Oncology

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Glaucoma October 2019

Structure-Function Agreement Is Better Than Commonly Thought in Eyes With Early Glaucoma

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Donald C. Hood; Emmanouil Tsamis; Nikhil K. Bommakanti; Devon B. Joiner; Lama L. Al-Aswad; Dana M. Blumberg; George A. Cioffi; Jeffrey M. Liebmann; Carlos G. De Moraes
TAGS: adams-stokes syndrome, angelman syndrome, ankylosing spondylitis, aortic valve stenosis, arsenic, arteriosclerosis, atherosclerosis, atrial fibrillation, eye, glaucoma
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4241-4248. doi: 10.1167/iovs.19-27920

Biochemistry and Molecular Biology October 2019

Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

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Chandrani Chattopadhyay; Junna Oba; Jason Roszik; Joseph R. Marszalek; Ken Chen; Yuan Qi; Karina Eterovic; A. Gordon Robertson; Jared K. Burks; Tara A. McCannel; Elizabeth A. Grimm; Scott E. Woodman
TAGS: genes, intraocular melanoma, metabolism, neoplasms, sdha gene, cancer, cell lines, monosomy, mitomycin, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4187-4195. doi: 10.1167/iovs.19-28082

Includes: Supplemental Content

Articles September 2019

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability

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Wayne Heaselgrave; Anas Hamad; Steven Coles; Scott Hau
TAGS: acanthamoeba, cysts, ophthalmic agents, trophozoite, bronchioloalveolar carcinoma, toxic effect
Trans. Vis. Sci. Tech.. 2019; 8(5):17. doi: 10.1167/tvst.8.5.17

Articles September 2019

Magnetic Hyperthermia in Y79 Retinoblastoma and ARPE-19 Retinal Epithelial Cells: Tumor Selective Apoptotic Activity of Iron Oxide Nanoparticle

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Hakan Demirci; Naziha Slimani; Mercy Pawar; Ronald E. Kumon; Prem Vaishnava; Cagri G. Besirli
TAGS: ferumoxytol, hyperthermia, nanoparticles, neoplasms, retinoblastoma, epithelial cells
Trans. Vis. Sci. Tech.. 2019; 8(5):18. doi: 10.1167/tvst.8.5.18

Includes: Supplemental Content

Cornea September 2019

Therapeutic Effects of STAT3 Inhibition on Experimental Murine Dry Eye

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Mingli Qu; Xia Qi; Qian Wang; Lei Wan; Jing Li; Wei Li; Yingli Li; Qingjun Zhou
TAGS: dry eye syndromes, mice, stat3 protein
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3776-3785. doi: 10.1167/iovs.19-26928

Anatomy and Pathology/Oncology August 2019

Multi-Modality Analysis Improves Survival Prediction in Enucleated Uveal Melanoma Patients

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Wojtek Drabarek; Serdar Yavuzyigitoglu; Askar Obulkasim; Job van Riet; Kyra N. Smit; Natasha M. van Poppelen; Jolanda Vaarwater; Tom Brands; Bert Eussen; Robert M. Verdijk; Nicole C. Naus; Hanneke W. Mensink; Dion Paridaens; Eric Boersma; Harmen J. G. van de Werken; Emine Kilic; Annelies de Klein; for the Rotterdam Ocular Melanoma Study Group
TAGS: copy number polymorphism, histopathology tests, intraocular melanoma, mutation, neoplasms, single nucleotide polymorphism, bap1 gene, neoplasm metastasis, sf3b1 gene, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3595-3605. doi: 10.1167/iovs.18-24818

Includes: Supplemental Content

Editorial August 2019

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2019; 8(4):r. doi: 10.1167/tvst.8.4.r

Retina July 2019

Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases

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Beiying Qiu; Alison Tan; Amutha Barathi Veluchamy; Yong Li; Hannah Murray; Wei Cheng; Chenghao Liu; Joanna Marie Busoy; Qi-Yin Chen; Srivani Sistla; Walter Hunziker; Chui Ming Gemmy Cheung; Tien Yin Wong; Wanjin Hong; Hendrik Luesch; Xiaomeng Wang
TAGS: angiogenesis, mice, natural products, aflibercept, neovascularization, pathologic, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3254-3263. doi: 10.1167/iovs.19-26936

Includes: Supplemental Content

Anatomy and Pathology/Oncology July 2019

Chemokine Receptor Expression Pattern Correlates to Progression of Conjunctival Melanocytic Lesions

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Jolique A. van Ipenburg; Nadine E. de Waard; Nicole C. Naus; Martine J. Jager; Dion Paridaens; Robert M. Verdijk
TAGS: atypical, chemokine receptors, chemokines, conjunctiva, cxcr4 receptors, melanoma, nevus, neoplasm metastasis, immune reconstitution inflammatory syndrome, insulin receptor substrate proteins
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2950-2957. doi: 10.1167/iovs.19-27162

Anatomy and Pathology/Oncology June 2019

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

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Ikram El Zaoui; Maya Bucher; Donata Rimoldi; Michael Nicolas; Gurkan Kaya; Rosanna Pescini Gobert; Nicola Bedoni; Ann Schalenbourg; Ezziat Sakina; Leonidas Zografos; Serge Leyvraz; Nicolo Riggi; Carlo Rivolta; Alexandre P. Moulin
TAGS: 1-phosphatidylinositol 3-kinase, malignant melanoma of conjunctiva, mitogen-activated protein kinases, molecular targeted therapy, mtor serine-threonine kinases, phosphoinositide 3-kinase, braf gene, proto-oncogene proteins c-akt, melanoma, mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2764-2772. doi: 10.1167/iovs.18-26508

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2019

CD166 high Uveal Melanoma Cells Represent a Subpopulation With Enhanced Migratory Capacity

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Luna Djirackor; Helen Kalirai; Sarah E. Coupland; Goran Petrovski
TAGS: anoikis, cell lines, central serous chorioretinopathy, flow cytometry, intraocular melanoma, neoplasms, nestin protein, ngfr protein
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2696-2704. doi: 10.1167/iovs.18-26431

Includes: Supplemental Content

Articles June 2019

In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection

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Jing Shen; Qingfeng Liang; Guanyu Su; Yang Zhang; Zhiqun Wang; Christophe Baudouin; Antoine Labbé
TAGS: antimicrobials, chemotherapy regimen, infection, mass or substance concentration per volume, staphylococcus aureus, staphylococcus epidermidis, tolonium chloride, bacteria, anti-bacterial agents, photosensitizing agents
Trans. Vis. Sci. Tech.. 2019; 8(3):45. doi: 10.1167/tvst.8.3.45

Anatomy and Pathology/Oncology June 2019

Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations

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Getachew Boru; Colleen M. Cebulla; Klarke M. Sample; James B. Massengill; Frederick H. Davidorf; Mohamed H. Abdel-Rahman
TAGS: heterogeneity, intraocular melanoma, mitogen-activated protein kinases, mutation, neoplasms, cell lines, immunohistochemistry, transfection
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2474-2480. doi: 10.1167/iovs.18-26452

Includes: Supplemental Content

Articles May 2019

Smartphone-Based, Rapid, Wide-Field Fundus Photography for Diagnosis of Pediatric Retinal Diseases

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Tapan P. Patel; Tyson N. Kim; Gina Yu; Vaidehi S. Dedania; Philip Lieu; Cynthia X. Qian; Cagri G. Besirli; Hakan Demirci; Todd Margolis; Daniel A. Fletcher; Yannis M. Paulus
TAGS: child, pediatrics, retinal diseases, diagnostic imaging, retina, fundus photography, cell phones, quality, diagnostic imaging of retina
Trans. Vis. Sci. Tech.. 2019; 8(3):29. doi: 10.1167/tvst.8.3.29

Immunology and Microbiology May 2019

PD-L1/PD1 Expression, Composition of Tumor-Associated Immune Infiltrate, and HPV Status in Conjunctival Squamous Cell Carcinoma

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Priyadharsini Nagarajan; Christian El-Hadad; Stephen K. Gruschkus; Jing Ning; Courtney W. Hudgens; Oded Sagiv; Neil Gross; Michael T. Tetzlaff; Bita Esmaeli
TAGS: squamous cell carcinoma, human papillomavirus, conjunctiva, neoplasms, tumor cells, infiltrates, programmed cell death 1 ligand 1
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2388-2398. doi: 10.1167/iovs.19-26894

Includes: Supplemental Content

Immunology and Microbiology May 2019

TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual Symptoms

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Robert M. Duvoisin; Gaoying Ren; Tammie L. Haley; Matthew H. Taylor; Catherine W. Morgans
TAGS: autoantibodies, melanoma, malignant melanoma, cutaneous, visual symptoms, self-report
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2330-2335. doi: 10.1167/iovs.19-26775

Articles May 2019

Detection of Malignancy in Ocular Surface Lesions by Inverse Spectroscopic Optical Coherence Tomography and Two-Photon Autofluorescence

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Hyunjoo Jean Lee; Lei Zhang; Sui Zhang; Ji Yi
TAGS: cancer, photons, precancerous conditions, body tissue, diagnostic imaging, optical coherence tomography, autofluorescence
Trans. Vis. Sci. Tech.. 2019; 8(3):16. doi: 10.1167/tvst.8.3.16

Articles May 2019

Digital Image Analysis of BAP-1 Accurately Predicts Uveal Melanoma Metastasis

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Gustav Stålhammar; Thonnie Rose O. See; Stephen Phillips; Stefan Seregard; Hans E. Grossniklaus
TAGS: gene expression, cohort studies, neoplasm metastasis, neoplasms, intraocular melanoma, digital image analysis, digital immunoassays
Trans. Vis. Sci. Tech.. 2019; 8(3):11. doi: 10.1167/tvst.8.3.11

Includes: Supplemental Content

Retina April 2019

Surface-Modified Melphalan Nanoparticles for Intravitreal Chemotherapy of Retinoblastoma

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Lee B. Sims; Kevin M. Tyo; Sanaya Stocke; Mohamed Y. Mahmoud; Aparna Ramasubramanian; Jill M. Steinbach-Rankins
TAGS: chemotherapy regimen, melphalan, retinoblastoma
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1696-1705. doi: 10.1167/iovs.18-26251

Includes: Supplemental Content

Articles April 2019

Next-Generation Sequencing of Uveal Melanoma for Detection of Genetic Alterations Predicting Metastasis

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Armin R. Afshar; Bertil E. Damato; Jay M. Stewart; Lydia B. Zablotska; Ritu Roy; Adam B. Olshen; Nancy M. Joseph; Boris C. Bastian
TAGS: mutation, chromosomes, human, pair 3, gene expression profiling, neoplasm metastasis, genetics, neoplasms, intraocular melanoma, histopathology tests, massively-parallel genome sequencing
Trans. Vis. Sci. Tech.. 2019; 8(2):18. doi: 10.1167/tvst.8.2.18

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Structure-Function Agreement Is Better Than Commonly Thought in Eyes With Early Glaucoma

Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability

Magnetic Hyperthermia in Y79 Retinoblastoma and ARPE-19 Retinal Epithelial Cells: Tumor Selective Apoptotic Activity of Iron Oxide Nanoparticle

Therapeutic Effects of STAT3 Inhibition on Experimental Murine Dry Eye

Multi-Modality Analysis Improves Survival Prediction in Enucleated Uveal Melanoma Patients

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases

Chemokine Receptor Expression Pattern Correlates to Progression of Conjunctival Melanocytic Lesions

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

CD166 high Uveal Melanoma Cells Represent a Subpopulation With Enhanced Migratory Capacity

In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection

Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations

Smartphone-Based, Rapid, Wide-Field Fundus Photography for Diagnosis of Pediatric Retinal Diseases

PD-L1/PD1 Expression, Composition of Tumor-Associated Immune Infiltrate, and HPV Status in Conjunctival Squamous Cell Carcinoma

TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual Symptoms

Detection of Malignancy in Ocular Surface Lesions by Inverse Spectroscopic Optical Coherence Tomography and Two-Photon Autofluorescence

Digital Image Analysis of BAP-1 Accurately Predicts Uveal Melanoma Metastasis

Surface-Modified Melphalan Nanoparticles for Intravitreal Chemotherapy of Retinoblastoma

Next-Generation Sequencing of Uveal Melanoma for Detection of Genetic Alterations Predicting Metastasis

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