Pharmacology

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Physiology and Pharmacology July 2019

Oral Delivery of the P2Y 12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4 −/− Mouse Model of Retinal Degeneration

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Wennan Lu; Keith E. Campagno; Huen-Yee Tso; Aurora Cenaj; Alan M. Laties; Leif G. Carlsson; Claire H. Mitchell
TAGS: mice, photoreceptors, retinal degeneration, ticagrelor, antagonists, administration, oral
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3046-3053. doi: 10.1167/iovs.19-27241

Immunology and Microbiology July 2019

Glycyrrhizin Use for Multi-Drug Resistant Pseudomonas aeruginosa : In Vitro and In Vivo Studies

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Linda D. Hazlett; Sandamali A. Ekanayaka; Sharon A. McClellan; Rebecca Francis
TAGS: ciprofloxacin, glycyrrhizic acid, keratitis, pseudomonas aeruginosa
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2978-2989. doi: 10.1167/iovs.19-27200

New Developments in Vision Research June 2019

In Vitro Antimicrobial Efficacy of Silver Lens Cases Used With a Multipurpose Disinfecting Solution

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Ananya Datta; Mark Willcox; Fiona Stapleton
TAGS: antimicrobials, contact lens storage case, disinfection, silver, contact lenses
Trans. Vis. Sci. Tech.. 2019; 8(3):52. doi: 10.1167/tvst.8.3.52

Articles June 2019

Controlled Release of Vancomycin From a Thermoresponsive Hydrogel System for the Prophylactic Treatment of Postoperative Acute Endophthalmitis

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Emily Dosmar; Wenqiang Liu; Geeya Patel; Alison Rogozinski; William F. Mieler; Jennifer J. Kang-Mieler
TAGS: endophthalmitis, hydrogel, vancomycin, infection, postoperative care, prevention, injections, saline solutions
Trans. Vis. Sci. Tech.. 2019; 8(3):53. doi: 10.1167/tvst.8.3.53

Article June 2019

Visual plasticity and exercise revisited: No evidence for a “cycling lane”

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Abigail E. Finn; Alex S. Baldwin; Alexandre Reynaud; Robert F. Hess
TAGS: exercise, ocular dominance
Journal of Vision. 2019; 19(6):21. doi: 10.1167/19.6.21

Review June 2019

Sleep–Wake Disturbance Related to Ocular Disease: A Systematic Review of Phase-Shifting Pharmaceutical Therapies

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Colm D. Andrews; Russell G. Foster; Iona Alexander; Sridhar Vasudevan; Susan M. Downes; Carl Heneghan; Annette Plüddemann
TAGS: eye diseases, melatonin, pharmacy (field), sleep, systematic reviews, tasimelteon
Trans. Vis. Sci. Tech.. 2019; 8(3):49. doi: 10.1167/tvst.8.3.49

Includes: Supplemental Content

Articles June 2019

In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection

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Jing Shen; Qingfeng Liang; Guanyu Su; Yang Zhang; Zhiqun Wang; Christophe Baudouin; Antoine Labbé
TAGS: antimicrobials, chemotherapy regimen, infection, mass or substance concentration per volume, staphylococcus aureus, staphylococcus epidermidis, tolonium chloride, bacteria, anti-bacterial agents, photosensitizing agents
Trans. Vis. Sci. Tech.. 2019; 8(3):45. doi: 10.1167/tvst.8.3.45

Clinical Trials June 2019

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

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Katarzyna Konieczka; Simone Koch; Daniela Hauenstein; Thomas Navin Chackathayil; Tatjana Binggeli; Andreas Schoetzau; Josef Flammer
TAGS: brimonidine, latanoprost, antiglaucoma medications, cornea, temperature
Trans. Vis. Sci. Tech.. 2019; 8(3):47. doi: 10.1167/tvst.8.3.47

Articles June 2019

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

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Young Hyun Kim; Andrew D. Graham; Wing Li; Clayton J. Radke; Meng C. Lin
TAGS: evaporation, eye, heterogeneity of variance, loa, sample size, tear production, dry eye syndromes, humidity, reading (activity), anesthetics, clinical trial protocol document, body temperature
Trans. Vis. Sci. Tech.. 2019; 8(3):40. doi: 10.1167/tvst.8.3.40

Articles June 2019

Evaluation of Liposomal and Conventional Amphotericin B in Experimental Fungal Keratitis Rabbit Model

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Anup Kumar Ghosh; Shivaprakash Mandya Rudramurthy; Amit Gupta; Hansraj Choudhary; Shreya Singh; Anchal Thakur; Manu Jatana
TAGS: amphotericin b, antifungal agents, cornea, did not receive therapy or drug, fungal keratitis, liposomes, oryctolagus cuniculus, keratitis
Trans. Vis. Sci. Tech.. 2019; 8(3):35. doi: 10.1167/tvst.8.3.35

Articles June 2019

Tracking the Reflective Light Particles Spreading on the Cornea: An Emerging Assessment for Tear Film Homeostasis

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Hung-Yin Lai; Ming-Tse Kuo; Po-Chiung Fang; Chi-Chang Lin; Chun-Chih Chien; Wan-Hua Cho; Alexander Chen; Ing-Chou Lai
TAGS: homeostasis, cornea, tear film finding, liposomal amikacin for inhalation
Trans. Vis. Sci. Tech.. 2019; 8(3):32. doi: 10.1167/tvst.8.3.32

Includes: Multimedia, Supplemental Content

Articles May 2019

Hydrofluoric Acid and Other Impurities in Toxic Perfluorooctane Batches

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Dirk-Henning Menz; Nicolas Feltgen; Thorsten Lechner; Helge Menz; Bernd-Kristof Müller; Joachim Dresp; Hans Hoerauf
TAGS: olive oil, heart failure, patent foramen ovale, hydrofluoric acid, gas chromatography-mass spectrometry, body tissue, toxic effect, retinal toxicity, catabolism, perfluorooctane
Trans. Vis. Sci. Tech.. 2019; 8(3):24. doi: 10.1167/tvst.8.3.24

Retina May 2019

Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR

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Jakob Grauslund; Ulrik Frydkjaer-Olsen; Tunde Peto; Jimena Fernández-Carneado; Berta Ponsati; Cristina Hernández; José Cunha-Vaz; Rafael Simó; for the EUROCONDOR
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, dilatation, pathologic, somatostatin, brimonidine, retinal vascular caliber
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2257-2262. doi: 10.1167/iovs.18-26487

Retina May 2019

Intravitreal Fluocinolone Acetonide May Decelerate Diabetic Retinal Neurodegeneration

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Stephanie K. Lynch; Kyungmoo Lee; Zhi Chen; James C. Folk; Ursula Schmidt-Erfurth; Bianca S. Gerendas; Andreas Wahle; Charles C. Wykoff; Michael D. Abràmoff
TAGS: diabetes mellitus, fluocinolone acetonide, nerve degeneration, left ventricular area fractional change, cyclophosphamide/doxorubicin/fluorouracil protocol, right ventricular fractional area change
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2134-2139. doi: 10.1167/iovs.18-24643

Clinical Trials May 2019

A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

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Christine Mun; Shilpa Gulati; Sapna Tibrewal; Yi-Fan Chen; Seungwon An; Bayasgalan Surenkhuu; Ilangovan Raju; Morgan Buwick; Anna Ahn; Ji-Eun Kwon; Nour Atassi; Anubhav Pradeep; Damiano Rondelli; Sandeep Jain
TAGS: deoxyribonuclease i, deoxyribonucleases, dry eye syndromes, placebos, eyedrops
Trans. Vis. Sci. Tech.. 2019; 8(3):10. doi: 10.1167/tvst.8.3.10

Retinal Cell Biology April 2019

Activation of the BMP4/Smad1 Pathway Promotes Retinal Ganglion Cell Survival and Axon Regeneration

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Adam Thompson; Martin Berry; Ann Logan; Zubair Ahmed
TAGS: rapamycin, peptides, neuronal outgrowth, rna, messenger, retinal ganglion cells, axon, neurites
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1748-1759. doi: 10.1167/iovs.18-26449

Visual Neuroscience April 2019

ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice

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Run-Ze Cui; Lu Wang; Sheng-Nan Qiao; Yong-Chen Wang; Xin Wang; Fei Yuan; Shi-Jun Weng; Xiong-Li Yang; Yong-Mei Zhong
TAGS: diabetes mellitus, streptozocin, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1644-1656. doi: 10.1167/iovs.18-26359

Retina April 2019

Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT

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Bruce A. Berkowitz; Robert H. Podolsky; Karen M. Lins-Childers; Yichao Li; Haohua Qian
TAGS: oxidative stress, diltiazem, mice, apraxia of speech, aneurysms-osteoarthritis syndrome, saline solutions
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1566-1570. doi: 10.1167/iovs.18-26164

Glaucoma April 2019

Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation

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Yan Hu; Arturo O. Barron; Sofya Gindina; Sandeep Kumar; Shravan Chintala; Ashima Nayyar; John Danias
TAGS: alteplase, urokinase, gelatinase b, platelet count measurement, mice, regulation, fibrinolysis pathway
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1571-1580. doi: 10.1167/iovs.18-25698

Clinical and Epidemiologic Research April 2019

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

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Emily E. Brown; Jacob D. Ball; Zhaoyi Chen; Gibran S. Khurshid; Mattia Prosperi; John D. Ash
TAGS: metformin, age-related macular degeneration, antidiabetics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1470-1477. doi: 10.1167/iovs.18-26422

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Oral Delivery of the P2Y 12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4 −/− Mouse Model of Retinal Degeneration

Glycyrrhizin Use for Multi-Drug Resistant Pseudomonas aeruginosa : In Vitro and In Vivo Studies

In Vitro Antimicrobial Efficacy of Silver Lens Cases Used With a Multipurpose Disinfecting Solution

Controlled Release of Vancomycin From a Thermoresponsive Hydrogel System for the Prophylactic Treatment of Postoperative Acute Endophthalmitis

Visual plasticity and exercise revisited: No evidence for a “cycling lane”

Sleep–Wake Disturbance Related to Ocular Disease: A Systematic Review of Phase-Shifting Pharmaceutical Therapies

In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

Evaluation of Liposomal and Conventional Amphotericin B in Experimental Fungal Keratitis Rabbit Model

Tracking the Reflective Light Particles Spreading on the Cornea: An Emerging Assessment for Tear Film Homeostasis

Hydrofluoric Acid and Other Impurities in Toxic Perfluorooctane Batches

Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR

Intravitreal Fluocinolone Acetonide May Decelerate Diabetic Retinal Neurodegeneration

A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

Activation of the BMP4/Smad1 Pathway Promotes Retinal Ganglion Cell Survival and Axon Regeneration

ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice

Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT

Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

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