Retinal Imaging

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Genetics July 2025

A Phenotypic Study of CRB1 Retinopathy Secondary to the Variant p.(Pro836Thr) Prevalent in Those of Black African Ancestry

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Wendy M. Wong; Anthony G. Robson; Rebecca A. Baker; Gavin Arno; Joseph Van Aerschot; Siying Lin; Mariya Moosajee; Michel Michaelides; Omar A. Mahroo; Andrew R. Webster
TAGS: phenotype, retinal diseases, electroretinography, retinal dystrophies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):3. https://doi.org/10.1167/iovs.66.9.3

Includes: Supplemental Content

Retina July 2025

A Method to Evaluate the Frequency Dependence of Retinal Vascular and Neural Metrics to Stimulus Modulation

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Anthony E. Felder; Giri Balasubramanian; Aldo Arroyo; Jason C. Park; Mahnaz Shahidi; J. Jason McAnany
TAGS: photopsia
Trans. Vis. Sci. Tech.. 2025; 14(7):3. https://doi.org/10.1167/tvst.14.7.3

Artificial Intelligence July 2025

Equitable Deep Learning for Diabetic Retinopathy Detection Using Multidimensional Retinal Imaging With Fair Adaptive Scaling

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Min Shi; Muhammad Muneeb Afzal; Hao Huang; Congcong Wen; Yan Luo; Muhammad Osama Khan; Yu Tian; Leo Kim; Yi Fang; Mengyu Wang
TAGS: datasets, deep learning, diabetic retinopathy, retinal imaging, health disparity, color, scanning laser ophthalmoscopy, gender
Trans. Vis. Sci. Tech.. 2025; 14(7):1. https://doi.org/10.1167/tvst.14.7.1

Includes: Supplemental Content

Artificial Intelligence June 2025

Optic Cup and Disc Segmentation of Fundus Images Using Artificial Intelligence Externally Validated With Optical Coherence Tomography Measurements

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Scott Kinder; Steve McNamara; Christopher Clark; Benjamin Bearce; Upasana Thakuria; Yoga Advaith Veturi; Galia Deitz; Talisa E. de Carlo Forest; Naresh Mandava; Malik Y. Kahook; Praveer Singh; Jayashree Kalpathy-Cramer
TAGS: artificial intelligence, datasets, glaucoma, optic cup, optic disk, optical coherence tomography, training, electronic medical records
Trans. Vis. Sci. Tech.. 2025; 14(6):30. https://doi.org/10.1167/tvst.14.6.30

Includes: Supplemental Content

Letters to the Editor June 2025

Advancing Retinal Imaging Interpretation: The Role of Optical Properties and Wavelength Selection

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Jessica Galvan; Mariana Gouveia Bastos Meirelles; Ricardo Luz Leitão Guerra
TAGS: optics, retinal imaging
Trans. Vis. Sci. Tech.. 2025; 14(6):28. https://doi.org/10.1167/tvst.14.6.28

Genetics June 2025

Clinical and Biochemical Characterization of Specific GUCY2D Alleles Associated With a Rare Form of Night Blindness

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Rola Ba-Abbad; Igor V. Peshenko; Malena Daich Varela; Siying Lin; Gavin Arno; Omar A. Mahroo; Catherine Egan; Anthony G. Robson; Elena V. Olshevskaya; Alexander M. Dizhoor; Andrew R. Webster
TAGS: alleles, night blindness, retinal cone, electroretinography, rod photoreceptors, phenotype, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):22. https://doi.org/10.1167/iovs.66.6.22

Includes: Supplemental Content

Genetics June 2025

Investigating the Immunogenic Potential of Variations in Host Cell Protein Levels in Clinical-Grade AAV8 Products

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Immanuel P. Seitz; Eduardo Rodríguez-Bocanegra; Kirsten Bucher; Felix F. Reichel; Stylianos Michalakis; Dimitri Romanovsky; Martin Biel; Bernd Wissinger; Karl-Ulrich Bartz-Schmidt; Tobias Peters; Manuel D. Fischer; on behalf of the RD-CURE Consortium
TAGS: disease vectors, proteins, spatial vectors, cytokine, thp-1 cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):38. https://doi.org/10.1167/iovs.66.6.38

Includes: Supplemental Content

Retina June 2025

Minimizing Pupil Size Dependence in Flicker ERG Using Stiles–Crawford Compensation

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Kumiko Kato; C. Quentin Davis; Nooshin Zeinali; Asako Sugawara; Hisashi Matsubara; Masahiko Sugimoto; Yuzen Kashima; Keitaro Mizumoto; Hidetaka Kudo; Eiichiro Nagasaka; Daphne L. McCulloch; Mineo Kondo
TAGS: electroretinography, photopsia, pupil size, pupil, luminance
Trans. Vis. Sci. Tech.. 2025; 14(6):23. https://doi.org/10.1167/tvst.14.6.23

Includes: Supplemental Content

Retina June 2025

Ocular Characteristics and Genotype-Oriented Disease Spectrum of Alström Syndrome in Taiwan

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Chien-Chien Cheng; Chien-Yu Lin; Ting-Chieh Ko; Yu-Shu Huang; Chu-Hsuan Huang; Chang-Hao Yang; Tzyy-Chang Ho; Pei-Lung Chen; Ta-Ching Chen
TAGS: alstrom syndrome, genotype, taiwan, obesity, electroretinography, massively-parallel genome sequencing, visual impairment
Trans. Vis. Sci. Tech.. 2025; 14(6):22. https://doi.org/10.1167/tvst.14.6.22

Includes: Supplemental Content

Retina June 2025

High-Resolution, Motion-Corrected, Volume-Fused OCT for Investigating Longitudinal Changes in Subretinal Drusenoid Deposits in Intermediate AMD

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Jungeun Won; Antonio Yaghy; Stefan B. Ploner; Stephanie Kaiser; Jessica M. Girgis; Yunchan Hwang; Muhammad Usman Jamil; Andreas Maier; Nadia K. Waheed; James G. Fujimoto
TAGS: face, motion, volume, eye, diagnostic imaging
Trans. Vis. Sci. Tech.. 2025; 14(6):15. https://doi.org/10.1167/tvst.14.6.15

Retina June 2025

Electroretinography With the RM Electrode: Normative Reference Ranges, Variation With Age, and Comparison With the Burian–Allen Electrode

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Brett G. Jeffrey; Xueyang Yin; Christina Appleman; Sobany Suy; Anna Papadogiannis; Daniel Claus; Brian P. Brooks; Marisa Boyle; Laryssa A. Huryn; Wadih M. Zein
TAGS: electroretinography, erg protein, human, reference values
Trans. Vis. Sci. Tech.. 2025; 14(6):13. https://doi.org/10.1167/tvst.14.6.13

Includes: Supplemental Content

Physiology and Pharmacology June 2025

Impact of Second-Generation PDE 5 Inhibitor, Avanafil, on Retinal Function: Studies From Ex Vivo ERG

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Sama Saeid; Frans Vinberg; Ari Koskelainen
TAGS: avanafil, electroretinography, phosphodiesterase 5 inhibitors, rod photoreceptors, phototransduction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):14. https://doi.org/10.1167/iovs.66.6.14

Glaucoma June 2025

Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study

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Louay Almidani; Jasdeep Sabharwal; Anoush Shahidzadeh; Ana Collazo Martinez; Shu Jie Ting; Brinda Vaidya; Xuejuan Jiang; Tim Kowalczyk; Alexa Beiser; Lucia Sobrin; Sudha Seshadri; Pradeep Ramulu; Amir H. Kashani
TAGS: eye, framingham heart study, glaucoma, retinal nerve fiber layer, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(6):7. https://doi.org/10.1167/tvst.14.6.7

Includes: Supplemental Content

Glaucoma June 2025

Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography

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Jie Wang; Karine D. Bojikian; Aiyin Chen; Ping Wei; Liang Liu; Yali Jia; David Huang
TAGS: angiogram, ganglia, optical coherence tomography, nerve fibers
Trans. Vis. Sci. Tech.. 2025; 14(6):5. https://doi.org/10.1167/tvst.14.6.5

Retina May 2025

Clic6 Deficiency Triggers Aberrant Apical Microvilli in RPE

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Sangwan Park; Naran Suvarnpradip; Niusha Kasiri; Glenn Yiu; Sara M. Thomasy; Denise M. Imai; K. C. Kent Lloyd; Brian C. Leonard; Ala Moshiri
TAGS: mice, microvilli, precipitating factors, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):44. https://doi.org/10.1167/iovs.66.5.44

Includes: Supplemental Content

Article May 2025

Characterizing the circularly oriented macular pigment using spatiotemporal sensitivity to structured light entoptic phenomena

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Dmitry A. Pushin; Davis V. Garrad; Connor Kapahi; Andrew E. Silva; Pinki Chahal; David G. Cory; Mukhit Kulmaganbetov; Iman Salehi; Melanie A. Mungalsingh; Taranjit Singh; Benjamin Thompson; Daniel Yu; Dusan Sarenac
TAGS: macular pigment
Journal of Vision. 2025; 25(6):11. https://doi.org/10.1167/jov.25.6.11

Retina May 2025

Peptide Lv Deficiency Adversely Impacts the Structural and Functional Integrity of the Neural Retina

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Kofi Owusu-Ansah; Dylan L. Pham; Brower C. Strong; Lora Liberoni; Travis W. Hein; Lih Kuo; Michael Lee Ko; Gladys Yi-Ping Ko
TAGS: neural retina, peptides, personal integrity, adult, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):37. https://doi.org/10.1167/iovs.66.5.37

Includes: Supplemental Content

Retina May 2025

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases

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Olubayo U. Kolawole; Ethan Bensinger; Jessica Wong; Nicholas Rinella; Katharina G. Foote; Hao Zhou; Ruikang K. Wang; Jacque L. Duncan; Austin Roorda
TAGS: diagnostic imaging, eye, macular disorders, atrophoderma maculatum, retinal cone, fovea centralis, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):18. https://doi.org/10.1167/iovs.66.5.18

Includes: Supplemental Content

Methods May 2025

Distance From the Foveal Center: A Method for the Calculation of Eccentric Fixation

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Thales A. C. de Guimaraes; Angelos Kalitzeos; James Bainbridge; Michel Michaelides
TAGS: eccentric fixation, eye
Trans. Vis. Sci. Tech.. 2025; 14(5):9. https://doi.org/10.1167/tvst.14.5.9

Immunology and Microbiology May 2025

Comparative Efficacy of Interleukin-7 and -15 Blockade in Alleviating Experimental Chronic Uveitis and Suppressing Pathogenic Memory CD4 + T Cells

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Qiurong Zhu; Maryam Shayan; Rachel M. Huckfeldt; Yihe Chen
TAGS: interleukin-15, interleukin-7, memory, t-lymphocytes, uveitis, mice, neutralization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):9. https://doi.org/10.1167/iovs.66.5.9

Includes: Supplemental Content

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A Phenotypic Study of CRB1 Retinopathy Secondary to the Variant p.(Pro836Thr) Prevalent in Those of Black African Ancestry

A Method to Evaluate the Frequency Dependence of Retinal Vascular and Neural Metrics to Stimulus Modulation

Equitable Deep Learning for Diabetic Retinopathy Detection Using Multidimensional Retinal Imaging With Fair Adaptive Scaling

Optic Cup and Disc Segmentation of Fundus Images Using Artificial Intelligence Externally Validated With Optical Coherence Tomography Measurements

Advancing Retinal Imaging Interpretation: The Role of Optical Properties and Wavelength Selection

Clinical and Biochemical Characterization of Specific GUCY2D Alleles Associated With a Rare Form of Night Blindness

Investigating the Immunogenic Potential of Variations in Host Cell Protein Levels in Clinical-Grade AAV8 Products

Minimizing Pupil Size Dependence in Flicker ERG Using Stiles–Crawford Compensation

Ocular Characteristics and Genotype-Oriented Disease Spectrum of Alström Syndrome in Taiwan

High-Resolution, Motion-Corrected, Volume-Fused OCT for Investigating Longitudinal Changes in Subretinal Drusenoid Deposits in Intermediate AMD

Electroretinography With the RM Electrode: Normative Reference Ranges, Variation With Age, and Comparison With the Burian–Allen Electrode

Impact of Second-Generation PDE 5 Inhibitor, Avanafil, on Retinal Function: Studies From Ex Vivo ERG

Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study

Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography

Clic6 Deficiency Triggers Aberrant Apical Microvilli in RPE

Characterizing the circularly oriented macular pigment using spatiotemporal sensitivity to structured light entoptic phenomena

Peptide Lv Deficiency Adversely Impacts the Structural and Functional Integrity of the Neural Retina

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases

Distance From the Foveal Center: A Method for the Calculation of Eccentric Fixation

Comparative Efficacy of Interleukin-7 and -15 Blockade in Alleviating Experimental Chronic Uveitis and Suppressing Pathogenic Memory CD4 + T Cells

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