Retina

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Retina July 2025

Choroidal Features of Cynomolgus Macaques in Relation to Age and Axial Length

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Guitong Ye; Yuan Zhang; Shaofen Huang; Jinan Zhan; Ruiyu Luo; Rui Xie; Yuyao Ling; Ye Deng; Caibin Deng; Wei Liu; Zhiwei Huang; Chusheng Zhang; Junshu Wu; Zhidong Li; Yehong Zhuo
TAGS: cardiovascular imaging, choroid, cortical blindness, macaca, macaca fascicularis, myopia, eye, antidepressive agents, tricyclic, trichloroacetic acid, adult
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):17. https://doi.org/10.1167/iovs.66.9.17

Includes: Supplemental Content

Retinal Cell Biology July 2025

Intravenous Sodium Iodate Administration Induces Macula-Specific RPE Damage and Rod-Dominant Apoptosis in the Cynomolgus Monkey

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Shoji Notomi; Guannan Wu; Takaharu Nagaoka; Nao Yotsumoto; Tomoaki Araki; Mitsuru Arima; Toshio Hisatomi; Koh-Hei Sonoda; Kazutoshi Sawada
TAGS: apoptosis, cercopithecidae, iodates, macaca fascicularis, macula lutea, macular degeneration, rod photoreceptors, sodium, young adult, histopathology tests
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):18. https://doi.org/10.1167/iovs.66.9.18

Includes: Supplemental Content

Retina July 2025

In Vivo Characterization of Bruch’s Membrane Breaks in Neovascular Age-Related Macular Degeneration Using High-Resolution Optical Coherence Tomography

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Mai Alhelaly; Ceren Soylu; Giulia Corradetti; Federico Corvi; Alireza Mahmoudi; Rouzbeh Abbasgholizadeh; Giovanni Bellisario; Ye He; Alberto Quarta; Muneeswar G. Nittala; Giovanni Staurenghi; SriniVas R. Sadda
TAGS: bruch's basal membrane, exudative age-related macular degeneration, eye, macular neovascularization, optical coherence tomography, injections, diagnostic imaging, visual acuity, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):19. https://doi.org/10.1167/iovs.66.9.19

Glaucoma July 2025

Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length

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Tingting Liu; Ya Xing Wang; Jost B. Jonas; Quan V. Hoang; Michaël J. A. Girard; Xiaofei Wang
TAGS: eye, gaze, myopia, optic disk, eye movement, sclera, adduction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):21. https://doi.org/10.1167/iovs.66.9.21

Includes: Supplemental Content

Retina July 2025

Hyperreflective Foci in the Ectopic Inner Foveal Layer of Advanced Idiopathic Epiretinal Membranes

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Nicola Valsecchi; Maurizio Mete; Giulio Rapezzi; Matteo Elifani; Giulia Folgaria; Alessandro Finzi; Antonio Moramarco; Luigi Fontana
TAGS: epiretinal membrane, eye, heart failure, surgical procedures, operative, postoperative care
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):14. https://doi.org/10.1167/iovs.66.9.14

Article July 2025

Computational evidence for an inverse relationship between retinal and brain complexity

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Mitchell B. Slapik
TAGS: brain, datasets, retina
Journal of Vision. 2025; 25(8):9. https://doi.org/10.1167/jov.25.8.9

Includes: Supplemental Content

Genetics July 2025

Quantitative Choroidal Analysis of Molecularly Characterized Retinitis Pigmentosa

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Kirk A. J. Stephenson; Tiffany Tse; Jiwon Hwang; Andrii Kavetskyi; Shanil R. Dhanji; Olubayo U. Kolawole; Cheryl Y. Gregory-Evans; Kaivon Pakzad-Vaezi; Zaid N. Mammo; Kevin Gregory-Evans; Myeong Jin Ju
TAGS: cardiovascular imaging, cortical blindness, eye, genotype, retinitis pigmentosa, myopia, cohort studies, pseudophakia, volume, choroid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):11. https://doi.org/10.1167/iovs.66.9.11

Includes: Supplemental Content

Retina July 2025

Diabetes-Induced Dysregulation of Peripapillary and Macular Neurovascular Units

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Mizuho Mitamura; Satoru Kase; Hiroaki Endo; Michiyuki Saito; Satoshi Katsuta; Susumu Ishida
TAGS: diabetes mellitus, diabetes mellitus, type 2, eye, retinal nerve fiber layer
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):10. https://doi.org/10.1167/iovs.66.9.10

Immunology and Microbiology July 2025

The Gut Microbial System Responds to Retinal Injury and Modulates the Outcomes by Regulating Innate Immune Activation

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Xuexue Cui; Caijiao Yi; Jian Liu; Jinyan Qi; Wen Deng; Xiangling Yuan; Ruiqi Zhou; Mei Chen; Qiang Xiang; Heping Xu
TAGS: antibiotics, gastrointestinal microbiome, mice, retinal injuries, wounds and injuries, laser injuries, attenuation, lasers
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):6. https://doi.org/10.1167/iovs.66.9.6

Includes: Supplemental Content

Visual Neuroscience July 2025

Evidence for M 2 Muscarinic Receptor Antagonist Delay of Myopia Development Through Activation of Kir3.4 Channel in the Retina of Guinea Pigs

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Hong Zhou; Guimei Zhou; Qin Yang; Jiahao Niu; Runzhe Wang; Huilan Liu; Suwen Hou; Hongsheng Bi; Xuan Liao
TAGS: antagonists, caviidae, muscarinic acetylcholine receptor, myopia, retina, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):5. https://doi.org/10.1167/iovs.66.9.5

Retina July 2025

Retinal Angiogenesis in Methamphetamine Self-Administration Rats

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Minsup Lee; Bo J. Wood; Hyeon Hak Jeong; Hyung W. Nam; Courtney M. Keller; Bonggi Lee; Jae-Il Kim; Kevin S. Murnane; Nicholas E. Goeders; Norman R. Harris
TAGS: angiogenesis, methamphetamine, rats, self administration, retina, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):8. https://doi.org/10.1167/iovs.66.9.8

Retina July 2025

Fundus Refraction Offset as a Personalized Biomarker for 12-Year Risk of Retinal Detachment

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Fabian Yii; Ian J. C. MacCormick; Niall Strang; Miguel O. Bernabeu; Tom MacGillivray
TAGS: biological markers, refraction, retinal detachment, eye, medical history, uk biobank, sensitivity analysis, cox proportional hazards models, myopia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):1. https://doi.org/10.1167/iovs.66.9.1

Includes: Supplemental Content

Genetics July 2025

A Phenotypic Study of CRB1 Retinopathy Secondary to the Variant p.(Pro836Thr) Prevalent in Those of Black African Ancestry

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Wendy M. Wong; Anthony G. Robson; Rebecca A. Baker; Gavin Arno; Joseph Van Aerschot; Siying Lin; Mariya Moosajee; Michel Michaelides; Omar A. Mahroo; Andrew R. Webster
TAGS: phenotype, retinal diseases, electroretinography, retinal dystrophies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):3. https://doi.org/10.1167/iovs.66.9.3

Includes: Supplemental Content

Retina July 2025

The Impact of Hypertension on Macular Perfusion in Patients With Referable Diabetic Retinopathy: An OCTA Analysis

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Janika Shah; Shinji Kakihara; Anna Busza; Amani A. Fawzi
TAGS: diabetic retinopathy, hypertension, perfusion, eye
Trans. Vis. Sci. Tech.. 2025; 14(7):2. https://doi.org/10.1167/tvst.14.7.2

Artificial Intelligence July 2025

Equitable Deep Learning for Diabetic Retinopathy Detection Using Multidimensional Retinal Imaging With Fair Adaptive Scaling

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Min Shi; Muhammad Muneeb Afzal; Hao Huang; Congcong Wen; Yan Luo; Muhammad Osama Khan; Yu Tian; Leo Kim; Yi Fang; Mengyu Wang
TAGS: datasets, deep learning, diabetic retinopathy, retinal imaging, health disparity, color, scanning laser ophthalmoscopy, gender
Trans. Vis. Sci. Tech.. 2025; 14(7):1. https://doi.org/10.1167/tvst.14.7.1

Includes: Supplemental Content

Retina June 2025

Significant Correlation Between Retinal Blood Flow and Oxygen Saturation During Intravitreal Aflibercept Treatment for Central Retinal Vein Occlusion

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Yukiko Miyoshi; Yuki Nakano; Yuta Koyama; Rie Osaka; Junichiro Akimitsu; Aki Booka; Kiyoshi Suzuma
TAGS: aflibercept, central retinal vein occlusion, oxygen saturation measurement, vascular flow
Trans. Vis. Sci. Tech.. 2025; 14(6):35. https://doi.org/10.1167/tvst.14.6.35

Retina June 2025

Histological Assessment of Foveal Mechanical Instability and Potential Implications for Macular Diseases

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Isabela Martins Melo; Jeffrey D. Messinger; Christine A. Curcio; Rajeev H. Muni
TAGS: body tissue, cysts, eye, fovea centralis, macular disorders, photoreceptors, retina, stability, malignant hyperthermia due to anesthesia, donors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):82. https://doi.org/10.1167/iovs.66.6.82

Includes: Multimedia, Supplemental Content

Biochemistry and Molecular Biology June 2025

The Sialome of the Retina, Alteration in Age-Related Macular Degeneration Pathology, and Potential Impacts on Complement Factor H

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Jaclyn Swan; Christopher B. Toomey; Max Bergstrand; Hector A. Cuello; Jesse Robie; Hai Yu; Yue Yuan; Anoopjit Singh Kooner; Xi Chen; Jutamas Shaughnessy; Sanjay Ram; Ajit Varki; Pascal Gagneux
TAGS: age-related macular degeneration, complement factor h, n-acetylneuraminic acid, pathology, retina, polysaccharides, biological response modifiers, proteins, 3,3-dimethylbutan-1-ol, high pressure liquid chromatography procedure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):81. https://doi.org/10.1167/iovs.66.6.81

Includes: Supplemental Content

Retina June 2025

Increment Thresholds in Retinitis Pigmentosa: Association With Retinal Thickness

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Robert A. Hyde; Jason C. Park; J. Jason McAnany
TAGS: retinitis pigmentosa, fovea centralis, retinal cone, visual fields
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):78. https://doi.org/10.1167/iovs.66.6.78

Artificial Intelligence June 2025

Optic Cup and Disc Segmentation of Fundus Images Using Artificial Intelligence Externally Validated With Optical Coherence Tomography Measurements

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Scott Kinder; Steve McNamara; Christopher Clark; Benjamin Bearce; Upasana Thakuria; Yoga Advaith Veturi; Galia Deitz; Talisa E. de Carlo Forest; Naresh Mandava; Malik Y. Kahook; Praveer Singh; Jayashree Kalpathy-Cramer
TAGS: artificial intelligence, datasets, glaucoma, optic cup, optic disk, optical coherence tomography, training, electronic medical records
Trans. Vis. Sci. Tech.. 2025; 14(6):30. https://doi.org/10.1167/tvst.14.6.30

Includes: Supplemental Content

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Choroidal Features of Cynomolgus Macaques in Relation to Age and Axial Length

Intravenous Sodium Iodate Administration Induces Macula-Specific RPE Damage and Rod-Dominant Apoptosis in the Cynomolgus Monkey

In Vivo Characterization of Bruch’s Membrane Breaks in Neovascular Age-Related Macular Degeneration Using High-Resolution Optical Coherence Tomography

Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length

Hyperreflective Foci in the Ectopic Inner Foveal Layer of Advanced Idiopathic Epiretinal Membranes

Computational evidence for an inverse relationship between retinal and brain complexity

Quantitative Choroidal Analysis of Molecularly Characterized Retinitis Pigmentosa

Diabetes-Induced Dysregulation of Peripapillary and Macular Neurovascular Units

The Gut Microbial System Responds to Retinal Injury and Modulates the Outcomes by Regulating Innate Immune Activation

Evidence for M 2 Muscarinic Receptor Antagonist Delay of Myopia Development Through Activation of Kir3.4 Channel in the Retina of Guinea Pigs

Retinal Angiogenesis in Methamphetamine Self-Administration Rats

Fundus Refraction Offset as a Personalized Biomarker for 12-Year Risk of Retinal Detachment

A Phenotypic Study of CRB1 Retinopathy Secondary to the Variant p.(Pro836Thr) Prevalent in Those of Black African Ancestry

The Impact of Hypertension on Macular Perfusion in Patients With Referable Diabetic Retinopathy: An OCTA Analysis

Equitable Deep Learning for Diabetic Retinopathy Detection Using Multidimensional Retinal Imaging With Fair Adaptive Scaling

Significant Correlation Between Retinal Blood Flow and Oxygen Saturation During Intravitreal Aflibercept Treatment for Central Retinal Vein Occlusion

Histological Assessment of Foveal Mechanical Instability and Potential Implications for Macular Diseases

The Sialome of the Retina, Alteration in Age-Related Macular Degeneration Pathology, and Potential Impacts on Complement Factor H

Increment Thresholds in Retinitis Pigmentosa: Association With Retinal Thickness

Optic Cup and Disc Segmentation of Fundus Images Using Artificial Intelligence Externally Validated With Optical Coherence Tomography Measurements

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