayama
TAGS: stem cells, epithelium, body tissue, transplantation, lacrimal gland, injection therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES174-DES182. doi: 10.1167/iovs.17-23528

Articles November 2018

Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma

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Ian Pitha; Ericka Oglesby; Amanda Chow; Elizabeth Kimball; Mary Ellen Pease; Julie Schaub; Harry Quigley
TAGS: fibroblasts, glaucoma, collagen, patient isolation, phosphotransferases, transforming growth factors, eye, intraocular pressure, sclera, myofibroblasts
Trans. Vis. Sci. Tech.. 2018; 7(6):6. doi: 10.1167/tvst.7.6.6

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology October 2018

Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis

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Mary C. Whitman; Elaine H. Nguyen; Jessica L. Bell; Alan P. Tenney; Alon Gelber; Elizabeth C. Engle
TAGS: signal transduction, axon, embryo, motor neurons, oculomotor nerve, cxcr4 receptors, synkinesis, oculomotor synkinesis, stromal cell-derived factor 1
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5201-5209. doi: 10.1167/iovs.18-25190

Includes: Multimedia, Supplemental Content

Cornea October 2018

Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts

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Koji Sugioka; Aya Kodama-Takahshi; Tomoko Sato; Kiyotaka Okada; Junko Murakami; Ah-Mee Park; Hiroshi Mishima; Yoshikazu Shimomura; Shunji Kusaka; Teruo Nishida
TAGS: urokinase, fibroblasts, collagen, gel, plasminogen, cornea, catabolism
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5098-5107. doi: 10.1167/iovs.18-24925

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Differentiation Capacity of Human Mesenchymal Stem Cells into Keratocyte Lineage

Inhibition by Epigallocatechin Gallate of IL-1–Induced Urokinase-Type Plasminogen Activator Expression and Collagen Degradation by Corneal Fibroblasts

Subretinal Transplantation of Human Central Nervous System Stem Cells Stimulates Controlled Proliferation of Endogenous Retinal Pigment Epithelium

Magnetic Human Corneal Endothelial Cell Transplant: Delivery, Retention, and Short-Term Efficacy

Transplantation of Mature Photoreceptors in Rodents With Retinal Degeneration

MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells

Relationship Between Neutralizing Antibodies Against Adeno-Associated Virus in the Vitreous and Serum: Effects on Retinal Gene Therapy

Mycoplasma Ocular Infection in Subretinal Graft Transplantation of iPS Cells-Derived Retinal Pigment Epithelial Cells

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

A Novel Tissue-Engineered Corneal Stromal Equivalent Based on Amniotic Membrane and Keratocytes

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis

Comparison of Artificial Anterior Chamber Internal Pressures and Cutting Systems for Descemet's Stripping Automated Endothelial Keratoplasty

Regeneration of Lacrimal Gland Function to Maintain the Health of the Ocular Surface

Advances in Functional Restoration of the Lacrimal Glands

Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma

Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis

Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts

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