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Multidisciplinary Ophthalmic Imaging April 2021

Early Identification of Retinal Neuropathy in Subclinical Diabetic Eyes by Reduced Birefringence of the Peripapillary Retinal Nerve Fiber Layer

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Andreas Pollreisz; Sylvia Desissaire; Aleksandra Sedova; Dorottya Hajdu; Felix Datlinger; Florian Schwarzhans; Stefan Steiner; Irene Steiner; Clemens Vass; Christoph K. Hitzenberger; Michael Pircher; Ursula Schmidt-Erfurth
TAGS: birefringence, diabetes mellitus, early diagnosis, eye, neuropathy, retinal nerve fiber layer, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):24. doi: https://doi.org/10.1167/iovs.62.4.24

Clinical and Epidemiologic Research April 2021

Higher Serum Uric Acid Levels Are Associated With an Increased Risk of Vision-Threatening Diabetic Retinopathy in Type 2 Diabetes Patients

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Yanan Hu; Zhulin Chan; Chunxia Li; Ya Shi; Xinping She; Chufeng Gu; Yujie Wang; Chuandi Zhou; Shuzhi Zhao; Zhi Zheng; Haibing Chen
TAGS: diabetes mellitus, type 2, diabetic retinopathy, hyperuricemia, urate measurement, serum, uric acid, vision
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):23. doi: https://doi.org/10.1167/iovs.62.4.23

Includes: Supplemental Content

Retinal Cell Biology April 2021

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

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Yi Chen; Binxin Wu; Jian Feng He; Jingyao Chen; Zi Wei Kang; Dandan Liu; Junjie Luo; Kexin Fang; Xiaoxu Leng; Haibin Tian; Jingying Xu; Caixia Jin; Jieping Zhang; Juan Wang; Jingfa Zhang; Qingjian Ou; Lixia Lu; Furong Gao; Guo-Tong Xu
TAGS: epithelial to mesenchymal transition, retinal pigment cell, signal transduction inhibitor, primary eosinophilic endomyocardial cardiomyopathy
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):21. doi: https://doi.org/10.1167/iovs.62.4.21

Includes: Supplemental Content

Article April 2021

Salience of spatiochromatic patterns

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Amanda C. Hardman; Jasna Martinovic
TAGS: color, luminance, perception, photopsia, spatial frequency
Journal of Vision. 2021; 21(4):7. doi: https://doi.org/10.1167/jov.21.4.7

Articles April 2021

Automated Quantification of Pathological Fluids in Neovascular Age-Related Macular Degeneration, and Its Repeatability Using Deep Learning

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Irmela Mantel; Agata Mosinska; Ciara Bergin; Maria Sole Polito; Jacopo Guidotti; Stefanos Apostolopoulos; Carlos Ciller; Sandro De Zanet
TAGS: body fluid, datasets, deep learning, exudative age-related macular degeneration, volume, training, spectral domain-optical coherence tomography, pixel
Trans. Vis. Sci. Tech.. 2021; 10(4):17. doi: https://doi.org/10.1167/tvst.10.4.17

Includes: Supplemental Content

Articles April 2021

Strategies to Improve Convolutional Neural Network Generalizability and Reference Standards for Glaucoma Detection From OCT Scans

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Kaveri A. Thakoor; Xinhui Li; Emmanouil Tsamis; Zane Z. Zemborain; Carlos Gustavo De Moraes; Paul Sajda; Donald C. Hood
TAGS: convolutional neural networks, datasets, glaucoma, reference standards, retinal nerve fiber layer, training, maps
Trans. Vis. Sci. Tech.. 2021; 10(4):16. doi: https://doi.org/10.1167/tvst.10.4.16

Includes: Supplemental Content

Articles April 2021

Longitudinal Development of Refractive Error in Children Treated With Intravitreal Bevacizumab or Laser for Retinopathy of Prematurity

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Michael Simmons; Jingyun Wang; Joel N. Leffler; Shanshan Li; Sarah E. Morale; Angie de la Cruz; Eileen E. Birch
TAGS: anisometropia, bevacizumab, child, lasers, refractive errors, retinopathy of prematurity, visual acuity, myopia, astigmatism
Trans. Vis. Sci. Tech.. 2021; 10(4):14. doi: https://doi.org/10.1167/tvst.10.4.14

Includes: Supplemental Content

Articles April 2021

Can the Macula be Attached if View Is Obscured by a Bullous Retinal Detachment? A Mathematical Consideration

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William E. Smiddy; Lev Kapitanski; Harry W. Flynn
TAGS: macula lutea, mathematics, retina, retinal detachment, fovea centralis
Trans. Vis. Sci. Tech.. 2021; 10(4):13. doi: https://doi.org/10.1167/tvst.10.4.13

Includes: Supplemental Content

Articles April 2021

Evaluating Contrast Sensitivity in Asian Indian Pre-Term Infants With and Without Retinopathy of Prematurity

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Rwituja Thomas; Anand Vinekar; Shwetha Mangalesh; Thirumalesh Basavaraj Mochi; Puja Sarbajna; Bhujang Shetty
TAGS: asian indians, contrast sensitivity, infant, infant, premature, retinopathy of prematurity, visual acuity
Trans. Vis. Sci. Tech.. 2021; 10(4):12. doi: https://doi.org/10.1167/tvst.10.4.12

Includes: Multimedia, Supplemental Content

Articles April 2021

Initiation of L-DOPA Treatment After Detection of Diabetes-Induced Retinal Dysfunction Reverses Retinopathy and Provides Neuroprotection in Rats

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Kyle Chesler; Cara Motz; Harrison Vo; Amber Douglass; Rachael S. Allen; Andrew J. Feola; Machelle T. Pardue
TAGS: diabetes mellitus, levodopa, rats, diabetes mellitus, type 2, dopamine, pathophysiology, retinal diseases, diabetic retinopathy
Trans. Vis. Sci. Tech.. 2021; 10(4):8. doi: https://doi.org/10.1167/tvst.10.4.8

Includes: Supplemental Content

Articles April 2021

Predictive Association of Pre-Operative Defect Areas in the Outer Retinal Layers With Visual Acuity in Macular Hole Surgery

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Carmen Baumann; Danilo Iannetta; Ziyaad Sultan; Ian A. Pearce; Chris P. Lohmann; Yalin Zheng; Stephen B. Kaye
TAGS: embryonic lethal mutation, repair of hole of macula lutea, visual acuity, postoperative care
Trans. Vis. Sci. Tech.. 2021; 10(4):7. doi: https://doi.org/10.1167/tvst.10.4.7

Glaucoma April 2021

Racial Differences in the Rate of Change in Anterior Lamina Cribrosa Surface Depth in the African Descent and Glaucoma Evaluation Study

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Christopher A. Girkin; Akram Belghith; Christopher Bowd; Felipe A. Medeiros; Robert N. Weinreb; Jeffrey M. Liebmann; James A. Proudfoot; Linda M. Zangwill; Massimo A. Fazio
TAGS: cribriform plate, glaucoma, optic disk, racial differences
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):12. doi: https://doi.org/10.1167/iovs.62.4.12

Includes: Supplemental Content

Retina April 2021

Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage

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Balasubramaniam Annamalai; Nathaniel Parsons; Crystal Nicholson; Elisabeth Obert; Bryan Jones; Bärbel Rohrer
TAGS: complement system proteins, familial hypercholesterolemia, family history, mice, adeno-associated virus
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):11. doi: https://doi.org/10.1167/iovs.62.4.11

Glaucoma April 2021

Longitudinal Observation of Border Tissue Configuration During Axial Elongation in Childhood

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Yong Woo Kim; Jin Ju Choi; Michael J. A. Girard; Jean Martial Mari; Dong Gyu Choi; Ki Ho Park
TAGS: body tissue, child, eye, nose
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):10. doi: https://doi.org/10.1167/iovs.62.4.10

Includes: Multimedia, Supplemental Content

Retina April 2021

Radial Peripapillary Capillary Plexus Sparing and Underlying Retinal Vascular Impairment in Intermediate Age-Related Macular Degeneration

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Matt Trinh; Michael Kalloniatis; Lisa Nivison-Smith
TAGS: age-related macular degeneration, blood capillaries, eye, impairment, maps, face, retinal vasculature, tissue degeneration, macula lutea
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):2. doi: https://doi.org/10.1167/iovs.62.4.2

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology March 2021

Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses

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Noriko Nishikawa; Jacqueline Chua; Yuriya Kawaguchi; Tomoko Ro-Mase; Leopold Schmetterer; Yasuo Yanagi; Akitoshi Yoshida
TAGS: amblyopia, amblyopia, pediatric, macular vasculature, magnification, eye
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):39. doi: https://doi.org/10.1167/iovs.62.3.39

Includes: Supplemental Content

Articles March 2021

Ellipsoid Zone Defects in Retinal Vein Occlusion Correlates With Visual Acuity Prognosis: SCORE2 Report 14

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Tyler Etheridge; Ellen T. A. Dobson; Marcel Wiedenmann; Neal Oden; Paul VanVeldhuisen; Ingrid U. Scott; Michael S. Ip; Kevin W. Eliceiri; Barbara A. Blodi; Amitha Domalpally
TAGS: eye, retinal vein occlusion, spectral domain-optical coherence tomography, visual acuity
Trans. Vis. Sci. Tech.. 2021; 10(3):31. doi: https://doi.org/10.1167/tvst.10.3.31

Articles March 2021

Visible Light Optical Coherence Tomography (OCT) Quantifies Subcellular Contributions to Outer Retinal Band 4

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Tingwei Zhang; Aaron M. Kho; Glenn Yiu; Vivek J. Srinivasan
TAGS: optical coherence tomography, visible light, fovea centralis
Trans. Vis. Sci. Tech.. 2021; 10(3):30. doi: https://doi.org/10.1167/tvst.10.3.30

Includes: Multimedia, Supplemental Content

Retina March 2021

Association of Near-Infrared and Short-Wavelength Autofluorescence With the Retinal Sensitivity in Eyes With Resolved Central Serous Chorioretinopathy

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Hirotsugu Soga; Ryo Asaoka; Kazuaki Kadonosono; Maiko Maruyama-Inoue; Nozomi Igarashi; Marie Kitano; Kohdai Kitamoto; Keiko Azuma; Ryo Obata; Tatsuya Inoue
TAGS: autofluorescence, central serous chorioretinopathy, eye, perimetry, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):36. doi: https://doi.org/10.1167/iovs.62.3.36

Articles March 2021

Longitudinal Higher-Order OCT Assessment of Quantitative Fluid Dynamics and the Total Retinal Fluid Index in Neovascular AMD

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Justis P. Ehlers; Julie Clark; Atsuro Uchida; Natalia Figueiredo; Amy Babiuch; Katherine E. Talcott; Leina Lunasco; Thuy K. Le; Xiangyi Meng; Ming Hu; Jamie Reese; Sunil K. Srivastava
TAGS: aflibercept, brolucizumab, exudative age-related macular degeneration, fluid dynamics, volume
Trans. Vis. Sci. Tech.. 2021; 10(3):29. doi: https://doi.org/10.1167/tvst.10.3.29

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Early Identification of Retinal Neuropathy in Subclinical Diabetic Eyes by Reduced Birefringence of the Peripapillary Retinal Nerve Fiber Layer

Higher Serum Uric Acid Levels Are Associated With an Increased Risk of Vision-Threatening Diabetic Retinopathy in Type 2 Diabetes Patients

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

Salience of spatiochromatic patterns

Automated Quantification of Pathological Fluids in Neovascular Age-Related Macular Degeneration, and Its Repeatability Using Deep Learning

Strategies to Improve Convolutional Neural Network Generalizability and Reference Standards for Glaucoma Detection From OCT Scans

Longitudinal Development of Refractive Error in Children Treated With Intravitreal Bevacizumab or Laser for Retinopathy of Prematurity

Can the Macula be Attached if View Is Obscured by a Bullous Retinal Detachment? A Mathematical Consideration

Evaluating Contrast Sensitivity in Asian Indian Pre-Term Infants With and Without Retinopathy of Prematurity

Initiation of L-DOPA Treatment After Detection of Diabetes-Induced Retinal Dysfunction Reverses Retinopathy and Provides Neuroprotection in Rats

Predictive Association of Pre-Operative Defect Areas in the Outer Retinal Layers With Visual Acuity in Macular Hole Surgery

Racial Differences in the Rate of Change in Anterior Lamina Cribrosa Surface Depth in the African Descent and Glaucoma Evaluation Study

Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage

Longitudinal Observation of Border Tissue Configuration During Axial Elongation in Childhood

Radial Peripapillary Capillary Plexus Sparing and Underlying Retinal Vascular Impairment in Intermediate Age-Related Macular Degeneration

Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses

Ellipsoid Zone Defects in Retinal Vein Occlusion Correlates With Visual Acuity Prognosis: SCORE2 Report 14

Visible Light Optical Coherence Tomography (OCT) Quantifies Subcellular Contributions to Outer Retinal Band 4

Association of Near-Infrared and Short-Wavelength Autofluorescence With the Retinal Sensitivity in Eyes With Resolved Central Serous Chorioretinopathy

Longitudinal Higher-Order OCT Assessment of Quantitative Fluid Dynamics and the Total Retinal Fluid Index in Neovascular AMD

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