Vitreous Disorders

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Anatomy and Pathology/Oncology March 2025

Vitreous Fibrillar Structure and Interfibrillar Composition in Adult Mice

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Patricia Jaramillo-Garcés; Judit Pampalona; Ana Carretero; Eduard José Cunilleras; David Ramos; Jesús Ruberte
TAGS: fibril, mice, vitreous body, adult
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):60. https://doi.org/10.1167/iovs.66.3.60

Includes: Supplemental Content

Immunology and Microbiology March 2025

An Approach to Predict Intraocular Diseases by Machine Learning Based on Vitreous Humor Immune Mediator Profile

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Risa Sugawara; Yoshihiko Usui; Akira Saito; Naoya Nezu; Hiroyuki Komatsu; Kinya Tsubota; Masaki Asakage; Naoyuki Yamakawa; Yoshihiro Wakabayashi; Masahiro Sugimoto; Masahiko Kuroda; Hiroshi Goto
TAGS: biological response modifiers, immune mediator, machine learning, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):38. https://doi.org/10.1167/iovs.66.3.38

Clinical and Epidemiologic Research February 2025

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

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Ying-Yi Chen; Chung-May Yang; Chang-Hao Yang; Tzyy-Chang Ho; Yi-Ting Hsieh; Tso-Ting Lai; Tzu-Hsun Tsai; Shu-Yi Huang
TAGS: ceramides, vitreous body, diabetic retinopathy, proliferative diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):28. https://doi.org/10.1167/iovs.66.2.28

Genetics February 2025

Gene Variant Spectrum in Probands With Familial Exudative Vitreoretinopathy Using an Expanded Panel

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Sarah van der Ende; Karen Bedard; Karin Wallace; Michael P. Mackley; Mathew Nightingale; Daniel Gaston; M. Jill Beis; Marissa A. Leblanc; Roxanne Gillett; Alex V. Levin; Ian H. Clark; Élise Héon; Rajeev H. Muni; Elias I. Traboulsi; Christopher J. Lyons; Christopher R. McMaster; Johane M. Robitaille; on behalf of The FEVR Consortium
TAGS: familial exudative vitreoretinopathies, genes, proband
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):23. https://doi.org/10.1167/iovs.66.2.23

Includes: Supplemental Content

Genetics February 2025

Genotype–Phenotype Spectrum of eyeGENE Patients With Familial Exudative Vitreoretinopathy: Novel Variants in Norrin/β-Catenin Signaling Pathway Genes

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Fulya Yaylacıoğlu Tuncay; Melissa J. Reeves; Sairah Yousaf; Ehsan Ullah; Bin Guan; Kerry E. Goetz; Santa J. Tumminia; Robert B. Hufnagel
TAGS: cohort studies, familial exudative vitreoretinopathies, genes, genotype, phenotype, signal pathway, signal transduction pathways, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):9. https://doi.org/10.1167/iovs.66.2.9

Includes: Supplemental Content

Letters to the Editor December 2024

Letter to the Editor: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

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Yang Pan; Takeshi Iwata
TAGS: age-related macular degeneration, genetic risk, htra1 gene, proteins, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):27. https://doi.org/10.1167/iovs.65.14.27

Letters to the Editor December 2024

Author Response: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

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Brandi L. Williams; Moussa A. Zouache; Gregory S. Hageman
TAGS: age-related macular degeneration, genetic risk, htra1 gene, proteins, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):26. https://doi.org/10.1167/iovs.65.14.26

Retina December 2024

Epiretinal Membrane: Correlations Among Clinical, Immunohistochemical, and Biochemical Features and Their Prognostic Implications

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Hyun Seung Yang; Suho Choi; Soojin Kim; Chan Hong Min; Dongwoo Kim; Youngseop Lee; Minji Kim; Donghoon Koo; Jaiyoung Ryu; Jeongmin Kim
TAGS: body tissue, cytokine, epiretinal membrane, patient prognosis, postoperative care, preoperative care, prognostic factors, surgical procedures, operative, n-cadherins, proteins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):25. https://doi.org/10.1167/iovs.65.14.25

Physiology and Pharmacology November 2024

Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

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Sabrina Wohlfart; Jonathan Herth; Manuel Ben Böhmann; Giulia Pander; Lorenz Herbster; Walter Mier; Gerd Uwe Auffarth; Philipp Uhl; Maximilian Hammer
TAGS: antibodies, anti-vascular endothelial growth factor therapy, bevacizumab, silicone oils, trastuzumab, vascular endothelial growth factor a, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):56. https://doi.org/10.1167/iovs.65.13.56

Includes: Supplemental Content

Immunology and Microbiology November 2024

Age-Associated Alterations in the Metabolome of Human Vitreous in Bacterial Endophthalmitis

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Sreyasi Maiti; Lakshminarayanan Gowtham; Dhanwini Rudraprasad; Vivek P. Dave; Joveeta Joseph
TAGS: bacterial endophthalmitis, endophthalmitis, metabolic disturbance, metabolites, metabolome, vitreous body, metabolomics, older adult
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):6. https://doi.org/10.1167/iovs.65.13.6

Includes: Supplemental Content

Article November 2024

Ocular biometric responses to simulated polychromatic defocus

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Sowmya Ravikumar; Elise N. Harb; Karen E. Molina; Sarah E. Singh; Joel Segre; Christine F. Wildsoet
TAGS: biometry, color, eye
Journal of Vision. 2024; 24(12):3. https://doi.org/10.1167/jov.24.12.3

Includes: Supplemental Content

Retina November 2024

Midperipheral Microvascular Defects and Their Associations With Vitreoretinal Abnormalities in Early-Stage Familial Exudative Vitreoretinopathy

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Juan Zhang; Lu Ruan; Chen Jiang; Qian Yang; Qing Chang; Xin Huang
TAGS: familial exudative vitreoretinopathies
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):4. https://doi.org/10.1167/iovs.65.13.4

Includes: Supplemental Content

Retina October 2024

Preoperative Widefield Swept-Source Optical Coherence Tomography Versus Intraoperative Findings in Detecting Posterior Vitreous Detachment

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Zhuangling Lin; Kai Gao; Rebiya Tuxun; Chin-Ling Tsai; Zhuojun Xu; Lan Jiang; Yaping Liu; Ziye Chen; Zitong Chen; Baoyi Liu; Yuan Ma; Xiaoyue Wei; Kunbei Lai; Tao Li
TAGS: epiretinal membrane, intraoperative care, macular holes, optical coherence tomography, preoperative care, surgical procedures, operative, vitreous body, vitreous detachment, eye
Trans. Vis. Sci. Tech.. 2024; 13(10):39. https://doi.org/10.1167/tvst.13.10.39

Includes: Supplemental Content

Retina October 2024

A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location

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Patricia Lamirande; Eamonn A. Gaffney; Michael Gertz; Philip K. Maini; Jessica R. Crawshaw; Antonello Caruso
TAGS: drug delivery systems, eye, injections, vitreous body, immunoglobulin g, molecule, drug elimination routes, drug excretion
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):21. https://doi.org/10.1167/iovs.65.12.21

Includes: Supplemental Content

Retina October 2024

Method for Quantitative Analysis of Vitreoretinal Adhesion in Ex Vivo Model

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Tara Suresh; Lauren Ong; Christopher B. Marotta; Will Keller; Dan Schwartz; Frank Brodie
TAGS: adhesions, plasmin, vitreous detachment
Trans. Vis. Sci. Tech.. 2024; 13(10):3. https://doi.org/10.1167/tvst.13.10.3

Retina September 2024

Efficacy of Foldable Capsular Vitreous Body Implants Filled With Light or Heavy Silicone Oil in the Treatment of Silicone Oil-dependent Eyes

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Haomin Lu; Yanan Shen; Pan Fan; Minghao Sun; Zhongyu Zhang; Bo Jiang; Dawei Sun
TAGS: eye, implants, postoperative care, silicone oils, silicones, vitreous body, postoperative complications, intraocular pressure, surgical procedures, operative, ocular trauma
Trans. Vis. Sci. Tech.. 2024; 13(9):2. https://doi.org/10.1167/tvst.13.9.2

Retina July 2024

Colorimetric Analyses of the Optic Nerve Head and Retina Indicate Increased Blood Flow After Vitrectomy

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Onur İnam; Ayman El-Baz; Henry J. Kaplan; Tongalp H. Tezel
TAGS: optic disk, retina, vascular flow, vitrectomy, perfusion, color, postoperative care
Trans. Vis. Sci. Tech.. 2024; 13(7):12. https://doi.org/10.1167/tvst.13.7.12

Retina July 2024

Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils

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Maximilian Hammer; Marcel Muuss; Lorenz Herbster; Jonathan Herth; Alexander Scheuerle; Ramin Khoramnia; Grzegorz Łabuz; Philipp Uhl; Gerd Uwe Auffarth
TAGS: aging, gel, hydrogels, injections, optics, silicone oils, suidae, surgical procedures, operative, vitreous body, tetracycline
Trans. Vis. Sci. Tech.. 2024; 13(7):5. https://doi.org/10.1167/tvst.13.7.5

Anatomy and Pathology/Oncology June 2024

Aqueous VEGF-A Levels as a Liquid Biopsy Biomarker of Retinoblastoma Vitreous Seed Response to Therapy

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Anthony B. Daniels; Kamakshi L. Sishtla; Carley M. Bogan; Janene M. Pierce; Sheau-Chiann Chen; Liya Xu; Jesse L. Berry; Timothy W. Corson
TAGS: biological markers, eye, oryctolagus cuniculus, retinoblastoma, seeds, vascular endothelial growth factor a, vitreous body, chemotherapy regimen, aqueous humor, transplantation, heterologous
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):18. https://doi.org/10.1167/iovs.65.6.18

Includes: Supplemental Content

Retina May 2024

Complement Cascade 8 - Alpha and Calpain-2 in Extracellular Vesicles of Human Vitreous as Biomarkers of Infectious Endophthalmitis

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Dhanwini Rudraprasad; Velmurugan K; Jayabalan Nirmal; Md. Hasnat Ali; Joveeta Joseph
TAGS: bacterial endophthalmitis, biological markers, calpain, complement system proteins, endophthalmitis, extracellular vesicles, vitreous body
Trans. Vis. Sci. Tech.. 2024; 13(5):14. https://doi.org/10.1167/tvst.13.5.14

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Vitreous Fibrillar Structure and Interfibrillar Composition in Adult Mice

An Approach to Predict Intraocular Diseases by Machine Learning Based on Vitreous Humor Immune Mediator Profile

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

Gene Variant Spectrum in Probands With Familial Exudative Vitreoretinopathy Using an Expanded Panel

Genotype–Phenotype Spectrum of eyeGENE Patients With Familial Exudative Vitreoretinopathy: Novel Variants in Norrin/β-Catenin Signaling Pathway Genes

Letter to the Editor: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

Author Response: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

Epiretinal Membrane: Correlations Among Clinical, Immunohistochemical, and Biochemical Features and Their Prognostic Implications

Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

Age-Associated Alterations in the Metabolome of Human Vitreous in Bacterial Endophthalmitis

Ocular biometric responses to simulated polychromatic defocus

Midperipheral Microvascular Defects and Their Associations With Vitreoretinal Abnormalities in Early-Stage Familial Exudative Vitreoretinopathy

Preoperative Widefield Swept-Source Optical Coherence Tomography Versus Intraoperative Findings in Detecting Posterior Vitreous Detachment

A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location

Method for Quantitative Analysis of Vitreoretinal Adhesion in Ex Vivo Model

Efficacy of Foldable Capsular Vitreous Body Implants Filled With Light or Heavy Silicone Oil in the Treatment of Silicone Oil-dependent Eyes

Colorimetric Analyses of the Optic Nerve Head and Retina Indicate Increased Blood Flow After Vitrectomy

Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils

Aqueous VEGF-A Levels as a Liquid Biopsy Biomarker of Retinoblastoma Vitreous Seed Response to Therapy

Complement Cascade 8 - Alpha and Calpain-2 in Extracellular Vesicles of Human Vitreous as Biomarkers of Infectious Endophthalmitis

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