Oncology

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Special Issue February 2020

A Clinician's Guide to Artificial Intelligence: How to Critically Appraise Machine Learning Studies

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Livia Faes; Xiaoxuan Liu; Siegfried K. Wagner; Dun Jack Fu; Konstantinos Balaskas; Dawn A. Sim; Lucas M. Bachmann; Pearse A. Keane; Alastair K. Denniston
TAGS: artificial intelligence, datasets, machine learning
Trans. Vis. Sci. Tech.. 2020; 9(2):7. doi: https://doi.org/10.1167/tvst.9.2.7

Articles February 2020

VEGFR1-Targeted Contrast-Enhanced Ultrasound Imaging Quantification of Vasculogenic Mimicry Microcirculation in a Mouse Model of Choroidal Melanoma

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Haiyun Liu; Min Gao; Jiying Gu; Xiaoling Wan; Hong Wang; Qing Gu; Yifan Zhou; Xiaodong Sun
TAGS: diagnostic imaging, malignant melanoma of choroid, melanoma, neoplasms, mice, ultrasonography, contrast-enhanced, microcirculation, modified barium swallow, eye melanomas
Trans. Vis. Sci. Tech.. 2020; 9(3):4. doi: https://doi.org/10.1167/tvst.9.3.4

Clinical and Epidemiologic Research November 2019

Long Noncoding RNA PVT1 Silencing Prevents the Development of Uveal Melanoma by Impairing MicroRNA-17-3p–Dependent MDM2 Upregulation

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Shuai Wu; Han Chen; Ning Han; Chunxia Zhang; Hongtao Yan
TAGS: intraocular melanoma, micrornas, rna, untranslated, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4904-4914. doi: https://doi.org/10.1167/iovs.19-27704

Anatomy and Pathology/Oncology November 2019

Aqueous Humor Biomarkers Identify Three Prognostic Groups in Uveal Melanoma

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Annemijn P. A. Wierenga; Jinfeng Cao; Henk Mouthaan; Christiaan van Weeghel; Robert M. Verdijk; Sjoerd G. van Duinen; Wilma G. M. Kroes; Mehmet Dogrusöz; Marina Marinkovic; Sjoerd S. H. van der Burg; Gregorius P. M. Luyten; Martine J. Jager
TAGS: aqueous humor, biological markers, biopsy, cytokine, intraocular melanoma, neoplasms, patient prognosis, histopathology tests, eye
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4740-4747. doi: https://doi.org/10.1167/iovs.19-28309

Includes: Supplemental Content

Articles November 2019

A Panel of Circulating MicroRNAs Detects Uveal Melanoma With High Precision

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Mitchell S. Stark; Elin S. Gray; Timothy Isaacs; Fred K. Chen; Michael Millward; Ashleigh McEvoy; Pauline Zaenker; Melanie Ziman; H. Peter Soyer; William J. Glasson; Sunil K. Warrier; Andrew L. Stark; Olivia J. Rolfe; Jane M. Palmer; Nicholas K. Hayward
TAGS: intraocular melanoma, micrornas, precision
Trans. Vis. Sci. Tech.. 2019; 8(6):12. doi: https://doi.org/10.1167/tvst.8.6.12

Includes: Supplemental Content

Anatomy and Pathology/Oncology October 2019

The Interplay of MicroRNA-34a, LGR4, EMT-Associated Factors, and MMP2 in Regulating Uveal Melanoma Cells

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Qiang Hou; Shuxian Han; Lin Yang; Shengwen Chen; Junxiu Chen; Nan Ma; Chao Wang; Jiajia Tang; Xiaogang Chen; Feng Chen; Xiang Da (Eric) Dong; LiLi Tu
TAGS: gelatinase a, intraocular melanoma, micrornas, epithelial to mesenchymal transition
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4503-4510. doi: https://doi.org/10.1167/iovs.18-26477

Includes: Supplemental Content

Biochemistry and Molecular Biology October 2019

Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

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Chandrani Chattopadhyay; Junna Oba; Jason Roszik; Joseph R. Marszalek; Ken Chen; Yuan Qi; Karina Eterovic; A. Gordon Robertson; Jared K. Burks; Tara A. McCannel; Elizabeth A. Grimm; Scott E. Woodman
TAGS: genes, intraocular melanoma, metabolism, neoplasms, sdha gene, cancer, cell lines, monosomy, mitomycin, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4187-4195. doi: https://doi.org/10.1167/iovs.19-28082

Includes: Supplemental Content

Glaucoma October 2019

Structure-Function Agreement Is Better Than Commonly Thought in Eyes With Early Glaucoma

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Donald C. Hood; Emmanouil Tsamis; Nikhil K. Bommakanti; Devon B. Joiner; Lama A. Al-Aswad; Dana M. Blumberg; George A. Cioffi; Jeffrey M. Liebmann; Carlos G. De Moraes
TAGS: adams-stokes syndrome, angelman syndrome, ankylosing spondylitis, aortic valve stenosis, arsenic, arteriosclerosis, atherosclerosis, atrial fibrillation, eye, glaucoma
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4241-4248. doi: https://doi.org/10.1167/iovs.19-27920

Articles September 2019

Magnetic Hyperthermia in Y79 Retinoblastoma and ARPE-19 Retinal Epithelial Cells: Tumor Selective Apoptotic Activity of Iron Oxide Nanoparticle

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Hakan Demirci; Naziha Slimani; Mercy Pawar; Ronald E. Kumon; Prem Vaishnava; Cagri G. Besirli
TAGS: ferumoxytol, hyperthermia, nanoparticles, neoplasms, retinoblastoma, epithelial cells
Trans. Vis. Sci. Tech.. 2019; 8(5):18. doi: https://doi.org/10.1167/tvst.8.5.18

Includes: Supplemental Content

Articles September 2019

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability

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Wayne Heaselgrave; Anas Hamad; Steven Coles; Scott Hau
TAGS: acanthamoeba, cysts, ophthalmic agents, trophozoite, bronchioloalveolar carcinoma, toxic effect
Trans. Vis. Sci. Tech.. 2019; 8(5):17. doi: https://doi.org/10.1167/tvst.8.5.17

Cornea September 2019

Therapeutic Effects of STAT3 Inhibition on Experimental Murine Dry Eye

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Mingli Qu; Xia Qi; Qian Wang; Lei Wan; Jing Li; Wei Li; Yingli Li; Qingjun Zhou
TAGS: dry eye syndromes, mice, stat3 protein
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3776-3785. doi: https://doi.org/10.1167/iovs.19-26928

Anatomy and Pathology/Oncology August 2019

Multi-Modality Analysis Improves Survival Prediction in Enucleated Uveal Melanoma Patients

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Wojtek Drabarek; Serdar Yavuzyigitoglu; Askar Obulkasim; Job van Riet; Kyra N. Smit; Natasha M. van Poppelen; Jolanda Vaarwater; Tom Brands; Bert Eussen; Robert M. Verdijk; Nicole C. Naus; Hanneke W. Mensink; Dion Paridaens; Eric Boersma; Harmen J. G. van de Werken; Emine Kilic; Annelies de Klein; for the Rotterdam Ocular Melanoma Study Group
TAGS: copy number polymorphism, histopathology tests, intraocular melanoma, mutation, neoplasms, single nucleotide polymorphism, bap1 gene, neoplasm metastasis, sf3b1 gene, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3595-3605. doi: https://doi.org/10.1167/iovs.18-24818

Includes: Supplemental Content

Editorial August 2019

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2019; 8(4):r. doi: https://doi.org/10.1167/tvst.8.4.r

Retina July 2019

Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases

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Beiying Qiu; Alison Tan; Amutha Barathi Veluchamy; Yong Li; Hannah Murray; Wei Cheng; Chenghao Liu; Joanna Marie Busoy; Qi-Yin Chen; Srivani Sistla; Walter Hunziker; Chui Ming Gemmy Cheung; Tien Yin Wong; Wanjin Hong; Hendrik Luesch; Xiaomeng Wang
TAGS: angiogenesis, mice, natural products, aflibercept, neovascularization, pathologic, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3254-3263. doi: https://doi.org/10.1167/iovs.19-26936

Includes: Supplemental Content

Anatomy and Pathology/Oncology July 2019

Chemokine Receptor Expression Pattern Correlates to Progression of Conjunctival Melanocytic Lesions

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Jolique A. van Ipenburg; Nadine E. de Waard; Nicole C. Naus; Martine J. Jager; Dion Paridaens; Robert M. Verdijk
TAGS: atypical, chemokine receptors, chemokines, conjunctiva, cxcr4 receptors, melanoma, nevus, neoplasm metastasis, immune reconstitution inflammatory syndrome, insulin receptor substrate proteins
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2950-2957. doi: https://doi.org/10.1167/iovs.19-27162

Anatomy and Pathology/Oncology June 2019

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

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Ikram El Zaoui; Maya Bucher; Donata Rimoldi; Michael Nicolas; Gurkan Kaya; Rosanna Pescini Gobert; Nicola Bedoni; Ann Schalenbourg; Ezziat Sakina; Leonidas Zografos; Serge Leyvraz; Nicolo Riggi; Carlo Rivolta; Alexandre P. Moulin
TAGS: 1-phosphatidylinositol 3-kinase, malignant melanoma of conjunctiva, mitogen-activated protein kinases, molecular targeted therapy, mtor serine-threonine kinases, phosphoinositide 3-kinase, braf gene, proto-oncogene proteins c-akt, melanoma, mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2764-2772. doi: https://doi.org/10.1167/iovs.18-26508

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2019

CD166 high Uveal Melanoma Cells Represent a Subpopulation With Enhanced Migratory Capacity

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Luna Djirackor; Helen Kalirai; Sarah E. Coupland; Goran Petrovski
TAGS: anoikis, cell lines, central serous chorioretinopathy, flow cytometry, intraocular melanoma, neoplasms, nestin protein, ngfr protein
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2696-2704. doi: https://doi.org/10.1167/iovs.18-26431

Includes: Supplemental Content

Articles June 2019

In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection

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Jing Shen; Qingfeng Liang; Guanyu Su; Yang Zhang; Zhiqun Wang; Christophe Baudouin; Antoine Labbé
TAGS: antimicrobials, chemotherapy regimen, infection, mass or substance concentration per volume, staphylococcus aureus, staphylococcus epidermidis, tolonium chloride, bacteria, anti-bacterial agents, photosensitizing agents
Trans. Vis. Sci. Tech.. 2019; 8(3):45. doi: https://doi.org/10.1167/tvst.8.3.45

Anatomy and Pathology/Oncology June 2019

Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations

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Getachew Boru; Colleen M. Cebulla; Klarke M. Sample; James B. Massengill; Frederick H. Davidorf; Mohamed H. Abdel-Rahman
TAGS: heterogeneity, intraocular melanoma, mitogen-activated protein kinases, mutation, neoplasms, cell lines, immunohistochemistry, transfection
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2474-2480. doi: https://doi.org/10.1167/iovs.18-26452

Includes: Supplemental Content

Articles May 2019

Smartphone-Based, Rapid, Wide-Field Fundus Photography for Diagnosis of Pediatric Retinal Diseases

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Tapan P. Patel; Tyson N. Kim; Gina Yu; Vaidehi S. Dedania; Philip Lieu; Cynthia X. Qian; Cagri G. Besirli; Hakan Demirci; Todd Margolis; Daniel A. Fletcher; Yannis M. Paulus
TAGS: child, pediatrics, retinal diseases, diagnostic imaging, retina, fundus photography, cell phones, quality, diagnostic imaging of retina
Trans. Vis. Sci. Tech.. 2019; 8(3):29. doi: https://doi.org/10.1167/tvst.8.3.29

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A Clinician's Guide to Artificial Intelligence: How to Critically Appraise Machine Learning Studies

VEGFR1-Targeted Contrast-Enhanced Ultrasound Imaging Quantification of Vasculogenic Mimicry Microcirculation in a Mouse Model of Choroidal Melanoma

Long Noncoding RNA PVT1 Silencing Prevents the Development of Uveal Melanoma by Impairing MicroRNA-17-3p–Dependent MDM2 Upregulation

Aqueous Humor Biomarkers Identify Three Prognostic Groups in Uveal Melanoma

A Panel of Circulating MicroRNAs Detects Uveal Melanoma With High Precision

The Interplay of MicroRNA-34a, LGR4, EMT-Associated Factors, and MMP2 in Regulating Uveal Melanoma Cells

Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

Structure-Function Agreement Is Better Than Commonly Thought in Eyes With Early Glaucoma

Magnetic Hyperthermia in Y79 Retinoblastoma and ARPE-19 Retinal Epithelial Cells: Tumor Selective Apoptotic Activity of Iron Oxide Nanoparticle

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability

Therapeutic Effects of STAT3 Inhibition on Experimental Murine Dry Eye

Multi-Modality Analysis Improves Survival Prediction in Enucleated Uveal Melanoma Patients

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases

Chemokine Receptor Expression Pattern Correlates to Progression of Conjunctival Melanocytic Lesions

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

CD166 high Uveal Melanoma Cells Represent a Subpopulation With Enhanced Migratory Capacity

In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection

Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations

Smartphone-Based, Rapid, Wide-Field Fundus Photography for Diagnosis of Pediatric Retinal Diseases

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