Pharmacology

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Immunology and Microbiology September 2018

In Vitro Amoebicidal Activity of Titanium Dioxide/UV-A Combination Against Acanthamoeba

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Gabrielle Gomart; Julie Denis; Tristan Bourcier; Anne Dory; Ahmed Abou-Bacar; Ermanno Candolfi; Arnaud Sauer
TAGS: acanthamoeba, cysts, ultraviolet a radiation, titanium dioxide, trophozoite
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4567-4571. doi: 10.1167/iovs.18-25003

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2018

Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

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JaeSang Ko; Ji-Young Kim; Eun Jig Lee; Jin Sook Yoon
TAGS: fibroblasts, 1-phosphatidylinositol 3-kinase, idelalisib
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4477-4485. doi: 10.1167/iovs.18-24509

Includes: Supplemental Content

Retina September 2018

Neuroprotective Effects of FGF2 and Minocycline in Two Animal Models of Inherited Retinal Degeneration

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Johnny Di Pierdomenico; Rebecca Scholz; F. Javier Valiente-Soriano; Maria C. Sánchez-Migallón; Manuel Vidal-Sanz; Thomas Langmann; Marta Agudo-Barriuso; Diego García-Ayuso; María Paz Villegas-Pérez
TAGS: ciliary neurotrophic factor, fibroblast growth factor 2, minocycline, animal model, photoreceptors, retinal degeneration, rats, neuroprotective effect
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4392-4403. doi: 10.1167/iovs.18-24621

Articles August 2018

A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules

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Nobuo Machinaga; Gary W. Ashley; Ralph Reid; Atsushi Yamasaki; Kyosuke Tanaka; Koichi Nakamura; Yoshiyuki Yabe; Yasushi Yoshigae; Daniel V. Santi
TAGS: half-life, injections, oryctolagus cuniculus, vitreous body, eye, molecule
Trans. Vis. Sci. Tech.. 2018; 7(4):21. doi: 10.1167/tvst.7.4.21

Includes: Supplemental Content

Retina August 2018

Mechanistic Evaluation of Panretinal Photocoagulation Versus Aflibercept in Proliferative Diabetic Retinopathy: CLARITY Substudy

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Luke Nicholson; Roxanne Crosby-Nwaobi; Joana C. Vasconcelos; A. Toby Prevost; Jayashree Ramu; Amy Riddell; James W. Bainbridge; Philip G. Hykin; Sobha Sivaprasad
TAGS: oximetry, eye, proliferative diabetic retinopathy, panretinal photocoagulation, aflibercept
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4277-4284. doi: 10.1167/iovs.17-23509

Includes: Supplemental Content

Retina August 2018

Anti-VEGF Monotherapy Versus Photodynamic Therapy and Anti-VEGF Combination Treatment for Neovascular Age-Related Macular Degeneration: A Meta-Analysis

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Yang Gao; Tao Yu; Yue Zhang; Guangfu Dang
TAGS: meta-analysis, combined modality therapy, photochemotherapy, verteporfin, exudative age-related macular degeneration, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4307-4317. doi: 10.1167/iovs.17-23747

Cornea August 2018

Ophthalmic Nonsteroidal Anti-Inflammatory Drugs as a Therapy for Corneal Dystrophies Caused by SLC4A11 Mutation

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Kumari Alka; Joseph R. Casey
TAGS: mutation, anti-inflammatory agents, non-steroidal, hereditary corneal dystrophy, diclofenac, eye, water, nepafenac
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4258-4267. doi: 10.1167/iovs.18-24301

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2018

Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway

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Na Wang; Chen Zou; Shuzhi Zhao; Yunzhi Wang; Changjing Han; Zhi Zheng
TAGS: apoptosis, diabetes mellitus, inflammation, glucose, diabetic retinopathy, rats, angptl3 gene, fenofibrate, integrins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4210-4217. doi: 10.1167/iovs.18-24155

Retina August 2018

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging

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Ignacio Melgar-Asensio; Irawati Kandela; Fraser Aird; Soesiawati R. Darjatmoko; Cristobal de los Rios; Christine M. Sorenson; Daniel M. Albert; Nader Sheibani; Jack Henkin
TAGS: arginine, drug clearance, drug delivery systems, peptides, oryctolagus cuniculus, vitreous body, diagnostic imaging, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4071-4081. doi: 10.1167/iovs.18-24087

Letters to the Editor August 2018

Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics

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Eric Wakshull; Robert Avery; Mauricio Maia
TAGS: vascular endothelial growth factor a, therapeutics, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4106-4106. doi: 10.1167/iovs.18-24792

Cornea August 2018

Higher Total Insulin Dose Has Positive Effect on Corneal Nerve Fibers in DM1 Patients

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Gabriela Mahelková; Marie Česká Burdová; Šárka Malá; Lucie Hoskovcová; Dagmar Dotřelová; Kateřina Štechová
TAGS: nerve fibers, cornea, insulin
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3800-3807. doi: 10.1167/iovs.18-24265

Glaucoma August 2018

Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury

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Hongdou Luo; Jiejie Zhuang; Piaopiao Hu; Wei Ye; Shanshan Chen; Yulian Pang; Ningfeng Li; Cong Deng; Xu Zhang
TAGS: apoptosis, inflammation, gliosis, reperfusion injury, wounds and injuries, retina, resveratrol, attenuation, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3879-3888. doi: 10.1167/iovs.18-23806

Cornea July 2018

Modulating Contact Lens Discomfort With Anti-Inflammatory Approaches: A Randomized Controlled Trial

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Laura E. Downie; Anne Gad; Chinn Yi Wong; John Henry V. Gray; Weiguang Zeng; David C. Jackson; Algis J. Vingrys
TAGS: anti-inflammatory agents, cytokine, inflammation, omega-3 fatty acids, fish oils, contact lenses, interleukin-17, placebos, randomized controlled trial, signs and symptoms, interleukin-6, topical corticosteroid, outcome measures
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3755-3766. doi: 10.1167/iovs.18-24758

Includes: Supplemental Content

Cornea July 2018

Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage

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Bing Wang; Pui-Kai Li; Jian-xing Ma; Danyang Chen
TAGS: vascular endothelial growth factor a, alkalies, eye, thalidomide, diabetes mellitus, retina, cornea, angiogenesis inhibitors, rats, streptozocin, intravitreal injections, corneal neovascularization, burns
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3630-3642. doi: 10.1167/iovs.18-24015

Includes: Supplemental Content

Cornea July 2018

0.005% Preservative-Free Latanoprost Induces Dry Eye-Like Ocular Surface Damage via Promotion of Inflammation in Mice

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Yiran Yang; Caihong Huang; Xiang Lin; Yang Wu; Weijie Ouyang; Liying Tang; Sihao Ye; Yuhong Wang; Wei Li; Xiaobo Zhang; Zuguo Liu
TAGS: inflammation, administration, topical, dry eye syndromes, mice, latanoprost, eyedrops
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3375-3384. doi: 10.1167/iovs.18-24013

Includes: Supplemental Content

Retinal Cell Biology June 2018

D- cis -Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo

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Bruce A. Berkowitz; Robert H. Podolsky; Benjamin Farrell; Hojun Lee; Christopher Trepanier; Ali M. Berri; Kristin Dernay; Emma Graffice; Fatema Shafie-Khorassani; Timothy S. Kern; Robin Roberts
TAGS: oxidative stress, diltiazem, magnetic resonance imaging, rod photoreceptors, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2999-3010. doi: 10.1167/iovs.18-23829

Cornea June 2018

Bacterial Coaggregation and Cohesion Among Isolates From Contact Lens Cases

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Ananya Datta; Fiona Stapleton; Mark D. P. Willcox
TAGS: staphylococcus, bacteria, contact lens storage case
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2729-2735. doi: 10.1167/iovs.17-23155

Retinal Cell Biology June 2018

Anti-CD160, Alone or in Combination With Bevacizumab, Is a Potent Inhibitor of Ocular Neovascularization in Rabbit and Monkey Models

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Thierry Menguy; Anne Briaux; Elisabeth Jeunesse; Jérôme Giustiniani; Alexandre Calcei; Thierry Guyon; Jacques Mizrahi; Hélène Haegel; Vanessa Duong; Vincent Soler; Pierre Brousset; Armand Bensussan; Isabelle Raymond Letron; Philippe Le Bouteiller
TAGS: vascular endothelial growth factor a, angiogenesis inhibitors, monoclonal antibodies, cercopithecidae, choroidal neovascularization, fibroblast growth factor 2, injection of therapeutic agent, lasers, neovascularization, pathologic, oryctolagus cuniculus, immunoglobulin g, cornea, bevacizumab, transverse spin relaxation rate, anti-vascular endothelial growth factor therapy, coefficient of determination
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2687-2698. doi: 10.1167/iovs.18-24024

Includes: Supplemental Content

Clinical and Epidemiologic Research May 2018

A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema

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Jeremy D. Gale; Brian Berger; Steven Gilbert; Serghei Popa; Marla B. Sultan; Ronald A. Schachar; Douglas Girgenti; Christelle Perros-Huguet
TAGS: safety, macular edema, diabetic, ranibizumab
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2659-2669. doi: 10.1167/iovs.17-22731

Includes: Supplemental Content

Glaucoma May 2018

FOXC1 Regulates Expression of Prostaglandin Receptors Leading to an Attenuated Response to Latanoprost

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Lance P. Doucette; Tim Footz; Michael A. Walter
TAGS: phenotype, prostaglandins, glaucoma, prostaglandin receptor, proteins, latanoprost, rna, rna, small interfering, attenuation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2548-2554. doi: 10.1167/iovs.17-23223

Includes: Supplemental Content

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In Vitro Amoebicidal Activity of Titanium Dioxide/UV-A Combination Against Acanthamoeba

Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

Neuroprotective Effects of FGF2 and Minocycline in Two Animal Models of Inherited Retinal Degeneration

A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules

Mechanistic Evaluation of Panretinal Photocoagulation Versus Aflibercept in Proliferative Diabetic Retinopathy: CLARITY Substudy

Anti-VEGF Monotherapy Versus Photodynamic Therapy and Anti-VEGF Combination Treatment for Neovascular Age-Related Macular Degeneration: A Meta-Analysis

Ophthalmic Nonsteroidal Anti-Inflammatory Drugs as a Therapy for Corneal Dystrophies Caused by SLC4A11 Mutation

Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging

Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics

Higher Total Insulin Dose Has Positive Effect on Corneal Nerve Fibers in DM1 Patients

Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury

Modulating Contact Lens Discomfort With Anti-Inflammatory Approaches: A Randomized Controlled Trial

Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage

0.005% Preservative-Free Latanoprost Induces Dry Eye-Like Ocular Surface Damage via Promotion of Inflammation in Mice

D- cis -Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo

Bacterial Coaggregation and Cohesion Among Isolates From Contact Lens Cases

Anti-CD160, Alone or in Combination With Bevacizumab, Is a Potent Inhibitor of Ocular Neovascularization in Rabbit and Monkey Models

A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema

FOXC1 Regulates Expression of Prostaglandin Receptors Leading to an Attenuated Response to Latanoprost

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