Oncology

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Anatomy and Pathology/Oncology July 2019

Chemokine Receptor Expression Pattern Correlates to Progression of Conjunctival Melanocytic Lesions

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Jolique A. van Ipenburg; Nadine E. de Waard; Nicole C. Naus; Martine J. Jager; Dion Paridaens; Robert M. Verdijk
TAGS: atypical, chemokine receptors, chemokines, conjunctiva, cxcr4 receptors, melanoma, nevus, neoplasm metastasis, immune reconstitution inflammatory syndrome, insulin receptor substrate proteins, malignant melanoma of conjunctiva, cell lines, internal revenue service
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2950-2957. doi: 10.1167/iovs.19-27162

Anatomy and Pathology/Oncology June 2019

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

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Ikram El Zaoui; Maya Bucher; Donata Rimoldi; Michael Nicolas; Gurkan Kaya; Rosanna Pescini Gobert; Nicola Bedoni; Ann Schalenbourg; Ezziat Sakina; Leonidas Zografos; Serge Leyvraz; Nicolo Riggi; Carlo Rivolta; Alexandre P. Moulin
TAGS: 1-phosphatidylinositol 3-kinase, malignant melanoma of conjunctiva, mitogen-activated protein kinases, molecular targeted therapy, mtor serine-threonine kinases, phosphoinositide 3-kinase, braf gene, proto-oncogene proteins c-akt, melanoma, mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2764-2772. doi: 10.1167/iovs.18-26508

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2019

CD166 high Uveal Melanoma Cells Represent a Subpopulation With Enhanced Migratory Capacity

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Luna Djirackor; Helen Kalirai; Sarah E. Coupland; Goran Petrovski
TAGS: anoikis, cell lines, central serous chorioretinopathy, flow cytometry, intraocular melanoma, neoplasms, nestin protein, ngfr protein
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2696-2704. doi: 10.1167/iovs.18-26431

Includes: Supplemental Content

Articles June 2019

In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection

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Jing Shen; Qingfeng Liang; Guanyu Su; Yang Zhang; Zhiqun Wang; Christophe Baudouin; Antoine Labbé
TAGS: antimicrobials, chemotherapy regimen, infection, mass or substance concentration per volume, staphylococcus aureus, staphylococcus epidermidis, tolonium chloride, bacteria, anti-bacterial agents, photosensitizing agents
Trans. Vis. Sci. Tech.. 2019; 8(3):45. doi: 10.1167/tvst.8.3.45

Anatomy and Pathology/Oncology June 2019

Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations

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Getachew Boru; Colleen M. Cebulla; Klarke M. Sample; James B. Massengill; Frederick H. Davidorf; Mohamed H. Abdel-Rahman
TAGS: heterogeneity, intraocular melanoma, mitogen-activated protein kinases, mutation, neoplasms, cell lines, immunohistochemistry, transfection
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2474-2480. doi: 10.1167/iovs.18-26452

Includes: Supplemental Content

Articles May 2019

Smartphone-Based, Rapid, Wide-Field Fundus Photography for Diagnosis of Pediatric Retinal Diseases

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Tapan P. Patel; Tyson N. Kim; Gina Yu; Vaidehi S. Dedania; Philip Lieu; Cynthia X. Qian; Cagri G. Besirli; Hakan Demirci; Todd Margolis; Daniel A. Fletcher; Yannis M. Paulus
TAGS: child, pediatrics, retinal diseases, diagnostic imaging, retina, fundus photography, cell phones, quality, diagnostic imaging of retina
Trans. Vis. Sci. Tech.. 2019; 8(3):29. doi: 10.1167/tvst.8.3.29

Immunology and Microbiology May 2019

PD-L1/PD1 Expression, Composition of Tumor-Associated Immune Infiltrate, and HPV Status in Conjunctival Squamous Cell Carcinoma

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Priyadharsini Nagarajan; Christian El-Hadad; Stephen K. Gruschkus; Jing Ning; Courtney W. Hudgens; Oded Sagiv; Neil Gross; Michael T. Tetzlaff; Bita Esmaeli
TAGS: squamous cell carcinoma, human papillomavirus, conjunctiva, neoplasms, tumor cells, infiltrates, programmed cell death 1 ligand 1
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2388-2398. doi: 10.1167/iovs.19-26894

Includes: Supplemental Content

Immunology and Microbiology May 2019

TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual Symptoms

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Robert M. Duvoisin; Gaoying Ren; Tammie L. Haley; Matthew H. Taylor; Catherine W. Morgans
TAGS: autoantibodies, melanoma, malignant melanoma, cutaneous, visual symptoms, self-report
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2330-2335. doi: 10.1167/iovs.19-26775

Articles May 2019

Detection of Malignancy in Ocular Surface Lesions by Inverse Spectroscopic Optical Coherence Tomography and Two-Photon Autofluorescence

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Hyunjoo Jean Lee; Lei Zhang; Sui Zhang; Ji Yi
TAGS: cancer, photons, precancerous conditions, body tissue, diagnostic imaging, optical coherence tomography, autofluorescence
Trans. Vis. Sci. Tech.. 2019; 8(3):16. doi: 10.1167/tvst.8.3.16

Articles May 2019

Digital Image Analysis of BAP-1 Accurately Predicts Uveal Melanoma Metastasis

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Gustav Stålhammar; Thonnie Rose O. See; Stephen Phillips; Stefan Seregard; Hans E. Grossniklaus
TAGS: gene expression, cohort studies, neoplasm metastasis, neoplasms, intraocular melanoma, digital image analysis, digital immunoassays
Trans. Vis. Sci. Tech.. 2019; 8(3):11. doi: 10.1167/tvst.8.3.11

Includes: Supplemental Content

Retina April 2019

Surface-Modified Melphalan Nanoparticles for Intravitreal Chemotherapy of Retinoblastoma

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Lee B. Sims; Kevin M. Tyo; Sanaya Stocke; Mohamed Y. Mahmoud; Aparna Ramasubramanian; Jill M. Steinbach-Rankins
TAGS: chemotherapy regimen, melphalan, retinoblastoma
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1696-1705. doi: 10.1167/iovs.18-26251

Includes: Supplemental Content

Articles April 2019

Next-Generation Sequencing of Uveal Melanoma for Detection of Genetic Alterations Predicting Metastasis

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Armin R. Afshar; Bertil E. Damato; Jay M. Stewart; Lydia B. Zablotska; Ritu Roy; Adam B. Olshen; Nancy M. Joseph; Boris C. Bastian
TAGS: mutation, chromosomes, human, pair 3, gene expression profiling, neoplasm metastasis, genetics, neoplasms, intraocular melanoma, histopathology tests, massively-parallel genome sequencing
Trans. Vis. Sci. Tech.. 2019; 8(2):18. doi: 10.1167/tvst.8.2.18

Review April 2019

Aqueous Humor Markers in Retinoblastoma, a Review

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Benjamin K. Ghiam; Liya Xu; Jesse L. Berry
TAGS: hypertension, child, retinoblastoma, aqueous humor, eye, neoplasms, proteins, survivin, enucleation procedure
Trans. Vis. Sci. Tech.. 2019; 8(2):13. doi: 10.1167/tvst.8.2.13

Includes: Supplemental Content

Cornea January 2019

Identification of Leukocytes Associated With Midday Fogging in the Post-Lens Tear Film of Scleral Contact Lens Wearers

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Cameron K. Postnikoff; Andrew D. Pucker; John Laurent; Carrie Huisingh; Gerald McGwin; Jason J. Nichols
TAGS: small cell carcinoma of lung, contact lenses, lens, crystalline, lens (device), leukocytes, eye, sclera, tear film finding
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):226-233. doi: 10.1167/iovs.18-24664

Perspective January 2019

Proceedings of the Association for Research in Vision and Ophthalmology and Champalimaud Foundation Ocular Oncogenesis and Oncology Conference

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Justine R. Smith; Jacob Pe'er; Rubens N. Belfort; Fatima Cardoso; Richard D. Carvajal; Carlos Carvalho; Sarah E. Coupland; Laurence Desjardins; Jasmine H. Francis; Brenda L. Gallie; Dan S. Gombos; Hans E. Grossniklaus; Steffen Heegaard; Martine J. Jager; Swathi Kaliki; Bruce R. Ksander; Markus Maeurer; Eduardo Moreno; Jose S. Pulido; Bettina Ryll; Arun D. Singh; Junyang Zhao; António Parreira; David J. Wilson; Joan M. O'Brien
TAGS: cancer, medical oncology, neoplasms, eye cancer, vision research, carcinogenesis, ophthalmology, tumorigenesis, intraocular melanoma
Trans. Vis. Sci. Tech.. 2019; 8(1):9. doi: 10.1167/tvst.8.1.9

Articles December 2018

Quantitative Analysis of Changes to Meibomian Gland Morphology Due to S-1 Chemotherapy

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Kazuyoshi Ohtomo; Reiko Arita; Rika Shirakawa; Tomohiko Usui; Hiroharu Yamashita; Yasuyuki Seto; Satoru Yamagami; for the TS-1 Multicenter Study Group
TAGS: eyelid, meibomian gland, chemotherapy regimen, language morphology, morphology
Trans. Vis. Sci. Tech.. 2018; 7(6):37. doi: 10.1167/tvst.7.6.37

Anatomy and Pathology/Oncology November 2018

Blood Flow in Monocular Retinoblastoma Assessed by Color Doppler and Correlations With High-Risk Pathologic Features

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Maria Teresa B. C. Bonanomi; Osmar C. Saito; Patricia Picciarelli de Lima; Roberta Chizzotti Bonanomi; Maria Cristina Chammas
TAGS: doppler color flow, vascular flow, doppler echocardiography, retinoblastoma, eye, neoplasms, optic nerve, particle image velocimetry
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5441-5446. doi: 10.1167/iovs.18-24777

Perspective October 2018

Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members

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W. Daniel Stamer; Andrew M. Williams; Stephen Pflugfelder; Sarah E. Coupland
TAGS: research personnel, body tissue, eye, surveys, quality
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4783-4792. doi: 10.1167/iovs.18-25319

Anatomy and Pathology/Oncology September 2018

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

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Zachary K. Goldsmith; William Coppess; Andrew S. Irvine; Kelley Yuan; Samuel R. Barsh; Madison K. Ritter; Matthew W. McEwen; Jacqueline Flores-Otero; Aileen Garcia-Vargas; Magaly Martinez-Ferrer; Rachel C. Brennan; Vanessa M. Morales-Tirado; Matthew W. Wilson
TAGS: signal transduction, cell culture techniques, western blotting, enzyme-linked immunosorbent assay, blood platelets, cell proliferation, flow cytometry, cell lines, cell survival, platelet-derived growth factor, platelet-derived growth factor receptor, retinoblastoma, rna, messenger, seeds, spheroids, cellular, vitreous body, diagnostic imaging, eye, neoplasms, rna, small interfering, nuclear translocation, proto-oncogene proteins c-akt, did not receive therapy or drug
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4486-4495. doi: 10.1167/iovs.18-24359

Article April 2018

More is better: Relative prevalence of multiple targets affects search accuracy

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Phillip (Xin) Cheng; Anina N. Rich
TAGS: prevalence
Journal of Vision. 2018; 18(4):2. doi: 10.1167/18.4.2

Includes: Supplemental Content

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Chemokine Receptor Expression Pattern Correlates to Progression of Conjunctival Melanocytic Lesions

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

CD166 high Uveal Melanoma Cells Represent a Subpopulation With Enhanced Migratory Capacity

In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection

Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations

Smartphone-Based, Rapid, Wide-Field Fundus Photography for Diagnosis of Pediatric Retinal Diseases

PD-L1/PD1 Expression, Composition of Tumor-Associated Immune Infiltrate, and HPV Status in Conjunctival Squamous Cell Carcinoma

TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual Symptoms

Detection of Malignancy in Ocular Surface Lesions by Inverse Spectroscopic Optical Coherence Tomography and Two-Photon Autofluorescence

Digital Image Analysis of BAP-1 Accurately Predicts Uveal Melanoma Metastasis

Surface-Modified Melphalan Nanoparticles for Intravitreal Chemotherapy of Retinoblastoma

Next-Generation Sequencing of Uveal Melanoma for Detection of Genetic Alterations Predicting Metastasis

Aqueous Humor Markers in Retinoblastoma, a Review

Identification of Leukocytes Associated With Midday Fogging in the Post-Lens Tear Film of Scleral Contact Lens Wearers

Proceedings of the Association for Research in Vision and Ophthalmology and Champalimaud Foundation Ocular Oncogenesis and Oncology Conference

Quantitative Analysis of Changes to Meibomian Gland Morphology Due to S-1 Chemotherapy

Blood Flow in Monocular Retinoblastoma Assessed by Color Doppler and Correlations With High-Risk Pathologic Features

Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

More is better: Relative prevalence of multiple targets affects search accuracy

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