Pharmacology

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Letters to the Editor January 2025

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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Blondy Kayembe Mulumba; Karen Leffondré; Pierre Joly; Marie-Noëlle Delyfer; Cécile Delcourt
TAGS: age-related macular degeneration, genetics, statins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):25. https://doi.org/10.1167/iovs.66.1.25

Anatomy and Pathology/Oncology January 2025

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

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Xiaoting Pei; Mengru Ba; Tingting Yang; Shuting Xuan; Duliurui Huang; Di Qi; Dingli Lu; Shenzhen Huang; Zhijie Li
TAGS: diabetes mellitus, diabetes mellitus, type 2, insulin, mice, langer-giedion syndrome, circadian rhythms, dry eye syndromes, gene expression
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):19. https://doi.org/10.1167/iovs.66.1.19

Includes: Supplemental Content

Immunology and Microbiology January 2025

Anti-Inflammatory Effects of Clarstatin, a Shared-Epitope–Antagonistic Cyclic Peptide, on Experimental Autoimmune Uveitis in Mice

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Shira Merzbach; Adi Schumacher-Klinger; Michal Klazas; Amnon Hoffman; Philip Lazarovici; Chaim Gilon; Gabriel Nussbaum; Radgonde Amer
TAGS: anti-inflammatory agents, autoimmunity, cyclic peptides, epitopes, mice, uveitis, mice, inbred c57bl, cd45 antigens, cytokine
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):13. https://doi.org/10.1167/iovs.66.1.13

Retina December 2024

Real-World Outcomes After Switch From Aflibercept to Faricimab in Eyes With Diabetic Macular Edema

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Kim Lien Huber; Heiko Stino; Irene Steiner; Philipp Fuchs; Felix Goldbach; Julia Mai; Bianca S. Gerendas; Katharina Kriechbaum; Ursula Schmidt-Erfurth; Andreas Pollreisz
TAGS: aflibercept, diabetic macular edema, eye, faricimab, injections, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):46. https://doi.org/10.1167/iovs.65.14.46

Includes: Supplemental Content

Editorial December 2024

Reviewers

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TAGS: bsnd gene, gangs, happiness, laparoscopic uterosacral nerve ablation, reading (activity), tolnaftate, acetylcholine, achondroplasia, camurati-engelmann syndrome, e-selectin
Trans. Vis. Sci. Tech.. 2024; 13(12):38. https://doi.org/10.1167/tvst.13.12.38

Editorial December 2024

Reviewers

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TAGS: angiotensin receptor-neprilysin inhibitors, basil, cataract-alopecia-sclerodactyly syndrome, chad, chin, christianity, happiness, ilex, iris, love
Journal of Vision. 2024; 24(13):16. https://doi.org/10.1167/jov.24.13.16

Editorial December 2024

Reviewers

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TAGS: acetylcholine, achondroplasia, arthritis, juvenile rheumatoid, betula, christianity, encephalomyelitis, acute disseminated, esters, gastroesophageal reflux disease, glycogen storage disease type iv, krypton
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):42. https://doi.org/10.1167/iovs.65.14.42

Retina December 2024

Changes in Aqueous Angiopoietin-1/2 Concentrations During the Induction Phase of Intravitreal Faricimab Injections for Diabetic Macular Edema

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Masahiko Shimura; Shotaro Sasaki; Ryota Nonaka; Ikumi Kashiwagi; Kanako Yasuda; Hidetaka Noma; Hitoshi Takagi
TAGS: angiopoietins, cytokine, diabetic macular edema, faricimab, injections, vascular endothelial growth factor a
Trans. Vis. Sci. Tech.. 2024; 13(12):35. https://doi.org/10.1167/tvst.13.12.35

Retina December 2024

Phase 1b Dose Escalation Study of Sozinibercept Inhibition of Vascular Endothelial Growth Factors C and D With Aflibercept for Diabetic Macular Edema

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David S. Boyer; Nathan C. Steinle; Joel A. Pearlman; Cameron M. Stone; Courtney Crawford; Sunil Gupta; Pravin U. Dugel; Megan E. Baldwin; Ian M. Leitch
TAGS: aflibercept, diabetic macular edema, vascular endothelial growth factor a, vascular endothelial growth factor c, vascular endothelial growth factors
Trans. Vis. Sci. Tech.. 2024; 13(12):32. https://doi.org/10.1167/tvst.13.12.32

Lens December 2024

Untargeted Metabolomics Reveals the Role of Lipocalin-2 in the Pathological Changes of Lens and Retina in Diabetic Mice

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Yu Yang; Cong Fan; Yue Zhang; Tianyi Kang; Jian Jiang
TAGS: diabetes mellitus, lens (device), lens, crystalline, metabolites, mice, retina, streptozocin, metabolic disturbance, lipocalin-2 protein, metabolomics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):19. https://doi.org/10.1167/iovs.65.14.19

Includes: Supplemental Content

Anatomy and Pathology/Oncology December 2024

Mimicking Retinoblastoma Treatment With Repeated Topotecan or Melphalan Develops Cross-Resistance to Classic Agents But Not to Repurposed Drugs

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María Belen Cancela; Ursula Winter; Santiago Zugbi; Milagros Dinardi; Daniela Alves da Quinta; Rosario Aschero; Daiana Ganiewich; Claudia Sampor; Mariana Sgroi; Eduardo Lagomarsino; Adriana Fandiño; Andrea S. Llera; Guillermo Chantada; Angel M. Carcaboso; Paula Schaiquevich
TAGS: melphalan, retinoblastoma, topotecan, parent, membrane transport proteins, inhibitory concentration 50
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):14. https://doi.org/10.1167/iovs.65.14.14

Includes: Supplemental Content

Clinical and Epidemiologic Research December 2024

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

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Panagiotis Laspas; Alica Hartmann; Ida Scholz; Esther Maria Hoffmann; Anthony P. Khawaja; Karl Johannes Lackner; Thomas Münzel; Jasmin Ghaemi Kerahrodi; Irene Schmidtmann; Oliver Tüscher; Jörn Markus Schattenberg; Norbert Pfeiffer; Stavros Konstantinides; Philipp Sebastian Wild; Alexander Karl-Georg Schuster
TAGS: intraocular pressure, pharmaceutical preparations, health, beta-blockers
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):4. https://doi.org/10.1167/iovs.65.14.4

Includes: Supplemental Content

Physiology and Pharmacology November 2024

Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

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Sabrina Wohlfart; Jonathan Herth; Manuel Ben Böhmann; Giulia Pander; Lorenz Herbster; Walter Mier; Gerd Uwe Auffarth; Philipp Uhl; Maximilian Hammer
TAGS: antibodies, anti-vascular endothelial growth factor therapy, bevacizumab, silicone oils, trastuzumab, vascular endothelial growth factor a, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):56. https://doi.org/10.1167/iovs.65.13.56

Includes: Supplemental Content

Retina November 2024

Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury

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David A. Antonetti; Cheng-Mao Lin; Sumathi Shanmugam; Heather Hager; Manjing Cao; Xuwen Liu; Alyssa Dreffs; Adam Habash; Steven F. Abcouwer
TAGS: diabetes mellitus, wounds and injuries, mice, retina, photoreceptors, reperfusion injury, streptozocin
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):46. https://doi.org/10.1167/iovs.65.13.46

Includes: Supplemental Content

Retina November 2024

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

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Nicole A. Muench; Heather M. Schmitt; Cassandra L. Schlamp; An-Jey A. Su; Kia Washington; Robert W. Nickells
TAGS: cryopreservation, eye, mice
Trans. Vis. Sci. Tech.. 2024; 13(11):24. https://doi.org/10.1167/tvst.13.11.24

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2024

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

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Charkira C. Patrick; Elisa Roztocil; Farha Husain; Steven E. Feldon; Collynn F. Woeller
TAGS: aryl hydrocarbon receptor, fibroblasts, graves' ophthalmopathy, ligands, signal transduction, tapinarof, platelet-derived growth factor, thymidylate synthase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):40. https://doi.org/10.1167/iovs.65.13.40

Includes: Supplemental Content

Cornea & External Disease November 2024

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

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Carol Beatty; Amy Estes; Hongyan Xu; Yutao Liu
TAGS: estrogen, keratoconus, pharmaceutical preparations, risk factors, obesity, medical history, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(11):18. https://doi.org/10.1167/tvst.13.11.18

Cornea November 2024

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

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Xiaowei Yang; Xingwu Zhong; Haotian Lin; Andrew J.W. Huang; Lixing W. Reneker
TAGS: atrophy, epithelium, fgfr2 gene, meibomian gland dysfunction, mice, tamoxifen
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):36. https://doi.org/10.1167/iovs.65.13.36

Includes: Supplemental Content

Cornea November 2024

Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost

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XiaoBo Zheng; Chong Wang; YiWen Fan; YuXin Hong; Han Bao; ErChi Zhang; Yi Jin; Peng Yang; LingQiao Li; JunJie Wang; ShiHao Chen; Ahmed Elsheikh; FangJun Bao
TAGS: cornea, oryctolagus cuniculus, travoprost, cardiac ct, multiple wake test, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):35. https://doi.org/10.1167/iovs.65.13.35

Retina November 2024

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis

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Huan Liu; Feiyan Wang; Ziqing Hu; Jing Wei
TAGS: diabetic retinopathy, drug delivery systems, mendelian randomization analysis, plasma proteins, proteins
Trans. Vis. Sci. Tech.. 2024; 13(11):17. https://doi.org/10.1167/tvst.13.11.17

Includes: Supplemental Content

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Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

Anti-Inflammatory Effects of Clarstatin, a Shared-Epitope–Antagonistic Cyclic Peptide, on Experimental Autoimmune Uveitis in Mice

Real-World Outcomes After Switch From Aflibercept to Faricimab in Eyes With Diabetic Macular Edema

Reviewers

Reviewers

Reviewers

Changes in Aqueous Angiopoietin-1/2 Concentrations During the Induction Phase of Intravitreal Faricimab Injections for Diabetic Macular Edema

Phase 1b Dose Escalation Study of Sozinibercept Inhibition of Vascular Endothelial Growth Factors C and D With Aflibercept for Diabetic Macular Edema

Untargeted Metabolomics Reveals the Role of Lipocalin-2 in the Pathological Changes of Lens and Retina in Diabetic Mice

Mimicking Retinoblastoma Treatment With Repeated Topotecan or Melphalan Develops Cross-Resistance to Classic Agents But Not to Repurposed Drugs

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis

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