Pharmacology

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Articles October 2019

Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314

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Alan G. Woodruff; Claudia M. Santamaria; Manisha Mehta; Grant L. Pemberton; Kathleen Cullion; Daniel S. Kohane
TAGS: cornea, lidocaine, qx-314
Trans. Vis. Sci. Tech.. 2019; 8(5):28. doi: 10.1167/tvst.8.5.28

Cornea October 2019

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

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Changjun Wang; Laura Schaefer; Fang Bian; Zhiyuan Yu; Stephen C. Pflugfelder; Robert A. Britton; Cintia S. de Paiva
TAGS: antibiotics, dysbiosis, inflammatory response, mice, microbiome, conjunctiva, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4224-4233. doi: 10.1167/iovs.19-27939

Articles September 2019

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability

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Wayne Heaselgrave; Anas Hamad; Steven Coles; Scott Hau
TAGS: acanthamoeba, cysts, ophthalmic agents, trophozoite, bronchioloalveolar carcinoma, toxic effect
Trans. Vis. Sci. Tech.. 2019; 8(5):17. doi: 10.1167/tvst.8.5.17

Lens September 2019

Resveratrol Inhibits Wound Healing and Lens Fibrosis: A Putative Candidate for Posterior Capsule Opacification Prevention

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Andrew J. O. Smith; Julie A. Eldred; I. Michael Wormstone
TAGS: lens, crystalline, resveratrol, wound healing, lens (device), after-cataract, prevention, fibrosis, epithelial to mesenchymal transition
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3863-3877. doi: 10.1167/iovs.18-26248

Articles September 2019

Δ 9 -Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure in Normotensive Rabbits

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Pranjal S. Taskar; Akash Patil; Prit Lakhani; Eman Ashour; Waseem Gul; Mahmoud A. ElSohly; Brian Murphy; Soumyajit Majumdar
TAGS: tetrahydrocannabinol, intraocular pressure, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2019; 8(5):15. doi: 10.1167/tvst.8.5.15

Glaucoma September 2019

Peripapillary Choroidal Vascularity Index and Microstructure of Parapapillary Atrophy

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Min Hee Suh; Jun Woo Park; Neha Khandelwal; Rupesh Agrawal
TAGS: atrophy, cortical blindness, antidepressive agents, tricyclic, trichloroacetic acid, spectral-domain optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3768-3775. doi: 10.1167/iovs.18-26286

Retina August 2019

Elevated Steroid Hormone Levels in Active Chronic Central Serous Chorioretinopathy

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Rosa L. Schellevis; Lebriz Altay; Asha Kalisingh; Timo W. F. Mulders; Vasilena Sitnilska; Carel B. Hoyng; Camiel J. F. Boon; Joannes M. M. Groenewoud; Eiko K. de Jong; Anneke I. den Hollander
TAGS: central serous chorioretinopathy, steroid hormone, steroids, hormones
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3407-3413. doi: 10.1167/iovs.19-26781

Includes: Supplemental Content

Retinal Cell Biology August 2019

COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells

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Keith D. Rochfort; Lara S. Carroll; Peter Barabas; Timothy M. Curtis; Balamurali K. Ambati; Niall Barron; Philip M. Cummins
TAGS: angiotensin i, hyperglycemia, hyperglycemic agents, endothelial cells, blood-retinal barrier, phenotype
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3547-3555. doi: 10.1167/iovs.19-27644

Includes: Supplemental Content

Editorial August 2019

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2019; 8(4):r. doi: 10.1167/tvst.8.4.r

Letters to the Editor August 2019

Chemical Considerations Regarding the H-Value Methodology and Its Relation With Toxicity Determination

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Girish K. Srivastava; Cristina Andrés-Iglesias; Rosa M. Coco; Ivan Fernandez-Bueno; Jesús Medina; Juan García-Serna; Antonio Dueñas; Fernando Rull; J. Carlos Pastor
TAGS: toxic effect
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3363-3364. doi: 10.1167/iovs.19-26948

Retina July 2019

Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases

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Beiying Qiu; Alison Tan; Amutha Barathi Veluchamy; Yong Li; Hannah Murray; Wei Cheng; Chenghao Liu; Joanna Marie Busoy; Qi-Yin Chen; Srivani Sistla; Walter Hunziker; Chui Ming Gemmy Cheung; Tien Yin Wong; Wanjin Hong; Hendrik Luesch; Xiaomeng Wang
TAGS: angiogenesis, mice, natural products, aflibercept, neovascularization, pathologic, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3254-3263. doi: 10.1167/iovs.19-26936

Includes: Supplemental Content

Retinal Cell Biology July 2019

Norgestrel, a Progesterone Analogue, Promotes Significant Long-Term Neuroprotection of Cone Photoreceptors in a Mouse Model of Retinal Disease

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Sarah L. Roche; Oksana Kutsyr; Nicolás Cuenca; Thomas G. Cotter
TAGS: mice, norgestrel, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3221-3235. doi: 10.1167/iovs.19-27246

Includes: Supplemental Content

Physiology and Pharmacology July 2019

Oral Delivery of the P2Y 12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4 −/− Mouse Model of Retinal Degeneration

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Wennan Lu; Keith E. Campagno; Huen-Yee Tso; Aurora Cenaj; Alan M. Laties; Leif G. Carlsson; Claire H. Mitchell
TAGS: mice, photoreceptors, retinal degeneration, ticagrelor, antagonists, administration, oral
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3046-3053. doi: 10.1167/iovs.19-27241

Immunology and Microbiology July 2019

Glycyrrhizin Use for Multi-Drug Resistant Pseudomonas aeruginosa : In Vitro and In Vivo Studies

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Linda D. Hazlett; Sandamali A. Ekanayaka; Sharon A. McClellan; Rebecca Francis
TAGS: ciprofloxacin, glycyrrhizic acid, keratitis, pseudomonas aeruginosa
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2978-2989. doi: 10.1167/iovs.19-27200

New Developments in Vision Research June 2019

In Vitro Antimicrobial Efficacy of Silver Lens Cases Used With a Multipurpose Disinfecting Solution

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Ananya Datta; Mark Willcox; Fiona Stapleton
TAGS: antimicrobials, contact lens storage case, disinfection, silver, contact lenses
Trans. Vis. Sci. Tech.. 2019; 8(3):52. doi: 10.1167/tvst.8.3.52

Articles June 2019

Controlled Release of Vancomycin From a Thermoresponsive Hydrogel System for the Prophylactic Treatment of Postoperative Acute Endophthalmitis

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Emily Dosmar; Wenqiang Liu; Geeya Patel; Alison Rogozinski; William F. Mieler; Jennifer J. Kang-Mieler
TAGS: endophthalmitis, hydrogel, vancomycin, infection, postoperative care, prevention, injections, saline solutions
Trans. Vis. Sci. Tech.. 2019; 8(3):53. doi: 10.1167/tvst.8.3.53

Article June 2019

Visual plasticity and exercise revisited: No evidence for a “cycling lane”

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Abigail E. Finn; Alex S. Baldwin; Alexandre Reynaud; Robert F. Hess
TAGS: exercise, ocular dominance
Journal of Vision. 2019; 19(6):21. doi: 10.1167/19.6.21

Review June 2019

Sleep–Wake Disturbance Related to Ocular Disease: A Systematic Review of Phase-Shifting Pharmaceutical Therapies

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Colm D. Andrews; Russell G. Foster; Iona Alexander; Sridhar Vasudevan; Susan M. Downes; Carl Heneghan; Annette Plüddemann
TAGS: eye diseases, melatonin, pharmacy (field), sleep, systematic reviews, tasimelteon
Trans. Vis. Sci. Tech.. 2019; 8(3):49. doi: 10.1167/tvst.8.3.49

Includes: Supplemental Content

Articles June 2019

In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection

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Jing Shen; Qingfeng Liang; Guanyu Su; Yang Zhang; Zhiqun Wang; Christophe Baudouin; Antoine Labbé
TAGS: antimicrobials, chemotherapy regimen, infection, mass or substance concentration per volume, staphylococcus aureus, staphylococcus epidermidis, tolonium chloride, bacteria, anti-bacterial agents, photosensitizing agents
Trans. Vis. Sci. Tech.. 2019; 8(3):45. doi: 10.1167/tvst.8.3.45

Clinical Trials June 2019

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

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Katarzyna Konieczka; Simone Koch; Daniela Hauenstein; Thomas Navin Chackathayil; Tatjana Binggeli; Andreas Schoetzau; Josef Flammer
TAGS: brimonidine, latanoprost, antiglaucoma medications, cornea, temperature
Trans. Vis. Sci. Tech.. 2019; 8(3):47. doi: 10.1167/tvst.8.3.47

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Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability

Resveratrol Inhibits Wound Healing and Lens Fibrosis: A Putative Candidate for Posterior Capsule Opacification Prevention

Δ 9 -Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure in Normotensive Rabbits

Peripapillary Choroidal Vascularity Index and Microstructure of Parapapillary Atrophy

Elevated Steroid Hormone Levels in Active Chronic Central Serous Chorioretinopathy

COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

Chemical Considerations Regarding the H-Value Methodology and Its Relation With Toxicity Determination

Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases

Norgestrel, a Progesterone Analogue, Promotes Significant Long-Term Neuroprotection of Cone Photoreceptors in a Mouse Model of Retinal Disease

Oral Delivery of the P2Y 12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4 −/− Mouse Model of Retinal Degeneration

Glycyrrhizin Use for Multi-Drug Resistant Pseudomonas aeruginosa : In Vitro and In Vivo Studies

In Vitro Antimicrobial Efficacy of Silver Lens Cases Used With a Multipurpose Disinfecting Solution

Controlled Release of Vancomycin From a Thermoresponsive Hydrogel System for the Prophylactic Treatment of Postoperative Acute Endophthalmitis

Visual plasticity and exercise revisited: No evidence for a “cycling lane”

Sleep–Wake Disturbance Related to Ocular Disease: A Systematic Review of Phase-Shifting Pharmaceutical Therapies

In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

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