Retina

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Artificial Intelligence January 2025

Noninvasive Anemia Detection and Hemoglobin Estimation from Retinal Images Using Deep Learning: A Scalable Solution for Resource-Limited Settings

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Rehana Khan; Vinod Maseedupally; Kaveri A. Thakoor; Rajiv Raman; Maitreyee Roy
TAGS: anemia, hemoglobin, deep learning, resource-limited settings
Trans. Vis. Sci. Tech.. 2025; 14(1):20. https://doi.org/10.1167/tvst.14.1.20

Includes: Supplemental Content

Retina January 2025

Fundus Autofluorescence Variation in Geographic Atrophy of Age-Related Macular Degeneration: A Clinicopathologic Correlation

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Christine A. Curcio; Jeffrey D. Messinger; Andreas Berlin; Kenneth R. Sloan; D. Scott McLeod; Malia M. Edwards; Jacques Bijon; K. Bailey Freund
TAGS: age-related macular degeneration, age-related macular degeneration, nonexudative, atrophic condition of skin, atrophy, autofluorescence, drusen, fundus autofluorescence imaging, histology, pathology, clinical, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):49. https://doi.org/10.1167/iovs.66.1.49

Includes: Multimedia, Supplemental Content

Perspective January 2025

The Landscape of Vascular Endothelial Growth Factor Inhibition in Retinal Diseases

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Joseph B. Lin; Rajendra S. Apte
TAGS: retinal diseases, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):47. https://doi.org/10.1167/iovs.66.1.47

Retina January 2025

Perfusion Capacity as a Predictive Index for Assessing Visual Functional Recovery in Patients With Idiopathic Epiretinal Membrane

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Jinlian Zhan; Chen Chen; Tong Wang; Qi Zhang; Xia Huang; Lin Lu; Xiujuan Zhao
TAGS: epiretinal membrane, perfusion, postoperative care, preoperative care, recovery of function, retinal vasculature, vision, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(1):19. https://doi.org/10.1167/tvst.14.1.19

Includes: Supplemental Content

Glaucoma January 2025

Using a Theoretical Model to Assess the Impact of Vascular Risk Factors on Autoregulation in the Retina

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Brendan C. Fry; Julia C. Arciero; Croix Gyurek; Amanda Albright; Brent Siesky; Alice Verticchio; Alon Harris
TAGS: fluid flow, homeostasis, intraocular pressure, models, theoretical, regulation, retina, risk factors, vascular flow, alveolar ventilation function, cell respiration
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):42. https://doi.org/10.1167/iovs.66.1.42

Retinal Cell Biology January 2025

Stress Granule Induction in Rat Retinas Damaged by Constant LED Light

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María M. Benedetto; Melisa Malcolm; Manuel G. Bruera; Laura G. Penazzi; Mario E. Guido; María A. Contín; Eduardo Garbarino-Pico
TAGS: retina, stress granules, arsenites, sodium, light exposure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):38. https://doi.org/10.1167/iovs.66.1.38

Includes: Supplemental Content

Retina January 2025

Age- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse

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Yan Wang; Dehuan Xu; Yuhang Zhao; Haiyu Zhu; Xiaoyu Xiu; Haiyan Jiang; Yimei Liu; Ge Shan; Shengzhou Wu
TAGS: mice, proteins, retina, serine, alzheimer's disease, regulation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):36. https://doi.org/10.1167/iovs.66.1.36

Includes: Supplemental Content

Retina January 2025

Visual Performance and Predictive OCT Biomarkers in Epiretinal Membrane Assessment: Beyond Distance Visual Acuity

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Francesco Gelormini; Federico Ricardi; Guglielmo Parisi; Veronica Vallino; Beatrice Ghezzo; Claudia Cucciarelli; Paola Marolo; Maria Vittoria Cicinelli; Andrea Govetto; Mario R. Romano; Enrico Borrelli; Michele Reibaldi
TAGS: biological markers, epiretinal membrane, visual acuity, reading (activity), near visual acuity
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):31. https://doi.org/10.1167/iovs.66.1.31

Physiology and Pharmacology January 2025

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

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Nina Riddell; Melanie J. Murphy; Sania Zahra; Isabella Robertson-Dixon; Sheila G. Crewther
TAGS: eye, lens (device), lens, crystalline, myopia, white light, blue light, refraction, photopsia, electroretinography, weight gain
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):30. https://doi.org/10.1167/iovs.66.1.30

Includes: Supplemental Content

Retina January 2025

A Comprehensive Analysis of Sex-Biased Gene Expression in the Aging Human Retina Through a Combination of Single-Cell and Bulk RNA Sequencing

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Hongling Liu; Xue Zhang; Qing Wang; Bowen Li; Baishijiao Bian; Yong Liu
TAGS: aging, gene expression, genes, retina, rna, small cytoplasmic, sequence analysis, rna, sex characteristics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):28. https://doi.org/10.1167/iovs.66.1.28

Includes: Supplemental Content

Retina January 2025

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

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Katharina Wall; Lilith P. Arend; Leon von der Emde; Marlene Saßmannshausen; Frank G. Holz; Thomas Ach
TAGS: diabetes mellitus, diagnostic imaging, optical coherence tomography, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(1):12. https://doi.org/10.1167/tvst.14.1.12

Retina January 2025

Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy

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Brandon D. Anderson; Brent A. Bell; Ying Song; Timothy T. Lee; Tan Wang; Joshua L. Dunaief
TAGS: age-related macular degeneration, nonexudative, atrophy, injections, iodates, sodium, mice, diagnostic imaging, retina
Trans. Vis. Sci. Tech.. 2025; 14(1):9. https://doi.org/10.1167/tvst.14.1.9

Includes: Supplemental Content

Retina January 2025

Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV

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Federico Corti; Filippo Locri; Flavia Plastino; Paola Perrotta; Krisztina Zsebo; Emma Ristori; Xiangyun Yin; Eric Song; Helder André; Michael Simons
TAGS: antibodies, choroidal neovascularization, edema, inflammation, lasers, mice, syndecan, vascular endothelial growth factor a, anti-vascular endothelial growth factor therapy, intravitreal injections
Trans. Vis. Sci. Tech.. 2025; 14(1):10. https://doi.org/10.1167/tvst.14.1.10

Includes: Supplemental Content

Retina January 2025

Retinal Sensitivity in KCNV2 -Associated Retinopathy

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Thales A. C. de Guimaraes; Isabela M. C. de Guimaraes; Manickam Nick Muthiah; Angelos Kalitzeos; Michel Michaelides
TAGS: retinal diseases, visual acuity, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):26. https://doi.org/10.1167/iovs.66.1.26

Letters to the Editor January 2025

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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Blondy Kayembe Mulumba; Karen Leffondré; Pierre Joly; Marie-Noëlle Delyfer; Cécile Delcourt
TAGS: age-related macular degeneration, genetics, statins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):25. https://doi.org/10.1167/iovs.66.1.25

Retina January 2025

Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis

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Shizhen Lei; Yani Liu
TAGS: gastrointestinal microbiome, genetic correlation analysis, genetics, mendelian randomization analysis, retinal vein occlusion
Trans. Vis. Sci. Tech.. 2025; 14(1):5. https://doi.org/10.1167/tvst.14.1.5

Includes: Supplemental Content

Retina January 2025

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment

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Lisong Wang; Gaocheng Zou; Yuanye Yan; Ronghua Shi; Yue Guo; Mei Zhang; Li Lu; Kai Dong
TAGS: idebenone, mice, oxidative phosphorylation defect, photoreceptors, retinal detachment, body tissue, mitochondria, retina, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):17. https://doi.org/10.1167/iovs.66.1.17

Includes: Supplemental Content

Immunology and Microbiology January 2025

C3aR1-Deletion Delays Retinal Degeneration in a White-Light Damage Mouse Model

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Verena Behnke; Anne Wolf; Mandy Hector; Thomas Langmann
TAGS: anaphylatoxins, mice, retina, retinal degeneration, white light, complement system proteins, complement membrane attack complex
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):15. https://doi.org/10.1167/iovs.66.1.15

Includes: Supplemental Content

Retina January 2025

Slab-Specific Projection-Resolved Optical Coherence Tomography Angiography for Enhancing En Face Polyp Detection in Polypoidal Choroidal Vasculopathy

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Nida Wongchaisuwat; Jie Wang; Tristan T. Hormel; Yali Jia; Elizabeth S. White; Nuttawut Rodanant; Nopasak Phasukkijwatana
TAGS: angiogram, face, polypoidal choroidal vasculopathy, polyps, optical coherence tomography, fluid flow
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):9. https://doi.org/10.1167/iovs.66.1.9

Multidisciplinary Ophthalmic Imaging January 2025

Retinal OCT-Derived Texture Features as Potential Biomarkers for Early Diagnosis and Progression of Diabetic Retinopathy

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Sara Oliveira; Pedro Guimarães; Elisa Julião Campos; Rosa Fernandes; João Martins; Miguel Castelo-Branco; Pedro Serranho; Paulo Matafome; Rui Bernardes; António Francisco Ambrósio
TAGS: biological markers, diabetes mellitus, diabetes mellitus, type 1, diabetic retinopathy, early diagnosis, retina, streptozocin, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):7. https://doi.org/10.1167/iovs.66.1.7

Includes: Supplemental Content

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Noninvasive Anemia Detection and Hemoglobin Estimation from Retinal Images Using Deep Learning: A Scalable Solution for Resource-Limited Settings

Fundus Autofluorescence Variation in Geographic Atrophy of Age-Related Macular Degeneration: A Clinicopathologic Correlation

The Landscape of Vascular Endothelial Growth Factor Inhibition in Retinal Diseases

Perfusion Capacity as a Predictive Index for Assessing Visual Functional Recovery in Patients With Idiopathic Epiretinal Membrane

Using a Theoretical Model to Assess the Impact of Vascular Risk Factors on Autoregulation in the Retina

Stress Granule Induction in Rat Retinas Damaged by Constant LED Light

Age- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse

Visual Performance and Predictive OCT Biomarkers in Epiretinal Membrane Assessment: Beyond Distance Visual Acuity

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

A Comprehensive Analysis of Sex-Biased Gene Expression in the Aging Human Retina Through a Combination of Single-Cell and Bulk RNA Sequencing

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy

Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV

Retinal Sensitivity in KCNV2 -Associated Retinopathy

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment

C3aR1-Deletion Delays Retinal Degeneration in a White-Light Damage Mouse Model

Slab-Specific Projection-Resolved Optical Coherence Tomography Angiography for Enhancing En Face Polyp Detection in Polypoidal Choroidal Vasculopathy

Retinal OCT-Derived Texture Features as Potential Biomarkers for Early Diagnosis and Progression of Diabetic Retinopathy

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