Translational Research

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Articles April 2021

Corneal Immune Cells Are Increased in Patients With Multiple Sclerosis

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Adnan Khan; Yi Li; Georgios Ponirakis; Naveed Akhtar; Hoda Gad; Pooja George; Faiza M. Ibrahim; Ioannis N. Petropoulos; Beatriz G. Canibano; Dirk Deleu; Ashfaq Shuaib; Saadat Kamran; Rayaz A. Malik
TAGS: cornea, multiple sclerosis, neurons, ciliary motility disorders, multiple sclerosis, relapsing-remitting, microscopy, confocal
Trans. Vis. Sci. Tech.. 2021; 10(4):19. doi: https://doi.org/10.1167/tvst.10.4.19

Articles April 2021

The ROCK Inhibitor Ripasudil Shows an Endothelial Protective Effect in Patients With Low Corneal Endothelial Cell Density After Cataract Surgery

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Hisitaka Fujimoto; Yoshinao Setoguchi; Junichi Kiryu
TAGS: cataract surgery, cornea, endothelial cells, endothelium, surgical procedures, operative, eye, glaucoma
Trans. Vis. Sci. Tech.. 2021; 10(4):18. doi: https://doi.org/10.1167/tvst.10.4.18

Includes: Supplemental Content

Articles April 2021

Automated Quantification of Pathological Fluids in Neovascular Age-Related Macular Degeneration, and Its Repeatability Using Deep Learning

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Irmela Mantel; Agata Mosinska; Ciara Bergin; Maria Sole Polito; Jacopo Guidotti; Stefanos Apostolopoulos; Carlos Ciller; Sandro De Zanet
TAGS: body fluid, datasets, deep learning, exudative age-related macular degeneration, volume, training, spectral domain-optical coherence tomography, pixel
Trans. Vis. Sci. Tech.. 2021; 10(4):17. doi: https://doi.org/10.1167/tvst.10.4.17

Includes: Supplemental Content

Articles April 2021

Strategies to Improve Convolutional Neural Network Generalizability and Reference Standards for Glaucoma Detection From OCT Scans

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Kaveri A. Thakoor; Xinhui Li; Emmanouil Tsamis; Zane Z. Zemborain; Carlos Gustavo De Moraes; Paul Sajda; Donald C. Hood
TAGS: convolutional neural networks, datasets, glaucoma, reference standards, retinal nerve fiber layer, training, maps
Trans. Vis. Sci. Tech.. 2021; 10(4):16. doi: https://doi.org/10.1167/tvst.10.4.16

Includes: Supplemental Content

Articles April 2021

Estimating Ganglion Cell Complex Rates of Change With Bayesian Hierarchical Models

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Vahid Mohammadzadeh; Erica Su; Sepideh Heydar Zadeh; Simon K. Law; Anne L. Coleman; Joseph Caprioli; Robert E. Weiss; Kouros Nouri-Mahdavi
TAGS: eye, ganglia, glaucoma, heterogeneity of variance, trend, inspection
Trans. Vis. Sci. Tech.. 2021; 10(4):15. doi: https://doi.org/10.1167/tvst.10.4.15

Includes: Supplemental Content

Articles April 2021

Longitudinal Development of Refractive Error in Children Treated With Intravitreal Bevacizumab or Laser for Retinopathy of Prematurity

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Michael Simmons; Jingyun Wang; Joel N. Leffler; Shanshan Li; Sarah E. Morale; Angie de la Cruz; Eileen E. Birch
TAGS: anisometropia, bevacizumab, child, lasers, refractive errors, retinopathy of prematurity, visual acuity, myopia, astigmatism
Trans. Vis. Sci. Tech.. 2021; 10(4):14. doi: https://doi.org/10.1167/tvst.10.4.14

Includes: Supplemental Content

Articles April 2021

Can the Macula be Attached if View Is Obscured by a Bullous Retinal Detachment? A Mathematical Consideration

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William E. Smiddy; Lev Kapitanski; Harry W. Flynn
TAGS: macula lutea, mathematics, retina, retinal detachment, fovea centralis
Trans. Vis. Sci. Tech.. 2021; 10(4):13. doi: https://doi.org/10.1167/tvst.10.4.13

Includes: Supplemental Content

Articles April 2021

Evaluating Contrast Sensitivity in Asian Indian Pre-Term Infants With and Without Retinopathy of Prematurity

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Rwituja Thomas; Anand Vinekar; Shwetha Mangalesh; Thirumalesh Basavaraj Mochi; Puja Sarbajna; Bhujang Shetty
TAGS: asian indians, contrast sensitivity, infant, infant, premature, retinopathy of prematurity, visual acuity
Trans. Vis. Sci. Tech.. 2021; 10(4):12. doi: https://doi.org/10.1167/tvst.10.4.12

Includes: Multimedia, Supplemental Content

Articles April 2021

Validation of a Novel Automated Algorithm to Measure Drusen Volume and Area Using Swept Source Optical Coherence Tomography Angiography

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Xiaoshuang Jiang; Mengxi Shen; Liang Wang; Luis de Sisternes; Mary K. Durbin; William Feuer; Philip J. Rosenfeld; Giovanni Gregori
TAGS: angiogram, drusen, optical coherence tomography, volume, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2021; 10(4):11. doi: https://doi.org/10.1167/tvst.10.4.11

Articles April 2021

Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome

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María Jesús Muniesa; Iván Benítez; Juan Ezpeleta; Manuel Sánchez de la Torre; Marta Pazos; Elena Millà; Ferrán Barbé
TAGS: contact lenses, continuous positive airway pressure, intraocular pressure, obstructive sleep apnea, sensor, night time
Trans. Vis. Sci. Tech.. 2021; 10(4):10. doi: https://doi.org/10.1167/tvst.10.4.10

Articles April 2021

Durability of VEGF Suppression With Intravitreal Aflibercept and Brolucizumab: Using Pharmacokinetic Modeling to Understand Clinical Outcomes

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Thomas Eissing; Michael W. Stewart; Cynthia X. Qian; Kay D. Rittenhouse
TAGS: aflibercept, anti-vascular endothelial growth factor therapy, brolucizumab, vascular endothelial growth factor a, treatment outcome, vitreous body, half-life, molar tooth
Trans. Vis. Sci. Tech.. 2021; 10(4):9. doi: https://doi.org/10.1167/tvst.10.4.9

Includes: Supplemental Content

Articles April 2021

Initiation of L-DOPA Treatment After Detection of Diabetes-Induced Retinal Dysfunction Reverses Retinopathy and Provides Neuroprotection in Rats

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Kyle Chesler; Cara Motz; Harrison Vo; Amber Douglass; Rachael S. Allen; Andrew J. Feola; Machelle T. Pardue
TAGS: diabetes mellitus, levodopa, rats, diabetes mellitus, type 2, dopamine, pathophysiology, retinal diseases, diabetic retinopathy
Trans. Vis. Sci. Tech.. 2021; 10(4):8. doi: https://doi.org/10.1167/tvst.10.4.8

Includes: Supplemental Content

Articles April 2021

Predictive Association of Pre-Operative Defect Areas in the Outer Retinal Layers With Visual Acuity in Macular Hole Surgery

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Carmen Baumann; Danilo Iannetta; Ziyaad Sultan; Ian A. Pearce; Chris P. Lohmann; Yalin Zheng; Stephen B. Kaye
TAGS: embryonic lethal mutation, repair of hole of macula lutea, visual acuity, postoperative care
Trans. Vis. Sci. Tech.. 2021; 10(4):7. doi: https://doi.org/10.1167/tvst.10.4.7

Articles April 2021

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

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Fumihito Hikage; Yosuke Ida; Yuika Ouchi; Megumi Watanabe; Hiroshi Ohguro
TAGS: agonists, fibroblasts, organoids, prostaglandins
Trans. Vis. Sci. Tech.. 2021; 10(4):6. doi: https://doi.org/10.1167/tvst.10.4.6

Includes: Supplemental Content

Articles April 2021

Association Between the Types of Posterior Staphyloma and Their Risk Factors in Pathological Myopia

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Guangqi An; Fangfang Dai; Rui Wang; Zhenhui Liu; Ju Guo; Meng Pan; Xuemin Jin; Bo Lei
TAGS: 3d mri, eye, myopia, risk factors, staphyloma, shape
Trans. Vis. Sci. Tech.. 2021; 10(4):5. doi: https://doi.org/10.1167/tvst.10.4.5

Methods April 2021

Low-Cost, Smartphone-Based Specular Imaging and Automated Analysis of the Corneal Endothelium

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Sreekar Mantena; Jay Chandra; Eryk Pecyna; Andrew Zhang; Dominic Garrity; Stephan Ong Tone; Srinivas Sastry; Madhu Uddaraju; Ula V. Jurkunas
TAGS: cell phones, corneal endothelium, diagnostic imaging, microscopes
Trans. Vis. Sci. Tech.. 2021; 10(4):4. doi: https://doi.org/10.1167/tvst.10.4.4

Includes: Supplemental Content

Review April 2021

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

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Ying Kai Chan; Andrew D. Dick; Sara Mary Hall; Thomas Langmann; Curtis L. Scribner; Brian C. Mansfield; for the Ocular Gene Therapy Inflammation Working Group
TAGS: blindness, gene therapy, inflammation, spatial vectors, disease vectors
Trans. Vis. Sci. Tech.. 2021; 10(4):3. doi: https://doi.org/10.1167/tvst.10.4.3

Articles April 2021

Intraocular Pressure Reduction Effect of 0.005% Latanoprost Eye Drops in a Hyaluronic Acid-Chitosan Nanoparticle Drug Delivery System in Albino Rabbits

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Ana Marie L. Rubenicia; Leo D. P. Cubillan; Victor Arni D. P. Sicam; Allan Patrick G. Macabeo; Oliver B. Villaflores; Agnes L. Castillo
TAGS: albinism, eyedrops, intraocular pressure, latanoprost, oryctolagus cuniculus, chitosan, drug delivery systems, nanoparticles
Trans. Vis. Sci. Tech.. 2021; 10(4):2. doi: https://doi.org/10.1167/tvst.10.4.2

Includes: Supplemental Content

Articles April 2021

Developmental Effects on Pattern Visual Evoked Potentials Characterized by Principal Component Analysis

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Carlyn Patterson Gentile; Nabin R. Joshi; Kenneth J. Ciuffreda; Kristy B. Arbogast; Christina Master; Geoffrey K. Aguirre
TAGS: evoked potentials, visual, principal component analysis, datasets, cohort studies, reliability
Trans. Vis. Sci. Tech.. 2021; 10(4):1. doi: https://doi.org/10.1167/tvst.10.4.1

Includes: Supplemental Content

Articles March 2021

Ellipsoid Zone Defects in Retinal Vein Occlusion Correlates With Visual Acuity Prognosis: SCORE2 Report 14

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Tyler Etheridge; Ellen T. A. Dobson; Marcel Wiedenmann; Neal Oden; Paul VanVeldhuisen; Ingrid U. Scott; Michael S. Ip; Kevin W. Eliceiri; Barbara A. Blodi; Amitha Domalpally
TAGS: eye, retinal vein occlusion, spectral domain-optical coherence tomography, visual acuity
Trans. Vis. Sci. Tech.. 2021; 10(3):31. doi: https://doi.org/10.1167/tvst.10.3.31

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Corneal Immune Cells Are Increased in Patients With Multiple Sclerosis

The ROCK Inhibitor Ripasudil Shows an Endothelial Protective Effect in Patients With Low Corneal Endothelial Cell Density After Cataract Surgery

Automated Quantification of Pathological Fluids in Neovascular Age-Related Macular Degeneration, and Its Repeatability Using Deep Learning

Strategies to Improve Convolutional Neural Network Generalizability and Reference Standards for Glaucoma Detection From OCT Scans

Estimating Ganglion Cell Complex Rates of Change With Bayesian Hierarchical Models

Longitudinal Development of Refractive Error in Children Treated With Intravitreal Bevacizumab or Laser for Retinopathy of Prematurity

Can the Macula be Attached if View Is Obscured by a Bullous Retinal Detachment? A Mathematical Consideration

Evaluating Contrast Sensitivity in Asian Indian Pre-Term Infants With and Without Retinopathy of Prematurity

Validation of a Novel Automated Algorithm to Measure Drusen Volume and Area Using Swept Source Optical Coherence Tomography Angiography

Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome

Durability of VEGF Suppression With Intravitreal Aflibercept and Brolucizumab: Using Pharmacokinetic Modeling to Understand Clinical Outcomes

Initiation of L-DOPA Treatment After Detection of Diabetes-Induced Retinal Dysfunction Reverses Retinopathy and Provides Neuroprotection in Rats

Predictive Association of Pre-Operative Defect Areas in the Outer Retinal Layers With Visual Acuity in Macular Hole Surgery

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

Association Between the Types of Posterior Staphyloma and Their Risk Factors in Pathological Myopia

Low-Cost, Smartphone-Based Specular Imaging and Automated Analysis of the Corneal Endothelium

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

Intraocular Pressure Reduction Effect of 0.005% Latanoprost Eye Drops in a Hyaluronic Acid-Chitosan Nanoparticle Drug Delivery System in Albino Rabbits

Developmental Effects on Pattern Visual Evoked Potentials Characterized by Principal Component Analysis

Ellipsoid Zone Defects in Retinal Vein Occlusion Correlates With Visual Acuity Prognosis: SCORE2 Report 14

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