Oncology

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Anatomy and Pathology/Oncology September 2018

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

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Zachary K. Goldsmith; William Coppess; Andrew S. Irvine; Kelley Yuan; Samuel R. Barsh; Madison K. Ritter; Matthew W. McEwen; Jacqueline Flores-Otero; Aileen Garcia-Vargas; Magaly Martinez-Ferrer; Rachel C. Brennan; Vanessa M. Morales-Tirado; Matthew W. Wilson
TAGS: signal transduction, cell culture techniques, western blotting, enzyme-linked immunosorbent assay, blood platelets, cell proliferation, flow cytometry, cell lines, cell survival, platelet-derived growth factor, platelet-derived growth factor receptor, retinoblastoma, rna, messenger, seeds, spheroids, cellular, vitreous body, diagnostic imaging, eye, neoplasms, rna, small interfering, nuclear translocation, proto-oncogene proteins c-akt, did not receive therapy or drug
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4486-4495. doi: 10.1167/iovs.18-24359

Article April 2018

More is better: Relative prevalence of multiple targets affects search accuracy

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Phillip (Xin) Cheng; Anina N. Rich
TAGS: prevalence
Journal of Vision. 2018; 18(4):2. doi: 10.1167/18.4.2

Includes: Supplemental Content

Retina March 2018

Genetic Risk Factors for Radiation Vasculopathy

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Thanos D. Papakostas; Margaux A. Morrison; Anne Marie Lane; Caroline Awh; Margaret M. DeAngelis; Evangelos S. Gragoudas; Ivana K. Kim
TAGS: vascular diseases, single nucleotide polymorphism, radiation, visual impairment, visual acuity, genetic risk
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1547-1553. doi: 10.1167/iovs.17-22791

Editorial March 2018

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2018; 7(2):7. doi: 10.1167/tvst.7.2.7

Anatomy and Pathology/Oncology March 2018

Quantitative Evaluation of Vascular Microcirculation Using Contrast-Enhanced Ultrasound Imaging In Rabbit Models of Choroidal Melanoma

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Min Gao; Jinhua Tang; Kun Liu; Ming Yang; Haiyun Liu
TAGS: melanoma, microcirculation, oryctolagus cuniculus, diagnostic imaging, neoplasms, ultrasonography, contrast-enhanced, malignant melanoma of choroid
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1251-1262. doi: 10.1167/iovs.17-22197

Includes: Supplemental Content

Articles February 2018

Crowd-sourced Ontology for Photoleukocoria: Identifying Common Internet Search Terms for a Potentially Important Pediatric Ophthalmic Sign

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Sandra E. Staffieri; Lisa S. Kearns; Paul G. Sanfilippo; Jamie E. Craig; David A. Mackey; Alex W. Hewitt
TAGS: internet, pediatrics, retinoblastoma, eye, help-seeking behavior
Trans. Vis. Sci. Tech.. 2018; 7(1):18. doi: 10.1167/tvst.7.1.18

Includes: Supplemental Content

Anatomy and Pathology/Oncology February 2018

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status

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Jinfeng Cao; Niels J. Brouwer; Ekaterina S. Jordanova; Marina Marinkovic; Sjoerd G. van Duinen; Nadine E. de Waard; Bruce R. Ksander; Arend Mulder; Frans H. J. Claas; Mirjam H. M. Heemskerk; Martine J. Jager
TAGS: human leukocyte antigens, cell lines, malignant melanoma of conjunctiva, human leukocyte antigen class i, programmed cell death 1 ligand 1
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):1005-1015. doi: 10.1167/iovs.17-23209

Includes: Supplemental Content

Anatomy and Pathology/Oncology February 2018

Leucine-Rich α-2-Glycoprotein-1 (LRG-1) Expression in Retinoblastoma

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Radgonde Amer; Liran Tiosano; Jacob Pe'er
TAGS: vascular endothelial growth factor a, glycoprotein, leucine, retinoblastoma, neoplasms
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):685-692. doi: 10.1167/iovs.17-22785

Anatomy and Pathology/Oncology January 2018

Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for Retinoblastoma

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Anthony B. Daniels; Michael T. Froehler; Janene M. Pierce; Amy H. Nunnally; M. Wade Calcutt; Thomas M. Bridges; David C. LaNeve; Phillip E. Williams; Kelli L. Boyd; Michelle L. Reyzer; Craig W. Lindsley; Debra L. Friedman; Ann Richmond
TAGS: chemotherapy regimen, melphalan, oryctolagus cuniculus, retinoblastoma, body tissue, vitreous body, eye, pharmacokinetics, toxic effect, treatment effectiveness
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):446-454. doi: 10.1167/iovs.17-22302

Anatomy and Pathology/Oncology January 2018

BRAF , NRAS , and GNAQ Mutations in Conjunctival Melanocytic Nevi

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Jasmine H. Francis; Hans E. Grossniklaus; Larissa A. Habib; Brian Marr; David H. Abramson; Klaus J. Busam
TAGS: mutation, nevus, melanocytic nevus, conjunctiva, nevus of conjunctiva, braf gene
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):117-121. doi: 10.1167/iovs.17-22517

Anatomy and Pathology/Oncology January 2018

ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells

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Salma Kaochar; Jianrong Dong; Marie Torres; Kimal Rajapakshe; Fotis Nikolos; Christel M. Davis; Erik A. Ehli; Cristian Coarfa; Nicholas Mitsiades; Vasiliki Poulaki
TAGS: transcription, genetic, cell cycle, cell lines, gene expression profiling, genes, neoplasm metastasis, transplantation, heterologous, intraocular melanoma, mtor serine-threonine kinases
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):132-143. doi: 10.1167/iovs.17-22454

Includes: Supplemental Content

Anatomy and Pathology/Oncology December 2017

Evaluation of ( fli:GFP ) Casper Zebrafish Embryos as a Model for Human Conjunctival Melanoma

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Kelly Cristine de Sousa Pontes; Arwin Groenewoud; Jinfeng Cao; Livia Maria Silva Ataide; Ewa Snaar-Jagalska; Martine J. Jager
TAGS: cell lines, embryo, zebrafish, malignant melanoma of conjunctiva, vemurafenib
Invest. Ophthalmol. Vis. Sci.. 2017; 58(14):6065-6071. doi: 10.1167/iovs.17-22023

Lens October 2017

Cataract Avoidance With Proton Therapy in Ocular Melanomas

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Juliette Thariat; Sophie Jacob; Jean-Pierre Caujolle; Celia Maschi; Stéphanie Baillif; Gaelle Angellier; Thibaud Mathis; Laurence Rosier; Adela Carnicer; Joel Hérault; Julia Salleron
TAGS: cataract, eye neoplasms, lens, crystalline, lens (device), protons, avoidance behavior, proton therapy, eye melanomas
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5378-5386. doi: 10.1167/iovs.17-22557

Includes: Supplemental Content

Anatomy and Pathology/Oncology October 2017

Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics

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Rachel E. Doherty; Karen Sisley; David W. Hammond; Ian G. Rennie; Neil A. Cross
TAGS: phenotype, aldehyde dehydrogenases, stem cells, cd44 antigens, cell lines, neoplasms, homing-associated cell adhesion molecule, intraocular melanoma, cancer stem cells
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5387-5395. doi: 10.1167/iovs.17-22272

Includes: Supplemental Content

Letters to the Editor October 2017

Letter to the Editor: Comparison of Alternative Tumor Size Classifications for Posterior Uveal Melanomas

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J. William Harbour; Manuel Paez-Escamilla
TAGS: intraocular melanoma, tumor size
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5444-5444. doi: 10.1167/iovs.17-22603

Anatomy and Pathology/Oncology October 2017

SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas

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Taisuke Mori; Aoi Sukeda; Shigeki Sekine; Shinsuke Shibata; Eijitsu Ryo; Hideyuki Okano; Shigenobu Suzuki; Nobuyoshi Hiraoka
TAGS: immunohistochemistry, mutation, pigment, neoplasms, braf gene, intraocular melanoma, ulnar-mammary syndrome, sox10 gene, ciliary epithelium
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5445-5451. doi: 10.1167/iovs.17-22362

Includes: Supplemental Content

Clinical and Epidemiologic Research October 2017

Conjunctival Melanoma in Chinese Patients: Local Recurrence, Metastasis, Mortality, and Comparisons With Caucasian Patients

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Chuandi Zhou; Yuxin Wang; Renbing Jia; Xianqun Fan
TAGS: neoplasm metastasis, recurrence, whites, mortality, neoplasms, malignant melanoma of conjunctiva, chinese people, chinese (other dialects)
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5452-5459. doi: 10.1167/iovs.17-22376

Anatomy and Pathology/Oncology September 2017

Anterior Chamber Invasion in Retinoblastoma: Not an Indication for Adjuvant Chemotherapy

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Kummamuri V. Sreelakshmi; Anita Chandra; Subramanian Krishnakumar; Viswanathan Natarajan; Vikas Khetan
TAGS: adjuvant chemotherapy, anterior chamber of eye, neoplasm metastasis, retinoblastoma, seeds, eye, enucleation procedure, histopathology tests
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4654-4661. doi: 10.1167/iovs.17-22111

Anatomy and Pathology/Oncology August 2017

PRiMeUM: A Model for Predicting Risk of Metastasis in Uveal Melanoma

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Jorge Vaquero-Garcia; Emilie Lalonde; Kathryn G. Ewens; Jessica Ebrahimzadeh; Jennifer Richard-Yutz; Carol L. Shields; Alejandro Barrera; Christopher J. Green; Yoseph Barash; Arupa Ganguly
TAGS: chromosomes, neoplasm metastasis, neoplasms, intraocular melanoma
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4096-4105. doi: 10.1167/iovs.17-22255

Includes: Supplemental Content

Retina August 2017

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity

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Alexandre Matet; Alejandra Daruich; Leonidas Zografos
TAGS: angiogram, fractals, protons, radiation, visual acuity, blood capillaries, eye, macular disorders, intraocular melanoma, optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):3851-3861. doi: 10.1167/iovs.17-22324

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Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

More is better: Relative prevalence of multiple targets affects search accuracy

Genetic Risk Factors for Radiation Vasculopathy

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

Quantitative Evaluation of Vascular Microcirculation Using Contrast-Enhanced Ultrasound Imaging In Rabbit Models of Choroidal Melanoma

Crowd-sourced Ontology for Photoleukocoria: Identifying Common Internet Search Terms for a Potentially Important Pediatric Ophthalmic Sign

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status

Leucine-Rich α-2-Glycoprotein-1 (LRG-1) Expression in Retinoblastoma

Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for Retinoblastoma

BRAF , NRAS , and GNAQ Mutations in Conjunctival Melanocytic Nevi

ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells

Evaluation of ( fli:GFP ) Casper Zebrafish Embryos as a Model for Human Conjunctival Melanoma

Cataract Avoidance With Proton Therapy in Ocular Melanomas

Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics

Letter to the Editor: Comparison of Alternative Tumor Size Classifications for Posterior Uveal Melanomas

SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas

Conjunctival Melanoma in Chinese Patients: Local Recurrence, Metastasis, Mortality, and Comparisons With Caucasian Patients

Anterior Chamber Invasion in Retinoblastoma: Not an Indication for Adjuvant Chemotherapy

PRiMeUM: A Model for Predicting Risk of Metastasis in Uveal Melanoma

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity

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